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MAN1B1 (mannosidase alpha class 1B member 1)

Identity

Alias_namesmannosidase
Alias_symbol (synonym)MANA-ER
MRT15
ERManI
Other aliasERMAN1
HGNC (Hugo) MAN1B1
LocusID (NCBI) 11253
Atlas_Id 46290
Location 9q34.3  [Link to chromosome band 9q34]
Location_base_pair Starts at 137086927 and ends at 137109187 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AMPD3 (11p15.4) / MAN1B1 (9q34.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAN1B1   6823
Cards
Entrez_Gene (NCBI)MAN1B1  11253  mannosidase alpha class 1B member 1
AliasesERMAN1; ERManI; MANA-ER; MRT15
GeneCards (Weizmann)MAN1B1
Ensembl hg19 (Hinxton)ENSG00000177239 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000177239 [Gene_View]  ENSG00000177239 [Sequence]  chr9:137086927-137109187 [Contig_View]  MAN1B1 [Vega]
ICGC DataPortalENSG00000177239
TCGA cBioPortalMAN1B1
AceView (NCBI)MAN1B1
Genatlas (Paris)MAN1B1
WikiGenes11253
SOURCE (Princeton)MAN1B1
Genetics Home Reference (NIH)MAN1B1
Genomic and cartography
GoldenPath hg38 (UCSC)MAN1B1  -     chr9:137086927-137109187 +  9q34.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAN1B1  -     9q34.3   [Description]    (hg19-Feb_2009)
EnsemblMAN1B1 - 9q34.3 [CytoView hg19]  MAN1B1 - 9q34.3 [CytoView hg38]
Mapping of homologs : NCBIMAN1B1 [Mapview hg19]  MAN1B1 [Mapview hg38]
OMIM604346   614202   
Gene and transcription
Genbank (Entrez)AB209276 AF145732 AF148509 AI312031 AK074559
RefSeq transcript (Entrez)NM_016219
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAN1B1
Cluster EST : UnigeneHs.279881 [ NCBI ]
CGAP (NCI)Hs.279881
Alternative Splicing GalleryENSG00000177239
Gene ExpressionMAN1B1 [ NCBI-GEO ]   MAN1B1 [ EBI - ARRAY_EXPRESS ]   MAN1B1 [ SEEK ]   MAN1B1 [ MEM ]
Gene Expression Viewer (FireBrowse)MAN1B1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11253
GTEX Portal (Tissue expression)MAN1B1
Human Protein AtlasENSG00000177239-MAN1B1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKM7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKM7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKM7
Splice isoforms : SwissVarQ9UKM7
PhosPhoSitePlusQ9UKM7
Domains : Interpro (EBI)6hp_glycosidase-like_sf    Glyco_hydro_47    Seven-hairpin_glycosidases   
Domain families : Pfam (Sanger)Glyco_hydro_47 (PF01532)   
Domain families : Pfam (NCBI)pfam01532   
Conserved Domain (NCBI)MAN1B1
DMDM Disease mutations11253
Blocks (Seattle)MAN1B1
PDB (RSDB)1FMI    1FO2    1FO3    1X9D    5KIJ    5KK7   
PDB Europe1FMI    1FO2    1FO3    1X9D    5KIJ    5KK7   
PDB (PDBSum)1FMI    1FO2    1FO3    1X9D    5KIJ    5KK7   
PDB (IMB)1FMI    1FO2    1FO3    1X9D    5KIJ    5KK7   
Structural Biology KnowledgeBase1FMI    1FO2    1FO3    1X9D    5KIJ    5KK7   
SCOP (Structural Classification of Proteins)1FMI    1FO2    1FO3    1X9D    5KIJ    5KK7   
CATH (Classification of proteins structures)1FMI    1FO2    1FO3    1X9D    5KIJ    5KK7   
SuperfamilyQ9UKM7
Human Protein Atlas [tissue]ENSG00000177239-MAN1B1 [tissue]
Peptide AtlasQ9UKM7
HPRD05068
IPIIPI00008207   IPI00383856   IPI00556490   IPI00470859   IPI01022404   IPI01021034   IPI01014739   IPI01011077   IPI01011486   IPI01011816   IPI01012245   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKM7
IntAct (EBI)Q9UKM7
FunCoupENSG00000177239
BioGRIDMAN1B1
STRING (EMBL)MAN1B1
ZODIACMAN1B1
Ontologies - Pathways
QuickGOQ9UKM7
