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MAP2K3 (mitogen-activated protein kinase kinase 3)

Identity

Alias (NCBI)MAPKK3
MEK3
MKK3
PRKMK3
SAPKK-2
SAPKK2
HGNC (Hugo) MAP2K3
HGNC Alias symbMEK3
MKK3
MAPKK3
HGNC Alias nameMAPK/ERK kinase 3
 MAP kinase kinase 3
 dual specificity mitogen activated protein kinase kinase 3
HGNC Previous namePRKMK3
LocusID (NCBI) 5606
Atlas_Id 41272
Location 17p11.2  [Link to chromosome band 17p11]
Location_base_pair Starts at 21284711 and ends at 21315215 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAP2K3 (17p11.2) / NKAIN3 (8q12.3)MAP2K3 (17p11.2) / SSR3 (3q25.31)NCOA2 (8q13.3) / MAP2K3 (17p11.2)
NLN (5q12.3) / MAP2K3 (17p11.2)RBMX (Xq26.3) / MAP2K3 (17p11.2)SSR3 (3q25.31) / MAP2K3 (17p11.2)
TVP23B (17p11.2) / MAP2K3 (17p11.2)MAP2K3 17p11.2 / NKAIN3 8q12.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)MAP2K3   6843
Cards
Entrez_Gene (NCBI)MAP2K3    mitogen-activated protein kinase kinase 3
AliasesMAPKK3; MEK3; MKK3; PRKMK3; 
SAPKK-2; SAPKK2
GeneCards (Weizmann)MAP2K3
Ensembl hg19 (Hinxton)ENSG00000034152 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000034152 [Gene_View]  ENSG00000034152 [Sequence]  chr17:21284711-21315215 [Contig_View]  MAP2K3 [Vega]
ICGC DataPortalENSG00000034152
TCGA cBioPortalMAP2K3
AceView (NCBI)MAP2K3
Genatlas (Paris)MAP2K3
SOURCE (Princeton)MAP2K3
Genetics Home Reference (NIH)MAP2K3
Genomic and cartography
GoldenPath hg38 (UCSC)MAP2K3  -     chr17:21284711-21315215 +  17p11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP2K3  -     17p11.2   [Description]    (hg19-Feb_2009)
GoldenPathMAP2K3 - 17p11.2 [CytoView hg19]  MAP2K3 - 17p11.2 [CytoView hg38]
ImmunoBaseENSG00000034152
genome Data Viewer NCBIMAP2K3 [Mapview hg19]  
OMIM602315   
Gene and transcription
Genbank (Entrez)AB451226 AB451349 AI758302 AK093838 AK223490
RefSeq transcript (Entrez)NM_001316332 NM_002756 NM_145109 NM_145110
Consensus coding sequences : CCDS (NCBI)MAP2K3
Alternative Splicing GalleryENSG00000034152
Gene ExpressionMAP2K3 [ NCBI-GEO ]   MAP2K3 [ EBI - ARRAY_EXPRESS ]   MAP2K3 [ SEEK ]   MAP2K3 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP2K3 [ Firebrowse - Broad ]
GenevisibleExpression of MAP2K3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5606
GTEX Portal (Tissue expression)MAP2K3
Human Protein AtlasENSG00000034152-MAP2K3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP46734   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP46734  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP46734
PhosPhoSitePlusP46734
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP2K3
SuperfamilyP46734
AlphaFold pdb e-kbP46734   
Human Protein Atlas [tissue]ENSG00000034152-MAP2K3 [tissue]
HPRD03816
Protein Interaction databases
DIP (DOE-UCLA)P46734
IntAct (EBI)P46734
BioGRIDMAP2K3
STRING (EMBL)MAP2K3
ZODIACMAP2K3
Ontologies - Pathways
QuickGOP46734
Ontology : AmiGOactivation of MAPK activity  activation of MAPK activity  regulation of cytokine production  MAP kinase kinase activity  transmembrane receptor protein tyrosine kinase activity  protein binding  ATP binding  nucleoplasm  cytosol  inflammatory response  signal transduction  membrane  peptidyl-tyrosine phosphorylation  protein kinase binding  negative regulation of hippo signaling  cellular response to vascular endothelial growth factor stimulus  p38MAPK cascade  positive regulation of blood vessel endothelial cell migration  positive regulation of protein kinase activity  positive regulation of transcription, DNA-templated  cardiac muscle contraction  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIactivation of