Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MAP1LC3A (microtubule associated protein 1 light chain 3 alpha)

Identity

Alias_symbol (synonym)MAP1BLC3
MAP1ALC3
LC3
LC3A
ATG8E
Other alias
HGNC (Hugo) MAP1LC3A
LocusID (NCBI) 84557
Atlas_Id 50647
Location 20q11.22  [Link to chromosome band 20q11]
Location_base_pair Starts at 34558697 and ends at 34560345 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BTN2A2 (6p22.2) / MAP1LC3A (20q11.22)PIGU (20q11.22) / MAP1LC3A (20q11.22)PIGU 20q11.22 / MAP1LC3A 20q11.22

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;5)(p23;q35) SQSTM1/ALK


External links

Nomenclature
HGNC (Hugo)MAP1LC3A   6838
Cards
Entrez_Gene (NCBI)MAP1LC3A  84557  microtubule associated protein 1 light chain 3 alpha
AliasesATG8E; LC3; LC3A; MAP1ALC3; 
MAP1BLC3
GeneCards (Weizmann)MAP1LC3A
Ensembl hg19 (Hinxton)ENSG00000101460 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000101460 [Gene_View]  chr20:34558697-34560345 [Contig_View]  MAP1LC3A [Vega]
ICGC DataPortalENSG00000101460
TCGA cBioPortalMAP1LC3A
AceView (NCBI)MAP1LC3A
Genatlas (Paris)MAP1LC3A
WikiGenes84557
SOURCE (Princeton)MAP1LC3A
Genetics Home Reference (NIH)MAP1LC3A
Genomic and cartography
GoldenPath hg38 (UCSC)MAP1LC3A  -     chr20:34558697-34560345 +  20q11.22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP1LC3A  -     20q11.22   [Description]    (hg19-Feb_2009)
EnsemblMAP1LC3A - 20q11.22 [CytoView hg19]  MAP1LC3A - 20q11.22 [CytoView hg38]
Mapping of homologs : NCBIMAP1LC3A [Mapview hg19]  MAP1LC3A [Mapview hg38]
OMIM601242   
Gene and transcription
Genbank (Entrez)AF276658 AL833855 AM392590 BC015810 BM740344
RefSeq transcript (Entrez)NM_032514 NM_181509
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP1LC3A
Cluster EST : UnigeneHs.632273 [ NCBI ]
CGAP (NCI)Hs.632273
Alternative Splicing GalleryENSG00000101460
Gene ExpressionMAP1LC3A [ NCBI-GEO ]   MAP1LC3A [ EBI - ARRAY_EXPRESS ]   MAP1LC3A [ SEEK ]   MAP1LC3A [ MEM ]
Gene Expression Viewer (FireBrowse)MAP1LC3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84557
GTEX Portal (Tissue expression)MAP1LC3A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H492   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H492  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H492
Splice isoforms : SwissVarQ9H492
PhosPhoSitePlusQ9H492
Domains : Interpro (EBI)Atg8-like    Ubiquitin-rel_dom   
Domain families : Pfam (Sanger)Atg8 (PF02991)   
Domain families : Pfam (NCBI)pfam02991   
Conserved Domain (NCBI)MAP1LC3A
DMDM Disease mutations84557
Blocks (Seattle)MAP1LC3A
PDB (SRS)3ECI    3WAL    3WAN    4ZDV    5CX3    5DPR   
PDB (PDBSum)3ECI    3WAL    3WAN    4ZDV    5CX3    5DPR   
PDB (IMB)3ECI    3WAL    3WAN    4ZDV    5CX3    5DPR   
PDB (RSDB)3ECI    3WAL    3WAN    4ZDV    5CX3    5DPR   
Structural Biology KnowledgeBase3ECI    3WAL    3WAN    4ZDV    5CX3    5DPR   
SCOP (Structural Classification of Proteins)3ECI    3WAL    3WAN    4ZDV    5CX3    5DPR   
CATH (Classification of proteins structures)3ECI    3WAL    3WAN    4ZDV    5CX3    5DPR   
SuperfamilyQ9H492
Human Protein AtlasENSG00000101460
Peptide AtlasQ9H492
HPRD03144
IPIIPI00415014   IPI00015423   
Protein Interaction databases
DIP (DOE-UCLA)Q9H492
IntAct (EBI)Q9H492
