LYNX1 (Ly6/neurotoxin 1)

2007-02-01  

Identity

HGNC
LYNX1
LOCATION
8q24.3
LOCUSID
66004
ALIAS
-

Other Information

Locus ID:

NCBI: 66004
MIM: 606110
HGNC: 29604
Ensembl: ENSG00000180155

Variants:

dbSNP: 66004
ClinVar: 66004
TCGA: ENSG00000180155
COSMIC: LYNX1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000180155ENST00000613110A0A087WYG6
ENSG00000180155ENST00000614268A0A087WZS0
ENSG00000180155ENST00000614491P0DP58
ENSG00000180155ENST00000620006P0DP58
ENSG00000180155ENST00000621401P0DP58
ENSG00000180155ENST00000652477P0DP58

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
185595152008Activated cholinergic signaling provides a target in squamous cell lung carcinoma.48
212522362011NMR structure and action on nicotinic acetylcholine receptors of water-soluble domain of human LYNX1.30
235855712013Water-soluble LYNX1 residues important for interaction with muscle-type and/or neuronal nicotinic receptors.21
255718742015Aberrant NMDA receptor DNA methylation detected by epigenome-wide analysis of hippocampus and prefrontal cortex in major depression.13
196391802009Metastatic effect of LY-6K gene in breast cancer cells.11
260255032015Role of Lynx1 and related Ly6 proteins as modulators of cholinergic signaling in normal and neoplastic bronchial epithelium.9
170890392006LY-6K gene: a novel molecular marker for human breast cancer.8
260334902015Transcriptional regulation of SLURP2, a psoriasis-associated gene, is under control of IL-22 in the skin: A special reference to the nested gene LYNX1.8
292068812017Deletion of lynx1 reduces the function of α6* nicotinic receptors.3

Citation

Dessen P

LYNX1 (Ly6/neurotoxin 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43968/lynx1