MAGEA4 (MAGE family member A4)

2003-10-01 Affiliation

Identity

HGNC

MAGEA4

LOCATION

Xq28

LOCUSID

4103

ALIAS

CT1.4,MAGE-41,MAGE-X2,MAGE4,MAGE4A,MAGE4B

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4103
MIM: 300175
HGNC: 6802
Ensembl: ENSG00000147381

Variants:

dbSNP: 4103
ClinVar: 4103
TCGA: ENSG00000147381
COSMIC: MAGEA4

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000147381	ENST00000276344	P43358
ENSG00000147381	ENST00000276344	A0A024RC12
ENSG00000147381	ENST00000360243	P43358
ENSG00000147381	ENST00000360243	A0A024RC12
ENSG00000147381	ENST00000370335	P43358
ENSG00000147381	ENST00000370335	A0A024RC12
ENSG00000147381	ENST00000370340	P43358
ENSG00000147381	ENST00000370340	A0A024RC12
ENSG00000147381	ENST00000393920	P43358
ENSG00000147381	ENST00000393920	A0A024RC12
ENSG00000147381	ENST00000393921	P43358
ENSG00000147381	ENST00000393921	A0A024RC12
ENSG00000147381	ENST00000416020	C9JK50
ENSG00000147381	ENST00000425182	C9J9C2
ENSG00000147381	ENST00000430273	C9JIR1
ENSG00000147381	ENST00000431963	C9JZJ5
ENSG00000147381	ENST00000431971	C9JIR1
ENSG00000147381	ENST00000441865	C9JIR1
ENSG00000147381	ENST00000448295	C9J9C2
ENSG00000147381	ENST00000457310	C9JIR1

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
19545928	2010	Clinical significance of cancer/testis antigens expression in patients with non-small cell lung cancer.	33
16596224	2006	Expression of the MAGE-A4 and NY-ESO-1 cancer-testis antigens and T cell infiltration in non-small cell lung carcinoma and their prognostic significance.	32
20715104	2011	Pattern and clinical significance of cancer-testis gene expression in head and neck squamous cell carcinoma.	25
12525503	2003	MAGE-A4 interacts with the liver oncoprotein gankyrin and suppresses its tumorigenic activity.	24
19533752	2009	High frequency of MAGE-A4 and MAGE-A9 expression in high-risk bladder cancer.	24
22323448	2012	Cancer/testis antigens are novel targets of immunotherapy for adult T-cell leukemia/lymphoma.	21
23172894	2013	Proteomic profiling of triple-negative breast carcinomas in combination with a three-tier orthogonal technology approach identifies Mage-A4 as potential therapeutic target in estrogen receptor negative breast cancer.	18
27377895	2016	A neomorphic cancer cell-specific role of MAGE-A4 in trans-lesion synthesis.	18
14739298	2004	A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells.	16
16114059	2006	Immunohistochemical expression of tumor antigens MAGE-A1, MAGE-A3/4, and NY-ESO-1 in cancerous and benign prostatic tissue.	16

Citation

Dessen P

MAGEA4 (MAGE family member A4)

Atlas Genet Cytogenet Oncol Haematol. 2003-10-01

Online version: http://atlasgeneticsoncology.org/gene/515/magea4