MAF1 (MAF1 homolog, negative regulator of RNA polymerase III)

2016-01-01  

Identity

HGNC
LOCATION
8q24.3
LOCUSID
ALIAS
-
FUSION GENES

Other Information

Locus ID:

NCBI: 84232
MIM: 610210
HGNC: 24966
Ensembl: ENSG00000179632

Variants:

dbSNP: 84232
ClinVar: 84232
TCGA: ENSG00000179632
COSMIC: MAF1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000179632ENST00000322428Q9H063
ENSG00000179632ENST00000527058E9PR76
ENSG00000179632ENST00000527572E9PJ05
ENSG00000179632ENST00000532522Q9H063
ENSG00000179632ENST00000534585E9PSH4
ENSG00000179632ENST00000534811H0YEV4

Expression (GTEx)

0
50
100
150
200
250

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125040222002Maf1 is an essential mediator of diverse signals that repress RNA polymerase III transcription.101
205431382010mTOR associates with TFIIIC, is found at tRNA and 5S rRNA genes, and targets their repressor Maf1.81
114386592001Maf1p, a negative effector of RNA polymerase III in Saccharomyces cerevisiae.73
174990432007Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.64
202337132010Requirement of the mTOR kinase for the regulation of Maf1 phosphorylation and control of RNA polymerase III-dependent transcription in cancer cells.59
172051382006Maf1, a new player in the regulation of human RNA polymerase III transcription.53
175055382007Human Maf1 negatively regulates RNA polymerase III transcription via the TFIIB family members Brf1 and Brf2.32
255025662014Maf1 is a novel target of PTEN and PI3K signaling that negatively regulates oncogenesis and lipid metabolism.32
213831832011Casein kinase II-mediated phosphorylation of general repressor Maf1 triggers RNA polymerase III activation.25
269412512016Human MAF1 targets and represses active RNA polymerase III genes by preventing recruitment rather than inducing long-term transcriptional arrest.24

Citation

Dessen P

MAF1 (MAF1 homolog, negative regulator of RNA polymerase III)

Atlas Genet Cytogenet Oncol Haematol. 2016-01-01

Online version: http://atlasgeneticsoncology.org/gene/55576/maf1