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MAOA (monoamine oxidase A)

Identity

Other namesMAO-A
HGNC (Hugo) MAOA
LocusID (NCBI) 4128
Atlas_Id 51747
Location Xp11.3
Location_base_pair Starts at 43514155 and ends at 43606071 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MAOA (Xp11.3) / ACTB (7p22.1)MAOA (Xp11.3) / MAOA (Xp11.3)MAOA (Xp11.3) / ZFPM1 (16q24.2)
OPHN1 (Xq12) / MAOA (Xp11.3)SPTLC3 (20p12.1) / MAOA (Xp11.3)OPHN1 Xq12 / MAOA Xp11.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Lung: Translocations in Adenocarcinoma

External links

Nomenclature
HGNC (Hugo)MAOA   6833
Cards
Entrez_Gene (NCBI)MAOA  4128  monoamine oxidase A
GeneCards (Weizmann)MAOA
Ensembl hg19 (Hinxton)ENSG00000189221 [Gene_View]  chrX:43514155-43606071 [Contig_View]  MAOA [Vega]
Ensembl hg38 (Hinxton)ENSG00000189221 [Gene_View]  chrX:43514155-43606071 [Contig_View]  MAOA [Vega]
ICGC DataPortalENSG00000189221
TCGA cBioPortalMAOA
AceView (NCBI)MAOA
Genatlas (Paris)MAOA
WikiGenes4128
SOURCE (Princeton)MAOA
Genomic and cartography
GoldenPath hg19 (UCSC)MAOA  -     chrX:43514155-43606071 +  Xp11.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAOA  -     Xp11.3   [Description]    (hg38-Dec_2013)
EnsemblMAOA - Xp11.3 [CytoView hg19]  MAOA - Xp11.3 [CytoView hg38]
Mapping of homologs : NCBIMAOA [Mapview hg19]  MAOA [Mapview hg38]
OMIM300615   309850   
Gene and transcription
Genbank (Entrez)AK223499 AK291769 AK293926 BC008064 BC044787
RefSeq transcript (Entrez)NM_000240 NM_001270458
RefSeq genomic (Entrez)NC_000023 NC_018934 NG_008957 NT_079573 NW_004929439
Consensus coding sequences : CCDS (NCBI)MAOA
Cluster EST : UnigeneHs.183109 [ NCBI ]
CGAP (NCI)Hs.183109
Alternative Splicing : Fast-db (Paris)GSHG0031474
Alternative Splicing GalleryENSG00000189221
Gene ExpressionMAOA [ NCBI-GEO ]   MAOA [ EBI - ARRAY_EXPRESS ]   MAOA [ SEEK ]   MAOA [ MEM ]
Gene Expression Viewer (FireBrowse)MAOA [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)4128
Protein : pattern, domain, 3D structure
UniProt/SwissProtP21397 (Uniprot)
NextProtP21397  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP21397
Splice isoforms : SwissVarP21397 (Swissvar)
Catalytic activity : Enzyme1.4.3.4 [ Enzyme-Expasy ]   1.4.3.41.4.3.4 [ IntEnz-EBI ]   1.4.3.4 [ BRENDA ]   1.4.3.4 [ KEGG ]   
PhosPhoSitePlusP21397
Domains : Interpro (EBI)Amino_oxidase    FAD/NAD-binding_dom    Flavin_amine_oxidase   
Domain families : Pfam (Sanger)Amino_oxidase (PF01593)   
Domain families : Pfam (NCBI)pfam01593   
DMDM Disease mutations4128
Blocks (Seattle)MAOA
PDB (SRS)1H8Q    2BXR    2BXS    2Z5X    2Z5Y   
PDB (PDBSum)1H8Q    2BXR    2BXS    2Z5X    2Z5Y   
PDB (IMB)1H8Q    2BXR    2BXS    2Z5X    2Z5Y   
PDB (RSDB)1H8Q    2BXR    2BXS    2Z5X    2Z5Y   
Structural Biology KnowledgeBase1H8Q    2BXR    2BXS    2Z5X    2Z5Y   
SCOP (Structural Classification of Proteins)1H8Q    2BXR    2BXS    2Z5X    2Z5Y   
CATH (Classification of proteins structures)1H8Q    2BXR    2BXS    2Z5X    2Z5Y   
SuperfamilyP21397
Human Protein AtlasENSG00000189221
Peptide AtlasP21397
HPRD02400
IPIIPI00008483   IPI00980468   
Protein Interaction databases
