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MAG (myelin associated glycoprotein)

Identity

Alias_namesGMA
Alias_symbol (synonym)SIGLEC4A
SIGLEC-4A
S-MAG
Other aliasSPG75
HGNC (Hugo) MAG
LocusID (NCBI) 4099
Atlas_Id 50654
Location 19q13.12  [Link to chromosome band 19q13]
Location_base_pair Starts at 35292086 and ends at 35313806 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CSPG5 (3p21.31) / MAG (19q13.12)MAG (19q13.12) / NMNAT3 (3q23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MAG   6783
Cards
Entrez_Gene (NCBI)MAG  4099  myelin associated glycoprotein
AliasesGMA; S-MAG; SIGLEC-4A; SIGLEC4A; 
SPG75
GeneCards (Weizmann)MAG
Ensembl hg19 (Hinxton)ENSG00000105695 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000105695 [Gene_View]  ENSG00000105695 [Sequence]  chr19:35292086-35313806 [Contig_View]  MAG [Vega]
ICGC DataPortalENSG00000105695
TCGA cBioPortalMAG
AceView (NCBI)MAG
Genatlas (Paris)MAG
WikiGenes4099
SOURCE (Princeton)MAG
Genetics Home Reference (NIH)MAG
Genomic and cartography
GoldenPath hg38 (UCSC)MAG  -     chr19:35292086-35313806 +  19q13.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAG  -     19q13.12   [Description]    (hg19-Feb_2009)
EnsemblMAG - 19q13.12 [CytoView hg19]  MAG - 19q13.12 [CytoView hg38]
Mapping of homologs : NCBIMAG [Mapview hg19]  MAG [Mapview hg38]
OMIM159460   616680   
Gene and transcription
Genbank (Entrez)AK094545 AK222649 AK222680 AK223562 AK294644
RefSeq transcript (Entrez)NM_001199216 NM_002361 NM_080600
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAG
Cluster EST : UnigeneHs.643440 [ NCBI ]
CGAP (NCI)Hs.643440
Alternative Splicing GalleryENSG00000105695
Gene ExpressionMAG [ NCBI-GEO ]   MAG [ EBI - ARRAY_EXPRESS ]   MAG [ SEEK ]   MAG [ MEM ]
Gene Expression Viewer (FireBrowse)MAG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4099
GTEX Portal (Tissue expression)MAG
Human Protein AtlasENSG00000105695-MAG [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP20916   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP20916  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP20916
Splice isoforms : SwissVarP20916
PhosPhoSitePlusP20916
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)CD80_C2-set    Ig-like_dom    Ig-like_fold    Ig_sub    Ig_sub2   
Domain families : Pfam (Sanger)C2-set_2 (PF08205)   
Domain families : Pfam (NCBI)pfam08205   
Domain families : Smart (EMBL)IG (SM00409)  IGc2 (SM00408)  
Conserved Domain (NCBI)MAG
DMDM Disease mutations4099
Blocks (Seattle)MAG
SuperfamilyP20916
Human Protein Atlas [tissue]ENSG00000105695-MAG [tissue]
Peptide AtlasP20916
HPRD01160
IPIIPI00026237   IPI01013298   IPI00979171   IPI00375253   
Protein Interaction databases
DIP (DOE-UCLA)P20916
IntAct (EBI)P20916
FunCoupENSG00000105695
BioGRIDMAG
STRING (EMBL)MAG
ZODIACMAG
Ontologies - Pathways
QuickGOP20916
Ontology : AmiGOreceptor binding  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  cell adhesion  negative regulation of neuron projection development  protein kinase binding  central nervous system myelination  carbohydrate binding  negative regulation of axon extension  positive regulation of myelination  paranode region of axon  sialic acid binding  myelin sheath adaxonal region  protein homodimerization activity  myelin sheath  compact myelin  Schmidt-Lanterman incisure  negative regulation of neuron apoptotic process  membrane raft  positive regulation of astrocyte differentiation  negative regulation of axonogenesis  leukocyte migration  cellular response to mechanical stimulus  mesaxon  cell-cell adhesion via plasma-membrane adhesion molecules  ganglioside GT1b binding  
Ontology : EGO-EBIreceptor binding  cytoplasm  plasma membrane  plasma membrane  integral component of plasma membrane  cell adhesion  negative regulation of neuron projection development  protein kinase binding  central nervous system myelination  carbohydrate binding  negative regulation of axon extension  positive regulation of myelination  paranode region of axon  sialic acid binding  myelin sheath adaxonal region  protein homodimerization activity  myelin sheath  compact myelin  Schmidt-Lanterman incisure  negative regulation of neuron apoptotic process  membrane raft  positive regulation of astrocyte differentiation  negative regulation of axonogenesis  leukocyte migration  cellular response to mechanical stimulus  mesaxon  cell-cell adhesion via plasma-membrane adhesion molecules  ganglioside GT1b binding  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkMAG
Atlas of Cancer Signalling NetworkMAG
Wikipedia pathwaysMAG
Orthology - Evolution
OrthoDB4099
GeneTree (enSembl)ENSG00000105695
Phylogenetic Trees/Animal Genes : TreeFamMAG
HOVERGENP20916
HOGENOMP20916
Homologs : HomoloGeneMAG
Homology/Alignments : Family Browser (UCSC)MAG
Gene fusions - Rearrangements
Fusion : QuiverMAG
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAG
dbVarMAG
ClinVarMAG
1000_GenomesMAG 
Exome Variant ServerMAG
ExAC (Exome Aggregation Consortium)ENSG00000105695
GNOMAD BrowserENSG00000105695
Genetic variants : HAPMAP4099
Genomic Variants (DGV)MAG [DGVbeta]
DECIPHERMAG [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAG 
Mutations
ICGC Data PortalMAG 
TCGA Data PortalMAG 
Broad Tumor PortalMAG
OASIS PortalMAG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAG  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAG
DgiDB (Drug Gene Interaction Database)MAG
DoCM (Curated mutations)MAG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAG (select a term)
intoGenMAG
Cancer3DMAG(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM159460    616680   
Orphanet23770   
DisGeNETMAG
MedgenMAG
Genetic Testing Registry MAG
NextProtP20916 [Medical]
TSGene4099
GENETestsMAG
Target ValidationMAG
Huge Navigator MAG [HugePedia]
snp3D : Map Gene to Disease4099
BioCentury BCIQMAG
ClinGenMAG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4099
Chemical/Pharm GKB GenePA30541
Clinical trialMAG
Miscellaneous
canSAR (ICR)MAG (select the gene name)
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAG
EVEXMAG
GoPubMedMAG
iHOPMAG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jun 22 16:34:35 CEST 2018
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