Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MAP2K1 (mitogen-activated protein kinase kinase 1)

Identity

Other namesMAPKK1
MEK1
MKK1
PRKMK1
HGNC (Hugo) MAP2K1
LocusID (NCBI) 5604
Location 15q22.31
Location_base_pair Starts at 66679211 and ends at 66783882 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MAP2K1   6840
Entrez_Gene (NCBI)MAP2K1  5604  mitogen-activated protein kinase kinase 1
Cards
GeneCards (Weizmann)MAP2K1
Ensembl (Hinxton)ENSG00000169032 [Gene_View]  chr15:66679211-66783882 [Contig_View]  MAP2K1 [Vega]
AceView (NCBI)MAP2K1
Genatlas (Paris)MAP2K1
SOURCE (Stanford)NM_002755
Genomic and cartography
GoldenPath (UCSC)MAP2K1  -  15q22.31   chr15:66679211-66783882 +  15q22.31   [Description]    (hg19-Feb_2009)
EnsemblMAP2K1 - 15q22.31 [CytoView]
Mapping of homologs : NCBIMAP2K1 [Mapview]
OMIM115150   176872   
Gene and transcription
Genbank (Entrez)AK291500 AK294322 AK312356 BC137459 BC139729
RefSeq transcript (SRS)NM_002755
RefSeq transcript (Entrez)NM_002755
RefSeq genomic (SRS)AC_000147 NC_000015 NC_018926 NG_008305 NT_010194 NW_001838218 NW_004078084
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_008305 NT_010194 NW_001838218 NW_004078084
Consensus coding sequences : CCDS (NCBI)MAP2K1
Cluster EST : UnigeneHs.145442 [ SRS ] Hs.145442 [ NCBI ]
CGAP (NCI)Hs.145442
Alternative Splicing : Fast-db (Paris)GSHG0009948
Alternative Splicing GalleryENSG00000169032
Gene ExpressionMAP2K1 [ NCBI-GEO ]   MAP2K1 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02750 (SRS) Q02750 (Uniprot)
NextProtQ02750
With graphics : InterProQ02750
Splice isoforms : SwissVarQ02750(Swissvar)
Domaine pattern : Prosite (SRS)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (SRS)Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Related proteins : CluSTrQ02750
Domain families : Pfam (SRS)Pkinase (PF00069)   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM5604
Blocks (Seattle)Q02750
PDB (SRS)1S9J    2P55    3DV3    3DY7    3E8N    3EQB    3EQC    3EQD    3EQF    3EQG    3EQH    3EQI    3MBL    3ORN    3OS3    3PP1    3SLS    3V01    3V04   
PDB (PDBSum)1S9J    2P55    3DV3    3DY7    3E8N    3EQB    3EQC    3EQD    3EQF    3EQG    3EQH    3EQI    3MBL    3ORN    3OS3    3PP1    3SLS    3V01    3V04   
PDB (IMB)1S9J    2P55    3DV3    3DY7    3E8N    3EQB    3EQC    3EQD    3EQF    3EQG    3EQH    3EQI    3MBL    3ORN    3OS3    3PP1    3SLS    3V01    3V04   
PDB (RSDB)1S9J    2P55    3DV3    3DY7    3E8N    3EQB    3EQC    3EQD    3EQF    3EQG    3EQH    3EQI    3MBL    3ORN    3OS3    3PP1    3SLS    3V01    3V04   
Human Protein AtlasENSG00000169032
HPRD01469
IPIIPI00219604   IPI00797850   
Protein Interaction databases
DIP (DOE-UCLA)Q02750
IntAct (EBI)Q02750
FunCoupENSG00000169032
REACTOMEMAP2K1
Protein Interaction Database5604
BioGRIDMAP2K1
InParanoidQ02750
Interologous Interaction database Q02750
IntegromeDBMAP2K1
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MAP2K1
SNP (GeneSNP Utah)MAP2K1
SNP : HGBaseMAP2K1
Genetic variants : HAPMAPMAP2K1
Somatic Mutations in Cancer : COSMICMAP2K1 
CONAN: Copy Number AnalysisMAP2K1 
Mutations and Diseases : HGMDMAP2K1
OMIM115150    176872   
GENETests115150    176872   
Disease Genetic AssociationMAP2K1
Huge Navigator MAP2K1 [HugePedia]  MAP2K1 [HugeCancerGEM]
Genomic VariantsMAP2K1  MAP2K1 [DGVbeta]
snp3D : Map Gene to Disease5604
General knowledge
Homologs : HomoloGeneMAP2K1
Homology/Alignments : Family Browser (UCSC)MAP2K1
Phylogenetic Trees/Animal Genes : TreeFamMAP2K1
Catalytic activity : Enzyme2.7.12.2 [ Enzyme-Expasy ]   2.7.12.2 [ Enzyme-SRS ]   2.7.12.2 [ IntEnz-EBI ]   2.7.12.2 [ BRENDA ]   2.7.12.2 [ KEGG ]   
Chemical/Protein Interactions : CTD5604
Chemical/Pharm GKB GenePA30584
Clinical trialMAP2K1
Cancer Resource (Charite)ENSG00000169032
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  activation of MAPK activity  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  regulation of vascular smooth muscle contraction  protein kinase activity  protein serine/threonine kinase activity  MAP kinase kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  receptor signaling protein tyrosine phosphatase activity  protein binding  ATP binding  nucleus  cytoplasm  mitochondrion  early endosome  late endosome  Golgi apparatus  spindle pole body  cytosol  microtubule  plasma membrane  focal adhesion  cell cortex  cellular component movement  chemotaxis  response to oxidative stress  cell cycle arrest  mitosis  signal transduction  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  Ras protein signal transduction  axon guidance  Toll signaling pathway  cell proliferation  negative regulation of cell proliferation  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  Ras GTPase binding  keratinocyte differentiation  positive regulation of cell migration  mitogen-activated protein kinase kinase kinase binding  positive regulation of Ras GTPase activity  melanosome transport  dendrite cytoplasm  regulation of stress-activated MAPK cascade  positive regulation of transcription elongation from RNA polymerase II promoter  axon part  negative regulation of homotypic cell-cell adhesion  toll-like receptor 1 signaling pathway  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  perikaryon  protein serine/threonine kinase activator activity  innate immune response  positive regulation of cell differentiation  positive regulation of Ras protein signal transduction  vesicle