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MAP2K2 (mitogen-activated protein kinase kinase 2)

Identity

Alias_namesPRKMK2
Alias_symbol (synonym)MEK2
Other aliasCFC4
MAPKK2
MKK2
HGNC (Hugo) MAP2K2
LocusID (NCBI) 5605
Atlas_Id 41271
Location 19p13.3  [Link to chromosome band 19p13]
Location_base_pair Starts at 4090320 and ends at 4124126 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CLU (8p21.1) / MAP2K2 (19p13.3)EEF2 (19p13.3) / MAP2K2 (19p13.3)GRHL2 (8q22.3) / MAP2K2 (19p13.3)
MAP2K2 (19p13.3) / CAMKK1 (17p13.2)MAP2K2 (19p13.3) / INSR (19p13.2)MAP2K2 (19p13.3) / MALAT1 (11q13.1)
MAP2K2 19p13.3 / CAMKK1 17p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Skin: Melanoma


External links

Nomenclature
HGNC (Hugo)MAP2K2   6842
LRG (Locus Reference Genomic)LRG_750
Cards
Entrez_Gene (NCBI)MAP2K2  5605  mitogen-activated protein kinase kinase 2
AliasesCFC4; MAPKK2; MEK2; MKK2; 
PRKMK2
GeneCards (Weizmann)MAP2K2
Ensembl hg19 (Hinxton)ENSG00000126934 [Gene_View]  chr19:4090320-4124126 [Contig_View]  MAP2K2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000126934 [Gene_View]  chr19:4090320-4124126 [Contig_View]  MAP2K2 [Vega]
ICGC DataPortalENSG00000126934
TCGA cBioPortalMAP2K2
AceView (NCBI)MAP2K2
Genatlas (Paris)MAP2K2
WikiGenes5605
SOURCE (Princeton)MAP2K2
Genetics Home Reference (NIH)MAP2K2
Genomic and cartography
GoldenPath hg19 (UCSC)MAP2K2  -     chr19:4090320-4124126 -  19p13.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAP2K2  -     19p13.3   [Description]    (hg38-Dec_2013)
EnsemblMAP2K2 - 19p13.3 [CytoView hg19]  MAP2K2 - 19p13.3 [CytoView hg38]
Mapping of homologs : NCBIMAP2K2 [Mapview hg19]  MAP2K2 [Mapview hg38]
OMIM601263   615280   
Gene and transcription
Genbank (Entrez)AA312322 AK093125 AK126446 AK129586 BC000471
RefSeq transcript (Entrez)NM_030662
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_007996 NT_011295 NW_004929412
Consensus coding sequences : CCDS (NCBI)MAP2K2
Cluster EST : UnigeneHs.465627 [ NCBI ]
CGAP (NCI)Hs.465627
Alternative Splicing GalleryENSG00000126934
Gene ExpressionMAP2K2 [ NCBI-GEO ]   MAP2K2 [ EBI - ARRAY_EXPRESS ]   MAP2K2 [ SEEK ]   MAP2K2 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP2K2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5605
GTEX Portal (Tissue expression)MAP2K2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP36507   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP36507  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP36507
Splice isoforms : SwissVarP36507
PhosPhoSitePlusP36507
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP2K2
DMDM Disease mutations5605
Blocks (Seattle)MAP2K2
PDB (SRS)1S9I    4H3Q   
PDB (PDBSum)1S9I    4H3Q   
PDB (IMB)1S9I    4H3Q   
PDB (RSDB)1S9I    4H3Q   
Structural Biology KnowledgeBase1S9I    4H3Q   
SCOP (Structural Classification of Proteins)1S9I    4H3Q   
CATH (Classification of proteins structures)1S9I    4H3Q   
SuperfamilyP36507
Human Protein AtlasENSG00000126934
Peptide AtlasP36507
HPRD03164
IPIIPI00003783   IPI00443029   IPI00795187   
Protein Interaction databases
DIP (DOE-UCLA)P36507
IntAct (EBI)P36507
FunCoupENSG00000126934
BioGRIDMAP2K2
STRING (EMBL)MAP2K2
ZODIACMAP2K2
Ontologies - Pathways
QuickGOP36507
Ontology : AmiGOMAPK cascade  activation of MAPK activity  protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  MAP kinase kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  extracellular region  nucleus  cytoplasm  mitochondrion  early endosome  late endosome  peroxisomal membrane  endoplasmic reticulum  Golgi apparatus  Golgi apparatus  cytosol  microtubule  cell-cell junction  focal adhesion  cell cortex  heart development  cytoplasmic side of plasma membrane  negative regulation of gene expression  peptidyl-tyrosine phosphorylation  PDZ domain binding  thyroid gland development  regulation of stress-activated MAPK cascade  protein complex scaffold  proteolysis in other organism  peptidyl-serine autophosphorylation  protein serine/threonine kinase activator activity  metal ion binding  perinuclear region of cytoplasm  thymus development  regulation of axon regeneration  positive regulation of axonogenesis  face development  trachea formation  epithelial cell proliferation involved in lung morphogenesis  ERK1 and ERK2 cascade  positive regulation of protein serine/threonine kinase activity  regulation of Golgi inheritance  scaffold protein binding  positive regulation of cell motility  regulation of early endosome to late endosome transport  
