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LYPLA2 (lysophospholipase II)

Identity

Alias_symbol (synonym)APT-2
Other aliasAPT2
DJ886K2.4
HGNC (Hugo) LYPLA2
LocusID (NCBI) 11313
Atlas_Id 53384
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 23791156 and ends at 23795539 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EPHB2 (1p36.12) / LYPLA2 (1p36.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LYPLA2   6738
Cards
Entrez_Gene (NCBI)LYPLA2  11313  lysophospholipase II
AliasesAPT-2; APT2; DJ886K2.4
GeneCards (Weizmann)LYPLA2
Ensembl hg19 (Hinxton)ENSG00000011009 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011009 [Gene_View]  chr1:23791156-23795539 [Contig_View]  LYPLA2 [Vega]
ICGC DataPortalENSG00000011009
TCGA cBioPortalLYPLA2
AceView (NCBI)LYPLA2
Genatlas (Paris)LYPLA2
WikiGenes11313
SOURCE (Princeton)LYPLA2
Genetics Home Reference (NIH)LYPLA2
Genomic and cartography
GoldenPath hg38 (UCSC)LYPLA2  -     chr1:23791156-23795539 +  1p36.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LYPLA2  -     1p36.11   [Description]    (hg19-Feb_2009)
EnsemblLYPLA2 - 1p36.11 [CytoView hg19]  LYPLA2 - 1p36.11 [CytoView hg38]
Mapping of homologs : NCBILYPLA2 [Mapview hg19]  LYPLA2 [Mapview hg38]
OMIM616143   
Gene and transcription
Genbank (Entrez)AF090423 AF098668 AK024724 BC017034 BC017193
RefSeq transcript (Entrez)NM_007260
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LYPLA2
Cluster EST : UnigeneHs.533479 [ NCBI ]
CGAP (NCI)Hs.533479
Alternative Splicing GalleryENSG00000011009
Gene ExpressionLYPLA2 [ NCBI-GEO ]   LYPLA2 [ EBI - ARRAY_EXPRESS ]   LYPLA2 [ SEEK ]   LYPLA2 [ MEM ]
Gene Expression Viewer (FireBrowse)LYPLA2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11313
GTEX Portal (Tissue expression)LYPLA2
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95372   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95372  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95372
Splice isoforms : SwissVarO95372
Catalytic activity : Enzyme3.1.2.- [ Enzyme-Expasy ]   3.1.2.-3.1.2.- [ IntEnz-EBI ]   3.1.2.- [ BRENDA ]   3.1.2.- [ KEGG ]   
PhosPhoSitePlusO95372
Domains : Interpro (EBI)AB_hydrolase    PLipase/COase/thioEstase   
Domain families : Pfam (Sanger)Abhydrolase_2 (PF02230)   
Domain families : Pfam (NCBI)pfam02230   
Conserved Domain (NCBI)LYPLA2
DMDM Disease mutations11313
Blocks (Seattle)LYPLA2
PDB (SRS)5SYN   
PDB (PDBSum)5SYN   
PDB (IMB)5SYN   
PDB (RSDB)5SYN   
Structural Biology KnowledgeBase5SYN   
SCOP (Structural Classification of Proteins)5SYN   
CATH (Classification of proteins structures)5SYN   
SuperfamilyO95372
Human Protein AtlasENSG00000011009
Peptide AtlasO95372
HPRD07127
IPIIPI00027032   IPI00646978   IPI00876921   IPI00644956   IPI00514267   IPI00513881   IPI00514798   
Protein Interaction databases
DIP (DOE-UCLA)O95372
IntAct (EBI)O95372
FunCoupENSG00000011009
BioGRIDLYPLA2
STRING (EMBL)LYPLA2
ZODIACLYPLA2
Ontologies - Pathways
QuickGOO95372
Ontology : AmiGOprotein depalmitoylation  cytoplasm  cytosol  fatty acid metabolic process  axon guidance  palmitoyl-(protein) hydrolase activity  palmitoyl-(protein) hydrolase activity  cadherin binding  carboxylic ester hydrolase activity  extracellular exosome  
Ontology : EGO-EBIprotein depalmitoylation  cytoplasm  cytosol  fatty acid metabolic process  axon guidance  palmitoyl-(protein) hydrolase activity  palmitoyl-(protein) hydrolase activity  cadherin binding  carboxylic ester hydrolase activity  extracellular exosome  
Pathways : KEGGGlycerophospholipid metabolism   
NDEx NetworkLYPLA2
Atlas of Cancer Signalling NetworkLYPLA2
Wikipedia pathwaysLYPLA2
Orthology - Evolution
OrthoDB11313
GeneTree (enSembl)ENSG00000011009
Phylogenetic Trees/Animal Genes : TreeFamLYPLA2
HOVERGENO95372
HOGENOMO95372
Homologs : HomoloGeneLYPLA2
Homology/Alignments : Family Browser (UCSC)LYPLA2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLYPLA2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LYPLA2
dbVarLYPLA2
ClinVarLYPLA2
1000_GenomesLYPLA2 
Exome Variant ServerLYPLA2
ExAC (Exome Aggregation Consortium)LYPLA2 (select the gene name)
Genetic variants : HAPMAP11313
Genomic Variants (DGV)LYPLA2 [DGVbeta]
DECIPHERLYPLA2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLYPLA2 
Mutations
ICGC Data PortalLYPLA2 
TCGA Data PortalLYPLA2 
Broad Tumor PortalLYPLA2
OASIS PortalLYPLA2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLYPLA2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLYPLA2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LYPLA2
DgiDB (Drug Gene Interaction Database)LYPLA2
DoCM (Curated mutations)LYPLA2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LYPLA2 (select a term)
intoGenLYPLA2
Cancer3DLYPLA2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616143   
Orphanet
MedgenLYPLA2
Genetic Testing Registry LYPLA2
NextProtO95372 [Medical]
TSGene11313
GENETestsLYPLA2
Target ValidationLYPLA2
Huge Navigator LYPLA2 [HugePedia]
snp3D : Map Gene to Disease11313
BioCentury BCIQLYPLA2
ClinGenLYPLA2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11313
Chemical/Pharm GKB GenePA30500
Clinical trialLYPLA2
Miscellaneous
canSAR (ICR)LYPLA2 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLYPLA2
EVEXLYPLA2
GoPubMedLYPLA2
iHOPLYPLA2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:16:45 CEST 2017

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