transport along microtubule  nerve growth factor receptor signaling pathway  Golgi inheritance  perinuclear region of cytoplasm  response to axon injury  cell motility  response to glucocorticoid stimulus  stress-activated MAPK cascade  placenta blood vessel development  labyrinthine layer development  positive regulation of protein serine/threonine kinase activity  regulation of Golgi inheritance  cellular senescence  regulation of early endosome to late endosome transport  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  activation of MAPK activity  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  regulation of vascular smooth muscle contraction  protein kinase activity  protein serine/threonine kinase activity  MAP kinase kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  receptor signaling protein tyrosine phosphatase activity  protein binding  ATP binding  nucleus  cytoplasm  mitochondrion  early endosome  late endosome  Golgi apparatus  spindle pole body  cytosol  microtubule  plasma membrane  focal adhesion  cell cortex  cellular component movement  chemotaxis  response to oxidative stress  cell cycle arrest  mitosis  signal transduction  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  Ras protein signal transduction  axon guidance  Toll signaling pathway  cell proliferation  negative regulation of cell proliferation  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  Ras GTPase binding  keratinocyte differentiation  positive regulation of cell migration  mitogen-activated protein kinase kinase kinase binding  positive regulation of Ras GTPase activity  melanosome transport  dendrite cytoplasm  regulation of stress-activated MAPK cascade  positive regulation of transcription elongation from RNA polymerase II promoter  axon part  negative regulation of homotypic cell-cell adhesion  toll-like receptor 1 signaling pathway  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  perikaryon  protein serine/threonine kinase activator activity  innate immune response  positive regulation of cell differentiation  positive regulation of Ras protein signal transduction  vesicle transport along microtubule  nerve growth factor receptor signaling pathway  Golgi inheritance  perinuclear region of cytoplasm  response to axon injury  cell motility  response to glucocorticoid stimulus  stress-activated MAPK cascade  placenta blood vessel development  labyrinthine layer development  positive regulation of protein serine/threonine kinase activity  regulation of Golgi inheritance  cellular senescence  regulation of early endosome to late endosome transport  
Pathways : BIOCARTAFc Epsilon Receptor I Signaling in Mast Cells [Genes]    IL 2 signaling pathway [Genes]    Role of MAL in Rho-Mediated Activation of SRF [Genes]    Roles of ¿-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling [Genes]    BCR Signaling Pathway [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    Role of ERBB2 in Signal Transduction and Oncology [Genes]    IGF-1 Signaling Pathway [Genes]    Integrin Signaling Pathway [Genes]    Ras-Independent pathway in NK cell-mediated cytotoxicity [Genes]    Ras Signaling Pathway [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    Cadmium induces DNA synthesis and proliferation in macrophages [Genes]    Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway [Genes]    Map Kinase Inactivation of SMRT Corepressor [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]    Inhibition of Cellular Proliferation by Gleevec [Genes]    Signaling Pathway from G-Protein Families [Genes]    Nerve growth factor pathway (NGF) [Genes]    Links between Pyk2 and Map Kinases [Genes]    Sprouty regulation of tyrosine kinase signals [Genes]    T Cell Receptor Signaling Pathway [Genes]    CCR3 signaling in Eosinophils [Genes]    TPO Signaling Pathway [Genes]    Anthrax Toxin Mechanism of Action [Genes]    Role of ¿-arrestins in the activation and targeting of MAP kinases [Genes]    Growth Hormone Signaling Pathway [Genes]    IL 3 signaling pathway [Genes]    Insulin Signaling Pathway [Genes]    Ceramide Signaling Pathway [Genes]    EGF Signaling Pathway [Genes]    IL 6 signaling pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    Keratinocyte Differentiation [Genes]    PDGF Signaling Pathway [Genes]    Erk and PI-3 Kinase Are Necessary for Collagen Binding in Corneal Epithelia [Genes]    Multiple antiapoptotic pathways from IGF-1R signaling lead to BAD phosphorylation [Genes]    CXCR4 Signaling Pathway [Genes]    EPO Signaling Pathway [Genes]    Erk1/Erk2 Mapk Signaling pathway [Genes]    Human Cytomegalovirus and Map Kinase Pathways [Genes]    MAPKinase Signaling Pathway [Genes]    NFAT and Hypertrophy of the heart (Transcription in the broken heart) [Genes]    Aspirin Blocks Signaling Pathway Involved in Platelet Activation [Genes]    TGF beta signaling pathway [Genes]   
Pathways : KEGGDorso-ventral axis formationFc epsilon RI signaling pathwayMAPK signaling pathwayColorectal cancerLong-term potentiationLong-term depressionFocal adhesionRegulation of actin cytoskeletonNatural killer cell mediated cytotoxicityGnRH signaling pathwayInsulin signaling pathwayGap junctionVEGF signaling pathway
Other databases
Probes
Litterature
PubMed261 Pubmed reference(s) in Entrez
PubGeneMAP2K1
iHOPMAP2K1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:32:50 CEST 2013
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