MAP2K5 (mitogen-activated protein kinase kinase 5)

2003-11-01  

Identity

HGNC
LOCATION
15q23
LOCUSID
ALIAS
HsT17454,MAPKK5,MEK5,PRKMK5
FUSION GENES

Other Information

Locus ID:

NCBI: 5607
MIM: 602520
HGNC: 6845
Ensembl: ENSG00000137764

Variants:

dbSNP: 5607
ClinVar: 5607
TCGA: ENSG00000137764
COSMIC: MAP2K5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137764ENST00000178640Q13163
ENSG00000137764ENST00000178640A0A024R5Y2
ENSG00000137764ENST00000340972A6NK28
ENSG00000137764ENST00000354498Q13163
ENSG00000137764ENST00000395476Q13163
ENSG00000137764ENST00000395476A0A024R5X5
ENSG00000137764ENST00000439036H7BZL1
ENSG00000137764ENST00000557869A0A087X0Z8
ENSG00000137764ENST00000559262A0A087WWX7

Expression (GTEx)

0
5
10
15
20
25

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Gap junctionKEGGko04540
MAPK signaling pathwayKEGGhsa04010
Gap junctionKEGGhsa04540
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
MAPK (ERK5) signalingKEGGhsa_M00690
MAPK (ERK5) signalingKEGGM00690
Signal TransductionREACTOMER-HSA-162582
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
Signalling to ERK5REACTOMER-HSA-198765
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA283MAPK8GenePathwayassociated20124951
PA30616MAPK1GenePathwayassociated20124951
PA30617MAPK10GenePathwayassociated20124951
PA30618MAPK11GenePathwayassociated20124951
PA30619MAPK12GenePathwayassociated20124951
PA30620MAPK13GenePathwayassociated20124951
PA30621MAPK14GenePathwayassociated20124951
PA30622MAPK3GenePathwayassociated20124951
PA30623MAPK4GenePathwayassociated20124951
PA30624MAPK6GenePathwayassociated20124951
PA30625MAPK7GenePathwayassociated20124951
PA30630MAPK9GenePathwayassociated20124951
PA34183RAF1GenePathwayassociated20124951

References

Pubmed IDYearTitleCitations
176377802007Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions.156
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
126187642003MEK5 overexpression is associated with metastatic prostate cancer, and stimulates proliferation, MMP-9 expression and invasion.71
180713192008Aberrant expression of extracellular signal-regulated kinase 5 in human prostate cancer.40
122190262002Identification of mitogen-activated protein kinase kinase as a chemoresistant pathway in MCF-7 cells by using gene expression microarray.39
251425702014Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD.31
178724952008HGF mediates cell proliferation of human mesothelioma cells through a PI3K/MEK5/Fra-1 pathway.27
192790212009Replication of restless legs syndrome loci in three European populations.27
211669292011MEK5 is activated by shear stress, activates ERK5 and induces KLF4 to modulate TNF responses in human dermal microvascular endothelial cells.24
153780072004Stat3 upregulates MEK5 expression in human breast cancer cells.20

Citation

Dessen P

MAP2K5 (mitogen-activated protein kinase kinase 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41273/map2k5