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MAGI1 (membrane associated guanylate kinase, WW and PDZ domain containing 1)

Identity

Alias (NCBI)AIP-3
AIP3
BAIAP1
BAP-1
BAP1
MAGI-1
MAGI-1b
Magi1d
TNRC19
WWP3
HGNC (Hugo) MAGI1
HGNC Alias symbBAP1
MAGI-1
TNRC19
AIP3
WWP3
HGNC Previous nameBAIAP1
HGNC Previous nameBAI1-associated protein 1
LocusID (NCBI) 9223
Atlas_Id 46855
Location 3p14.1  [Link to chromosome band 3p14]
Location_base_pair Starts at 65353526 and ends at 66038918 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DCN (12q21.33) / MAGI1 (3p14.1)GAK (4p16.3) / MAGI1 (3p14.1)GIT1 (17q11.2) / MAGI1 (3p14.1)
KIAA0141 (5q31.3) / MAGI1 (3p14.1)LINC00483 (17q21.33) / MAGI1 (3p14.1)LRRC27 (10q26.3) / MAGI1 (3p14.1)
MAGI1 (3p14.1) / DPH3 (3p25.1)MAGI1 (3p14.1) / FOXO1 (13q14.11)MAGI1 (3p14.1) / JUN (1p32.1)
MAGI1 (3p14.1) / MAGI1 (3p14.1)MAGI1 (3p14.1) / SPRY4 (5q31.3)MAGI1 (3p14.1) / TBC1D30 (12q14.3)
MLEC (12q24.31) / MAGI1 (3p14.1)NCOA1 (2p23.3) / MAGI1 (3p14.1)NME2 (17q21.33) / MAGI1 (3p14.1)
SMR3B (4q13.3) / MAGI1 (3p14.1)SMYD2 (1q32.3) / MAGI1 (3p14.1)GAK 4p16.3 / MAGI1 3p14.1
MAGI1 3p14.1 / DPH3 3p25.1MAGI1 3p14.1 / TBC1D30 12q14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MAGI1   946
Cards
Entrez_Gene (NCBI)MAGI1    membrane associated guanylate kinase, WW and PDZ domain containing 1
AliasesAIP-3; AIP3; BAIAP1; BAP-1; 
BAP1; MAGI-1; MAGI-1b; Magi1d; TNRC19; WWP3
GeneCards (Weizmann)MAGI1
Ensembl hg19 (Hinxton)ENSG00000151276 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000151276 [Gene_View]  ENSG00000151276 [Sequence]  chr3:65353526-66038918 [Contig_View]  MAGI1 [Vega]
ICGC DataPortalENSG00000151276
TCGA cBioPortalMAGI1
AceView (NCBI)MAGI1
Genatlas (Paris)MAGI1
SOURCE (Princeton)MAGI1
Genetics Home Reference (NIH)MAGI1
Genomic and cartography
GoldenPath hg38 (UCSC)MAGI1  -     chr3:65353526-66038918 -  3p14.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAGI1  -     3p14.1   [Description]    (hg19-Feb_2009)
GoldenPathMAGI1 - 3p14.1 [CytoView hg19]  MAGI1 - 3p14.1 [CytoView hg38]
ImmunoBaseENSG00000151276
Genome Data Viewer NCBIMAGI1 [Mapview hg19]  
OMIM602625   
Gene and transcription
Genbank (Entrez)AB010894 AF088016 AF401654 AF401655 AF401656
RefSeq transcript (Entrez)NM_001033057 NM_001365903 NM_001365904 NM_001365905 NM_004742 NM_015520
Consensus coding sequences : CCDS (NCBI)MAGI1
Gene ExpressionMAGI1 [ NCBI-GEO ]   MAGI1 [ EBI - ARRAY_EXPRESS ]   MAGI1 [ SEEK ]   MAGI1 [ MEM ]
Gene Expression Viewer (FireBrowse)MAGI1 [ Firebrowse - Broad ]
GenevisibleExpression of MAGI1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9223
GTEX Portal (Tissue expression)MAGI1
Human Protein AtlasENSG00000151276-MAGI1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96QZ7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96QZ7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96QZ7
PhosPhoSitePlusQ96QZ7
Domaine pattern : Prosite (Expaxy)GUANYLATE_KINASE_1 (PS00856)    GUANYLATE_KINASE_2 (PS50052)    PDZ (PS50106)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)GK/Ca_channel_bsu    Guanylate_kin-like_dom    Guanylate_kinase_CS    MAGI1    P-loop_NTPase    PDZ    PDZ_sf    WW_dom    WW_dom_sf   
Domain families : Pfam (Sanger)Guanylate_kin (PF00625)    PDZ (PF00595)    WW (PF00397)   
Domain families : Pfam (NCBI)pfam00625    pfam00595    pfam00397   
Domain families : Smart (EMBL)GuKc (SM00072)  PDZ (SM00228)  WW (SM00456)  
Conserved Domain (NCBI)MAGI1
PDB (RSDB)1WBP    2KPK    2KPL    2Q9V    2R4H    2YSD    2YSE    2ZAJ    3BPU    5N7D    5N7F    5N7G    6TWU    6TWX    6TWY   
PDB Europe1WBP    2KPK    2KPL    2Q9V    2R4H    2YSD    2YSE    2ZAJ    3BPU    5N7D    5N7F    5N7G    6TWU    6TWX    6TWY   
PDB (PDBSum)1WBP    2KPK    2KPL    2Q9V    2R4H    2YSD    2YSE    2ZAJ    3BPU    5N7D    5N7F    5N7G    6TWU    6TWX    6TWY   
