MAP1LC3A (microtubule associated protein 1 light chain 3 alpha)

2009-01-01  

Identity

HGNC
LOCATION
20q11.22
LOCUSID
ALIAS
ATG8E,LC3,LC3A,MAP1ALC3,MAP1BLC3
FUSION GENES

Other Information

Locus ID:

NCBI: 84557
MIM: 601242
HGNC: 6838
Ensembl: ENSG00000101460

Variants:

dbSNP: 84557
ClinVar: 84557
TCGA: ENSG00000101460
COSMIC: MAP1LC3A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000101460ENST00000360668Q9H492
ENSG00000101460ENST00000374837Q9H492
ENSG00000101460ENST00000397709Q9H492

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Cellular responses to stressREACTOMER-HSA-2262752
MacroautophagyREACTOMER-HSA-1632852
MitophagyREACTOMER-HSA-5205647
Pink/Parkin Mediated MitophagyREACTOMER-HSA-5205685
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
175803042007p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy.1552
205053592010Mammalian Atg18 (WIPI2) localizes to omegasome-anchored phagophores and positively regulates LC3 lipidation.229
225057142012Microtubule-associated protein 1 light chain 3 (LC3) interacts with Bnip3 protein to selectively remove endoplasmic reticulum and mitochondria via autophagy.187
186888772008Induction of incomplete autophagic response by hepatitis C virus via the unfolded protein response.183
206398712010Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation.156
193221942009The structure of Atg4B-LC3 complex reveals the mechanism of LC3 processing and delipidation during autophagy.149
232193902012Noncanonical autophagy is required for type I interferon secretion in response to DNA-immune complexes.146
151870942004HsAtg4B/HsApg4B/autophagin-1 cleaves the carboxyl termini of three human Atg8 homologues and delipidates microtubule-associated protein light chain 3- and GABAA receptor-associated protein-phospholipid conjugates.140
254981452015PLEKHM1 regulates autophagosome-lysosome fusion through HOPS complex and LC3/GABARAP proteins.135
256017542015Deacetylation of nuclear LC3 drives autophagy initiation under starvation.135

Citation

Dessen P

MAP1LC3A (microtubule associated protein 1 light chain 3 alpha)

Atlas Genet Cytogenet Oncol Haematol. 2009-01-01

Online version: http://atlasgeneticsoncology.org/gene/50647/map1lc3a