| Nomenclature |
|---|
| HGNC (Hugo) | MAP2K2 6842 |
| LRG (Locus Reference Genomic) | LRG_750 |
| Cards |
|---|
| Entrez_Gene (NCBI) | MAP2K2 5605 mitogen-activated protein kinase kinase 2 |
| Aliases | CFC4; MAPKK2; MEK2; MKK2; |
| PRKMK2 |
| GeneCards (Weizmann) | MAP2K2 |
| Ensembl hg19 (Hinxton) | ENSG00000126934 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000126934 [Gene_View] chr19:4090322-4124129 [Contig_View] MAP2K2 [Vega] |
| ICGC DataPortal | ENSG00000126934 |
| TCGA cBioPortal | MAP2K2 |
| AceView (NCBI) | MAP2K2 |
| Genatlas (Paris) | MAP2K2 |
| WikiGenes | 5605 |
| SOURCE (Princeton) | MAP2K2 |
| Genetics Home Reference (NIH) | MAP2K2 |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | MAP2K2 - chr19:4090322-4124129 - 19p13.3 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | MAP2K2 - 19p13.3 [Description] (hg19-Feb_2009) |
| Ensembl | MAP2K2 - 19p13.3 [CytoView hg19] MAP2K2 - 19p13.3 [CytoView hg38] |
| Mapping of homologs : NCBI | MAP2K2 [Mapview hg19] MAP2K2 [Mapview hg38] |
| OMIM | 601263 615280 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AA312322 AK093125 AK126446 AK129586 BC000471 |
| RefSeq transcript (Entrez) | NM_030662 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | MAP2K2 |
| Cluster EST : Unigene | Hs.465627 [ NCBI ] |
| CGAP (NCI) | Hs.465627 |
| Alternative Splicing Gallery | ENSG00000126934 |
| Gene Expression | MAP2K2 [ NCBI-GEO ] MAP2K2 [ EBI - ARRAY_EXPRESS ]
MAP2K2 [ SEEK ] MAP2K2 [ MEM ] |
| Gene Expression Viewer (FireBrowse) | MAP2K2 [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 5605 |
| GTEX Portal (Tissue expression) | MAP2K2 |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P36507 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P36507 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P36507 |
| Splice isoforms : SwissVar | P36507 |
| PhosPhoSitePlus | P36507 |
| Domaine pattern : Prosite (Expaxy) | PROTEIN_KINASE_ATP (PS00107) PROTEIN_KINASE_DOM (PS50011) PROTEIN_KINASE_ST (PS00108) |
| Domains : Interpro (EBI) | Kinase-like_dom Prot_kinase_dom Protein_kinase_ATP_BS Ser/Thr_kinase_AS |
| Domain families : Pfam (Sanger) | Pkinase (PF00069) |
| Domain families : Pfam (NCBI) | pfam00069 |
| Domain families : Smart (EMBL) | S_TKc (SM00220) |
| Conserved Domain (NCBI) | MAP2K2 |
| DMDM Disease mutations | 5605 |
| Blocks (Seattle) | MAP2K2 |
| PDB (SRS) | 1S9I 4H3Q |
| PDB (PDBSum) | 1S9I 4H3Q |
| PDB (IMB) | 1S9I 4H3Q |
| PDB (RSDB) | 1S9I 4H3Q |
| Structural Biology KnowledgeBase | 1S9I 4H3Q |
| SCOP (Structural Classification of Proteins) | 1S9I 4H3Q |
| CATH (Classification of proteins structures) | 1S9I 4H3Q |
| Superfamily | P36507 |
| Human Protein Atlas | ENSG00000126934 |
| Peptide Atlas | P36507 |
| HPRD | 03164 |
| IPI | IPI00003783 IPI00443029 IPI00795187 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P36507 |
| IntAct (EBI) | P36507 |
| FunCoup | ENSG00000126934 |
| BioGRID | MAP2K2 |
| STRING (EMBL) | MAP2K2 |
| ZODIAC | MAP2K2 |
| Ontologies - Pathways |
|---|
| QuickGO | P36507 |
| Ontology : AmiGO | MAPK cascade activation of MAPK activity protein serine/threonine kinase activity signal transducer, downstream of receptor, with serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity protein binding ATP binding extracellular region nucleus mitochondrion early endosome late endosome peroxisomal membrane endoplasmic reticulum Golgi apparatus Golgi apparatus cytosol cytosol microtubule plasma membrane cell-cell junction focal adhesion cytoplasmic side of plasma membrane negative regulation of gene expression peptidyl-tyrosine phosphorylation PDZ domain binding regulation of stress-activated MAPK cascade proteolysis in other organism peptidyl-serine autophosphorylation protein serine/threonine kinase activator activity positive regulation of transcription, DNA-templated metal ion binding perinuclear region of cytoplasm ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of protein serine/threonine kinase activity regulation of Golgi inheritance scaffold protein binding positive regulation of production of miRNAs involved in gene silencing by miRNA regulation of early endosome to late endosome transport |
