LYPLA2 (lysophospholipase 2)

2013-06-01  

Identity

HGNC
LYPLA2
LOCATION
1p36.11
LOCUSID
11313
ALIAS
APT-2,APT2,DJ886K2.4
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11313
MIM: 616143
HGNC: 6738
Ensembl: ENSG00000011009

Variants:

dbSNP: 11313
ClinVar: 11313
TCGA: ENSG00000011009
COSMIC: LYPLA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000011009ENST00000374501Q5QPQ0
ENSG00000011009ENST00000374502Q5QPQ3
ENSG00000011009ENST00000374503Q5QPQ2
ENSG00000011009ENST00000374505Q5QPN9
ENSG00000011009ENST00000374514O95372
ENSG00000011009ENST00000374514A0A140VJC9
ENSG00000011009ENST00000420982Q5QPQ1
ENSG00000011009ENST00000421070Q5QPN5

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycerophospholipid metabolismKEGGko00564
Glycerophospholipid metabolismKEGGhsa00564
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
L1CAM interactionsREACTOMER-HSA-373760

References

Pubmed IDYearTitleCitations
337077822021Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.22
337077822021Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains.22
304828052019Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling.22
304828052019Lysophospholipases cooperate to mediate lipid homeostasis and lysophospholipid signaling.22
258499162015Enzymatic protein depalmitoylation by acyl protein thioesterases.32
258499162015Enzymatic protein depalmitoylation by acyl protein thioesterases.32
253019512014Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells.8
253019512014Identification of the major prostaglandin glycerol ester hydrolase in human cancer cells.8
233969702013Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43.66
233969702013Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43.66
211520832010Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43.66
211520832010Acyl-protein thioesterase 2 catalyzes the deacylation of peripheral membrane-associated GAP-43.66

Citation

Dessen P

LYPLA2 (lysophospholipase 2)

Atlas Genet Cytogenet Oncol Haematol. 2013-06-01

Online version: http://atlasgeneticsoncology.org/gene/53384/lypla2