MAG (myelin associated glycoprotein)

2009-01-01  

Identity

HGNC
LOCATION
19q13.12
LOCUSID
ALIAS
GMA,S-MAG,SIGLEC-4A,SIGLEC4A,SPG75
FUSION GENES

Other Information

Locus ID:

NCBI: 4099
MIM: 159460
HGNC: 6783
Ensembl: ENSG00000105695

Variants:

dbSNP: 4099
ClinVar: 4099
TCGA: ENSG00000105695
COSMIC: MAG

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105695ENST00000361922P20916
ENSG00000105695ENST00000392213P20916
ENSG00000105695ENST00000537831P20916
ENSG00000105695ENST00000595791M0R3B9
ENSG00000105695ENST00000597035M0R3I4
ENSG00000105695ENST00000600291M0QZU4

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900

Pathways

PathwaySourceExternal ID
Cell adhesion molecules (CAMs)KEGGko04514
Cell adhesion molecules (CAMs)KEGGhsa04514
HemostasisREACTOMER-HSA-109582
Cell surface interactions at the vascular wallREACTOMER-HSA-202733
Basigin interactionsREACTOMER-HSA-210991
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
p75 NTR receptor-mediated signallingREACTOMER-HSA-193704
p75NTR regulates axonogenesisREACTOMER-HSA-193697
Axonal growth inhibition (RHOA activation)REACTOMER-HSA-193634

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
125288152003Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases.71
179641172008Expression of oligodendrocyte-associated genes in dorsolateral prefrontal cortex of patients with schizophrenia.41
179749632007MUC1 is a counter-receptor for myelin-associated glycoprotein (Siglec-4a) and their interaction contributes to adhesion in pancreatic cancer perineural invasion.36
241295692013LRP1 assembles unique co-receptor systems to initiate cell signaling in response to tissue-type plasminogen activator and myelin-associated glycoprotein.35
261799192015Myelin-associated glycoprotein gene mutation causes Pelizaeus-Merzbacher disease-like disorder.15
237267662013The possible relationship between allergic manifestations and elevated serum levels of brain specific auto-antibodies in autistic children.14
158203192005Possible association of the MAG locus with schizophrenia in a Chinese Han cohort of family trios.12
160390572005Polymorphisms of myelin-associated glycoprotein gene are associated with schizophrenia in the Chinese Han population.12
160390572005Polymorphisms of myelin-associated glycoprotein gene are associated with schizophrenia in the Chinese Han population.12
229406292013An essential role of MAG in mediating axon-myelin attachment in Charcot-Marie-Tooth 1A disease.12

Citation

Dessen P

MAG (myelin associated glycoprotein)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50654/mag