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MAN2C1 (mannosidase alpha class 2C member 1)

Identity

Alias_namesMANA1
MANA
mannosidase
Other aliasMAN6A8
HGNC (Hugo) MAN2C1
LocusID (NCBI) 4123
Atlas_Id 50614
Location 15q24.2  [Link to chromosome band 15q24]
Location_base_pair Starts at 75648133 and ends at 75660968 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LOC100507412 (-) / MAN2C1 (15q24.2)MAN2C1 (15q24.2) / CORO2A (9q22.33)MAN2C1 (15q24.2) / MAN2C1 (15q24.2)
MAN2C1 (15q24.2) / MESP2 (15q26.1)MAN2C1 (15q24.2) / RPL27A (11p15.4)MAN2C1 (15q24.2) / SIN3A (15q24.2)
MAN2C1 15q24.2 / MESP2 15q26.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAN2C1   6827
Cards
Entrez_Gene (NCBI)MAN2C1  4123  mannosidase alpha class 2C member 1
AliasesMAN6A8; MANA; MANA1
GeneCards (Weizmann)MAN2C1
Ensembl hg19 (Hinxton)ENSG00000140400 [Gene_View]  chr15:75648133-75660968 [Contig_View]  MAN2C1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000140400 [Gene_View]  chr15:75648133-75660968 [Contig_View]  MAN2C1 [Vega]
ICGC DataPortalENSG00000140400
TCGA cBioPortalMAN2C1
AceView (NCBI)MAN2C1
Genatlas (Paris)MAN2C1
WikiGenes4123
SOURCE (Princeton)MAN2C1
Genetics Home Reference (NIH)MAN2C1
Genomic and cartography
GoldenPath hg19 (UCSC)MAN2C1  -     chr15:75648133-75660968 -  15q24.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAN2C1  -     15q24.2   [Description]    (hg38-Dec_2013)
EnsemblMAN2C1 - 15q24.2 [CytoView hg19]  MAN2C1 - 15q24.2 [CytoView hg38]
Mapping of homologs : NCBIMAN2C1 [Mapview hg19]  MAN2C1 [Mapview hg38]
OMIM154580   
Gene and transcription
Genbank (Entrez)AB209141 AF044414 AK225145 AK294892 AK295265
RefSeq transcript (Entrez)NM_001256494 NM_001256495 NM_001256496 NM_006715
RefSeq genomic (Entrez)NC_000015 NC_018926 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)MAN2C1
Cluster EST : UnigeneHs.598731 [ NCBI ]
CGAP (NCI)Hs.598731
Alternative Splicing GalleryENSG00000140400
Gene ExpressionMAN2C1 [ NCBI-GEO ]   MAN2C1 [ EBI - ARRAY_EXPRESS ]   MAN2C1 [ SEEK ]   MAN2C1 [ MEM ]
Gene Expression Viewer (FireBrowse)MAN2C1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4123
GTEX Portal (Tissue expression)MAN2C1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NTJ4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NTJ4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NTJ4
Splice isoforms : SwissVarQ9NTJ4
Catalytic activity : Enzyme3.2.1.24 [ Enzyme-Expasy ]   3.2.1.243.2.1.24 [ IntEnz-EBI ]   3.2.1.24 [ BRENDA ]   3.2.1.24 [ KEGG ]   
PhosPhoSitePlusQ9NTJ4
Domains : Interpro (EBI)Gal_mutarotase_SF_dom    Glyco_hydro/deAcase_b/a-brl    Glyco_hydro_38/57_N    Glyco_hydro_38_C    Glyco_hydro_38_cen    Glyco_hydro_38_N    Glyco_hydro_57/38_cen   
Domain families : Pfam (Sanger)Alpha-mann_mid (PF09261)    Glyco_hydro_38 (PF01074)    Glyco_hydro_38C (PF07748)   
Domain families : Pfam (NCBI)pfam09261    pfam01074    pfam07748   
Domain families : Smart (EMBL)Alpha-mann_mid (SM00872)  
Conserved Domain (NCBI)MAN2C1
