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MAN1A2 (mannosidase alpha class 1A member 2)

Identity

Alias (NCBI)MAN1B
HGNC (Hugo) MAN1A2
HGNC Alias symbMAN1B
HGNC Previous namemannosidase, alpha, class 1A, member 2
LocusID (NCBI) 10905
Atlas_Id 54441
Location 1p12  [Link to chromosome band 1p12]
Location_base_pair Starts at 117367449 and ends at 117528870 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALDOC (17q11.2) / MAN1A2 (1p12)CSPP1 (8q13.1) / MAN1A2 (1p12)DST (6p12.1) / MAN1A2 (1p12)
EML2 (19q13.32) / MAN1A2 (1p12)IGSF3 (1p13.1) / MAN1A2 (1p12)LONP1 (19p13.3) / MAN1A2 (1p12)
MAN1A2 (1p12) / ALDOC (17q11.2)MAN1A2 (1p12) / CD101 (1p13.1)MAN1A2 (1p12) / GYPC (2q14.3)
MAN1A2 (1p12) / LONP1 (19p13.3)MAN1A2 (1p12) / MAN1A2 (1p12)MAN1A2 (1p12) / TTF2 (1p13.1)
MAN1A2 (1p12) / USF3 (3q13.2)MAN1A2 (1p12) / VANGL1 (1p13.1)MAN1A2 (1p12) / ZYX (7q34)
REL (2p16.1) / MAN1A2 (1p12)TAF15 (17q12) / MAN1A2 (1p12)CSPP1 8q13.1 / MAN1A2 1p12
IGSF3 1p13.1 / MAN1A2 1p12MAN1A2 1p12 / CD101 1p13.1MAN1A2 1p12 / TTF2 1p13.1
MAN1A2 1p12 / VANGL1 1p13.1REL 2p16.1 / MAN1A2 1p12TAF15 17q12 / MAN1A2 1p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MAN1A2   6822
Cards
Entrez_Gene (NCBI)MAN1A2    mannosidase alpha class 1A member 2
AliasesMAN1B
GeneCards (Weizmann)MAN1A2
Ensembl hg19 (Hinxton)ENSG00000198162 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198162 [Gene_View]  ENSG00000198162 [Sequence]  chr1:117367449-117528870 [Contig_View]  MAN1A2 [Vega]
ICGC DataPortalENSG00000198162
TCGA cBioPortalMAN1A2
AceView (NCBI)MAN1A2
Genatlas (Paris)MAN1A2
SOURCE (Princeton)MAN1A2
Genetics Home Reference (NIH)MAN1A2
Genomic and cartography
GoldenPath hg38 (UCSC)MAN1A2  -     chr1:117367449-117528870 +  1p12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAN1A2  -     1p12   [Description]    (hg19-Feb_2009)
GoldenPathMAN1A2 - 1p12 [CytoView hg19]  MAN1A2 - 1p12 [CytoView hg38]
ImmunoBaseENSG00000198162
Genome Data Viewer NCBIMAN1A2 [Mapview hg19]  
OMIM604345   
Gene and transcription
Genbank (Entrez)AF027156 AK001970 AK090840 AK098129 AK307842
RefSeq transcript (Entrez)NM_006699
Consensus coding sequences : CCDS (NCBI)MAN1A2
Gene ExpressionMAN1A2 [ NCBI-GEO ]   MAN1A2 [ EBI - ARRAY_EXPRESS ]   MAN1A2 [ SEEK ]   MAN1A2 [ MEM ]
Gene Expression Viewer (FireBrowse)MAN1A2 [ Firebrowse - Broad ]
GenevisibleExpression of MAN1A2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10905
GTEX Portal (Tissue expression)MAN1A2
Human Protein AtlasENSG00000198162-MAN1A2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60476   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60476  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60476
PhosPhoSitePlusO60476
Domains : Interpro (EBI)6hp_glycosidase-like_sf    Glyco_hydro_47    Seven-hairpin_glycosidases   
Domain families : Pfam (Sanger)Glyco_hydro_47 (PF01532)   
Domain families : Pfam (NCBI)pfam01532   
Conserved Domain (NCBI)MAN1A2
SuperfamilyO60476
AlphaFold pdb e-kbO60476   
Human Protein Atlas [tissue]ENSG00000198162-MAN1A2 [tissue]
HPRD05067
Protein Interaction databases
DIP (DOE-UCLA)O60476
IntAct (EBI)O60476
BioGRIDMAN1A2
STRING (EMBL)MAN1A2
ZODIACMAN1A2
Ontologies - Pathways
QuickGOO60476
