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LYZ (lysozyme)

Identity

Alias_nameslysozyme (renal amyloidosis)
Other aliasLYZF1
LZM
HGNC (Hugo) LYZ
LocusID (NCBI) 4069
Atlas_Id 46133
Location 12q15  [Link to chromosome band 12q15]
Location_base_pair Starts at 69348354 and ends at 69354233 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ALCAM (3q13.11) / LYZ (12q15)CUL1 (7q36.1) / LYZ (12q15)FRS2 (12q15) / LYZ (12q15)
LCN1 (9q34.3) / LYZ (12q15)LEMD3 (12q14.3) / LYZ (12q15)LILRB1 (19q13.42) / LYZ (12q15)
LYZ (12q15) / ABHD2 (15q26.1)LYZ (12q15) / AFF1 (4q21.3)LYZ (12q15) / AP4M1 (7q22.1)
LYZ (12q15) / DDOST (1p36.12)LYZ (12q15) / HINT3 (6q22.32)LYZ (12q15) / MS4A7 (11q12.2)
LYZ (12q15) / RSAD2 (2p25.2)LYZ (12q15) / ZNF667 (19q13.43)LYZ (12q15) / ZZZ3 (1p31.1)
MRPS30 (5p12) / LYZ (12q15)NAALADL2 (3q26.31) / LYZ (12q15)NFU1 (2p13.3) / LYZ (12q15)
PRKCA (17q24.2) / LYZ (12q15)RFK (9q21.13) / LYZ (12q15)TMEM63A (1q42.12) / LYZ (12q15)
YEATS4 (12q15) / LYZ (12q15)FRS2 12q15 / LYZ 12q15LEMD3 12q14.3 / LYZ 12q15
YEATS4 12q15 / LYZ 12q15

