MANEA (mannosidase endo-alpha)

2014-11-01  

Identity

HGNC
MANEA
LOCATION
6q16.1
LOCUSID
79694
ALIAS
ENDO,hEndo

Other Information

Locus ID:

NCBI: 79694
MIM: 612327
HGNC: 21072
Ensembl: ENSG00000172469

Variants:

dbSNP: 79694
ClinVar: 79694
TCGA: ENSG00000172469
COSMIC: MANEA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172469ENST00000358812Q5SRI9
ENSG00000172469ENST00000369293X6R7A2

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Asparagine N-linked glycosylationREACTOMER-HSA-446203
Transport to the Golgi and subsequent modificationREACTOMER-HSA-948021
N-glycan trimming and elongation in the cis-GolgiREACTOMER-HSA-964739

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
184386862008Substance dependence low-density whole genome association study in two distinct American populations.16
192553762009Association of variants in MANEA with cocaine-related behaviors.15
192553762009Association of variants in MANEA with cocaine-related behaviors.15
156773812005Intact {alpha}-1,2-endomannosidase is a typical type II membrane protein.2
244734442014The α-endomannosidase gene (MANEA) is associated with panic disorder and social anxiety disorder.1

Citation

Dessen P

MANEA (mannosidase endo-alpha)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68783/manea