| Nomenclature |
|---|
| HGNC (Hugo) | MAP2K1 6840 |
| LRG (Locus Reference Genomic) | LRG_725 |
| Cards |
|---|
| Entrez_Gene (NCBI) | MAP2K1 5604 mitogen-activated protein kinase kinase 1 |
| Aliases | CFC3; MAPKK1; MEK1; MKK1; |
| PRKMK1 |
| GeneCards (Weizmann) | MAP2K1 |
| Ensembl hg19 (Hinxton) | ENSG00000169032 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000169032 [Gene_View] chr15:66386873-66491544 [Contig_View] MAP2K1 [Vega] |
| ICGC DataPortal | ENSG00000169032 |
| TCGA cBioPortal | MAP2K1 |
| AceView (NCBI) | MAP2K1 |
| Genatlas (Paris) | MAP2K1 |
| WikiGenes | 5604 |
| SOURCE (Princeton) | MAP2K1 |
| Genetics Home Reference (NIH) | MAP2K1 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | MAP2K1 - chr15:66386873-66491544 + 15q22.31 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | MAP2K1 - 15q22.31 [Description] (hg19-Feb_2009) |
| Ensembl | MAP2K1 - 15q22.31 [CytoView hg19] MAP2K1 - 15q22.31 [CytoView hg38] |
| Mapping of homologs : NCBI | MAP2K1 [Mapview hg19] MAP2K1 [Mapview hg38] |
| OMIM | 163950 176872 615279 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AK022276 AK291500 AK294322 AK312356 BC137459 |
| RefSeq transcript (Entrez) | NM_002755 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | MAP2K1 |
| Cluster EST : Unigene | Hs.677223 [ NCBI ] |
| CGAP (NCI) | Hs.677223 |
| Alternative Splicing Gallery | ENSG00000169032 |
| Gene Expression | MAP2K1 [ NCBI-GEO ] MAP2K1 [ EBI - ARRAY_EXPRESS ]
MAP2K1 [ SEEK ] MAP2K1 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | MAP2K1 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 5604 |
| GTEX Portal (Tissue expression) | MAP2K1 |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q02750 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q02750 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q02750 |
| Splice isoforms : SwissVar | Q02750 |
| Catalytic activity : Enzyme | 2.7.12.2 [ Enzyme-Expasy ] 2.7.12.22.7.12.2 [ IntEnz-EBI ] 2.7.12.2 [ BRENDA ] 2.7.12.2 [ KEGG ] |
| PhosPhoSitePlus | Q02750 |
| Domaine pattern : Prosite (Expaxy) | PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_ST (PS00108) |
| Domains : Interpro (EBI) | Kinase-like_dom Prot_kinase_dom Protein_kinase_ATP_BS Ser/Thr_kinase_AS |
| Domain families : Pfam (Sanger) | Pkinase (PF00069) |
| Domain families : Pfam (NCBI) | pfam00069 |
| Domain families : Smart (EMBL) | S_TKc (SM00220) |
| Conserved Domain (NCBI) | MAP2K1 |
| DMDM Disease mutations | 5604 |
| Blocks (Seattle) | MAP2K1 |
| PDB (SRS) | 1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3W8Q 3WIG 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK 4LMN 4MNE 4U7Z 4U80 4U81 5BX0 5EYM |
| PDB (PDBSum) | 1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3W8Q 3WIG 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK 4LMN 4MNE 4U7Z 4U80 4U81 5BX0 5EYM |
| PDB (IMB) | 1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3W8Q 3WIG 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK 4LMN 4MNE 4U7Z 4U80 4U81 5BX0 5EYM |
| PDB (RSDB) | 1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3W8Q 3WIG 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK 4LMN 4MNE 4U7Z 4U80 4U81 5BX0 5EYM |
| Structural Biology KnowledgeBase | 1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3W8Q 3WIG 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK 4LMN 4MNE 4U7Z 4U80 4U81 5BX0 5EYM |
| SCOP (Structural Classification of Proteins) | 1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3W8Q 3WIG 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK 4LMN 4MNE 4U7Z 4U80 4U81 5BX0 5EYM |
| CATH (Classification of proteins structures) | 1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3VVH 3W8Q 3WIG 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK 4LMN 4MNE 4U7Z 4U80 4U81 5BX0 5EYM |
| Superfamily | Q02750 |
| Human Protein Atlas | ENSG00000169032 |
| Peptide Atlas | Q02750 |
| HPRD | 01469 |
| IPI | IPI00219604 IPI00797850 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q02750 |
| IntAct (EBI) | Q02750 |
| FunCoup | ENSG00000169032 |
| BioGRID | MAP2K1 |
| STRING (EMBL) | MAP2K1 |
| ZODIAC | MAP2K1 |
| Ontologies - Pathways |
|---|
| QuickGO | Q02750 |
| Ontology : AmiGO | MAPK cascade activation of MAPK activity activation of MAPK activity protein kinase activity protein serine/threonine kinase activity signal transducer, downstream of receptor, with serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine phosphatase activity protein binding ATP binding nucleus mitochondrion early endosome late endosome endoplasmic reticulum Golgi apparatus microtubule organizing center cytosol cytosol plasma membrane plasma membrane focal adhesion movement of cell or subcellular component chemotaxis cell cycle arrest signal transduction heart development protein C-terminus binding negative regulation of cell proliferation positive regulation of gene expression negative regulation of gene expression peptidyl-tyrosine phosphorylation cerebellar cortex formation neuron differentiation keratinocyte differentiation thyroid gland development