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LYPLA1 (lysophospholipase I)

Identity

Alias_symbol (synonym)LPL1
Other aliasAPT-1
APT1
LPL-I
hAPT1
HGNC (Hugo) LYPLA1
LocusID (NCBI) 10434
Atlas_Id 53380
Location 8q11.23  [Link to chromosome band 8q11]
Location_base_pair Starts at 54046367 and ends at 54102017 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ADAMTSL3 (15q25.2) / LYPLA1 (8q11.23)LYPLA1 (8q11.23) / PFKP (10p15.2)SSSCA1 (11q13.1) / LYPLA1 (8q11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LYPLA1   6737
Cards
Entrez_Gene (NCBI)LYPLA1  10434  lysophospholipase I
AliasesAPT-1; APT1; LPL-I; LPL1; 
hAPT1
GeneCards (Weizmann)LYPLA1
Ensembl hg19 (Hinxton)ENSG00000120992 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000120992 [Gene_View]  chr8:54046367-54102017 [Contig_View]  LYPLA1 [Vega]
ICGC DataPortalENSG00000120992
TCGA cBioPortalLYPLA1
AceView (NCBI)LYPLA1
Genatlas (Paris)LYPLA1
WikiGenes10434
SOURCE (Princeton)LYPLA1
Genetics Home Reference (NIH)LYPLA1
Genomic and cartography
GoldenPath hg38 (UCSC)LYPLA1  -     chr8:54046367-54102017 -  8q11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LYPLA1  -     8q11.23   [Description]    (hg19-Feb_2009)
EnsemblLYPLA1 - 8q11.23 [CytoView hg19]  LYPLA1 - 8q11.23 [CytoView hg38]
Mapping of homologs : NCBILYPLA1 [Mapview hg19]  LYPLA1 [Mapview hg38]
OMIM605599   
Gene and transcription
Genbank (Entrez)AA307642 AA827237 AF035293 AF052112 AF077198
RefSeq transcript (Entrez)NM_001279356 NM_001279357 NM_001279358 NM_001279359 NM_001279360 NM_006330
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LYPLA1
Cluster EST : UnigeneHs.744046 [ NCBI ]
CGAP (NCI)Hs.744046
Alternative Splicing GalleryENSG00000120992
Gene ExpressionLYPLA1 [ NCBI-GEO ]   LYPLA1 [ EBI - ARRAY_EXPRESS ]   LYPLA1 [ SEEK ]   LYPLA1 [ MEM ]
Gene Expression Viewer (FireBrowse)LYPLA1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10434
GTEX Portal (Tissue expression)LYPLA1
Protein : pattern, domain, 3D structure
UniProt/SwissProtO75608   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO75608  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO75608
Splice isoforms : SwissVarO75608
Catalytic activity : Enzyme3.1.2.- [ Enzyme-Expasy ]   3.1.2.-3.1.2.- [ IntEnz-EBI ]   3.1.2.- [ BRENDA ]   3.1.2.- [ KEGG ]   
PhosPhoSitePlusO75608
Domains : Interpro (EBI)AB_hydrolase    PLipase/COase/thioEstase   
Domain families : Pfam (Sanger)Abhydrolase_2 (PF02230)   
Domain families : Pfam (NCBI)pfam02230   
Conserved Domain (NCBI)LYPLA1
DMDM Disease mutations10434
Blocks (Seattle)LYPLA1
PDB (SRS)1FJ2    5SYM   
PDB (PDBSum)1FJ2    5SYM   
PDB (IMB)1FJ2    5SYM   
PDB (RSDB)1FJ2    5SYM   
Structural Biology KnowledgeBase1FJ2    5SYM   
SCOP (Structural Classification of Proteins)1FJ2    5SYM   
CATH (Classification of proteins structures)1FJ2    5SYM   
SuperfamilyO75608
Human Protein AtlasENSG00000120992
Peptide AtlasO75608
HPRD07063
IPIIPI00398727   IPI00007321   IPI00909991   IPI00984941   IPI00983098   IPI00974146   IPI00981294   IPI00978557   IPI00974142   IPI00973805   
Protein Interaction databases
DIP (DOE-UCLA)O75608
IntAct (EBI)O75608
FunCoupENSG00000120992
BioGRIDLYPLA1
STRING (EMBL)LYPLA1
ZODIACLYPLA1
Ontologies - Pathways
QuickGOO75608
Ontology : AmiGOprotein depalmitoylation  lysophospholipase activity  cytoplasm  mitochondrion  cytosol  fatty acid metabolic process  palmitoyl-(protein) hydrolase activity  palmitoyl-(protein) hydrolase activity  lipase activity  negative regulation of Golgi to plasma membrane protein transport  regulation of nitric-oxide synthase activity  extracellular exosome  
Ontology : EGO-EBIprotein depalmitoylation  lysophospholipase activity  cytoplasm  mitochondrion  cytosol  fatty acid metabolic process  palmitoyl-(protein) hydrolase activity  palmitoyl-(protein) hydrolase activity  lipase activity  negative regulation of Golgi to plasma membrane protein transport  regulation of nitric-oxide synthase activity  extracellular exosome  
Pathways : KEGGGlycerophospholipid metabolism   
NDEx NetworkLYPLA1
Atlas of Cancer Signalling NetworkLYPLA1
Wikipedia pathwaysLYPLA1
Orthology - Evolution
OrthoDB10434
GeneTree (enSembl)ENSG00000120992
Phylogenetic Trees/Animal Genes : TreeFamLYPLA1
HOVERGENO75608
HOGENOMO75608
Homologs : HomoloGeneLYPLA1
Homology/Alignments : Family Browser (UCSC)LYPLA1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLYPLA1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LYPLA1
dbVarLYPLA1
ClinVarLYPLA1
1000_GenomesLYPLA1 
Exome Variant ServerLYPLA1
ExAC (Exome Aggregation Consortium)LYPLA1 (select the gene name)
Genetic variants : HAPMAP10434
Genomic Variants (DGV)LYPLA1 [DGVbeta]
DECIPHERLYPLA1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLYPLA1 
Mutations
ICGC Data PortalLYPLA1 
TCGA Data PortalLYPLA1 
Broad Tumor PortalLYPLA1
OASIS PortalLYPLA1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLYPLA1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLYPLA1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LYPLA1
DgiDB (Drug Gene Interaction Database)LYPLA1
DoCM (Curated mutations)LYPLA1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LYPLA1 (select a term)
intoGenLYPLA1
Cancer3DLYPLA1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605599   
Orphanet
MedgenLYPLA1
Genetic Testing Registry LYPLA1
NextProtO75608 [Medical]
TSGene10434
GENETestsLYPLA1
Target ValidationLYPLA1
Huge Navigator LYPLA1 [HugePedia]
snp3D : Map Gene to Disease10434
BioCentury BCIQLYPLA1
ClinGenLYPLA1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10434
Chemical/Pharm GKB GenePA30499
Clinical trialLYPLA1
Miscellaneous
canSAR (ICR)LYPLA1 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLYPLA1
EVEXLYPLA1
GoPubMedLYPLA1
iHOPLYPLA1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 25 19:16:45 CEST 2017

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