LY9 (lymphocyte antigen 9)

2014-10-01  

Identity

HGNC
LY9
LOCATION
1q23.3
LOCUSID
4063
ALIAS
CD229,SLAMF3,hly9,mLY9

Other Information

Locus ID:

NCBI: 4063
MIM: 600684
HGNC: 6730
Ensembl: ENSG00000122224

Variants:

dbSNP: 4063
ClinVar: 4063
TCGA: ENSG00000122224
COSMIC: LY9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122224ENST00000263285Q9HBG7
ENSG00000122224ENST00000368035Q5VYI1
ENSG00000122224ENST00000368037Q9HBG7
ENSG00000122224ENST00000368039A0A0C4DFU4
ENSG00000122224ENST00000392203Q5VYH9
ENSG00000122224ENST00000474998V9GY30
ENSG00000122224ENST00000490902R4GNG7

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
182168652008Association of LY9 in UK and Canadian SLE families.30
182168652008Association of LY9 in UK and Canadian SLE families.30
159055462005CD229 (Ly9) lymphocyte cell surface receptor interacts homophilically through its N-terminal domain and relocalizes to the immunological synapse.29
202374962010New genetic associations detected in a host response study to hepatitis B vaccine.27
221847272012Increased expression of SLAM receptors SLAMF3 and SLAMF6 in systemic lupus erythematosus T lymphocytes promotes Th17 differentiation.26
158790902005Identification of Grb2 as a novel binding partner of the signaling lymphocytic activation molecule-associated protein binding receptor CD229.15
216061602011Surface molecule CD229 as a novel target for the diagnosis and treatment of multiple myeloma.12
239564182013Systemic lupus erythematosus immune complexes increase the expression of SLAM family members CD319 (CRACC) and CD229 (LY-9) on plasmacytoid dendritic cells and CD319 on CD56(dim) NK cells.9
229898742012CD3-T cell receptor co-stimulation through SLAMF3 and SLAMF6 receptors enhances RORγt recruitment to the IL17A promoter in human T lymphocytes.7
262219722015A polymorphism in a phosphotyrosine signalling motif of CD229 (Ly9, SLAMF3) alters SH2 domain binding and T-cell activation.6

Citation

Dessen P

LY9 (lymphocyte antigen 9)

Atlas Genet Cytogenet Oncol Haematol. 2014-10-01

Online version: http://atlasgeneticsoncology.org/gene/54925/ly9