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MAP2K3 (mitogen-activated protein kinase kinase 3)

Identity

Alias_namesPRKMK3
Alias_symbol (synonym)MEK3
MKK3
MAPKK3
Other aliasSAPKK-2
SAPKK2
HGNC (Hugo) MAP2K3
LocusID (NCBI) 5606
Atlas_Id 41272
Location 17p11.2  [Link to chromosome band 17p11]
Location_base_pair Starts at 21187968 and ends at 21218551 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MAP2K3 (17p11.2) / NKAIN3 (8q12.3)MAP2K3 (17p11.2) / SSR3 (3q25.31)NCOA2 (8q13.3) / MAP2K3 (17p11.2)
NLN (5q12.3) / MAP2K3 (17p11.2)RBMX (Xq26.3) / MAP2K3 (17p11.2)SSR3 (3q25.31) / MAP2K3 (17p11.2)
TVP23B (17p11.2) / MAP2K3 (17p11.2)MAP2K3 17p11.2 / NKAIN3 8q12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 2 ]
  Breast: Ductal carcinoma
Lung: Translocations in Squamous Cell Carcinoma


External links

Nomenclature
HGNC (Hugo)MAP2K3   6843
Cards
Entrez_Gene (NCBI)MAP2K3  5606  mitogen-activated protein kinase kinase 3
AliasesMAPKK3; MEK3; MKK3; PRKMK3; 
SAPKK-2; SAPKK2
GeneCards (Weizmann)MAP2K3
Ensembl hg19 (Hinxton)ENSG00000034152 [Gene_View]  chr17:21187968-21218551 [Contig_View]  MAP2K3 [Vega]
Ensembl hg38 (Hinxton)ENSG00000034152 [Gene_View]  chr17:21187968-21218551 [Contig_View]  MAP2K3 [Vega]
ICGC DataPortalENSG00000034152
TCGA cBioPortalMAP2K3
AceView (NCBI)MAP2K3
Genatlas (Paris)MAP2K3
WikiGenes5606
SOURCE (Princeton)MAP2K3
Genetics Home Reference (NIH)MAP2K3
Genomic and cartography
GoldenPath hg19 (UCSC)MAP2K3  -     chr17:21187968-21218551 +  17p11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAP2K3  -     17p11.2   [Description]    (hg38-Dec_2013)
EnsemblMAP2K3 - 17p11.2 [CytoView hg19]  MAP2K3 - 17p11.2 [CytoView hg38]
Mapping of homologs : NCBIMAP2K3 [Mapview hg19]  MAP2K3 [Mapview hg38]
OMIM602315   
Gene and transcription
Genbank (Entrez)AB451226 AB451349 AI758302 AK093838 AK223490
RefSeq transcript (Entrez)NM_001316332 NM_002756 NM_145109 NM_145110
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_028256 NT_010718 NW_004929405
Consensus coding sequences : CCDS (NCBI)MAP2K3
Cluster EST : UnigeneHs.514012 [ NCBI ]
CGAP (NCI)Hs.514012
Alternative Splicing GalleryENSG00000034152
Gene ExpressionMAP2K3 [ NCBI-GEO ]   MAP2K3 [ EBI - ARRAY_EXPRESS ]   MAP2K3 [ SEEK ]   MAP2K3 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP2K3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5606
GTEX Portal (Tissue expression)MAP2K3
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46734   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46734  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46734
Splice isoforms : SwissVarP46734
Catalytic activity : Enzyme2.7.12.2 [ Enzyme-Expasy ]   2.7.12.22.7.12.2 [ IntEnz-EBI ]   2.7.12.2 [ BRENDA ]   2.7.12.2 [ KEGG ]   
PhosPhoSitePlusP46734
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP2K3
DMDM Disease mutations5606
Blocks (Seattle)MAP2K3
SuperfamilyP46734
Human Protein AtlasENSG00000034152
Peptide AtlasP46734
HPRD03816
IPIIPI00220438   IPI00218857   IPI00218858   IPI01025376   IPI00978897   IPI00980088   IPI00979591   
Protein Interaction databases
DIP (DOE-UCLA)P46734
IntAct (EBI)P46734
FunCoupENSG00000034152
BioGRIDMAP2K3
STRING (EMBL)MAP2K3
ZODIACMAP2K3
Ontologies - Pathways
QuickGOP46734
Ontology : AmiGOMAPK cascade  activation of MAPK activity  receptor signaling protein serine/threonine kinase activity  MAP kinase kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleoplasm  cytoplasm  cytosol  inflammatory response  signal transduction  membrane  peptidyl-tyrosine phosphorylation  protein kinase binding  proteolysis in other organism  regulation of cytokine biosynthetic process  positive regulation of protein kinase activity  positive regulation of transcription, DNA-templated  cardiac muscle contraction  