PDB (IMB)1WBP    2KPK    2KPL    2Q9V    2R4H    2YSD    2YSE    2ZAJ    3BPU    5N7D    5N7F    5N7G    6TWU    6TWX    6TWY   
Structural Biology KnowledgeBase1WBP    2KPK    2KPL    2Q9V    2R4H    2YSD    2YSE    2ZAJ    3BPU    5N7D    5N7F    5N7G    6TWU    6TWX    6TWY   
SCOP (Structural Classification of Proteins)1WBP    2KPK    2KPL    2Q9V    2R4H    2YSD    2YSE    2ZAJ    3BPU    5N7D    5N7F    5N7G    6TWU    6TWX    6TWY   
CATH (Classification of proteins structures)1WBP    2KPK    2KPL    2Q9V    2R4H    2YSD    2YSE    2ZAJ    3BPU    5N7D    5N7F    5N7G    6TWU    6TWX    6TWY   
SuperfamilyQ96QZ7
AlphaFold pdb e-kbQ96QZ7   
Human Protein Atlas [tissue]ENSG00000151276-MAGI1 [tissue]
HPRD04020
Protein Interaction databases
DIP (DOE-UCLA)Q96QZ7
IntAct (EBI)Q96QZ7
BioGRIDMAGI1
STRING (EMBL)MAGI1
ZODIACMAGI1
Ontologies - Pathways
QuickGOQ96QZ7
Ontology : AmiGOprotein binding  ATP binding  nucleoplasm  nucleolus  cytoplasm  cytoplasm  plasma membrane  cell-cell junction  cell-cell junction  adherens junction  bicellular tight junction  cell adhesion  signal transduction  cell surface receptor signaling pathway  protein C-terminus binding  positive regulation of cell-cell adhesion  cell junction  cell projection  alpha-actinin binding  molecular adaptor activity  protein-containing complex assembly  cell periphery  
Ontology : EGO-EBIprotein binding  ATP binding  nucleoplasm  nucleolus  cytoplasm  cytoplasm  plasma membrane  cell-cell junction  cell-cell junction  adherens junction  bicellular tight junction  cell adhesion  signal transduction  cell surface receptor signaling pathway  protein C-terminus binding  positive regulation of cell-cell adhesion  cell junction  cell projection  alpha-actinin binding  molecular adaptor activity  protein-containing complex assembly  cell periphery  
Pathways : KEGGRap1 signaling pathway    Tight junction   
NDEx NetworkMAGI1
Atlas of Cancer Signalling NetworkMAGI1
Wikipedia pathwaysMAGI1
Orthology - Evolution
OrthoDB9223
GeneTree (enSembl)ENSG00000151276
Phylogenetic Trees/Animal Genes : TreeFamMAGI1
Homologs : HomoloGeneMAGI1
Homology/Alignments : Family Browser (UCSC)MAGI1
Gene fusions - Rearrangements
Fusion : MitelmanGAK/MAGI1 [4p16.3/3p14.1]  
Fusion : MitelmanMAGI1/DPH3 [3p14.1/3p25.1]  
Fusion : MitelmanMAGI1/TBC1D30 [3p14.1/12q14.3]  
Fusion : MitelmanNCOA1/MAGI1 [2p23.3/3p14.1]  
Fusion : QuiverMAGI1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAGI1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAGI1
dbVarMAGI1
ClinVarMAGI1
MonarchMAGI1
1000_GenomesMAGI1 
Exome Variant ServerMAGI1
GNOMAD BrowserENSG00000151276
Varsome BrowserMAGI1
ACMGMAGI1 variants
VarityQ96QZ7
Genomic Variants (DGV)MAGI1 [DGVbeta]
DECIPHERMAGI1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAGI1 
Mutations
ICGC Data PortalMAGI1 
TCGA Data PortalMAGI1 
Broad Tumor PortalMAGI1
OASIS PortalMAGI1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAGI1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAGI1
Mutations and Diseases : HGMDMAGI1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMAGI1
DgiDB (Drug Gene Interaction Database)MAGI1
DoCM (Curated mutations)MAGI1
CIViC (Clinical Interpretations of Variants in Cancer)MAGI1
Cancer3DMAGI1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602625   
Orphanet
DisGeNETMAGI1
MedgenMAGI1
Genetic Testing Registry MAGI1
NextProtQ96QZ7 [Medical]
GENETestsMAGI1
Target ValidationMAGI1
Huge Navigator MAGI1 [HugePedia]
ClinGenMAGI1
Clinical trials, drugs, therapy
MyCancerGenomeMAGI1
Protein Interactions : CTDMAGI1
Pharm GKB GenePA164742006
PharosQ96QZ7
Clinical trialMAGI1
Miscellaneous
canSAR (ICR)MAGI1
HarmonizomeMAGI1
DataMed IndexMAGI1
Probes
Litterature
PubMed90 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMAGI1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:17:34 CEST 2021

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