DIP (DOE-UCLA)P21397
IntAct (EBI)P21397
FunCoupENSG00000189221
BioGRIDMAOA
STRING (EMBL)MAOA
ZODIACMAOA
Ontologies - Pathways
QuickGOP21397
Ontology : AmiGOmitochondrion  mitochondrial outer membrane  cellular biogenic amine metabolic process  primary amine oxidase activity  integral component of membrane  neurotransmitter metabolic process  neurotransmitter catabolic process  dopamine catabolic process  serotonin metabolic process  phenylethylamine metabolic process  flavin adenine dinucleotide binding  serotonin binding  oxidation-reduction process  
Ontology : EGO-EBImitochondrion  mitochondrial outer membrane  cellular biogenic amine metabolic process  primary amine oxidase activity  integral component of membrane  neurotransmitter metabolic process  neurotransmitter catabolic process  dopamine catabolic process  serotonin metabolic process  phenylethylamine metabolic process  flavin adenine dinucleotide binding  serotonin binding  oxidation-reduction process  
Pathways : KEGGGlycine, serine and threonine metabolism    Arginine and proline metabolism    Histidine metabolism    Tyrosine metabolism    Phenylalanine metabolism    Tryptophan metabolism    Drug metabolism - cytochrome P450    Serotonergic synapse    Dopaminergic synapse    Cocaine addiction    Amphetamine addiction    Alcoholism   
NDEx Network
Atlas of Cancer Signalling NetworkMAOA
Wikipedia pathwaysMAOA
Orthology - Evolution
OrthoDB4128
GeneTree (enSembl)ENSG00000189221
Phylogenetic Trees/Animal Genes : TreeFamMAOA
Homologs : HomoloGeneMAOA
Homology/Alignments : Family Browser (UCSC)MAOA
Gene fusions - Rearrangements
Fusion: TCGAOPHN1 Xq12 MAOA Xp11.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerMAOA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAOA
dbVarMAOA
ClinVarMAOA
1000_GenomesMAOA 
Exome Variant ServerMAOA
ExAC (Exome Aggregation Consortium)MAOA (select the gene name)
SNP (GeneSNP Utah)MAOA
SNP : HGBaseMAOA
Genetic variants : HAPMAPMAOA
Genomic Variants (DGV)MAOA [DGVbeta]
Mutations
ICGC Data PortalMAOA 
TCGA Data PortalMAOA 
Broad Tumor PortalMAOA
OASIS PortalMAOA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAOA 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
BioMutasearch MAOA
DgiDB (Drug Gene Interaction Database)MAOA
DoCM (Curated mutations)MAOA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAOA (select a term)
intoGenMAOA
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)X:43514155-43606071
CONAN: Copy Number AnalysisMAOA 
Mutations and Diseases : HGMDMAOA
OMIM300615    309850   
MedgenMAOA
Genetic Testing Registry MAOA
NextProtP21397 [Medical]
TSGene4128
GENETestsMAOA
Huge Navigator MAOA [HugePedia]  MAOA [HugeCancerGEM]
snp3D : Map Gene to Disease4128
BioCentury BCIQMAOA
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4128
Chemical/Pharm GKB GenePA236
Clinical trialMAOA
Miscellaneous
canSAR (ICR)MAOA (select the gene name)
Probes
Litterature
PubMed491 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAOA
GoPubMedMAOA
iHOPMAOA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Apr 16 17:52:21 CEST 2016

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