LVRN (laeverin)

2015-06-01  

Identity

HGNC
LVRN
LOCATION
5q23.1
LOCUSID
206338
ALIAS
APQ,AQPEP,TAQPEP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 206338
MIM: 610046
HGNC: 26904
Ensembl: ENSG00000172901

Variants:

dbSNP: 206338
ClinVar: 206338
TCGA: ENSG00000172901
COSMIC: LVRN

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172901ENST00000357872Q6Q4G3
ENSG00000172901ENST00000395528A0A0A0MS63
ENSG00000172901ENST00000503329Q6Q4G3
ENSG00000172901ENST00000504467Q6Q4G3
ENSG00000172901ENST00000512314Q6Q4G3
ENSG00000172901ENST00000514509Q6Q4G3

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
195788762009The ERAP2 gene is associated with preeclampsia in Australian and Norwegian populations.39
168048652006Identification of genes modulated in rheumatoid arthritis using complementary DNA microarray analysis of lymphoblastoid B cell lines from disease-discordant monozygotic twins.36
175251582007Laeverin/aminopeptidase Q, a novel bestatin-sensitive leucine aminopeptidase belonging to the M1 family of aminopeptidases.11
147066362004Human extravillous trophoblasts express laeverin, a novel protein that belongs to membrane-bound gluzincin metallopeptidases.10
158970202005Regulation of human extravillous trophoblast function by membrane-bound peptidases.10
224022062012Laeverin/aminopeptidase Q induces trophoblast invasion during human early placentation.7
249596552014Placental expression of aminopeptidase-Q (laeverin) and its role in the pathophysiology of preeclampsia.4
198198732009Histidine 379 of human laeverin/aminopeptidase Q, a nonconserved residue within the exopeptidase motif, defines its distinctive enzymatic properties.2
212125122011Involvement of glutamine-238 in the substrate specificity of human laeverin/aminopeptidase Q.0

Citation

Dessen P

LVRN (laeverin)

Atlas Genet Cytogenet Oncol Haematol. 2015-06-01

Online version: http://atlasgeneticsoncology.org/gene/77616/lvrn