Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MAP2K2 (mitogen-activated protein kinase kinase 2)

Identity

Alias_namesPRKMK2
Alias_symbol (synonym)MEK2
Other aliasCFC4
MAPKK2
MKK2
HGNC (Hugo) MAP2K2
LocusID (NCBI) 5605
Atlas_Id 41271
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 4090322 and ends at 4124129 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CLU (8p21.1) / MAP2K2 (19p13.3)EEF2 (19p13.3) / MAP2K2 (19p13.3)GRHL2 (8q22.3) / MAP2K2 (19p13.3)
MAP2K2 (19p13.3) / CAMKK1 (17p13.2)MAP2K2 (19p13.3) / INSR (19p13.2)MAP2K2 (19p13.3) / MALAT1 (11q13.1)
MAP2K2 19p13.3 / CAMKK1 17p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;19)(p12;p13) MAP2K2/MLLT10

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  Skin: Melanoma
t(17;19)(p13;p13) MAP2K2/CAMKK1
MAP2K2/INSR (19p13)

External links

Nomenclature
HGNC (Hugo)MAP2K2   6842
LRG (Locus Reference Genomic)LRG_750
Cards
Entrez_Gene (NCBI)MAP2K2  5605  mitogen-activated protein kinase kinase 2
AliasesCFC4; MAPKK2; MEK2; MKK2; 
PRKMK2
GeneCards (Weizmann)MAP2K2
Ensembl hg19 (Hinxton)ENSG00000126934 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000126934 [Gene_View]  ENSG00000126934 [Sequence]  chr19:4090322-4124129 [Contig_View]  MAP2K2 [Vega]
ICGC DataPortalENSG00000126934
TCGA cBioPortalMAP2K2
AceView (NCBI)MAP2K2
Genatlas (Paris)MAP2K2
WikiGenes5605
SOURCE (Princeton)MAP2K2
Genetics Home Reference (NIH)MAP2K2
Genomic and cartography
GoldenPath hg38 (UCSC)MAP2K2  -     chr19:4090322-4124129 -  19p13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP2K2  -     19p13.3   [Description]    (hg19-Feb_2009)
GoldenPathMAP2K2 - 19p13.3 [CytoView hg19]  MAP2K2 - 19p13.3 [CytoView hg38]
ImmunoBaseENSG00000126934
Mapping of homologs : NCBIMAP2K2 [Mapview hg19]  MAP2K2 [Mapview hg38]
OMIM601263   615280   
Gene and transcription
Genbank (Entrez)AA312322 AK093125 AK126446 AK129586 BC000471
RefSeq transcript (Entrez)NM_030662
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP2K2
Alternative Splicing GalleryENSG00000126934
Gene ExpressionMAP2K2 [ NCBI-GEO ]   MAP2K2 [ EBI - ARRAY_EXPRESS ]   MAP2K2 [ SEEK ]   MAP2K2 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP2K2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5605
GTEX Portal (Tissue expression)MAP2K2
Human Protein AtlasENSG00000126934-MAP2K2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36507   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36507  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36507
Splice isoforms : SwissVarP36507
PhosPhoSitePlusP36507
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP2K2
DMDM Disease mutations5605
Blocks (Seattle)MAP2K2
PDB (RSDB)1S9I    4H3Q   
PDB Europe1S9I    4H3Q   
PDB (PDBSum)1S9I    4H3Q   
PDB (IMB)1S9I    4H3Q   
Structural Biology KnowledgeBase1S9I    4H3Q   
SCOP (Structural Classification of Proteins)1S9I    4H3Q   
CATH (Classification of proteins structures)1S9I    4H3Q   
SuperfamilyP36507
Human Protein Atlas [tissue]ENSG00000126934-MAP2K2 [tissue]
Peptide AtlasP36507
HPRD03164
IPIIPI00003783   IPI00443029   IPI00795187   
Protein Interaction databases
DIP (DOE-UCLA)P36507
IntAct (EBI)P36507
FunCoupENSG00000126934
BioGRIDMAP2K2
STRING (EMBL)MAP2K2
ZODIACMAP2K2
Ontologies - Pathways
QuickGOP36507
Ontology : AmiGOMAPK cascade  activation of MAPK activity  activation of MAPK activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  MAP kinase kinase activity  MAP kinase kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  extracellular region  nucleus  cytoplasm  mitochondrion  early endosome  late endosome  peroxisomal membrane  endoplasmic reticulum  Golgi apparatus  Golgi apparatus  cytosol  microtubule  cell-cell junction  focal adhesion  cell cortex  heart development  cytoplasmic side of plasma membrane  negative regulation of gene expression  peptidyl-tyrosine phosphorylation  signal transduction by protein phosphorylation  PDZ domain binding  thyroid gland development  activation of protein kinase activity  regulation of stress-activated MAPK cascade  peptidyl-serine autophosphorylation  regulation of protein heterodimerization activity  protein serine/threonine kinase activator activity  positive regulation of transcription, DNA-templated  metal ion binding  perinuclear region of cytoplasm  thymus development  regulation of axon regeneration  positive regulation of axonogenesis  molecular adaptor activity  face development  trachea formation  epithelial cell proliferation involved in lung morphogenesis  ERK1 and ERK2 cascade  ERK1 and ERK2 cascade  positive regulation of protein serine/threonine kinase activity  regulation of Golgi inheritance  scaffold protein binding  positive regulation of production of miRNAs involved in gene silencing by miRNA  positive regulation of cell motility  regulation of early endosome to late endosome transport  
