Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MAP2K1 (mitogen-activated protein kinase kinase 1)

Identity

Other namesCFC3
MAPKK1
MEK1
MKK1
PRKMK1
HGNC (Hugo) MAP2K1
LocusID (NCBI) 5604
Location 15q22.31
Location_base_pair Starts at 66679211 and ends at 66783882 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MAP2K1   6840
Cards
Entrez_Gene (NCBI)MAP2K1  5604  mitogen-activated protein kinase kinase 1
GeneCards (Weizmann)MAP2K1
Ensembl hg19 (Hinxton) [Gene_View]  chr15:66679211-66783882 [Contig_View]  MAP2K1 [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr15:66679211-66783882 [Contig_View]  MAP2K1 [Vega]
cBioPortalMAP2K1
AceView (NCBI)MAP2K1
Genatlas (Paris)MAP2K1
WikiGenes5604
SOURCE (Princeton)MAP2K1
Genomic and cartography
GoldenPath hg19 (UCSC)MAP2K1  -     chr15:66679211-66783882 +  15q22.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAP2K1  -     15q22.31   [Description]    (hg38-Dec_2013)
EnsemblMAP2K1 - 15q22.31 [CytoView hg19]  MAP2K1 - 15q22.31 [CytoView hg38]
Mapping of homologs : NCBIMAP2K1 [Mapview hg19]  MAP2K1 [Mapview hg38]
OMIM176872   615279   
Gene and transcription
Genbank (Entrez)AK291500 AK294322 AK312356 BC137459 BC139729
RefSeq transcript (Entrez)NM_002755
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_008305 NT_010194 NW_001838218 NW_004929398
Consensus coding sequences : CCDS (NCBI)MAP2K1
Cluster EST : UnigeneHs.145442 [ NCBI ]
CGAP (NCI)Hs.145442
Alternative Splicing : Fast-db (Paris)GSHG0009948
Gene ExpressionMAP2K1 [ NCBI-GEO ]     MAP2K1 [ SEEK ]   MAP2K1 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02750 (Uniprot)
NextProtQ02750  [Medical]
With graphics : InterProQ02750
Splice isoforms : SwissVarQ02750 (Swissvar)
Catalytic activity : Enzyme2.7.12.2 [ Enzyme-Expasy ]   2.7.12.22.7.12.2 [ IntEnz-EBI ]   2.7.12.2 [ BRENDA ]   2.7.12.2 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Related proteins : CluSTrQ02750
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM Disease mutations5604
Blocks (Seattle)Q02750
PDB (SRS)1S9J    2P55    3DV3    3DY7    3E8N    3EQB    3EQC    3EQD    3EQF    3EQG    3EQH    3EQI    3MBL    3ORN    3OS3    3PP1    3SLS    3V01    3V04    3VVH    3W8Q    3ZLS    3ZLW    3ZLX    3ZLY    3ZM4    4AN2    4AN3    4AN9    4ANB    4ARK    4LMN   
PDB (PDBSum)1S9J    2P55    3DV3    3DY7    3E8N    3EQB    3EQC    3EQD    3EQF    3EQG    3EQH    3EQI    3MBL    3ORN    3OS3    3PP1    3SLS    3V01    3V04    3VVH    3W8Q    3ZLS    3ZLW    3ZLX    3ZLY    3ZM4    4AN2    4AN3    4AN9    4ANB    4ARK    4LMN   
PDB (IMB)1S9J    2P55    3DV3    3DY7    3E8N    3EQB    3EQC    3EQD    3EQF    3EQG    3EQH    3EQI    3MBL    3ORN    3OS3    3PP1    3SLS    3V01    3V04    3VVH    3W8Q    3ZLS    3ZLW    3ZLX    3ZLY    3ZM4    4AN2    4AN3    4AN9    4ANB    4ARK    4LMN   
PDB (RSDB)1S9J    2P55    3DV3    3DY7    3E8N    3EQB    3EQC    3EQD    3EQF    3EQG    3EQH    3EQI    3MBL    3ORN    3OS3    3PP1    3SLS    3V01    3V04    3VVH    3W8Q    3ZLS    3ZLW    3ZLX    3ZLY    3ZM4    4AN2    4AN3    4AN9    4ANB    4ARK    4LMN   
Peptide AtlasQ02750
HPRD01469
IPIIPI00219604   IPI00797850   
Protein Interaction databases
DIP (DOE-UCLA)Q02750
IntAct (EBI)Q02750
BioGRIDMAP2K1
IntegromeDBMAP2K1
STRING (EMBL)MAP2K1
Ontologies - Pathways
QuickGOQ02750
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  activation of MAPK activity  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  regulation of vascular smooth muscle contraction  protein kinase activity  protein serine/threonine kinase activity  MAP kinase kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  receptor signaling protein tyrosine phosphatase activity  protein binding  ATP binding  nucleus  cytoplasm  mitochondrion  early endosome  late endosome  Golgi apparatus  microtubule organizing center  cytosol  plasma membrane  focal adhesion  cell cortex  cellular component movement  chemotaxis  response to oxidative stress  cell cycle arrest  mitotic nuclear division  signal transduction  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  Ras protein signal transduction  axon guidance  cell proliferation  negative regulation of cell proliferation  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  positive regulation of gene expression  Ras GTPase binding  peptidyl-tyrosine phosphorylation  keratinocyte