Ontology : AmiGOmannosyl-oligosaccharide 1,2-alpha-mannosidase activity  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity  calcium ion binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  protein glycosylation  N-glycan processing  oligosaccharide metabolic process  membrane  membrane  membrane  integral component of membrane  ubiquitin-dependent ERAD pathway  ubiquitin-dependent ERAD pathway  protein alpha-1,2-demannosylation  protein alpha-1,2-demannosylation  trimming of terminal mannose on B branch  trimming of terminal mannose on B branch  trimming of terminal mannose on B branch  trimming of terminal mannose on C branch  trimming of first mannose on A branch  trimming of second mannose on A branch  endoplasmic reticulum quality control compartment  endoplasmic reticulum quality control compartment  extracellular vesicle  endoplasmic reticulum mannose trimming  mannose trimming involved in glycoprotein ERAD pathway  mannose trimming involved in glycoprotein ERAD pathway  
Ontology : EGO-EBImannosyl-oligosaccharide 1,2-alpha-mannosidase activity  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity  mannosyl-oligosaccharide 1,2-alpha-mannosidase activity  calcium ion binding  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum  endoplasmic reticulum membrane  Golgi apparatus  protein glycosylation  N-glycan processing  oligosaccharide metabolic process  membrane  membrane  membrane  integral component of membrane  ubiquitin-dependent ERAD pathway  ubiquitin-dependent ERAD pathway  protein alpha-1,2-demannosylation  protein alpha-1,2-demannosylation  trimming of terminal mannose on B branch  trimming of terminal mannose on B branch  trimming of terminal mannose on B branch  trimming of terminal mannose on C branch  trimming of first mannose on A branch  trimming of second mannose on A branch  endoplasmic reticulum quality control compartment  endoplasmic reticulum quality control compartment  extracellular vesicle  endoplasmic reticulum mannose trimming  mannose trimming involved in glycoprotein ERAD pathway  mannose trimming involved in glycoprotein ERAD pathway  
Pathways : KEGGN-Glycan biosynthesis    Protein processing in endoplasmic reticulum   
NDEx NetworkMAN1B1
Atlas of Cancer Signalling NetworkMAN1B1
Wikipedia pathwaysMAN1B1
Orthology - Evolution
OrthoDB11253
GeneTree (enSembl)ENSG00000177239
Phylogenetic Trees/Animal Genes : TreeFamMAN1B1
HOGENOMQ9UKM7
Homologs : HomoloGeneMAN1B1
Homology/Alignments : Family Browser (UCSC)MAN1B1
Gene fusions - Rearrangements
Fusion : QuiverMAN1B1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAN1B1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAN1B1
dbVarMAN1B1
ClinVarMAN1B1
1000_GenomesMAN1B1 
Exome Variant ServerMAN1B1
ExAC (Exome Aggregation Consortium)ENSG00000177239
GNOMAD BrowserENSG00000177239
Varsome BrowserMAN1B1
Genetic variants : HAPMAP11253
Genomic Variants (DGV)MAN1B1 [DGVbeta]
DECIPHERMAN1B1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAN1B1 
Mutations
ICGC Data PortalMAN1B1 
TCGA Data PortalMAN1B1 
Broad Tumor PortalMAN1B1
OASIS PortalMAN1B1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAN1B1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAN1B1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Mendelian genes
BioMutasearch MAN1B1
DgiDB (Drug Gene Interaction Database)MAN1B1
DoCM (Curated mutations)MAN1B1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAN1B1 (select a term)
intoGenMAN1B1
Cancer3DMAN1B1(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604346    614202   
Orphanet22709    11804   
DisGeNETMAN1B1
MedgenMAN1B1
Genetic Testing Registry MAN1B1
NextProtQ9UKM7 [Medical]
TSGene11253
GENETestsMAN1B1
Target ValidationMAN1B1
Huge Navigator MAN1B1 [HugePedia]
snp3D : Map Gene to Disease11253
BioCentury BCIQMAN1B1
ClinGenMAN1B1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11253
Chemical/Pharm GKB GenePA30572
Clinical trialMAN1B1
Miscellaneous
canSAR (ICR)MAN1B1 (select the gene name)
DataMed IndexMAN1B1
Probes
Litterature
PubMed72 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAN1B1
EVEXMAN1B1
GoPubMedMAN1B1
iHOPMAN1B1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 17 18:22:05 CET 2019

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