Ontology : EGO-EBIMAPK cascade  activation of MAPK activity  protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  MAP kinase kinase activity  protein serine/threonine/tyrosine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  extracellular region  nucleus  cytoplasm  mitochondrion  early endosome  late endosome  peroxisomal membrane  endoplasmic reticulum  Golgi apparatus  Golgi apparatus  cytosol  microtubule  cell-cell junction  focal adhesion  cell cortex  heart development  cytoplasmic side of plasma membrane  negative regulation of gene expression  peptidyl-tyrosine phosphorylation  PDZ domain binding  thyroid gland development  regulation of stress-activated MAPK cascade  protein complex scaffold  proteolysis in other organism  peptidyl-serine autophosphorylation  protein serine/threonine kinase activator activity  metal ion binding  perinuclear region of cytoplasm  thymus development  regulation of axon regeneration  positive regulation of axonogenesis  face development  trachea formation  epithelial cell proliferation involved in lung morphogenesis  ERK1 and ERK2 cascade  positive regulation of protein serine/threonine kinase activity  regulation of Golgi inheritance  scaffold protein binding  positive regulation of cell motility  regulation of early endosome to late endosome transport  
Pathways : BIOCARTAErk1/Erk2 Mapk Signaling pathway [Genes]    MAPKinase Signaling Pathway [Genes]    Angiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    Human Cytomegalovirus and Map Kinase Pathways [Genes]    Anthrax Toxin Mechanism of Action [Genes]    Integrin Signaling Pathway [Genes]    Phosphorylation of MEK1 by cdk5/p35 down regulates the MAP kinase pathway [Genes]    Links between Pyk2 and Map Kinases [Genes]    Roles of -arrestin-dependent Recruitment of Src Kinases in GPCR Signaling [Genes]    Role of MAL in Rho-Mediated Activation of SRF [Genes]    Role of -arrestins in the activation and targeting of MAP kinases [Genes]    Bioactive Peptide Induced Signaling Pathway [Genes]    Signaling of Hepatocyte Growth Factor Receptor [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Ras signaling pathway    Rap1 signaling pathway    HIF-1 signaling pathway    FoxO signaling pathway    PI3K-Akt signaling pathway    Vascular smooth muscle contraction    VEGF signaling pathway    Gap junction    Toll-like receptor signaling pathway    Natural killer cell mediated cytotoxicity    T cell receptor signaling pathway    B cell receptor signaling pathway    Fc epsilon RI signaling pathway    Long-term potentiation    Neurotrophin signaling pathway    Long-term depression    Regulation of actin cytoskeleton    Insulin signaling pathway    GnRH signaling pathway    Estrogen signaling pathway    Melanogenesis    Prolactin signaling pathway    Thyroid hormone signaling pathway    Prion diseases    Hepatitis B    Influenza A    Pathways in cancer    Proteoglycans in cancer    MicroRNAs in cancer    Renal cell carcinoma    Endometrial cancer    Glioma    Prostate cancer    Thyroid cancer    Melanoma    Bladder cancer    Chronic myeloid leukemia    Acute myeloid leukemia    Non-small cell lung cancer   
NDEx NetworkMAP2K2
Atlas of Cancer Signalling NetworkMAP2K2
Wikipedia pathwaysMAP2K2
Orthology - Evolution
OrthoDB5605
GeneTree (enSembl)ENSG00000126934
Phylogenetic Trees/Animal Genes : TreeFamMAP2K2
HOVERGENP36507
HOGENOMP36507
Homologs : HomoloGeneMAP2K2
Homology/Alignments : Family Browser (UCSC)MAP2K2
Gene fusions - Rearrangements
Fusion : MitelmanMAP2K2/CAMKK1 [19p13.3/17p13.2]  
Fusion: TCGAMAP2K2 19p13.3 CAMKK1 17p13.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP2K2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP2K2
dbVarMAP2K2
ClinVarMAP2K2
1000_GenomesMAP2K2 
Exome Variant ServerMAP2K2
ExAC (Exome Aggregation Consortium)MAP2K2 (select the gene name)
Genetic variants : HAPMAP5605
Genomic Variants (DGV)MAP2K2 [DGVbeta]
DECIPHER (Syndromes)19:4090320-4124126  ENSG00000126934
CONAN: Copy Number AnalysisMAP2K2 
Mutations
ICGC Data PortalMAP2K2 
TCGA Data PortalMAP2K2 
Broad Tumor PortalMAP2K2
OASIS PortalMAP2K2 [ Somatic mutations - Copy number]
Cancer Gene: CensusMAP2K2 
Somatic Mutations in Cancer : COSMICMAP2K2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP2K2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP2K2
DgiDB (Drug Gene Interaction Database)MAP2K2
DoCM (Curated mutations)MAP2K2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP2K2 (select a term)
intoGenMAP2K2
Cancer3DMAP2K2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601263    615280   
Orphanet930    1559   
MedgenMAP2K2
Genetic Testing Registry MAP2K2
NextProtP36507 [Medical]
TSGene5605
GENETestsMAP2K2
Huge Navigator MAP2K2 [HugePedia]
snp3D : Map Gene to Disease5605
BioCentury BCIQMAP2K2
ClinGenMAP2K2 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5605
Chemical/Pharm GKB GenePA30587
Clinical trialMAP2K2
Miscellaneous
canSAR (ICR)MAP2K2 (select the gene name)
Probes
Litterature
PubMed176 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP2K2
EVEXMAP2K2
GoPubMedMAP2K2
iHOPMAP2K2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:08:26 CEST 2017

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