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MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3)

Identity

Other namesMAGI-3
dJ730K3.2
HGNC (Hugo) MAGI3
LocusID (NCBI) 260425
Atlas_Id 43638
Location 1p13.2  [Link to chromosome band 1p13]
Location_base_pair Starts at 113933475 and ends at 114228545 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
ATG16L2 (11q13.4) / MAGI3 (1p13.2)MAGI3 (1p13.2) / AKT3 (1q43)MAGI3 (1p13.2) / ATF6 (1q23.3)
MAGI3 (1p13.2) / DENND5A (11p15.4)MAGI3 (1p13.2) / MAGI3 (1p13.2)MAGI3 (1p13.2) / NOTCH2 (1p12)
MAGI3 (1p13.2) / RAP1A (1p13.2)MAGI3 (1p13.2) / SPAG17 (1p12)MAGI3 1p13.2 / ATF6 1q23.3
MAGI3 1p13.2 / DENND5A 11p15.4MAGI3 1p13.2 / NOTCH2 1p12MAGI3 1p13.2 / RAP1A 1p13.2
MAGI3 1p13.2 / SPAG17 1p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAGI3   29647
Cards
Entrez_Gene (NCBI)MAGI3  260425  membrane associated guanylate kinase, WW and PDZ domain containing 3
AliasesMAGI-3; dJ730K3.2
GeneCards (Weizmann)MAGI3
Ensembl hg19 (Hinxton)ENSG00000081026 [Gene_View]  chr1:113933475-114228545 [Contig_View]  MAGI3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000081026 [Gene_View]  chr1:113933475-114228545 [Contig_View]  MAGI3 [Vega]
ICGC DataPortalENSG00000081026
TCGA cBioPortalMAGI3
AceView (NCBI)MAGI3
Genatlas (Paris)MAGI3
WikiGenes260425
SOURCE (Princeton)MAGI3
Genomic and cartography
GoldenPath hg19 (UCSC)MAGI3  -     chr1:113933475-114228545 +  1p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAGI3  -     1p13.2   [Description]    (hg38-Dec_2013)
EnsemblMAGI3 - 1p13.2 [CytoView hg19]  MAGI3 - 1p13.2 [CytoView hg38]
Mapping of homologs : NCBIMAGI3 [Mapview hg19]  MAGI3 [Mapview hg38]
OMIM615943   
Gene and transcription
Genbank (Entrez)AA992863 AB046854 AF213259 AK026417 AK311589
RefSeq transcript (Entrez)NM_001142782 NM_020965 NM_152900
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_032977 NW_004929290
Consensus coding sequences : CCDS (NCBI)MAGI3
Cluster EST : UnigeneHs.486189 [ NCBI ]
CGAP (NCI)Hs.486189
Alternative Splicing GalleryENSG00000081026
Gene ExpressionMAGI3 [ NCBI-GEO ]   MAGI3 [ EBI - ARRAY_EXPRESS ]   MAGI3 [ SEEK ]   MAGI3 [ MEM ]
Gene Expression Viewer (FireBrowse)MAGI3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)260425
GTEX Portal (Tissue expression)MAGI3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5TCQ9 (Uniprot)
NextProtQ5TCQ9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5TCQ9
Splice isoforms : SwissVarQ5TCQ9 (Swissvar)
PhosPhoSitePlusQ5TCQ9
Domaine pattern : Prosite (Expaxy)GUANYLATE_KINASE_1 (PS00856)    GUANYLATE_KINASE_2 (PS50052)    PDZ (PS50106)    WW_DOMAIN_1 (PS01159)    WW_DOMAIN_2 (PS50020)   
Domains : Interpro (EBI)GK/Ca_channel_bsu    Guanylate_kin-like_dom    Guanylate_kinase_CS    MAGI3    P-loop_NTPase    PDZ    WW_dom   
Domain families : Pfam (Sanger)Guanylate_kin (PF00625)    PDZ (PF00595)    WW (PF00397)   
Domain families : Pfam (NCBI)pfam00625    pfam00595    pfam00397   
Domain families : Smart (EMBL)GuKc (SM00072)  PDZ (SM00228)  WW (SM00456)  
DMDM Disease mutations260425
Blocks (Seattle)MAGI3
PDB (SRS)3SOE   
PDB (PDBSum)3SOE   
PDB (IMB)3SOE   
PDB (RSDB)3SOE   