Ontology : AmiGOGolgi membrane  Golgi membrane  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity  calcium ion binding  endoplasmic reticulum  Golgi apparatus  carbohydrate metabolic process  protein glycosylation  N-glycan processing  respiratory gaseous exchange by respiratory system  membrane  integral component of membrane  lung alveolus development  extracellular exosome  Golgi apparatus mannose trimming  
Ontology : EGO-EBIGolgi membrane  Golgi membrane  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity  calcium ion binding  endoplasmic reticulum  Golgi apparatus  carbohydrate metabolic process  protein glycosylation  N-glycan processing  respiratory gaseous exchange by respiratory system  membrane  integral component of membrane  lung alveolus development  extracellular exosome  Golgi apparatus mannose trimming  
Pathways : BIOCARTASteps in the Glycosylation of Mammalian N-linked Oligosaccarides [Genes]    ER?associated degradation (ERAD) Pathway [Genes]   
Pathways : KEGGN-Glycan biosynthesis    Protein processing in endoplasmic reticulum   
NDEx NetworkMAN1A2
Atlas of Cancer Signalling NetworkMAN1A2
Wikipedia pathwaysMAN1A2
Orthology - Evolution
OrthoDB10905
GeneTree (enSembl)ENSG00000198162
Phylogenetic Trees/Animal Genes : TreeFamMAN1A2
Homologs : HomoloGeneMAN1A2
Homology/Alignments : Family Browser (UCSC)MAN1A2
Gene fusions - Rearrangements
Fusion : MitelmanALDOC/MAN1A2 [17q11.2/1p12]  
Fusion : MitelmanCSPP1/MAN1A2 [8q13.1/1p12]  
Fusion : MitelmanIGSF3/MAN1A2 [1p13.1/1p12]  
Fusion : MitelmanMAN1A2/ALDOC [1p12/17q11.2]  
Fusion : MitelmanMAN1A2/CD101 [1p12/1p13.1]  
Fusion : MitelmanMAN1A2/TTF2 [1p12/1p13.1]  
Fusion : MitelmanMAN1A2/VANGL1 [1p12/1p13.1]  
Fusion : MitelmanREL/MAN1A2 [2p16.1/1p12]  
Fusion : QuiverMAN1A2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAN1A2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAN1A2
dbVarMAN1A2
ClinVarMAN1A2
MonarchMAN1A2
1000_GenomesMAN1A2 
Exome Variant ServerMAN1A2
GNOMAD BrowserENSG00000198162
Varsome BrowserMAN1A2
ACMGMAN1A2 variants
VarityO60476
Genomic Variants (DGV)MAN1A2 [DGVbeta]
DECIPHERMAN1A2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAN1A2 
Mutations
ICGC Data PortalMAN1A2 
TCGA Data PortalMAN1A2 
Broad Tumor PortalMAN1A2
OASIS PortalMAN1A2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAN1A2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAN1A2
Mutations and Diseases : HGMDMAN1A2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMAN1A2
DgiDB (Drug Gene Interaction Database)MAN1A2
DoCM (Curated mutations)MAN1A2
CIViC (Clinical Interpretations of Variants in Cancer)MAN1A2
Cancer3DMAN1A2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604345   
Orphanet
DisGeNETMAN1A2
MedgenMAN1A2
Genetic Testing Registry MAN1A2
NextProtO60476 [Medical]
GENETestsMAN1A2
Target ValidationMAN1A2
Huge Navigator MAN1A2 [HugePedia]
ClinGenMAN1A2
Clinical trials, drugs, therapy
MyCancerGenomeMAN1A2
Protein Interactions : CTDMAN1A2
Pharm GKB GenePA30571
PharosO60476
Clinical trialMAN1A2
Miscellaneous
canSAR (ICR)MAN1A2
HarmonizomeMAN1A2
DataMed IndexMAN1A2
Probes
Litterature
PubMed41 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMAN1A2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:17:37 CEST 2021

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