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MAP2K5 (mitogen-activated protein kinase kinase 5)

Identity

Other namesHsT17454
MAPKK5
MEK5
PRKMK5
HGNC (Hugo) MAP2K5
LocusID (NCBI) 5607
Location 15q23
Location_base_pair Starts at 67841342 and ends at 68099455 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MAP2K5   6845
Cards
Entrez_Gene (NCBI)MAP2K5  5607  mitogen-activated protein kinase kinase 5
GeneCards (Weizmann)MAP2K5
Ensembl (Hinxton)ENSG00000137764 [Gene_View]  chr15:67841342-68099455 [Contig_View]  MAP2K5 [Vega]
ICGC DataPortalENSG00000137764
AceView (NCBI)MAP2K5
Genatlas (Paris)MAP2K5
WikiGenes5607
SOURCE (Princeton)NM_001206804 NM_002757 NM_145160 NM_145161 NM_145162
Genomic and cartography
GoldenPath (UCSC)MAP2K5  -  15q23   chr15:67841342-68099455 +  15q23   [Description]    (hg19-Feb_2009)
EnsemblMAP2K5 - 15q23 [CytoView]
Mapping of homologs : NCBIMAP2K5 [Mapview]
OMIM602520   
Gene and transcription
Genbank (Entrez)AK024766 AK057521 AK293459 AK315435 BC008838
RefSeq transcript (Entrez)NM_001206804 NM_002757 NM_145160 NM_145161 NM_145162
RefSeq genomic (Entrez)AC_000147 NC_000015 NC_018926 NG_029143 NT_010194 NW_001838218 NW_004929398
Consensus coding sequences : CCDS (NCBI)MAP2K5
Cluster EST : UnigeneHs.114198 [ NCBI ]
CGAP (NCI)Hs.114198
Alternative Splicing : Fast-db (Paris)GSHG0009958
Alternative Splicing GalleryENSG00000137764
Gene ExpressionMAP2K5 [ NCBI-GEO ]     MAP2K5 [ SEEK ]   MAP2K5 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13163 (Uniprot)
NextProtQ13163  [Medical]
With graphics : InterProQ13163
Splice isoforms : SwissVarQ13163 (Swissvar)
Catalytic activity : Enzyme2.7.12.2 [ Enzyme-Expasy ]   2.7.12.22.7.12.2 [ IntEnz-EBI ]   2.7.12.2 [ BRENDA ]   2.7.12.2 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    OPR_PB1    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Related proteins : CluSTrQ13163
Domain families : Pfam (Sanger)PB1 (PF00564)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00564    pfam00069   
Domain families : Smart (EMBL)PB1 (SM00666)  S_TKc (SM00220)  
DMDM Disease mutations5607
Blocks (Seattle)Q13163
PDB (SRS)2NPT    2O2V    4IC7   
PDB (PDBSum)2NPT    2O2V    4IC7   
PDB (IMB)2NPT    2O2V    4IC7   
PDB (RSDB)2NPT    2O2V    4IC7   
Human Protein AtlasENSG00000137764
Peptide AtlasQ13163
HPRD03951
IPIIPI00158248   IPI00219607   IPI00185860   IPI01009250   IPI00788893   IPI00375287   
Protein Interaction databases
DIP (DOE-UCLA)Q13163
IntAct (EBI)Q13163
FunCoupENSG00000137764
BioGRIDMAP2K5
IntegromeDBMAP2K5
STRING (EMBL)MAP2K5
Ontologies - Pathways
QuickGOQ13163
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  activation of MAPK activity  protein kinase activity  protein serine/threonine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  spindle  cytosol  signal transduction  heart development  peptidyl-tyrosine phosphorylation  positive regulation of cell growth  negative regulation of NF-kappaB transcription factor activity  negative regulation of heterotypic cell-cell adhesion  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of interleukin-8 biosynthetic process  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  neurotrophin TRK receptor signaling pathway  positive regulation of epithelial cell proliferation  positive regulation of protein metabolic process  negative regulation of response to cytokine stimulus  ERK5 cascade  cellular response to growth factor stimulus  cellular response to laminar fluid shear stress  negative regulation of cell migration involved in sprouting angiogenesis  negative regulation of chemokine (C-X-C motif) ligand 2 production  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  activation of MAPK activity  protein kinase activity  protein serine/threonine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  spindle  cytosol  signal transduction  heart development  peptidyl-tyrosine phosphorylation  positive regulation of cell growth  negative regulation of NF-kappaB transcription factor activity  negative regulation of heterotypic cell-cell adhesion  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of interleukin-8 biosynthetic process  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  neurotrophin TRK receptor signaling pathway  positive regulation of epithelial cell proliferation  positive regulation of protein metabolic process  negative regulation of response to cytokine stimulus  ERK5 cascade  cellular response to growth factor stimulus  cellular response to laminar fluid shear stress  negative regulation of cell migration involved in sprouting angiogenesis  negative regulation of chemokine (C-X-C motif) ligand 2 production  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Gap junction    Neurotrophin signaling pathway   
Protein Interaction DatabaseMAP2K5
Wikipedia pathwaysMAP2K5
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MAP2K5
SNP (GeneSNP Utah)MAP2K5
SNP : HGBaseMAP2K5
Genetic variants : HAPMAPMAP2K5
1000_GenomesMAP2K5 
ICGC programENSG00000137764 
CONAN: Copy Number AnalysisMAP2K5 
Somatic Mutations in Cancer : COSMICMAP2K5 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
DECIPHER (Syndromes)15:67841342-68099455
Mutations and Diseases : HGMDMAP2K5
OMIM602520   
MedgenMAP2K5
GENETestsMAP2K5
Disease Genetic AssociationMAP2K5
Huge Navigator MAP2K5 [HugePedia]  MAP2K5 [HugeCancerGEM]
Genomic VariantsMAP2K5  MAP2K5 [DGVbeta]
Exome VariantMAP2K5
dbVarMAP2K5
ClinVarMAP2K5
snp3D : Map Gene to Disease5607
General knowledge
Homologs : HomoloGeneMAP2K5
Homology/Alignments : Family Browser (UCSC)MAP2K5
Phylogenetic Trees/Animal Genes : TreeFamMAP2K5
Chemical/Protein Interactions : CTD5607
Chemical/Pharm GKB GenePA30590
Clinical trialMAP2K5
Cancer Resource (Charite)ENSG00000137764
Other databases
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
CoreMineMAP2K5
GoPubMedMAP2K5
iHOPMAP2K5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Nov 8 17:39:24 CET 2014

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