MAPK activity  activation of MAPK activity  regulation of cytokine production  MAP kinase kinase activity  transmembrane receptor protein tyrosine kinase activity  protein binding  ATP binding  nucleoplasm  cytosol  inflammatory response  signal transduction  membrane  peptidyl-tyrosine phosphorylation  protein kinase binding  negative regulation of hippo signaling  cellular response to vascular endothelial growth factor stimulus  p38MAPK cascade  positive regulation of blood vessel endothelial cell migration  positive regulation of protein kinase activity  positive regulation of transcription, DNA-templated  cardiac muscle contraction  protein serine kinase activity  protein threonine kinase activity  
Pathways : BIOCARTAToll-Like Receptor Pathway [Genes]    MAPKinase Signaling Pathway [Genes]    Human Cytomegalovirus and Map Kinase Pathways [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]    Keratinocyte Differentiation [Genes]    Links between Pyk2 and Map Kinases [Genes]    GATA3 participate in activating the Th2 cytokine genes expression [Genes]    Signal transduction through IL1R [Genes]    NFkB activation by Nontypeable Hemophilus influenzae [Genes]    TNF/Stress Related Signaling [Genes]   
Pathways : KEGGMAPK signaling pathway    Rap1 signaling pathway    Toll-like receptor signaling pathway    Fc epsilon RI signaling pathway    TNF signaling pathway    GnRH signaling pathway    Amyotrophic lateral sclerosis (ALS)    Toxoplasmosis    Influenza A    Epstein-Barr virus infection   
NDEx NetworkMAP2K3
Atlas of Cancer Signalling NetworkMAP2K3
Wikipedia pathwaysMAP2K3
Orthology - Evolution
OrthoDB5606
GeneTree (enSembl)ENSG00000034152
Phylogenetic Trees/Animal Genes : TreeFamMAP2K3
Homologs : HomoloGeneMAP2K3
Homology/Alignments : Family Browser (UCSC)MAP2K3
Gene fusions - Rearrangements
Fusion : MitelmanMAP2K3/NKAIN3 [17p11.2/8q12.3]  
Fusion : MitelmanMAP2K3/SSR3 [17p11.2/3q25.31]  
Fusion : MitelmanSSR3/MAP2K3 [3q25.31/17p11.2]  
Fusion PortalMAP2K3 17p11.2 NKAIN3 8q12.3 BRCA
Fusion : QuiverMAP2K3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP2K3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP2K3
dbVarMAP2K3
ClinVarMAP2K3
MonarchMAP2K3
1000_GenomesMAP2K3 
Exome Variant ServerMAP2K3
GNOMAD BrowserENSG00000034152
Varsome BrowserMAP2K3
Genomic Variants (DGV)MAP2K3 [DGVbeta]
DECIPHERMAP2K3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP2K3 
Mutations
ICGC Data PortalMAP2K3 
TCGA Data PortalMAP2K3 
Broad Tumor PortalMAP2K3
OASIS PortalMAP2K3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP2K3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAP2K3
Mutations and Diseases : HGMDMAP2K3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutasearch MAP2K3
DgiDB (Drug Gene Interaction Database)MAP2K3
DoCM (Curated mutations)MAP2K3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP2K3 (select a term)
Cancer3DMAP2K3(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602315   
Orphanet
DisGeNETMAP2K3
MedgenMAP2K3
Genetic Testing Registry MAP2K3
NextProtP46734 [Medical]
GENETestsMAP2K3
Target ValidationMAP2K3
Huge Navigator MAP2K3 [HugePedia]
ClinGenMAP2K3
Clinical trials, drugs, therapy
MyCancerGenomeMAP2K3
Protein Interactions : CTDMAP2K3
Pharm GKB GenePA30588
Pharm GKB PathwaysPA165985892   PA2032   
PharosP46734
Clinical trialMAP2K3
Miscellaneous
canSAR (ICR)MAP2K3
HarmonizomeMAP2K3
DataMed IndexMAP2K3
Probes
Litterature
PubMed119 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMAP2K3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Sep 15 22:22:39 CEST 2021

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