LUM (lumican)

2004-05-01  

Identity

HGNC
LOCATION
12q21.33
LOCUSID
ALIAS
LDC,SLRR2D
FUSION GENES

Other Information

Locus ID:

NCBI: 4060
MIM: 600616
HGNC: 6724
Ensembl: ENSG00000139329

Variants:

dbSNP: 4060
ClinVar: 4060
TCGA: ENSG00000139329
COSMIC: LUM

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000139329ENST00000266718P51884
ENSG00000139329ENST00000266718A0A384N669

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Proteoglycans in cancerKEGGhsa05205
Proteoglycans in cancerKEGGko05205
DiseaseREACTOMER-HSA-1643685
Diseases of glycosylationREACTOMER-HSA-3781865
Diseases associated with glycosaminoglycan metabolismREACTOMER-HSA-3560782
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)REACTOMER-HSA-3656244
Defective CHST6 causes MCDC1REACTOMER-HSA-3656225
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Glycosaminoglycan metabolismREACTOMER-HSA-1630316
Keratan sulfate/keratin metabolismREACTOMER-HSA-1638074
Keratan sulfate biosynthesisREACTOMER-HSA-2022854
Keratan sulfate degradationREACTOMER-HSA-2022857
Extracellular matrix organizationREACTOMER-HSA-1474244
ECM proteoglycansREACTOMER-HSA-3000178
Integrin cell surface interactionsREACTOMER-HSA-216083
Defective ST3GAL3 causes MCT12 and EIEE15REACTOMER-HSA-3656243

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
193308632009Differential expression of lumican and fatty acid binding protein-1: new insights into the histologic spectrum of nonalcoholic fatty liver disease.48
190082262009Homologous sequence in lumican and fibromodulin leucine-rich repeat 5-7 competes for collagen binding.38
151498592004The small leucine-rich proteoglycan lumican inhibits melanoma progression.34
186206072008Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues.34
195691802010Identification of cisplatin-resistance related genes in head and neck squamous cell carcinoma.33
214210732011Lumican regulates osteosarcoma cell adhesion by modulating TGFβ2 activity.29
248042152014Extracellular matrix proteins expression profiling in chemoresistant variants of the A2780 ovarian cancer cell line.26
263516692015TNF-α-stimulated fibroblasts secrete lumican to promote fibrocyte differentiation.26
169024022006The association of single nucleotide polymorphisms in the 5'-regulatory region of the lumican gene with susceptibility to high myopia in Taiwan.25

Citation

Dessen P

LUM (lumican)

Atlas Genet Cytogenet Oncol Haematol. 2004-05-01

Online version: http://atlasgeneticsoncology.org/gene/254/lum