| | ACADL (2q34) / MAML2 (11q21) | C11orf95 (11q13.1) / MAML2 (11q21) | CHD6 (20q12) / MAML2 (11q21) |
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CRTC1 (19p13.11) / MAML2 (11q21) | CRTC3 (15q26.1) / MAML2 (11q21) | CXCR4 (2q22.1) / MAML2 (11q21) |
| |
KMT2A (11q23.3) / MAML2 (11q21) | MALAT1 (11q13.1) / MAML2 (11q21) | MAML2 (11q21) / CEP57 (11q21) |
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MAML2 (11q21) / CNTN5 (11q22.1) | MAML2 (11q21) / CRTC1 (19p13.11) | MAML2 (11q21) / CRTC3 (15q26.1) |
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MAML2 (11q21) / EPHB2 (1p36.12) | MAML2 (11q21) / KMT2A (11q23.3) | MAML2 (11q21) / MAML2 (11q21) |
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MAML2 (11q21) / MYO5A (15q21.2) | MAML2 (11q21) / PATJ (1p31.3) | MAML2 (11q21) / RTKN (2p13.1) |
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MTMR2 (11q21) / MAML2 (11q21) | MYB (6q23.3) / MAML2 (11q21) | TANC1 (2q24.2) / MAML2 (11q21) |
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YAP1 (11q22.1) / MAML2 (11q21) |
| Note | |
| | |
| Entity | mucoepidermoid carcinoma with t(11;19)(q21-22;p13). |
| Disease | - Most common type of malignant salivary gland tumor;
- Second most frequent lung tumor of bronchial gland origin;
- Rare tumour in the thyroid.
The t(11;19) was found in samples from the three different sites. |
| Prognosis | - Mucoepidermoid carcinomas have an unpredictable behaviour.
- The CRTC1-MAML2 fusion transcript was found equally in low, intermediate and high grade tumours; however, tumours lacking the fusion transcript were significantly associated with metastases; they may represent a subset of aggressive tumours.
- In another study, the median survival for fusion-positive patients was greater than 10 years compared to 1.6 years for fusion-negative patients. |
| Hybrid/Mutated Gene | CRTC1-MAML2; exon 1 of CRTC1 fused to exons 2-5 of MAML2. Note: CRTC1 is also known as MECT1, or WAMTP1. |
| Abnormal Protein | CRTC1-MAML2. In the fusion protein, the first 171 aa including the basic domain of MAML2 are replaced by 42 aa of CRTC1; there are no sequence similarities in the N-terminal domains of MAML2 and CRTC1. The fusion protein activates transcription of the Notch target gene HES1 independently of both Notch ligand and CSL.
Transforming activity of CRTC1-MAML2 fusion oncoprotein is mediated by mimicking constitutive activation of cAMP signaling, by activating CREB directly. |
| | |
| | |
| Entity | Warthin's tumor with t(11;19)(q21-22;p13). |
| Note | In rare instances mucoepidermoid carcinoma may arise from or coexist with Warthin's tumors. |
| Disease | Warthin's tumor is a salivary gland neoplasm consisting of benign epithelial and lymphoid components; malignant transformation is extremely rare. |
| Hybrid/Mutated Gene | CRTC1-MAML2 |
| | |
| | |
| Entity | Clear Cell Hidradenomas of the skin with t(11;19)(q21-22;p13) |
| Disease | Clear Cell Hidradenomas of the skin are benign sweat gland tumors of eccrine duct origin. |
| Hybrid/Mutated Gene | CRTC1-MAML2; exon 1 of CRTC1 fused to exons 2 of MAML2. |
| | |
| | |
| Entity | inv(11)(q21q23) in therapy related leukemias |
| Disease | therapy-related acute leukemia and MDS. |
| Hybrid/Mutated Gene | MLL-MAML2; exon 1-7 of MLL fused to exons 2-5 of MAML2. |
| Abnormal Protein | Hybrid transcript MLL/MAML2 contains the following domains: from MLL: AT-hook, DNA-Methyltransferase; from MAML2: Q rich domain, acidic domain. |
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| | |
| Molecular classification of mucoepidermoid carcinomas-prognostic significance of the MECT1-MAML2 fusion oncogene. |
| Behboudi A, Enlund F, Winnes M, Andrén Y, Nordkvist A, Leivo I, Flaberg E, Szekely L, Mäkitie A, Grenman R, Mark J, Stenman G |
| Genes, chromosomes & cancer. 2006 ; 45 (5) : 470-481. |
| PMID 16444749 |
| |
| Translocation t(11;19)(q21;p13.1) as the sole chromosome abnormality in a cystadenolymphoma (Warthin's tumor) of the parotid gland. |
| Bullerdiek J, Haubrich J, Meyer K, Bartnitzke S |
| Cancer genetics and cytogenetics. 1988 ; 35 (1) : 129-132. |
| PMID 3180001 |
