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MAN2B2 (mannosidase alpha class 2B member 2)

Identity

Alias_namesmannosidase, alpha, class 2B, member 2
Alias_symbol (synonym)KIAA0935
Other alias-
HGNC (Hugo) MAN2B2
LocusID (NCBI) 23324
Atlas_Id 68781
Location 4p16.1  [Link to chromosome band 4p16]
Location_base_pair Starts at 6575174 and ends at 6622406 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MAN2B2 (4p16.1) / TACC3 (4p16.3)MAN2B2 (4p16.1) / TP63 (3q28)PBXIP1 (1q21.3) / MAN2B2 (4p16.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAN2B2   29623
Cards
Entrez_Gene (NCBI)MAN2B2  23324  mannosidase alpha class 2B member 2
Aliases
GeneCards (Weizmann)MAN2B2
Ensembl hg19 (Hinxton)ENSG00000013288 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000013288 [Gene_View]  chr4:6575174-6622406 [Contig_View]  MAN2B2 [Vega]
ICGC DataPortalENSG00000013288
TCGA cBioPortalMAN2B2
AceView (NCBI)MAN2B2
Genatlas (Paris)MAN2B2
WikiGenes23324
SOURCE (Princeton)MAN2B2
Genetics Home Reference (NIH)MAN2B2
Genomic and cartography
GoldenPath hg38 (UCSC)MAN2B2  -     chr4:6575174-6622406 +  4p16.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAN2B2  -     4p16.1   [Description]    (hg19-Feb_2009)
EnsemblMAN2B2 - 4p16.1 [CytoView hg19]  MAN2B2 - 4p16.1 [CytoView hg38]
Mapping of homologs : NCBIMAN2B2 [Mapview hg19]  MAN2B2 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AA453331 AB023152 AK025803 AK075246 AK301473
RefSeq transcript (Entrez)NM_001292038 NM_015274
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAN2B2
Cluster EST : UnigeneHs.188464 [ NCBI ]
CGAP (NCI)Hs.188464
Alternative Splicing GalleryENSG00000013288
Gene ExpressionMAN2B2 [ NCBI-GEO ]   MAN2B2 [ EBI - ARRAY_EXPRESS ]   MAN2B2 [ SEEK ]   MAN2B2 [ MEM ]
Gene Expression Viewer (FireBrowse)MAN2B2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23324
GTEX Portal (Tissue expression)MAN2B2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2E5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2E5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2E5
Splice isoforms : SwissVarQ9Y2E5
Catalytic activity : Enzyme3.2.1.24 [ Enzyme-Expasy ]   3.2.1.243.2.1.24 [ IntEnz-EBI ]   3.2.1.24 [ BRENDA ]   3.2.1.24 [ KEGG ]   
PhosPhoSitePlusQ9Y2E5
Domains : Interpro (EBI)Gal_mutarotase_SF_dom    Glyco_hydro/deAcase_b/a-brl    Glyco_hydro_38/57_N    Glyco_hydro_38_C    Glyco_hydro_38_cen    Glyco_hydro_38_N    Glyco_hydro_57/38_cen    Glyco_hydro_b   
Domain families : Pfam (Sanger)Alpha-mann_mid (PF09261)    Glyco_hydro_38 (PF01074)    Glyco_hydro_38C (PF07748)   
Domain families : Pfam (NCBI)pfam09261    pfam01074    pfam07748   
Domain families : Smart (EMBL)Alpha-mann_mid (SM00872)  
Conserved Domain (NCBI)MAN2B2
DMDM Disease mutations23324
Blocks (Seattle)MAN2B2
SuperfamilyQ9Y2E5
Human Protein AtlasENSG00000013288
Peptide AtlasQ9Y2E5
HPRD14355
IPIIPI00328488   IPI00604401   IPI00965096   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2E5
IntAct (EBI)Q9Y2E5
FunCoupENSG00000013288
BioGRIDMAN2B2
STRING (EMBL)MAN2B2
ZODIACMAN2B2
Ontologies - Pathways
QuickGOQ9Y2E5
Ontology : AmiGOalpha-mannosidase activity  extracellular space  mannose metabolic process  protein deglycosylation  zinc ion binding  mannan endo-1,6-alpha-mannosidase activity  oligosaccharide catabolic process  carbohydrate binding  lysosomal lumen  extracellular exosome  
Ontology : EGO-EBIalpha-mannosidase activity  extracellular space  mannose metabolic process  protein deglycosylation  zinc ion binding  mannan endo-1,6-alpha-mannosidase activity  oligosaccharide catabolic process  carbohydrate binding  lysosomal lumen  extracellular exosome  
Pathways : KEGGOther glycan degradation   
NDEx NetworkMAN2B2
Atlas of Cancer Signalling NetworkMAN2B2
Wikipedia pathwaysMAN2B2
Orthology - Evolution
OrthoDB23324
GeneTree (enSembl)ENSG00000013288
Phylogenetic Trees/Animal Genes : TreeFamMAN2B2
HOVERGENQ9Y2E5
HOGENOMQ9Y2E5
Homologs : HomoloGeneMAN2B2
Homology/Alignments : Family Browser (UCSC)MAN2B2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAN2B2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAN2B2
dbVarMAN2B2
ClinVarMAN2B2
1000_GenomesMAN2B2 
Exome Variant ServerMAN2B2
ExAC (Exome Aggregation Consortium)MAN2B2 (select the gene name)
Genetic variants : HAPMAP23324
Genomic Variants (DGV)MAN2B2 [DGVbeta]
DECIPHERMAN2B2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAN2B2 
Mutations
ICGC Data PortalMAN2B2 
TCGA Data PortalMAN2B2 
Broad Tumor PortalMAN2B2
OASIS PortalMAN2B2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAN2B2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAN2B2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAN2B2
DgiDB (Drug Gene Interaction Database)MAN2B2
DoCM (Curated mutations)MAN2B2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAN2B2 (select a term)
intoGenMAN2B2
Cancer3DMAN2B2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenMAN2B2
Genetic Testing Registry MAN2B2
NextProtQ9Y2E5 [Medical]
TSGene23324
GENETestsMAN2B2
Target ValidationMAN2B2
Huge Navigator MAN2B2 [HugePedia]
snp3D : Map Gene to Disease23324
BioCentury BCIQMAN2B2
ClinGenMAN2B2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23324
Chemical/Pharm GKB GenePA128394625
Clinical trialMAN2B2
Miscellaneous
canSAR (ICR)MAN2B2 (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAN2B2
EVEXMAN2B2
GoPubMedMAN2B2
iHOPMAN2B2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:26:53 CEST 2017

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