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)LYZ   6740
LRG (Locus Reference Genomic)LRG_768
Cards
Entrez_Gene (NCBI)LYZ  4069  lysozyme
AliasesLYZF1; LZM
GeneCards (Weizmann)LYZ
Ensembl hg19 (Hinxton)ENSG00000090382 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000090382 [Gene_View]  chr12:69348354-69354233 [Contig_View]  LYZ [Vega]
ICGC DataPortalENSG00000090382
TCGA cBioPortalLYZ
AceView (NCBI)LYZ
Genatlas (Paris)LYZ
WikiGenes4069
SOURCE (Princeton)LYZ
Genetics Home Reference (NIH)LYZ
Genomic and cartography
GoldenPath hg38 (UCSC)LYZ  -     chr12:69348354-69354233 +  12q15   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)LYZ  -     12q15   [Description]    (hg19-Feb_2009)
EnsemblLYZ - 12q15 [CytoView hg19]  LYZ - 12q15 [CytoView hg38]
Mapping of homologs : NCBILYZ [Mapview hg19]  LYZ [Mapview hg38]
OMIM105200   153450   
Gene and transcription
Genbank (Entrez)AK130127 AK130149 AK310930 AK311779 BC004147
RefSeq transcript (Entrez)NM_000239
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)LYZ
Cluster EST : UnigeneHs.524579 [ NCBI ]
CGAP (NCI)Hs.524579
Alternative Splicing GalleryENSG00000090382
Gene ExpressionLYZ [ NCBI-GEO ]   LYZ [ EBI - ARRAY_EXPRESS ]   LYZ [ SEEK ]   LYZ [ MEM ]
Gene Expression Viewer (FireBrowse)LYZ [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4069
GTEX Portal (Tissue expression)LYZ
Protein : pattern, domain, 3D structure
UniProt/SwissProtP61626   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP61626  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP61626
Splice isoforms : SwissVarP61626
Catalytic activity : Enzyme3.2.1.17 [ Enzyme-Expasy ]   3.2.1.173.2.1.17 [ IntEnz-EBI ]   3.2.1.17 [ BRENDA ]   3.2.1.17 [ KEGG ]   
PhosPhoSitePlusP61626
Domaine pattern : Prosite (Expaxy)LACTALBUMIN_LYSOZYME_1 (PS00128)    LACTALBUMIN_LYSOZYME_2 (PS51348)   
Domains : Interpro (EBI)Glyco_hydro_22    Glyco_hydro_22_CS    Glyco_hydro_22_lys    Lysozyme-like_dom   
Domain families : Pfam (Sanger)Lys (PF00062)   
Domain families : Pfam (NCBI)pfam00062   
Domain families : Smart (EMBL)LYZ1 (SM00263)  
Conserved Domain (NCBI)LYZ
DMDM Disease mutations4069
Blocks (Seattle)LYZ
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP61626
Human Protein AtlasENSG00000090382
Peptide AtlasP61626
HPRD01085
IPIIPI00019038   IPI01022818   IPI01023021   
Protein Interaction databases
DIP (DOE-UCLA)P61626
IntAct (EBI)P61626
FunCoupENSG00000090382
BioGRIDLYZ
STRING (EMBL)LYZ
ZODIACLYZ
Ontologies - Pathways
QuickGOP61626
Ontology : AmiGOretina homeostasis  lysozyme activity  extracellular region  extracellular space  extracellular space  inflammatory response  antimicrobial humoral response  cytolysis  azurophil granule lumen  specific granule lumen  defense response to bacterium  identical protein binding  neutrophil degranulation  cellular protein metabolic process  extracellular exosome  tertiary granule lumen  
Ontology : EGO-EBIretina homeostasis  lysozyme activity  extracellular region  extracellular space  extracellular space  inflammatory response  antimicrobial humoral response  cytolysis  azurophil granule lumen  specific granule lumen  defense response to bacterium  identical protein binding  neutrophil degranulation  cellular protein metabolic process  extracellular exosome  tertiary granule lumen  
Pathways : KEGGSalivary secretion   
NDEx NetworkLYZ
Atlas of Cancer Signalling NetworkLYZ
Wikipedia pathwaysLYZ
Orthology - Evolution
OrthoDB4069
GeneTree (enSembl)ENSG00000090382
Phylogenetic Trees/Animal Genes : TreeFamLYZ
HOVERGENP61626
HOGENOMP61626
Homologs : HomoloGeneLYZ
Homology/Alignments : Family Browser (UCSC)LYZ
Gene fusions - Rearrangements
Fusion : MitelmanLEMD3/LYZ [12q14.3/12q15]  [t(12;12)(q14;q15)]  
Fusion: TCGAFRS2 12q15 LYZ 12q15 BRCA LUAD
Fusion: TCGALEMD3 12q14.3 LYZ 12q15 BRCA
Fusion: TCGAYEATS4 12q15 LYZ 12q15 BLCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerLYZ [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)LYZ
dbVarLYZ
ClinVarLYZ
1000_GenomesLYZ 
Exome Variant ServerLYZ
ExAC (Exome Aggregation Consortium)LYZ (select the gene name)
Genetic variants : HAPMAP4069
Genomic Variants (DGV)LYZ [DGVbeta]
DECIPHERLYZ [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisLYZ 
Mutations
ICGC Data PortalLYZ 
TCGA Data PortalLYZ 
Broad Tumor PortalLYZ
OASIS PortalLYZ [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICLYZ  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDLYZ
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch LYZ
DgiDB (Drug Gene Interaction Database)LYZ
DoCM (Curated mutations)LYZ (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)LYZ (select a term)
intoGenLYZ
Cancer3DLYZ(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM105200    153450   
Orphanet12403   
MedgenLYZ
Genetic Testing Registry LYZ
NextProtP61626 [Medical]
TSGene4069
GENETestsLYZ
Target ValidationLYZ
Huge Navigator LYZ [HugePedia]
snp3D : Map Gene to Disease4069
BioCentury BCIQLYZ
ClinGenLYZ
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4069
Chemical/Pharm GKB GenePA30503
Clinical trialLYZ
Miscellaneous
canSAR (ICR)LYZ (select the gene name)
Probes
Litterature
PubMed109 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineLYZ
EVEXLYZ
GoPubMedLYZ
iHOPLYZ
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:58:27 CEST 2017

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