DMDM Disease mutations4123
Blocks (Seattle)MAN2C1
SuperfamilyQ9NTJ4
Human Protein AtlasENSG00000140400
Peptide AtlasQ9NTJ4
HPRD01109
IPIIPI00783434   IPI01013598   IPI00910681   IPI00555574   IPI00746198   
Protein Interaction databases
DIP (DOE-UCLA)Q9NTJ4
IntAct (EBI)Q9NTJ4
FunCoupENSG00000140400
BioGRIDMAN2C1
STRING (EMBL)MAN2C1
ZODIACMAN2C1
Ontologies - Pathways
QuickGOQ9NTJ4
Ontology : AmiGOalpha-mannosidase activity  alpha-mannosidase activity  vacuole  cytosol  mannose metabolic process  protein deglycosylation  zinc ion binding  oligosaccharide catabolic process  carbohydrate binding  
Ontology : EGO-EBIalpha-mannosidase activity  alpha-mannosidase activity  vacuole  cytosol  mannose metabolic process  protein deglycosylation  zinc ion binding  oligosaccharide catabolic process  carbohydrate binding  
Pathways : BIOCARTASteps in the Glycosylation of Mammalian N-linked Oligosaccarides [Genes]    ERĝassociated degradation (ERAD) Pathway [Genes]   
Pathways : KEGGOther glycan degradation   
NDEx NetworkMAN2C1
Atlas of Cancer Signalling NetworkMAN2C1
Wikipedia pathwaysMAN2C1
Orthology - Evolution
OrthoDB4123
GeneTree (enSembl)ENSG00000140400
Phylogenetic Trees/Animal Genes : TreeFamMAN2C1
HOVERGENQ9NTJ4
HOGENOMQ9NTJ4
Homologs : HomoloGeneMAN2C1
Homology/Alignments : Family Browser (UCSC)MAN2C1
Gene fusions - Rearrangements
Fusion : MitelmanMAN2C1/MESP2 [15q24.2/15q26.1]  
Fusion: TCGAMAN2C1 15q24.2 MESP2 15q26.1 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAN2C1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAN2C1
dbVarMAN2C1
ClinVarMAN2C1
1000_GenomesMAN2C1 
Exome Variant ServerMAN2C1
ExAC (Exome Aggregation Consortium)MAN2C1 (select the gene name)
Genetic variants : HAPMAP4123
Genomic Variants (DGV)MAN2C1 [DGVbeta]
DECIPHER (Syndromes)15:75648133-75660968  ENSG00000140400
CONAN: Copy Number AnalysisMAN2C1 
Mutations
ICGC Data PortalMAN2C1 
TCGA Data PortalMAN2C1 
Broad Tumor PortalMAN2C1
OASIS PortalMAN2C1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAN2C1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAN2C1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAN2C1
DgiDB (Drug Gene Interaction Database)MAN2C1
DoCM (Curated mutations)MAN2C1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAN2C1 (select a term)
intoGenMAN2C1
Cancer3DMAN2C1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM154580   
Orphanet
MedgenMAN2C1
Genetic Testing Registry MAN2C1
NextProtQ9NTJ4 [Medical]
TSGene4123
GENETestsMAN2C1
Huge Navigator MAN2C1 [HugePedia]
snp3D : Map Gene to Disease4123
BioCentury BCIQMAN2C1
ClinGenMAN2C1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4123
Chemical/Pharm GKB GenePA30576
Clinical trialMAN2C1
Miscellaneous
canSAR (ICR)MAN2C1 (select the gene name)
Probes
Litterature
PubMed44 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAN2C1
EVEXMAN2C1
GoPubMedMAN2C1
iHOPMAN2C1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:14:19 CET 2017

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