regulation of stress-activated MAPK cascade proteolysis in other organism protein serine/threonine kinase activator activity positive regulation of transcription, DNA-templated protein N-terminus binding thymus development regulation of axon regeneration cell motility positive regulation of axonogenesis Bergmann glial cell differentiation face development trachea formation epithelial cell proliferation involved in lung morphogenesis placenta blood vessel development labyrinthine layer development extracellular exosome ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of protein serine/threonine kinase activity regulation of Golgi inheritance cellular senescence positive regulation of production of miRNAs involved in gene silencing by miRNA regulation of early endosome to late endosome transport |
| Ontology : EGO-EBI | MAPK cascade activation of MAPK activity activation of MAPK activity protein kinase activity protein serine/threonine kinase activity signal transducer, downstream of receptor, with serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity signal transducer, downstream of receptor, with protein tyrosine phosphatase activity protein binding ATP binding nucleus mitochondrion early endosome late endosome endoplasmic reticulum Golgi apparatus microtubule organizing center cytosol cytosol plasma membrane plasma membrane focal adhesion movement of cell or subcellular component chemotaxis cell cycle arrest signal transduction heart development protein C-terminus binding negative regulation of cell proliferation positive regulation of gene expression negative regulation of gene expression peptidyl-tyrosine phosphorylation cerebellar cortex formation neuron differentiation keratinocyte differentiation thyroid gland development regulation of stress-activated MAPK cascade proteolysis in other organism protein serine/threonine kinase activator activity positive regulation of transcription, DNA-templated protein N-terminus binding thymus development regulation of axon regeneration cell motility positive regulation of axonogenesis Bergmann glial cell differentiation face development trachea formation epithelial cell proliferation involved in lung morphogenesis placenta blood vessel development labyrinthine layer development extracellular exosome ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of protein serine/threonine kinase activity regulation of Golgi inheritance cellular senescence positive regulation of production of miRNAs involved in gene silencing by miRNA regulation of early endosome to late endosome transport |
| Pathways : BIOCARTA | [Genes] |
| Pathways : KEGG | |
| NDEx Network | MAP2K1 |
| Atlas of Cancer Signalling Network | MAP2K1 |
| Wikipedia pathways | MAP2K1 |
| Orthology - Evolution |
|---|
| OrthoDB | 5604 |
| GeneTree (enSembl) | ENSG00000169032 |
| Phylogenetic Trees/Animal Genes : TreeFam | MAP2K1 |
| HOVERGEN | Q02750 |
| HOGENOM | Q02750 |
| Homologs : HomoloGene | MAP2K1 |
| Homology/Alignments : Family Browser (UCSC) | MAP2K1 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | MAP2K1/CUX1 [15q22.31/7q22.1] |
| Fusion: TCGA | MAP2K1 15q22.31 CUX1 7q22.1 KIRC |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | MAP2K1 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | MAP2K1 |
| dbVar | MAP2K1 |
| ClinVar | MAP2K1 |
| 1000_Genomes | MAP2K1 |
| Exome Variant Server | MAP2K1 |
| ExAC (Exome Aggregation Consortium) | MAP2K1 (select the gene name) |
| Genetic variants : HAPMAP | 5604 |
| Genomic Variants (DGV) | MAP2K1 [DGVbeta] |
| DECIPHER | MAP2K1 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | MAP2K1 |
| Mutations |
|---|
| ICGC Data Portal | MAP2K1 |
| TCGA Data Portal | MAP2K1 |
| Broad Tumor Portal | MAP2K1 |
| OASIS Portal | MAP2K1 [ Somatic mutations - Copy number] |
| Cancer Gene: Census | MAP2K1 |
| Somatic Mutations in Cancer : COSMIC | MAP2K1 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | MAP2K1 |
| intOGen Portal | MAP2K1 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| LOVD (Leiden Open Variation Database) | The Globin Gene Server |
| BioMuta | search MAP2K1 |
| DgiDB (Drug Gene Interaction Database) | MAP2K1 |
| DoCM (Curated mutations) | MAP2K1 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | MAP2K1 (select a term) |
| intoGen | MAP2K1 |
| Cancer3D | MAP2K1(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 163950 176872 615279 |
| Orphanet | 1559 |
| Medgen | MAP2K1 |
| Genetic Testing Registry | MAP2K1
|
| NextProt | Q02750 [Medical] |
| TSGene | 5604 |
| GENETests | MAP2K1 |
| Target Validation | MAP2K1 |
| Huge Navigator |
MAP2K1 [HugePedia] |
| snp3D : Map Gene to Disease | 5604 |
| BioCentury BCIQ | MAP2K1 |
| ClinGen | MAP2K1 (curated) |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 5604 |
| Chemical/Pharm GKB Gene | PA30584 |
| Clinical trial | MAP2K1 |
| Miscellaneous |
|---|
| canSAR (ICR) | MAP2K1 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 365 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | MAP2K1 |
| EVEX | MAP2K1 |
| GoPubMed | MAP2K1 |
| iHOP | MAP2K1 |
