LYZ (lysozyme)

2007-02-01  

Identity

HGNC
LOCATION
12q15
LOCUSID
ALIAS
LYZF1,LZM
FUSION GENES

Other Information

Locus ID:

NCBI: 4069
MIM: 153450
HGNC: 6740
Ensembl: ENSG00000090382

Variants:

dbSNP: 4069
ClinVar: 4069
TCGA: ENSG00000090382
COSMIC: LYZ

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000090382ENST00000261267P61626
ENSG00000090382ENST00000261267B2R4C5
ENSG00000090382ENST00000548839F8VV32
ENSG00000090382ENST00000549690A0A0B4J259

Expression (GTEx)

0
1000
2000
3000
4000
5000
6000
7000
8000
9000
10000

Pathways

PathwaySourceExternal ID
Salivary secretionKEGGko04970
Salivary secretionKEGGhsa04970
Metabolism of proteinsREACTOMER-HSA-392499
Amyloid fiber formationREACTOMER-HSA-977225
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Antimicrobial peptidesREACTOMER-HSA-6803157
Neutrophil degranulationREACTOMER-HSA-6798695

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
164160292006Antimicrobial skin peptides and proteins.56
118871822002Local cooperativity in the unfolding of an amyloidogenic variant of human lysozyme.52
206738682010A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).36
157134622005Reduced global cooperativity is a common feature underlying the amyloidogenicity of pathogenic lysozyme mutations.34
183441362008Effects of exercise intensity on salivary antimicrobial proteins and markers of stress in active men.33
121835362002Streptococcal inhibitor of complement inhibits two additional components of the mucosal innate immune system: secretory leukocyte proteinase inhibitor and lysozyme.26
174077822007The extracellular chaperone clusterin potently inhibits human lysozyme amyloid formation by interacting with prefibrillar species.26
204524822010Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.26
173603672007Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme.21
151555662004Formation of amyloid aggregates from human lysozyme and its disease-associated variants using hydrostatic pressure.19

Citation

Dessen P

LYZ (lysozyme)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46133/lyz