differentiation  positive regulation of cell migration  mitogen-activated protein kinase kinase kinase binding  positive regulation of Ras GTPase activity  melanosome transport  dendrite cytoplasm  regulation of stress-activated MAPK cascade  positive regulation of transcription elongation from RNA polymerase II promoter  negative regulation of homotypic cell-cell adhesion  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 5 signaling pathway  toll-like receptor 9 signaling pathway  toll-like receptor 10 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  Fc-epsilon receptor signaling pathway  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  perikaryon  protein serine/threonine kinase activator activity  innate immune response  positive regulation of cell differentiation  positive regulation of Ras protein signal transduction  vesicle transport along microtubule  neurotrophin TRK receptor signaling pathway  Golgi inheritance  perinuclear region of cytoplasm  response to axon injury  cell motility  protein heterooligomerization  response to glucocorticoid  stress-activated MAPK cascade  placenta blood vessel development  labyrinthine layer development  extracellular vesicular exosome  positive regulation of protein serine/threonine kinase activity  regulation of Golgi inheritance  cellular senescence  regulation of early endosome to late endosome transport  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  activation of MAPK activity  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  regulation of vascular smooth muscle contraction  protein kinase activity  protein serine/threonine kinase activity  MAP kinase kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  receptor signaling protein tyrosine phosphatase activity  protein binding  ATP binding  nucleus  cytoplasm  mitochondrion  early endosome  late endosome  Golgi apparatus  microtubule organizing center  cytosol  plasma membrane  focal adhesion  cell cortex  cellular component movement  chemotaxis  response to oxidative stress  cell cycle arrest  mitotic nuclear division  signal transduction  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  Ras protein signal transduction  axon guidance  cell proliferation  negative regulation of cell proliferation  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  positive regulation of gene expression  Ras GTPase binding  peptidyl-tyrosine phosphorylation  keratinocyte differentiation  positive regulation of cell migration  mitogen-activated protein kinase kinase kinase binding  positive regulation of Ras GTPase activity  melanosome transport  dendrite cytoplasm  regulation of stress-activated MAPK cascade  positive regulation of transcription elongation from RNA polymerase II promoter  negative regulation of homotypic cell-cell adhesion  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 5 signaling pathway  toll-like receptor 9 signaling pathway  toll-like receptor 10 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  Fc-epsilon receptor signaling pathway  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  perikaryon  protein serine/threonine kinase activator activity  innate immune response  positive regulation of cell differentiation  positive regulation of Ras protein signal transduction  vesicle transport along microtubule  neurotrophin TRK receptor signaling pathway  Golgi inheritance  perinuclear region of cytoplasm  response to axon injury  cell motility  protein heterooligomerization  response to glucocorticoid  stress-activated MAPK cascade  placenta blood vessel development  labyrinthine layer development  extracellular vesicular exosome  positive regulation of protein serine/threonine kinase activity  regulation of Golgi inheritance  cellular senescence  regulation of early endosome to late endosome transport  
