MAP2K1 (mitogen-activated protein kinase kinase 1)

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MAP2K1 (mitogen-activated protein kinase kinase 1)

Identity

Other names	CFC3
	MAPKK1
	MEK1
	MKK1
	PRKMK1
HGNC (Hugo)	MAP2K1
LocusID (NCBI)	5604
Location	15q22.31
Location_base_pair	Starts at 66679211 and ends at 66783882 bp from pter ( according to hg19-Feb_2009)
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

DNA/RNA

External links

	Nomenclature
HGNC (Hugo)	MAP2K1 6840
	Cards
Entrez_Gene (NCBI)	MAP2K1 5604 mitogen-activated protein kinase kinase 1
GeneCards (Weizmann)	MAP2K1
Ensembl (Hinxton)	[Gene_View] chr15:66679211-66783882 [Contig_View] MAP2K1 [Vega]
AceView (NCBI)	MAP2K1
Genatlas (Paris)	MAP2K1
WikiGenes	5604
SOURCE (Princeton)	NM_002755
	Genomic and cartography
GoldenPath (UCSC)	MAP2K1 - 15q22.31 chr15:66679211-66783882 + 15q22.31 [Description] (hg19-Feb_2009)
Ensembl	MAP2K1 - 15q22.31 [CytoView]
Mapping of homologs : NCBI	MAP2K1 [Mapview]
OMIM	115150 176872 615279
	Gene and transcription
Genbank (Entrez)	AK291500 AK294322 AK312356 BC137459 BC139729
RefSeq transcript (Entrez)	NM_002755
RefSeq genomic (Entrez)	AC_000147 NC_000015 NC_018926 NG_008305 NT_010194 NW_001838218 NW_004929398
Consensus coding sequences : CCDS (NCBI)	MAP2K1
Cluster EST : Unigene	Hs.145442 [ NCBI ]
CGAP (NCI)	Hs.145442
Alternative Splicing : Fast-db (Paris)	GSHG0009948
Gene Expression	MAP2K1 [ NCBI-GEO ] MAP2K1 [ SEEK ] MAP2K1 [ MEM ]
	Protein : pattern, domain, 3D structure
UniProt/SwissProt	Q02750 (Uniprot)
NextProt	Q02750 [Medical]
With graphics : InterPro	Q02750
Splice isoforms : SwissVar	Q02750 (Swissvar)
Catalytic activity : Enzyme	2.7.12.2 [ Enzyme-Expasy ] 2.7.12.2 2.7.12.2 [ IntEnz-EBI ] 2.7.12.2 [ BRENDA ] 2.7.12.2 [ KEGG ]
Domaine pattern : Prosite (Expaxy)	PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_ST (PS00108)
Domains : Interpro (EBI)	Kinase-like_dom Prot_kinase_dom Protein_kinase_ATP_BS Ser/Thr_dual-sp_kinase_dom Ser/Thr_kinase_AS
Related proteins : CluSTr	Q02750
Domain families : Pfam (Sanger)	Pkinase (PF00069)
Domain families : Pfam (NCBI)	pfam00069
Domain families : Smart (EMBL)	S_TKc (SM00220)
DMDM Disease mutations	5604
Blocks (Seattle)	Q02750
PDB (SRS)	1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK
PDB (PDBSum)	1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK
PDB (IMB)	1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK
PDB (RSDB)	1S9J 2P55 3DV3 3DY7 3E8N 3EQB 3EQC 3EQD 3EQF 3EQG 3EQH 3EQI 3MBL 3ORN 3OS3 3PP1 3SLS 3V01 3V04 3ZLS 3ZLW 3ZLX 3ZLY 3ZM4 4AN2 4AN3 4AN9 4ANB 4ARK
Peptide Atlas	Q02750
HPRD	01469
IPI	IPI00219604 IPI00797850
	Protein Interaction databases
DIP (DOE-UCLA)	Q02750
IntAct (EBI)	Q02750
BioGRID	MAP2K1
InParanoid	Q02750
Interologous Interaction database	Q02750
IntegromeDB	MAP2K1
STRING (EMBL)	MAP2K1
	Ontologies - Pathways
Ontology : AmiGO	MAPK cascade activation of MAPKK activity activation of MAPK activity toll-like receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway regulation of vascular smooth muscle contraction protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity receptor signaling protein tyrosine phosphatase activity protein binding ATP binding nucleus cytoplasm mitochondrion early endosome late endosome Golgi apparatus spindle pole body cytosol plasma membrane focal adhesion cell cortex cellular component movement chemotaxis response to oxidative stress cell cycle arrest mitosis signal transduction epidermal growth factor receptor signaling pathway small GTPase mediated signal transduction Ras protein signal transduction axon guidance cell proliferation negative regulation of cell proliferation insulin receptor signaling pathway fibroblast growth factor receptor signaling pathway Ras GTPase binding keratinocyte differentiation positive regulation of cell migration mitogen-activated protein kinase kinase kinase