MAP2K2 (mitogen-activated protein kinase kinase 2)

Identity

Other names	FLJ26075
	MAPKK2
	MEK2
	MKK2
	PRKMK2
HGNC	MAP2K2
Location	19p13.3
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	MAP2K2   6842
Entrez_Gene	MAP2K2  5605  mitogen-activated protein kinase kinase 2
	Cards
GeneCards	MAP2K2
Ensembl	MAP2K2 [Search_View]   ENSG00000126934 [Gene_View]
Genatlas	MAP2K2
GeneLynx	MAP2K2
eGenome	MAP2K2
euGene	5605
	Genomic and cartography
GoldenPath	MAP2K2  -  19p13.3   chr19:4041320-4075126 -  19p13.3   [Description]    (hg18-March_2006)
Ensembl	MAP2K2 - 19p13.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	MAP2K2
	Gene and transcription
Genbank	AA312322 [ ENTREZ ]
Genbank	AK093125 [ ENTREZ ]
Genbank	AK126446 [ ENTREZ ]
Genbank	AK129586 [ ENTREZ ]
Genbank	BC000471 [ ENTREZ ]
RefSeq	NM_030662 [ SRS ]    NM_030662 [ ENTREZ ]
RefSeq	AC_000062 [ SRS ]    AC_000062 [ ENTREZ ]
RefSeq	AC_000151 [ SRS ]    AC_000151 [ ENTREZ ]
RefSeq	NC_000019 [ SRS ]    NC_000019 [ ENTREZ ]
RefSeq	NG_007996 [ SRS ]    NG_007996 [ ENTREZ ]
RefSeq	NT_011255 [ SRS ]    NT_011255 [ ENTREZ ]
RefSeq	NW_001838477 [ SRS ]    NW_001838477 [ ENTREZ ]
RefSeq	NW_927173 [ SRS ]    NW_927173 [ ENTREZ ]
AceView	MAP2K2 AceView - NCBI
Unigene	Hs.465627 [ SRS ]    Hs.465627 [ NCBI ]     HS465627 [ spliceNest ]
Fast-db	2410 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P36507 [ SRS]    P36507 [ EXPASY ]     P36507 [ INTERPRO ]     P36507 [ UNIPROT ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
Interpro	IPR002290 Ser_thr_pkinase [ SRS ]    IPR002290 Ser_thr_pkinase [ EBI ]
CluSTr	P36507
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Smart	SM00220 S_TKc [EMBL]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P36507 MP2K2_HUMAN [ Domain structure ]   P36507 MP2K2_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P36507
PDB	1S9I [ SRS ]    1S9I [ PdbSum ],   1S9I [ IMB ]   1S9I [ RSDB ]
HPRD	03164
	Protein Interaction databases
DIP	P36507
IntAct	P36507
	Polymorphism : SNP, mutations, diseases
OMIM	115150;601263    [ map ]
GENECLINICS	115150;601263
SNP	MAP2K2 [dbSNP-NCBI]
SNP	NM_030662 [SNP-NCI]
SNP	MAP2K2 [GeneSNPs - Utah]  MAP2K2] [HGBASE - SRS]
HAPMAP	MAP2K2 [HAPMAP]
COSMIC	MAP2K2 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	MAP2K2
	General knowledge
Family Browser	MAP2K2 [UCSC Family Browser]
SOURCE	NM_030662
SMD	Hs.465627
SAGE	Hs.465627
Enzyme	2.7.12.2 [ Enzyme-Expasy ]   2.7.12.2 [ Enzyme-SRS ]   2.7.12.2 [ IntEnz-EBI ]   2.7.12.2 [ BRENDA ]   2.7.12.2 [ KEGG ]   2.7.12.2 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	protein tyrosine kinase activity [Amigo]  protein tyrosine kinase activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	extracellular region [Amigo]  extracellular region
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	Ras protein signal transduction [Amigo]  Ras protein signal transduction
GO	transferase activity [Amigo]  transferase activity
BIOCARTA	Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling    [Genes]
BIOCARTA	Anthrax Toxin Mechanism of Action    [Genes]
BIOCARTA	Roles of ß-arrestin-dependent Recruitment of Src Kinases in GPCR Signaling    [Genes]
BIOCARTA	Role of ß-arrestins in the activation and targeting of MAP kinases    [Genes]
BIOCARTA	Bioactive Peptide Induced Signaling Pathway    [Genes]
BIOCARTA	Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway    [Genes]
BIOCARTA	Erk1/Erk2 Mapk Signaling pathway    [Genes]
BIOCARTA	fMLP induced chemokine gene expression in HMC-1 cells    [Genes]
BIOCARTA	Human Cytomegalovirus and Map Kinase Pathways    [Genes]
BIOCARTA	Integrin Signaling Pathway    [Genes]
BIOCARTA	Role of MAL in Rho-Mediated Activation of SRF    [Genes]
BIOCARTA	MAPKinase Signaling Pathway    [Genes]
BIOCARTA	Signaling of Hepatocyte Growth Factor Receptor    [Genes]
BIOCARTA	Links between Pyk2 and Map Kinases    [Genes]
KEGG	MAPK signaling pathway
KEGG	VEGF signaling pathway
KEGG	Gap junction
KEGG	Natural killer cell mediated cytotoxicity
KEGG	Fc epsilon RI signaling pathway
KEGG	Long-term potentiation
KEGG	Long-term depression
KEGG	Regulation of actin cytoskeleton
KEGG	Insulin signaling pathway
KEGG	GnRH signaling pathway
PubGene	MAP2K2
TreeFam	MAP2K2
CTD	5605 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	MAP2K2 Related clones (RZPD - Berlin)
	PubMed
PubMed	90 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

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Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:19:11 2008