MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3)

2007-02-01  

Identity

HGNC
LOCATION
1p13.2
LOCUSID
ALIAS
MAGI-3,dJ730K3.2
FUSION GENES

Other Information

Locus ID:

NCBI: 260425
MIM: 615943
HGNC: 29647
Ensembl: ENSG00000081026

Variants:

dbSNP: 260425
ClinVar: 260425
TCGA: ENSG00000081026
COSMIC: MAGI3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000081026ENST00000307546Q5TCQ9
ENSG00000081026ENST00000369611Q5TCQ9
ENSG00000081026ENST00000369615Q5TCQ9
ENSG00000081026ENST00000369617Q5TCQ9

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
169042892007MAGI-3 regulates LPA-induced activation of Erk and RhoA.27
211343772011MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.27
262487342015MAGI3 Suppresses Glioma Cell Proliferation via Upregulation of PTEN Expression.8
272058832016Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer.7
293623922018Premature polyadenylation of MAGI3 is associated with diminished N6-methyladenosine in its large internal exon.7
185189782008Comparison of p53 and the PDZ domain containing protein MAGI-3 regulation by the E6 protein from high-risk human papillomaviruses.6
121407592002Oncogenic human papillomavirus E6 proteins target the MAGI-2 and MAGI-3 proteins for degradation.0
126159702003Junctional protein MAGI-3 interacts with receptor tyrosine phosphatase beta (RPTP beta) and tyrosine-phosphorylated proteins.0
264522192015MAGI3 negatively regulates Wnt/β-catenin signaling and suppresses malignant phenotypes of glioma cells.0

Citation

Dessen P

MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43638/magi3