| Ontology : EGO-EBI | MAPK cascade activation of MAPK activity protein serine/threonine kinase activity signal transducer, downstream of receptor, with serine/threonine kinase activity MAP kinase kinase activity protein serine/threonine/tyrosine kinase activity protein tyrosine kinase activity protein binding ATP binding extracellular region nucleus mitochondrion early endosome late endosome peroxisomal membrane endoplasmic reticulum Golgi apparatus Golgi apparatus cytosol cytosol microtubule plasma membrane cell-cell junction focal adhesion cytoplasmic side of plasma membrane negative regulation of gene expression peptidyl-tyrosine phosphorylation PDZ domain binding regulation of stress-activated MAPK cascade proteolysis in other organism peptidyl-serine autophosphorylation protein serine/threonine kinase activator activity positive regulation of transcription, DNA-templated metal ion binding perinuclear region of cytoplasm ERK1 and ERK2 cascade positive regulation of ERK1 and ERK2 cascade positive regulation of protein serine/threonine kinase activity regulation of Golgi inheritance scaffold protein binding positive regulation of production of miRNAs involved in gene silencing by miRNA regulation of early endosome to late endosome transport |
| Pathways : BIOCARTA | [Genes] |
| Pathways : KEGG | |
| NDEx Network | MAP2K2 |
| Atlas of Cancer Signalling Network | MAP2K2 |
| Wikipedia pathways | MAP2K2 |
| Orthology - Evolution |
|---|
| OrthoDB | 5605 |
| GeneTree (enSembl) | ENSG00000126934 |
| Phylogenetic Trees/Animal Genes : TreeFam | MAP2K2 |
| HOVERGEN | P36507 |
| HOGENOM | P36507 |
| Homologs : HomoloGene | MAP2K2 |
| Homology/Alignments : Family Browser (UCSC) | MAP2K2 |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | MAP2K2/CAMKK1 [19p13.3/17p13.2] |
| Fusion: TCGA | MAP2K2 19p13.3 CAMKK1 17p13.2 BRCA |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | MAP2K2 [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | MAP2K2 |
| dbVar | MAP2K2 |
| ClinVar | MAP2K2 |
| 1000_Genomes | MAP2K2 |
| Exome Variant Server | MAP2K2 |
| ExAC (Exome Aggregation Consortium) | MAP2K2 (select the gene name) |
| Genetic variants : HAPMAP | 5605 |
| Genomic Variants (DGV) | MAP2K2 [DGVbeta] |
| DECIPHER | MAP2K2 [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | MAP2K2 |
| Mutations |
|---|
| ICGC Data Portal | MAP2K2 |
| TCGA Data Portal | MAP2K2 |
| Broad Tumor Portal | MAP2K2 |
| OASIS Portal | MAP2K2 [ Somatic mutations - Copy number] |
| Cancer Gene: Census | MAP2K2 |
| Somatic Mutations in Cancer : COSMIC | MAP2K2 [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | MAP2K2 |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search MAP2K2 |
| DgiDB (Drug Gene Interaction Database) | MAP2K2 |
| DoCM (Curated mutations) | MAP2K2 (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | MAP2K2 (select a term) |
| intoGen | MAP2K2 |
| Cancer3D | MAP2K2(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 601263 615280 |
| Orphanet | 930 1559 |
| Medgen | MAP2K2 |
| Genetic Testing Registry | MAP2K2
|
| NextProt | P36507 [Medical] |
| TSGene | 5605 |
| GENETests | MAP2K2 |
| Target Validation | MAP2K2 |
| Huge Navigator |
MAP2K2 [HugePedia] |
| snp3D : Map Gene to Disease | 5605 |
| BioCentury BCIQ | MAP2K2 |
| ClinGen | MAP2K2 (curated) |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 5605 |
| Chemical/Pharm GKB Gene | PA30587 |
| Clinical trial | MAP2K2 |
| Miscellaneous |
|---|
| canSAR (ICR) | MAP2K2 (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 186 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | MAP2K2 |
| EVEX | MAP2K2 |
| GoPubMed | MAP2K2 |
| iHOP | MAP2K2 |