binding positive regulation of Ras GTPase activity melanosome transport dendrite cytoplasm regulation of stress-activated MAPK cascade positive regulation of transcription elongation from RNA polymerase II promoter negative regulation of homotypic cell-cell adhesion toll-like receptor 2 signaling pathway toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor 5 signaling pathway toll-like receptor 9 signaling pathway toll-like receptor 10 signaling pathway TRIF-dependent toll-like receptor signaling pathway Fc-epsilon receptor signaling pathway toll-like receptor TLR1:TLR2 signaling pathway toll-like receptor TLR6:TLR2 signaling pathway perikaryon protein serine/threonine kinase activator activity innate immune response positive regulation of cell differentiation positive regulation of Ras protein signal transduction vesicle transport along microtubule neurotrophin TRK receptor signaling pathway Golgi inheritance perinuclear region of cytoplasm response to axon injury cell motility protein heterooligomerization response to glucocorticoid stress-activated MAPK cascade placenta blood vessel development labyrinthine layer development positive regulation of protein serine/threonine kinase activity regulation of Golgi inheritance cellular senescence regulation of early endosome to late endosome transport
Ontology : EGO-EBI	MAPK cascade activation of MAPKK activity activation of MAPK activity toll-like receptor signaling pathway MyD88-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway regulation of vascular smooth muscle contraction protein kinase activity protein serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity receptor signaling protein tyrosine phosphatase activity protein binding ATP binding nucleus cytoplasm mitochondrion early endosome late endosome Golgi apparatus spindle pole body cytosol plasma membrane focal adhesion cell cortex cellular component movement chemotaxis response to oxidative stress cell cycle arrest mitosis signal transduction epidermal growth factor receptor signaling pathway small GTPase mediated signal transduction Ras protein signal transduction axon guidance cell proliferation negative regulation of cell proliferation insulin receptor signaling pathway fibroblast growth factor receptor signaling pathway Ras GTPase binding keratinocyte differentiation positive regulation of cell migration mitogen-activated protein kinase kinase kinase binding positive regulation of Ras GTPase activity melanosome transport dendrite cytoplasm regulation of stress-activated MAPK cascade positive regulation of transcription elongation from RNA polymerase II promoter negative regulation of homotypic cell-cell adhesion toll-like receptor 2 signaling pathway toll-like receptor 3 signaling pathway toll-like receptor 4 signaling pathway toll-like receptor 5 signaling pathway toll-like receptor 9 signaling pathway toll-like receptor 10 signaling pathway TRIF-dependent toll-like receptor signaling pathway Fc-epsilon receptor signaling pathway toll-like receptor TLR1:TLR2 signaling pathway toll-like receptor TLR6:TLR2 signaling pathway perikaryon protein serine/threonine kinase activator activity innate immune response positive regulation of cell differentiation positive regulation of Ras protein signal transduction vesicle transport along microtubule neurotrophin TRK receptor signaling pathway Golgi inheritance perinuclear region of cytoplasm response to axon injury cell motility protein heterooligomerization response to glucocorticoid stress-activated MAPK cascade placenta blood vessel development labyrinthine layer development positive regulation of protein serine/threonine kinase activity regulation of Golgi inheritance cellular senescence regulation of early endosome to late endosome transport
