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MANBA (mannosidase beta)

Identity

Other namesMANB1
HGNC (Hugo) MANBA
LocusID (NCBI) 4126
Atlas_Id 41267
Location 4q24
Location_base_pair Starts at 103552643 and ends at 103682151 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CHIC2 (4q12) / MANBA (4q24)MANBA (4q24) / LIMCH1 (4p13)MANBA (4q24) / UBE2D3 (4q24)
NFKB1 (4q24) / MANBA (4q24)CHIC2 4q12 / MANBA 4q24MANBA 4q24 / LIMCH1 4p13
NFKB1 4q24 / MANBA 4q24

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MANBA   6831
Cards
Entrez_Gene (NCBI)MANBA  4126  mannosidase beta
GeneCards (Weizmann)MANBA
Ensembl hg19 (Hinxton)ENSG00000109323 [Gene_View]  chr4:103552643-103682151 [Contig_View]  MANBA [Vega]
Ensembl hg38 (Hinxton)ENSG00000109323 [Gene_View]  chr4:103552643-103682151 [Contig_View]  MANBA [Vega]
ICGC DataPortalENSG00000109323
TCGA cBioPortalMANBA
AceView (NCBI)MANBA
Genatlas (Paris)MANBA
WikiGenes4126
SOURCE (Princeton)MANBA
Genomic and cartography
GoldenPath hg19 (UCSC)MANBA  -     chr4:103552643-103682151 -  4q24   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MANBA  -     4q24   [Description]    (hg38-Dec_2013)
EnsemblMANBA - 4q24 [CytoView hg19]  MANBA - 4q24 [CytoView hg38]
Mapping of homologs : NCBIMANBA [Mapview hg19]  MANBA [Mapview hg38]
OMIM248510   609489   
Gene and transcription
Genbank (Entrez)AB209846 AI079197 AK291598 AK300015 AK312827
RefSeq transcript (Entrez)NM_005908
RefSeq genomic (Entrez)NC_000004 NC_018915 NG_012804 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)MANBA
Cluster EST : UnigeneHs.480415 [ NCBI ]
CGAP (NCI)Hs.480415
Alternative Splicing : Fast-db (Paris)GSHG0023442
Alternative Splicing GalleryENSG00000109323
Gene ExpressionMANBA [ NCBI-GEO ]   MANBA [ EBI - ARRAY_EXPRESS ]   MANBA [ SEEK ]   MANBA [ MEM ]
Gene Expression Viewer (FireBrowse)MANBA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)4126
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00462 (Uniprot)
NextProtO00462  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00462
Splice isoforms : SwissVarO00462 (Swissvar)
Catalytic activity : Enzyme3.2.1.25 [ Enzyme-Expasy ]   3.2.1.253.2.1.25 [ IntEnz-EBI ]   3.2.1.25 [ BRENDA ]   3.2.1.25 [ KEGG ]   
PhosPhoSitePlusO00462
Domains : Interpro (EBI)Galactose-bd-like    Glyco_hydro_2/20_Ig-like    Glyco_hydro_2_cat    Glyco_hydro_2_Ig-like    Glyco_hydro_2_N    Glyco_hydro_catalytic_dom    Glycoside_hydrolase_SF   
Domain families : Pfam (Sanger)Glyco_hydro_2_C (PF02836)    Glyco_hydro_2_N (PF02837)   
Domain families : Pfam (NCBI)pfam02836    pfam02837   
DMDM Disease mutations4126
Blocks (Seattle)MANBA
SuperfamilyO00462
Human Protein AtlasENSG00000109323
Peptide AtlasO00462
HPRD02008
IPIIPI00298793   IPI00965393   IPI00965173   
Protein Interaction databases
DIP (DOE-UCLA)O00462
IntAct (EBI)O00462
FunCoupENSG00000109323
BioGRIDMANBA
STRING (EMBL)MANBA
ZODIACMANBA
Ontologies - Pathways
QuickGOO00462
Ontology : AmiGObeta-mannosidase activity  mannose binding  carbohydrate metabolic process  cellular protein modification process  oligosaccharide catabolic process  lysosomal lumen  intracellular membrane-bounded organelle  
Ontology : EGO-EBIbeta-mannosidase activity  mannose binding  carbohydrate metabolic process  cellular protein modification process  oligosaccharide catabolic process  lysosomal lumen  intracellular membrane-bounded organelle  
Pathways : KEGGOther glycan degradation    Lysosome   
NDEx Network
Atlas of Cancer Signalling NetworkMANBA
Wikipedia pathwaysMANBA
Orthology - Evolution
OrthoDB4126
GeneTree (enSembl)ENSG00000109323
Phylogenetic Trees/Animal Genes : TreeFamMANBA
Homologs : HomoloGeneMANBA
Homology/Alignments : Family Browser (UCSC)MANBA
Gene fusions - Rearrangements
Fusion: TCGACHIC2 4q12 MANBA 4q24 LUAD
Fusion: TCGAMANBA 4q24 LIMCH1 4p13 LUSC
Fusion: TCGANFKB1 4q24 MANBA 4q24 LGG
Polymorphisms : SNP, variants
NCBI Variation ViewerMANBA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MANBA
dbVarMANBA
ClinVarMANBA
1000_GenomesMANBA 
Exome Variant ServerMANBA
ExAC (Exome Aggregation Consortium)MANBA (select the gene name)
SNP (GeneSNP Utah)MANBA
SNP : HGBaseMANBA
Genetic variants : HAPMAPMANBA
Genomic Variants (DGV)MANBA [DGVbeta]
Mutations
ICGC Data PortalMANBA 
TCGA Data PortalMANBA 
Broad Tumor PortalMANBA
OASIS PortalMANBA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMANBA 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MANBA
DgiDB (Drug Gene Interaction Database)MANBA
DoCM (Curated mutations)MANBA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MANBA (select a term)
intoGenMANBA
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)4:103552643-103682151
CONAN: Copy Number AnalysisMANBA 
Mutations and Diseases : HGMDMANBA
OMIM248510    609489   
MedgenMANBA
Genetic Testing Registry MANBA
NextProtO00462 [Medical]
TSGene4126
GENETestsMANBA
Huge Navigator MANBA [HugePedia]  MANBA [HugeCancerGEM]
snp3D : Map Gene to Disease4126
BioCentury BCIQMANBA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4126
Chemical/Pharm GKB GenePA30577
Clinical trialMANBA
Miscellaneous
canSAR (ICR)MANBA (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMANBA
GoPubMedMANBA
iHOPMANBA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Apr 16 17:52:20 CEST 2016

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