Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MAP2K2 (mitogen-activated protein kinase kinase 2)

Identity

Other namesCFC4
MAPKK2
MEK2
MKK2
PRKMK2
HGNC (Hugo) MAP2K2
LocusID (NCBI) 5605
Location 19p13.3
Location_base_pair Starts at 4090320 and ends at 4124126 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MAP2K2   6842
Cards
Entrez_Gene (NCBI)MAP2K2  5605  mitogen-activated protein kinase kinase 2
GeneCards (Weizmann)MAP2K2
Ensembl (Hinxton)ENSG00000126934 [Gene_View]  chr19:4090320-4124126 [Contig_View]  MAP2K2 [Vega]
AceView (NCBI)MAP2K2
Genatlas (Paris)MAP2K2
WikiGenes5605
SOURCE (Princeton)NM_030662
Genomic and cartography
GoldenPath (UCSC)MAP2K2  -  19p13.3   chr19:4090320-4124126 -  19p13.3   [Description]    (hg19-Feb_2009)
EnsemblMAP2K2 - 19p13.3 [CytoView]
Mapping of homologs : NCBIMAP2K2 [Mapview]
OMIM115150   601263   615280   
Gene and transcription
Genbank (Entrez)AA312322 AK093125 AK126446 AK129586 BC000471
RefSeq transcript (Entrez)NM_030662
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_007996 NT_011255 NW_001838477 NW_004929412
Consensus coding sequences : CCDS (NCBI)MAP2K2
Cluster EST : UnigeneHs.465627 [ NCBI ]
CGAP (NCI)Hs.465627
Alternative Splicing : Fast-db (Paris)GSHG0015375
Alternative Splicing GalleryENSG00000126934
Gene ExpressionMAP2K2 [ NCBI-GEO ]     MAP2K2 [ SEEK ]   MAP2K2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36507 (Uniprot)
NextProtP36507  [Medical]
With graphics : InterProP36507
Splice isoforms : SwissVarP36507 (Swissvar)
Catalytic activity : Enzyme2.7.12.2 [ Enzyme-Expasy ]   2.7.12.22.7.12.2 [ IntEnz-EBI ]   2.7.12.2 [ BRENDA ]   2.7.12.2 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Related proteins : CluSTrP36507
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM Disease mutations5605
Blocks (Seattle)P36507
PDB (SRS)1S9I    4H3Q   
PDB (PDBSum)1S9I    4H3Q   
PDB (IMB)1S9I    4H3Q   
PDB (RSDB)1S9I    4H3Q   
Human Protein AtlasENSG00000126934
Peptide AtlasP36507
HPRD03164
IPIIPI00003783   IPI00443029   IPI00795187   
Protein Interaction databases
DIP (DOE-UCLA)P36507
IntAct (EBI)P36507
FunCoupENSG00000126934
BioGRIDMAP2K2
InParanoidP36507
Interologous Interaction database P36507
IntegromeDBMAP2K2
STRING (EMBL)MAP2K2
Ontologies - Pathways
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  activation of MAPK activity  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  protein serine/threonine kinase activity  protein serine/threonine kinase activity  MAP kinase kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  extracellular region  nucleus  mitochondrion  early endosome  late endosome  peroxisomal membrane  endoplasmic reticulum  Golgi apparatus  Golgi apparatus  cytosol  microtubule  cell-cell junction  focal adhesion  cell cortex  protein phosphorylation  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  Ras protein signal transduction  axon guidance  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  cytoplasmic side of plasma membrane  PDZ domain binding  regulation of stress-activated MAPK cascade  protein complex scaffold  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 5 signaling pathway  toll-like receptor 9 signaling pathway  toll-like receptor 10 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  peptidyl-serine autophosphorylation  Fc-epsilon receptor signaling pathway  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  protein serine/threonine kinase activator activity  innate immune response  neurotrophin TRK receptor signaling pathway  perinuclear region of cytoplasm  stress-activated MAPK cascade  ERK1 and ERK2 cascade  positive regulation of protein serine/threonine kinase activity  regulation of Golgi inheritance  scaffold protein binding  positive regulation of cell motility  regulation of early endosome to late endosome transport  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  activation of MAPK activity  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  protein serine/threonine kinase activity  protein serine/threonine kinase activity  MAP kinase kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  