MAFK (MAF bZIP transcription factor K)

2003-11-01  

Identity

HGNC
LOCATION
7p22.3
LOCUSID
ALIAS
NFE2U,P18
FUSION GENES

Other Information

Locus ID:

NCBI: 7975
MIM: 600197
HGNC: 6782
Ensembl: ENSG00000198517

Variants:

dbSNP: 7975
ClinVar: 7975
TCGA: ENSG00000198517
COSMIC: MAFK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000198517ENST00000343242O60675
ENSG00000198517ENST00000343242A0A024R804
ENSG00000198517ENST00000403150O60675
ENSG00000198517ENST00000403150A0A024R804
ENSG00000198517ENST00000406174O60675
ENSG00000198517ENST00000406174A0A024R804

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Factors involved in megakaryocyte development and platelet productionREACTOMER-HSA-983231

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164925725Toxic liver diseaseDiseaseClinicalAnnotationassociatedPD22341855, 29036176
PA166119041drug-induced liver injuryDiseaseClinicalAnnotationassociatedPD22341855, 29036176
PA283MAPK8GenePathwayassociated23922006
PA30621MAPK14GenePathwayassociated23922006
PA450112isoniazidChemicalClinicalAnnotationassociatedPD22341855, 29036176

References

Pubmed IDYearTitleCitations
228556092012Induction of functional platelets from mouse and human fibroblasts by p45NF-E2/Maf.24
237375272013Transforming growth factor-β induces transcription factors MafK and Bach1 to suppress expression of the heme oxygenase-1 gene.21
242320972013Jun dimerization protein 2 is a critical component of the Nrf2/MafK complex regulating the response to ROS homeostasis.17
242477322013MafK positively regulates NF-κB activity by enhancing CBP-mediated p65 acetylation.12
284005382017The transcription factor MAFK induces EMT and malignant progression of triple-negative breast cancer cells through its target GPNMB.10
262144102015Wnt1-induced MAFK expression promotes osteosarcoma cell proliferation.4
288394362017Genetic polymorphisms of MAFK, encoding a small Maf protein, are associated with susceptibility to ulcerative colitis in Japan.1

Citation

Dessen P

MAFK (MAF bZIP transcription factor K)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41239/mafk