Structural Biology KnowledgeBase3SOE   
SCOP (Structural Classification of Proteins)3SOE   
CATH (Classification of proteins structures)3SOE   
SuperfamilyQ5TCQ9
Human Protein AtlasENSG00000081026
Peptide AtlasQ5TCQ9
HPRD11290
IPIIPI00895871   IPI00387038   IPI00514954   IPI00170865   IPI00008382   IPI01011565   
Protein Interaction databases
DIP (DOE-UCLA)Q5TCQ9
IntAct (EBI)Q5TCQ9
FunCoupENSG00000081026
BioGRIDMAGI3
STRING (EMBL)MAGI3
ZODIACMAGI3
Ontologies - Pathways
QuickGOQ5TCQ9
Ontology : AmiGOguanylate kinase activity  protein binding  ATP binding  nucleus  plasma membrane  bicellular tight junction  apoptotic process  membrane  viral process  protein complex scaffold  intracellular signal transduction  GMP metabolic process  regulation of JNK cascade  GDP metabolic process  
Ontology : EGO-EBIguanylate kinase activity  protein binding  ATP binding  nucleus  plasma membrane  bicellular tight junction  apoptotic process  membrane  viral process  protein complex scaffold  intracellular signal transduction  GMP metabolic process  regulation of JNK cascade  GDP metabolic process  
Pathways : KEGGRap1 signaling pathway    Tight junction   
NDEx NetworkMAGI3
Atlas of Cancer Signalling NetworkMAGI3
Wikipedia pathwaysMAGI3
Orthology - Evolution
OrthoDB260425
GeneTree (enSembl)ENSG00000081026
Phylogenetic Trees/Animal Genes : TreeFamMAGI3
Homologs : HomoloGeneMAGI3
Homology/Alignments : Family Browser (UCSC)MAGI3
Gene fusions - Rearrangements
Fusion: TCGAMAGI3 1p13.2 ATF6 1q23.3 BRCA
Fusion: TCGAMAGI3 1p13.2 DENND5A 11p15.4 OV
Fusion: TCGAMAGI3 1p13.2 NOTCH2 1p12 BRCA
Fusion: TCGAMAGI3 1p13.2 RAP1A 1p13.2 BRCA
Fusion: TCGAMAGI3 1p13.2 SPAG17 1p12 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerMAGI3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAGI3
dbVarMAGI3
ClinVarMAGI3
1000_GenomesMAGI3 
Exome Variant ServerMAGI3
ExAC (Exome Aggregation Consortium)MAGI3 (select the gene name)
Genetic variants : HAPMAP260425
Genomic Variants (DGV)MAGI3 [DGVbeta]
Mutations
ICGC Data PortalMAGI3 
TCGA Data PortalMAGI3 
Broad Tumor PortalMAGI3
OASIS PortalMAGI3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAGI3 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAGI3
DgiDB (Drug Gene Interaction Database)MAGI3
DoCM (Curated mutations)MAGI3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAGI3 (select a term)
intoGenMAGI3
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:113933475-114228545  ENSG00000081026
CONAN: Copy Number AnalysisMAGI3 
Mutations and Diseases : HGMDMAGI3
OMIM615943   
MedgenMAGI3
Genetic Testing Registry MAGI3
NextProtQ5TCQ9 [Medical]
TSGene260425
GENETestsMAGI3
Huge Navigator MAGI3 [HugePedia]
snp3D : Map Gene to Disease260425
BioCentury BCIQMAGI3
ClinGenMAGI3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD260425
Chemical/Pharm GKB GenePA142671485
Clinical trialMAGI3
Miscellaneous
canSAR (ICR)MAGI3 (select the gene name)
Probes
Litterature
PubMed29 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAGI3
EVEXMAGI3
GoPubMedMAGI3
iHOPMAGI3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Sep 19 18:59:24 CEST 2016

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