extracellular region  nucleus  mitochondrion  early endosome  late endosome  peroxisomal membrane  endoplasmic reticulum  Golgi apparatus  Golgi apparatus  cytosol  microtubule  cell-cell junction  focal adhesion  cell cortex  protein phosphorylation  epidermal growth factor receptor signaling pathway  small GTPase mediated signal transduction  Ras protein signal transduction  axon guidance  insulin receptor signaling pathway  fibroblast growth factor receptor signaling pathway  cytoplasmic side of plasma membrane  PDZ domain binding  regulation of stress-activated MAPK cascade  protein complex scaffold  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 5 signaling pathway  toll-like receptor 9 signaling pathway  toll-like receptor 10 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  peptidyl-serine autophosphorylation  Fc-epsilon receptor signaling pathway  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  protein serine/threonine kinase activator activity  innate immune response  neurotrophin TRK receptor signaling pathway  perinuclear region of cytoplasm  stress-activated MAPK cascade  ERK1 and ERK2 cascade  positive regulation of protein serine/threonine kinase activity  regulation of Golgi inheritance  scaffold protein binding  positive regulation of cell motility  regulation of early endosome to late endosome transport  
Pathways : BIOCARTAErk1/Erk2 Mapk Signaling pathway [Genes]    MAPKinase Signaling Pathway [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    Human Cytomegalovirus and Map Kinase Pathways [Genes]    Anthrax Toxin Mechanism of Action [Genes]    Integrin Signaling Pathway [Genes]    Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway [Genes]    Links between Pyk2 and Map Kinases [Genes]    Roles of ¿-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling [Genes]    Role of MAL in Rho-Mediated Activation of SRF [Genes]    Role of ¿-arrestins in the activation and targeting of MAP kinases [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Ras signaling pathway    Rap1 signaling pathway    HIF-1 signaling pathway    FoxO signaling pathway    PI3K-Akt signaling pathway    Vascular smooth muscle contraction    VEGF signaling pathway    Gap junction    Toll-like receptor signaling pathway    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Long-term potentiation    Neurotrophin signaling pathway    Long-term depression    Regulation of actin cytoskeleton    Insulin signaling pathway    GnRH signaling pathway    Estrogen signaling pathway    Melanogenesis    Prolactin signaling pathway    Thyroid hormone signaling pathway    Prion diseases    Hepatitis B    Influenza A    Pathways in cancer    Proteoglycans in cancer    MicroRNAs in cancer    Renal cell carcinoma    Endometrial cancer    Glioma    Prostate cancer    Thyroid cancer    Melanoma    Bladder cancer    Chronic myeloid leukemia    Acute myeloid leukemia    Non-small cell lung cancer   
REACTOMEMAP2K2
Protein Interaction DatabaseMAP2K2
Wikipedia pathwaysMAP2K2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MAP2K2
SNP (GeneSNP Utah)MAP2K2
SNP : HGBaseMAP2K2
Genetic variants : HAPMAPMAP2K2
1000_GenomesMAP2K2 
ICGC programENSG00000126934 
Cancer Gene: CensusMAP2K2 
Somatic Mutations in Cancer : COSMICMAP2K2 
CONAN: Copy Number AnalysisMAP2K2 
Mutations and Diseases : HGMDMAP2K2
OMIM115150    601263    615280   
GENETestsMAP2K2
Disease Genetic AssociationMAP2K2
Huge Navigator MAP2K2 [HugePedia]  MAP2K2 [HugeCancerGEM]
Genomic VariantsMAP2K2  MAP2K2 [DGVbeta]
Exome VariantMAP2K2
dbVarMAP2K2
ClinVarMAP2K2
snp3D : Map Gene to Disease5605
General knowledge
Homologs : HomoloGeneMAP2K2
Homology/Alignments : Family Browser (UCSC)MAP2K2
Phylogenetic Trees/Animal Genes : TreeFamMAP2K2
Chemical/Protein Interactions : CTD5605
Chemical/Pharm GKB GenePA30587
Clinical trialMAP2K2
Cancer Resource (Charite)ENSG00000126934
Other databases
Probes
Litterature
PubMed158 Pubmed reference(s) in Entrez
CoreMineMAP2K2
iHOPMAP2K2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 15 13:45:43 CET 2014
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.