Ontology : EGO-EBIMAPK cascade  activation of MAPK activity  activation of MAPK activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  MAP kinase kinase activity  MAP kinase kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  extracellular region  nucleus  cytoplasm  mitochondrion  early endosome  late endosome  peroxisomal membrane  endoplasmic reticulum  Golgi apparatus  Golgi apparatus  cytosol  microtubule  cell-cell junction  focal adhesion  cell cortex  heart development  cytoplasmic side of plasma membrane  negative regulation of gene expression  peptidyl-tyrosine phosphorylation  signal transduction by protein phosphorylation  PDZ domain binding  thyroid gland development  activation of protein kinase activity  regulation of stress-activated MAPK cascade  peptidyl-serine autophosphorylation  regulation of protein heterodimerization activity  protein serine/threonine kinase activator activity  positive regulation of transcription, DNA-templated  metal ion binding  perinuclear region of cytoplasm  thymus development  regulation of axon regeneration  positive regulation of axonogenesis  molecular adaptor activity  face development  trachea formation  epithelial cell proliferation involved in lung morphogenesis  ERK1 and ERK2 cascade  ERK1 and ERK2 cascade  positive regulation of protein serine/threonine kinase activity  regulation of Golgi inheritance  scaffold protein binding  positive regulation of production of miRNAs involved in gene silencing by miRNA  positive regulation of cell motility  regulation of early endosome to late endosome transport  
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Ras signaling pathway    Rap1 signaling pathway    HIF-1 signaling pathway    FoxO signaling pathway    PI3K-Akt signaling pathway    Vascular smooth muscle contraction    VEGF signaling pathway    Gap junction    Toll-like receptor signaling pathway    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Long-term potentiation    Neurotrophin signaling pathway    Long-term depression    Regulation of actin cytoskeleton    Insulin signaling pathway    GnRH signaling pathway    Estrogen signaling pathway    Melanogenesis    Prolactin signaling pathway    Thyroid hormone signaling pathway    Prion diseases    Hepatitis B    Influenza A    Pathways in cancer    Proteoglycans in cancer    MicroRNAs in cancer    Renal cell carcinoma    Endometrial cancer    Glioma    Prostate cancer    Thyroid cancer    Melanoma    Bladder cancer    Chronic myeloid leukemia    Acute myeloid leukemia    Non-small cell lung cancer   
NDEx NetworkMAP2K2
Atlas of Cancer Signalling NetworkMAP2K2
Wikipedia pathwaysMAP2K2
Orthology - Evolution
OrthoDB5605
GeneTree (enSembl)ENSG00000126934
Phylogenetic Trees/Animal Genes : TreeFamMAP2K2
HOGENOMP36507
Homologs : HomoloGeneMAP2K2
Homology/Alignments : Family Browser (UCSC)MAP2K2
Gene fusions - Rearrangements
Fusion : MitelmanMAP2K2/CAMKK1 [19p13.3/17p13.2]  
Fusion PortalMAP2K2 19p13.3 CAMKK1 17p13.2 BRCA
Fusion : QuiverMAP2K2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP2K2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP2K2
dbVarMAP2K2
ClinVarMAP2K2
1000_GenomesMAP2K2 
Exome Variant ServerMAP2K2
ExAC (Exome Aggregation Consortium)ENSG00000126934
GNOMAD BrowserENSG00000126934
Varsome BrowserMAP2K2
Genetic variants : HAPMAP5605
Genomic Variants (DGV)MAP2K2 [DGVbeta]
DECIPHERMAP2K2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP2K2 
Mutations
ICGC Data PortalMAP2K2 
TCGA Data PortalMAP2K2 
Broad Tumor PortalMAP2K2
OASIS PortalMAP2K2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP2K2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAP2K2
Mutations and Diseases : HGMDMAP2K2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP2K2
DgiDB (Drug Gene Interaction Database)MAP2K2
DoCM (Curated mutations)MAP2K2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP2K2 (select a term)
intoGenMAP2K2
Cancer3DMAP2K2(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601263    615280   
Orphanet930    1559   
DisGeNETMAP2K2
MedgenMAP2K2
Genetic Testing Registry MAP2K2
NextProtP36507 [Medical]
TSGene5605
GENETestsMAP2K2
Target ValidationMAP2K2
Huge Navigator MAP2K2 [HugePedia]
snp3D : Map Gene to Disease5605
BioCentury BCIQMAP2K2
ClinGenMAP2K2 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5605
Chemical/Pharm GKB GenePA30587
Clinical trialMAP2K2
Miscellaneous
canSAR (ICR)MAP2K2 (select the gene name)
HarmonizomeMAP2K2
DataMed IndexMAP2K2
Probes
Litterature
PubMed210 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP2K2
EVEXMAP2K2
GoPubMedMAP2K2
iHOPMAP2K2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun May 10 12:21:42 CEST 2020
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