Pathways : BIOCARTA	Fc Epsilon Receptor I Signaling in Mast Cells [Genes] IL 2 signaling pathway [Genes] Role of MAL in Rho-Mediated Activation of SRF [Genes] Roles of ¿-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling [Genes] BCR Signaling Pathway [Genes] Bioactive Peptide Induced Signaling Pathway [Genes] Role of ERBB2 in Signal Transduction and Oncology [Genes] IGF-1 Signaling Pathway [Genes] Integrin Signaling Pathway [Genes] Ras-Independent pathway in NK cell-mediated cytotoxicity [Genes] Ras Signaling Pathway [Genes] Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes] Cadmium induces DNA synthesis and proliferation in macrophages [Genes] Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway [Genes] Map Kinase Inactivation of SMRT Corepressor [Genes] fMLP induced chemokine gene expression in HMC-1 cells [Genes] Inhibition of Cellular Proliferation by Gleevec [Genes] Signaling Pathway from G-Protein Families [Genes] Nerve growth factor pathway (NGF) [Genes] Links between Pyk2 and Map Kinases [Genes] Sprouty regulation of tyrosine kinase signals [Genes] T Cell Receptor Signaling Pathway [Genes] CCR3 signaling in Eosinophils [Genes] TPO Signaling Pathway [Genes] Anthrax Toxin Mechanism of Action [Genes] Role of ¿-arrestins in the activation and targeting of MAP kinases [Genes] Growth Hormone Signaling Pathway [Genes] IL 3 signaling pathway [Genes] Insulin Signaling Pathway [Genes] Ceramide Signaling Pathway [Genes] EGF Signaling Pathway [Genes] IL 6 signaling pathway [Genes] Signaling of Hepatocyte Growth Factor Receptor [Genes] Keratinocyte Differentiation [Genes] PDGF Signaling Pathway [Genes] Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia [Genes] Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation [Genes] CXCR4 Signaling Pathway [Genes] EPO Signaling Pathway [Genes] Erk1/Erk2 Mapk Signaling pathway [Genes] Human Cytomegalovirus and Map Kinase Pathways [Genes] MAPKinase Signaling Pathway [Genes] NFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes] Aspirin Blocks Signaling Pathway Involved in Platelet Activation [Genes] TGF beta signaling pathway [Genes]
Pathways : KEGG	Dorso-ventral axis formation Fc epsilon RI signaling pathway MAPK signaling pathway Colorectal cancer Long-term potentiation Long-term depression Focal adhesion Regulation of actin cytoskeleton Natural killer cell mediated cytotoxicity GnRH signaling pathway Insulin signaling pathway Gap junction VEGF signaling pathway
REACTOME	MAP2K1
Protein Interaction Database	MAP2K1
Wikipedia pathways	MAP2K1
	Gene fusion - rearrangments
	Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)	MAP2K1
SNP (GeneSNP Utah)	MAP2K1
SNP : HGBase	MAP2K1
Genetic variants : HAPMAP	MAP2K1
1000_Genomes	MAP2K1
Cancer Gene: Census	MAP2K1
Somatic Mutations in Cancer : COSMIC	MAP2K1
CONAN: Copy Number Analysis	MAP2K1
Mutations and Diseases : HGMD	MAP2K1
OMIM	115150 176872 615279
GENETests	MAP2K1
Disease Genetic Association	MAP2K1
Huge Navigator	MAP2K1 [HugePedia] MAP2K1 [HugeCancerGEM]
Genomic Variants	MAP2K1 MAP2K1 [DGVbeta]
Exome Variant	MAP2K1
dbVar	MAP2K1
ClinVar	MAP2K1
snp3D : Map Gene to Disease	5604
	General knowledge
Homologs : HomoloGene	MAP2K1
Homology/Alignments : Family Browser (UCSC)	MAP2K1
Phylogenetic Trees/Animal Genes : TreeFam	MAP2K1
Chemical/Protein Interactions : CTD	5604
Chemical/Pharm GKB Gene	PA30584
Clinical trial	MAP2K1
	Other databases
	Probes
	Litterature
PubMed	280 Pubmed reference(s) in Entrez
CoreMine	MAP2K1
iHOP	MAP2K1

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S

Updated	12-2013	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 8 14:29:26 CET 2014

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Atlas of Genetics and Cytogenetics in Oncology and Haematology

MAP2K1 (mitogen-activated protein kinase kinase 1)

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to How to contribute

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to How to contribute