| |
| Altered Notch signaling resulting from expression of a WAMTP1-MAML2 gene fusion in mucoepidermoid carcinomas and benign Warthin's tumors. |
| Enlund F, Behboudi A, Andrén Y, Oberg C, Lendahl U, Mark J, Stenman G |
| Experimental cell research. 2004 ; 292 (1) : 21-28. |
| PMID 14720503 |
| |
| Expression of an activated Notch-related int-3 transgene interferes with cell differentiation and induces neoplastic transformation in mammary and salivary glands. |
| Jhappan C, Gallahan D, Stahle C, Chu E, Smith GH, Merlino G, Callahan R |
| Genes & development. 1992 ; 6 (3) : 345-355. |
| PMID 1372276 |
| |
| Identification of new human mastermind proteins defines a family that consists of positive regulators for notch signaling. |
| Lin SE, Oyama T, Nagase T, Harigaya K, Kitagawa M |
| The Journal of biological chemistry. 2002 ; 277 (52) : 50612-50620. |
| PMID 12386158 |
| |
| Chromosomal patterns in Warthin's tumor. A second type of human benign salivary gland neoplasm. |
| Mark J, Dahlenfors R, Stenman G, Nordquist A |
| Cancer genetics and cytogenetics. 1990 ; 46 (1) : 35-39. |
| PMID 2331681 |
| |
| A study of MECT1-MAML2 in mucoepidermoid carcinoma and Warthin's tumor of salivary glands. |
| Martins C, Cavaco B, Tonon G, Kaye FJ, Soares J, Fonseca I |
| The Journal of molecular diagnostics : JMD. 2004 ; 6 (3) : 205-210. |
| PMID 15269296 |
| |
| Identification of a novel fusion gene MLL-MAML2 in secondary acute myelogenous leukemia and myelodysplastic syndrome with inv(11)(q21q23). |
| Nemoto N, Suzukawa K, Shimizu S, Shinagawa A, Takei N, Taki T, Hayashi Y, Kojima H, Kawakami Y, Nagasawa T |
| Genes, chromosomes & cancer. 2007 ; 46 (9) : 813-819. |
| PMID 17551948 |
| |
| Recurrent rearrangements of 11q14-22 in mucoepidermoid carcinoma. |
| Nordkvist A, Gustafsson H, Juberg-Ode M, Stenman G |
| Cancer genetics and cytogenetics. 1994 ; 74 (2) : 77-83. |
| PMID 8019965 |
| |
| A child with a t(11;19)(q14-21;p12) in a pulmonary mucoepidermoid carcinoma. |
| Stenman G, Petursdottir V, Mellgren G, Mark J |
| Virchows Archiv : an international journal of pathology. 1998 ; 433 (6) : 579-581. |
| PMID 9870694 |
| |
| CRTC1/MAML2 fusion transcript in high grade mucoepidermoid carcinomas of salivary and thyroid glands and Warthin's tumors: implications for histogenesis and biologic behavior. |
| Tirado Y, Williams MD, Hanna EY, Kaye FJ, Batsakis JG, El-Naggar AK |
| Genes, chromosomes & cancer. 2007 ; 46 (7) : 708-715. |
| PMID 17437281 |
| |
| t(11;19)(q21;p13) translocation in mucoepidermoid carcinoma creates a novel fusion product that disrupts a Notch signaling pathway. |
| Tonon G, Modi S, Wu L, Kubo A, Coxon AB, Komiya T, O'Neil K, Stover K, El-Naggar A, Griffin JD, Kirsch IR, Kaye FJ |
| Nature genetics. 2003 ; 33 (2) : 208-213. |
| PMID 12539049 |
| |
| Frequent fusion of the CRTC1 and MAML2 genes in clear cell variants of cutaneous hidradenomas. |
| Winnes M, Mölne L, Suurküla M, Andrén Y, Persson F, Enlund F, Stenman G |
| Genes, chromosomes & cancer. 2007 ; 46 (6) : 559-563. |
| PMID 17334997 |
| |
| MAML1, a human homologue of Drosophila mastermind, is a transcriptional co-activator for NOTCH receptors. |
| Wu L, Aster JC, Blacklow SC, Lake R, Artavanis-Tsakonas S, Griffin JD |
| Nature genetics. 2000 ; 26 (4) : 484-489. |
| PMID 11101851 |
| |
| Transforming activity of MECT1-MAML2 fusion oncoprotein is mediated by constitutive CREB activation. |
| Wu L, Liu J, Gao P, Nakamura M, Cao Y, Shen H, Griffin JD |
| The EMBO journal. 2005 ; 24 (13) : 2391-2402. |
| PMID 15961999 |
| |
| Identification of a family of mastermind-like transcriptional coactivators for mammalian notch receptors. |
| Wu L, Sun T, Kobayashi K, Gao P, Griffin JD |
| Molecular and cellular biology. 2002 ; 22 (21) : 7688-7700. |
| PMID 12370315 |
| |
| Conservation of the Notch signalling pathway in mammalian neurogenesis. |
| de la Pompa JL, Wakeham A, Correia KM, Samper E, Brown S, Aguilera RJ, Nakano T, Honjo T, Mak TW, Rossant J, Conlon RA |
| Development (Cambridge, England). 1997 ; 124 (6) : 1139-1148. |
| PMID 9102301 |
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