MAN2C1 (mannosidase alpha class 2C member 1)

2009-01-01  

Identity

HGNC
LOCATION
15q24.2
LOCUSID
ALIAS
MAN6A8,MANA,MANA1
FUSION GENES

Other Information

Locus ID:

NCBI: 4123
MIM: 154580
HGNC: 6827
Ensembl: ENSG00000140400

Variants:

dbSNP: 4123
ClinVar: 4123
TCGA: ENSG00000140400
COSMIC: MAN2C1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000140400ENST00000267978Q9NTJ4
ENSG00000140400ENST00000267978A0A140VJN9
ENSG00000140400ENST00000421803B4DH23
ENSG00000140400ENST00000561615H3BUW3
ENSG00000140400ENST00000562071H3BQJ2
ENSG00000140400ENST00000563622Q9NTJ4
ENSG00000140400ENST00000565683Q9NTJ4
ENSG00000140400ENST00000565784H3BRV3
ENSG00000140400ENST00000566256H3BQH9
ENSG00000140400ENST00000566634H3BRV3
ENSG00000140400ENST00000568374H3BRI3
ENSG00000140400ENST00000569355H3BMJ3
ENSG00000140400ENST00000569482Q9NTJ4
ENSG00000140400ENST00000570257H3BSE5
ENSG00000140400ENST00000618257A0A0C4DGU9

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Other glycan degradationKEGGko00511
Other glycan degradationKEGGhsa00511
MetabolismREACTOMER-HSA-1430728
Metabolism of carbohydratesREACTOMER-HSA-71387
Lysosomal oligosaccharide catabolismREACTOMER-HSA-8853383

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
215085152011Gene expression and methylation signatures of MAN2C1 are associated with PTSD.36
215560612011α-Mannosidase 2C1 attenuates PTEN function in prostate cancer cells.18
209780112011Overexpression of Man2C1 leads to protein underglycosylation and upregulation of endoplasmic reticulum-associated degradation pathway.6
234864762013Dual functions for cytosolic α-mannosidase (Man2C1): its down-regulation causes mitochondria-dependent apoptosis independently of its α-mannosidase activity.6
195722062010hMan2c1 transgene promotes tumor progress in mice.5
167213562006Inhibition of the alpha-mannosidase Man2c1 gene expression enhances adhesion of Jurkat cells.4
190187772008Inhibition of alpha-mannosidase Man2c1 gene expression suppresses growth of esophageal carcinoma cells through mitotic arrest and apoptosis.3
126434542002Inhibition of 6A8 alpha-mannosidase causes oncosis-like death of BJAB cells.1
273555852016Ancient Haplotypes at the 15q24.2 Microdeletion Region Are Linked to Brain Expression of MAN2C1 and Children's Intelligence.0

Citation

Dessen P

MAN2C1 (mannosidase alpha class 2C member 1)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50614/man2c1