Ontology : EGO-EBIMAPK cascade  activation of MAPK activity  receptor signaling protein serine/threonine kinase activity  MAP kinase kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleoplasm  cytoplasm  cytosol  inflammatory response  signal transduction  membrane  peptidyl-tyrosine phosphorylation  protein kinase binding  proteolysis in other organism  regulation of cytokine biosynthetic process  positive regulation of protein kinase activity  positive regulation of transcription, DNA-templated  cardiac muscle contraction  
Pathways : BIOCARTAToll-Like Receptor Pathway [Genes]    MAPKinase Signaling Pathway [Genes]    Human Cytomegalovirus and Map Kinase Pathways [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]    Keratinocyte Differentiation [Genes]    Links between Pyk2 and Map Kinases [Genes]    GATA3 participate in activating the Th2 cytokine genes expression [Genes]    Signal transduction through IL1R [Genes]    NFkB activation by Nontypeable Hemophilus influenzae [Genes]    TNF/Stress Related Signaling [Genes]   
Pathways : KEGGMAPK signaling pathway    Rap1 signaling pathway    Toll-like receptor signaling pathway    Fc epsilon RI signaling pathway    TNF signaling pathway    GnRH signaling pathway    Amyotrophic lateral sclerosis (ALS)    Toxoplasmosis    Influenza A    Epstein-Barr virus infection   
NDEx NetworkMAP2K3
Atlas of Cancer Signalling NetworkMAP2K3
Wikipedia pathwaysMAP2K3
Orthology - Evolution
OrthoDB5606
GeneTree (enSembl)ENSG00000034152
Phylogenetic Trees/Animal Genes : TreeFamMAP2K3
HOVERGENP46734
HOGENOMP46734
Homologs : HomoloGeneMAP2K3
Homology/Alignments : Family Browser (UCSC)MAP2K3
Gene fusions - Rearrangements
Fusion : MitelmanMAP2K3/NKAIN3 [17p11.2/8q12.3]  
Fusion : MitelmanMAP2K3/SSR3 [17p11.2/3q25.31]  [t(3;17)(q25;p11)]  
Fusion : MitelmanSSR3/MAP2K3 [3q25.31/17p11.2]  [t(3;17)(q25;p11)]  
Fusion: TCGAMAP2K3 17p11.2 NKAIN3 8q12.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP2K3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP2K3
dbVarMAP2K3
ClinVarMAP2K3
1000_GenomesMAP2K3 
Exome Variant ServerMAP2K3
ExAC (Exome Aggregation Consortium)MAP2K3 (select the gene name)
Genetic variants : HAPMAP5606
Genomic Variants (DGV)MAP2K3 [DGVbeta]
DECIPHER (Syndromes)17:21187968-21218551  ENSG00000034152
CONAN: Copy Number AnalysisMAP2K3 
Mutations
ICGC Data PortalMAP2K3 
TCGA Data PortalMAP2K3 
Broad Tumor PortalMAP2K3
OASIS PortalMAP2K3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP2K3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP2K3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP2K3
DgiDB (Drug Gene Interaction Database)MAP2K3
DoCM (Curated mutations)MAP2K3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP2K3 (select a term)
intoGenMAP2K3
Cancer3DMAP2K3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602315   
Orphanet
MedgenMAP2K3
Genetic Testing Registry MAP2K3
NextProtP46734 [Medical]
TSGene5606
GENETestsMAP2K3
Huge Navigator MAP2K3 [HugePedia]
snp3D : Map Gene to Disease5606
BioCentury BCIQMAP2K3
ClinGenMAP2K3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5606
Chemical/Pharm GKB GenePA30588
Clinical trialMAP2K3
Miscellaneous
canSAR (ICR)MAP2K3 (select the gene name)
Probes
Litterature
PubMed82 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP2K3
EVEXMAP2K3
GoPubMedMAP2K3
iHOPMAP2K3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:14:21 CET 2017

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