MAP1LC3B (microtubule associated protein 1 light chain 3 beta)

2009-11-01 Affiliation

Identity

HGNC

MAP1LC3B

LOCATION

16q24.2

LOCUSID

81631

ALIAS

ATG8F,LC3B,MAP1A/1BLC3,MAP1LC3B-a

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 81631
MIM: 609604
HGNC: 13352
Ensembl: ENSG00000140941

Variants:

dbSNP: 81631
ClinVar: 81631
TCGA: ENSG00000140941
COSMIC: MAP1LC3B

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000140941	ENST00000268607	Q9GZQ8
ENSG00000140941	ENST00000268607	Q658J6
ENSG00000140941	ENST00000564844	H3BM99
ENSG00000140941	ENST00000565788	H3BTL1
ENSG00000140941	ENST00000570189	H3BTE7
ENSG00000140941	ENST00000650688	Q9GZQ8
ENSG00000140941	ENST00000650688	Q658J6

Expression (GTEx)

100

150

200

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Vesicle-mediated transport	REACTOME	R-HSA-5653656
Membrane Trafficking	REACTOME	R-HSA-199991
Cellular responses to stress	REACTOME	R-HSA-2262752
Macroautophagy	REACTOME	R-HSA-1632852
Mitophagy	REACTOME	R-HSA-5205647
Pink/Parkin Mediated Mitophagy	REACTOME	R-HSA-5205685
TBC/RABGAPs	REACTOME	R-HSA-8854214
Ferroptosis	KEGG	ko04216
Ferroptosis	KEGG	hsa04216

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
20038797	2010	The unfolded protein response protects human tumor cells during hypoxia through regulation of the autophagy genes MAP1LC3B and ATG5.	254
15355958	2004	Human light chain 3/MAP1LC3B is cleaved at its carboxyl-terminal Met121 to expose Gly120 for lipidation and targeting to autophagosomal membranes.	104
12740394	2003	Post-translational modifications of three members of the human MAP1LC3 family and detection of a novel type of modification for MAP1LC3B.	91
22080440	2012	Punctate LC3B expression is a common feature of solid tumors and associated with proliferation, metastasis, and poor outcome.	90
11825910	2002	Human Apg3p/Aut1p homologue is an authentic E2 enzyme for multiple substrates, GATE-16, GABARAP, and MAP-LC3, and facilitates the conjugation of hApg12p to hApg5p.	79
20889906	2011	Autophagic protein LC3B confers resistance against hypoxia-induced pulmonary hypertension.	76
22170153	2012	Autophagy proteins LC3B, ATG5 and ATG12 participate in quality control after mitochondrial damage and influence lifespan.	53
22095627	2012	Hyperoxia-induced LC3B interacts with the Fas apoptotic pathway in epithelial cell death.	50
24983366	2014	Prognostic significance of p62/SQSTM1 subcellular localization and LC3B in oral squamous cell carcinoma.	44
23805866	2013	Structural basis for phosphorylation-triggered autophagic clearance of Salmonella.	40

Citation

Dessen P

MAP1LC3B (microtubule associated protein 1 light chain 3 beta)

Atlas Genet Cytogenet Oncol Haematol. 2009-11-01

Online version: http://atlasgeneticsoncology.org/gene/51202/map1lc3b