Pathways : BIOCARTAFc Epsilon Receptor I Signaling in Mast Cells [Genes]    IL 2 signaling pathway [Genes]    Role of MAL in Rho-Mediated Activation of SRF [Genes]    Roles of _-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling [Genes]    BCR Signaling Pathway [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]    IGF-1 Signaling Pathway [Genes]    Integrin Signaling Pathway [Genes]    Ras-Independent pathway in NK cell-mediated cytotoxicity [Genes]    Ras Signaling Pathway [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    Cadmium induces DNA synthesis and proliferation in macrophages [Genes]    Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway [Genes]    Map Kinase Inactivation of SMRT Corepressor [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]    Inhibition of Cellular Proliferation by Gleevec [Genes]    Signaling Pathway from G-Protein Families [Genes]    Nerve growth factor pathway (NGF) [Genes]    Links between Pyk2 and Map Kinases [Genes]    Sprouty regulation of tyrosine kinase signals [Genes]    T Cell Receptor Signaling Pathway [Genes]    CCR3 signaling in Eosinophils [Genes]    TPO Signaling Pathway [Genes]    Anthrax Toxin Mechanism of Action [Genes]    Role of _-arrestins in the activation and targeting of MAP kinases [Genes]    Growth Hormone Signaling Pathway [Genes]    IL 3 signaling pathway [Genes]    Insulin Signaling Pathway [Genes]    Ceramide Signaling Pathway [Genes]    EGF Signaling Pathway [Genes]    IL 6 signaling pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    Keratinocyte Differentiation [Genes]    PDGF Signaling Pathway [Genes]    Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia [Genes]    Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation [Genes]    CXCR4 Signaling Pathway [Genes]    EPO Signaling Pathway [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]    Human Cytomegalovirus and Map Kinase Pathways [Genes]    MAPKinase Signaling Pathway [Genes]    NFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]    Aspirin Blocks Signaling Pathway Involved in Platelet Activation [Genes]    TGF beta signaling pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Ras signaling pathway    Rap1 signaling pathway    Chemokine signaling pathway    HIF-1 signaling pathway    FoxO signaling pathway    Oocyte meiosis    PI3K-Akt signaling pathway    Vascular smooth muscle contraction    Dorso-ventral axis formation    VEGF signaling pathway    Osteoclast differentiation    Focal adhesion    Gap junction    Toll-like receptor signaling pathway    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Fc gamma R-mediated phagocytosis    TNF signaling pathway    Long-term potentiation    Neurotrophin signaling pathway    Cholinergic synapse    Serotonergic synapse    Long-term depression    Regulation of actin cytoskeleton    Insulin signaling pathway    GnRH signaling pathway    Progesterone-mediated oocyte maturation    Estrogen signaling pathway    Melanogenesis    Prolactin signaling pathway    Thyroid hormone signaling pathway    Prion diseases    Alcoholism    Hepatitis B    Influenza A    Pathways in cancer    Proteoglycans in cancer    MicroRNAs in cancer    Colorectal cancer    Renal cell carcinoma    Pancreatic cancer    Endometrial cancer    Glioma    Prostate cancer    Thyroid cancer    Melanoma    Bladder cancer    Chronic myeloid leukemia    Acute myeloid leukemia    Non-small cell lung cancer   
Protein Interaction DatabaseMAP2K1
DoCM (Curated mutations)MAP2K1
Wikipedia pathwaysMAP2K1
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerMAP2K1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP2K1
dbVarMAP2K1
ClinVarMAP2K1
1000_GenomesMAP2K1 
Exome Variant ServerMAP2K1
SNP (GeneSNP Utah)MAP2K1
SNP : HGBaseMAP2K1
Genetic variants : HAPMAPMAP2K1
Genomic VariantsMAP2K1  MAP2K1 [DGVbeta]
Mutations
Cancer Gene: CensusMAP2K1 
Somatic Mutations in Cancer : COSMICMAP2K1 
CONAN: Copy Number AnalysisMAP2K1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)The Globin Gene Server
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)15:66679211-66783882
Mutations and Diseases : HGMDMAP2K1
OMIM176872    615279   
MedgenMAP2K1
NextProtQ02750 [Medical]
GENETestsMAP2K1
Disease Genetic AssociationMAP2K1
Huge Navigator MAP2K1 [HugePedia]  MAP2K1 [HugeCancerGEM]
snp3D : Map Gene to Disease5604
DGIdb (Drug Gene Interaction db)MAP2K1
General knowledge
Homologs : HomoloGeneMAP2K1
Homology/Alignments : Family Browser (UCSC)MAP2K1
Phylogenetic Trees/Animal Genes : TreeFamMAP2K1
Chemical/Protein Interactions : CTD5604
Chemical/Pharm GKB GenePA30584
Clinical trialMAP2K1
Other databases
Probes
Litterature
PubMed299 Pubmed reference(s) in Entrez
CoreMineMAP2K1
GoPubMedMAP2K1
iHOPMAP2K1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Dec 20 23:34:13 CET 2014
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