FunCoupENSG00000101460
BioGRIDMAP1LC3A
STRING (EMBL)MAP1LC3A
ZODIACMAP1LC3A
Ontologies - Pathways
QuickGOQ9H492
Ontology : AmiGOautophagosome assembly  autophagosome assembly  autophagosome membrane  mitophagy  protein binding  phospholipid binding  late endosome  autophagosome  cytosol  cytosol  microtubule  phosphatidylethanolamine binding  response to iron(II) ion  response to lead ion  macroautophagy  organelle membrane  ubiquitin protein ligase binding  cellular response to amino acid starvation  response to morphine  autolysosome  cellular response to hydrogen peroxide  cellular response to copper ion  autophagosome maturation  
Ontology : EGO-EBIautophagosome assembly  autophagosome assembly  autophagosome membrane  mitophagy  protein binding  phospholipid binding  late endosome  autophagosome  cytosol  cytosol  microtubule  phosphatidylethanolamine binding  response to iron(II) ion  response to lead ion  macroautophagy  organelle membrane  ubiquitin protein ligase binding  cellular response to amino acid starvation  response to morphine  autolysosome  cellular response to hydrogen peroxide  cellular response to copper ion  autophagosome maturation  
NDEx NetworkMAP1LC3A
Atlas of Cancer Signalling NetworkMAP1LC3A
Wikipedia pathwaysMAP1LC3A
Orthology - Evolution
OrthoDB84557
GeneTree (enSembl)ENSG00000101460
Phylogenetic Trees/Animal Genes : TreeFamMAP1LC3A
HOVERGENQ9H492
HOGENOMQ9H492
Homologs : HomoloGeneMAP1LC3A
Homology/Alignments : Family Browser (UCSC)MAP1LC3A
Gene fusions - Rearrangements
Fusion : MitelmanPIGU/MAP1LC3A [20q11.22/20q11.22]  [t(20;20)(q11;q11)]  
Fusion: TCGAPIGU 20q11.22 MAP1LC3A 20q11.22 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP1LC3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP1LC3A
dbVarMAP1LC3A
ClinVarMAP1LC3A
1000_GenomesMAP1LC3A 
Exome Variant ServerMAP1LC3A
ExAC (Exome Aggregation Consortium)MAP1LC3A (select the gene name)
Genetic variants : HAPMAP84557
Genomic Variants (DGV)MAP1LC3A [DGVbeta]
DECIPHERMAP1LC3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP1LC3A 
Mutations
ICGC Data PortalMAP1LC3A 
TCGA Data PortalMAP1LC3A 
Broad Tumor PortalMAP1LC3A
OASIS PortalMAP1LC3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP1LC3A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP1LC3A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP1LC3A
DgiDB (Drug Gene Interaction Database)MAP1LC3A
DoCM (Curated mutations)MAP1LC3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP1LC3A (select a term)
intoGenMAP1LC3A
Cancer3DMAP1LC3A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601242   
Orphanet
MedgenMAP1LC3A
Genetic Testing Registry MAP1LC3A
NextProtQ9H492 [Medical]
TSGene84557
GENETestsMAP1LC3A
Target ValidationMAP1LC3A
Huge Navigator MAP1LC3A [HugePedia]
snp3D : Map Gene to Disease84557
BioCentury BCIQMAP1LC3A
ClinGenMAP1LC3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84557
Chemical/Pharm GKB GenePA30582
Clinical trialMAP1LC3A
Miscellaneous
canSAR (ICR)MAP1LC3A (select the gene name)
Probes
Litterature
PubMed202 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP1LC3A
EVEXMAP1LC3A
GoPubMedMAP1LC3A
iHOPMAP1LC3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 18 13:58:37 CEST 2017

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