Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MAP2K5 (mitogen-activated protein kinase kinase 5)

Identity

Alias_namesPRKMK5
Alias_symbol (synonym)MEK5
MAPKK5
HsT17454
HGNC (Hugo) MAP2K5
LocusID (NCBI) 5607
Atlas_Id 41273
Location 15q23  [Link to chromosome band 15q23]
Location_base_pair Starts at 67841342 and ends at 68099455 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DAPK2 (15q22.31) / MAP2K5 (15q23)FBXO11 (2p16.3) / MAP2K5 (15q23)MAP2K5 (15q23) / ADAMTSL3 (15q25.2)
MAP2K5 (15q23) / IQCH (15q23)MAP2K5 (15q23) / RAB27A (15q21.3)MAP2K5 (15q23) / SMAD6 (15q22.31)
MAP2K5 15q23 / ADAMTSL3 15q25.2MAP2K5 15q23 / IQCH 15q23MAP2K5 15q23 / RAB27A 15q21.3
MAP2K5 15q23 / SMAD6 15q22.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;5)(p23;q35) SQSTM1/ALK


External links

Nomenclature
HGNC (Hugo)MAP2K5   6845
Cards
Entrez_Gene (NCBI)MAP2K5  5607  mitogen-activated protein kinase kinase 5
AliasesHsT17454; MAPKK5; MEK5; PRKMK5
GeneCards (Weizmann)MAP2K5
Ensembl hg19 (Hinxton)ENSG00000137764 [Gene_View]  chr15:67841342-68099455 [Contig_View]  MAP2K5 [Vega]
Ensembl hg38 (Hinxton)ENSG00000137764 [Gene_View]  chr15:67841342-68099455 [Contig_View]  MAP2K5 [Vega]
ICGC DataPortalENSG00000137764
TCGA cBioPortalMAP2K5
AceView (NCBI)MAP2K5
Genatlas (Paris)MAP2K5
WikiGenes5607
SOURCE (Princeton)MAP2K5
Genetics Home Reference (NIH)MAP2K5
Genomic and cartography
GoldenPath hg19 (UCSC)MAP2K5  -     chr15:67841342-68099455 +  15q23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAP2K5  -     15q23   [Description]    (hg38-Dec_2013)
EnsemblMAP2K5 - 15q23 [CytoView hg19]  MAP2K5 - 15q23 [CytoView hg38]
Mapping of homologs : NCBIMAP2K5 [Mapview hg19]  MAP2K5 [Mapview hg38]
OMIM602520   
Gene and transcription
Genbank (Entrez)AK024766 AK057521 AK293459 AK315435 BC008838
RefSeq transcript (Entrez)NM_001206804 NM_002757 NM_145160 NM_145161 NM_145162
RefSeq genomic (Entrez)NC_000015 NC_018926 NG_029143 NT_010194 NW_004929398
Consensus coding sequences : CCDS (NCBI)MAP2K5
Cluster EST : UnigeneHs.114198 [ NCBI ]
CGAP (NCI)Hs.114198
Alternative Splicing GalleryENSG00000137764
Gene ExpressionMAP2K5 [ NCBI-GEO ]   MAP2K5 [ EBI - ARRAY_EXPRESS ]   MAP2K5 [ SEEK ]   MAP2K5 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP2K5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5607
GTEX Portal (Tissue expression)MAP2K5
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13163   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13163  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13163
Splice isoforms : SwissVarQ13163
Catalytic activity : Enzyme2.7.12.2 [ Enzyme-Expasy ]   2.7.12.22.7.12.2 [ IntEnz-EBI ]   2.7.12.2 [ BRENDA ]   2.7.12.2 [ KEGG ]   
PhosPhoSitePlusQ13163
Domaine pattern : Prosite (Expaxy)PB1 (PS51745)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    PB1_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)PB1 (PF00564)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00564    pfam00069   
Domain families : Smart (EMBL)PB1 (SM00666)  S_TKc (SM00220)  
Conserved Domain (NCBI)MAP2K5
DMDM Disease mutations5607
Blocks (Seattle)MAP2K5
PDB (SRS)2NPT    2O2V    4IC7   
PDB (PDBSum)2NPT    2O2V    4IC7   
PDB (IMB)2NPT    2O2V    4IC7   
PDB (RSDB)2NPT    2O2V    4IC7   
Structural Biology KnowledgeBase2NPT    2O2V    4IC7   
SCOP (Structural Classification of Proteins)2NPT    2O2V    4IC7   
CATH (Classification of proteins structures)2NPT    2O2V    4IC7   
SuperfamilyQ13163
Human Protein AtlasENSG00000137764
Peptide AtlasQ13163
HPRD03951
IPIIPI00158248   IPI00219607   IPI00185860   IPI01009250   IPI00788893   IPI00375287   
Protein Interaction databases
DIP (DOE-UCLA)Q13163
IntAct (EBI)Q13163
FunCoupENSG00000137764
BioGRIDMAP2K5
STRING (EMBL)MAP2K5
ZODIACMAP2K5
Ontologies - Pathways
QuickGOQ13163
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  activation of MAPK activity  protein kinase activity  receptor signaling protein serine/threonine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  spindle  cytosol  signal transduction  heart development  peptidyl-tyrosine phosphorylation  positive regulation of cell growth  negative regulation of NF-kappaB transcription factor activity  negative regulation of heterotypic cell-cell adhesion  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of interleukin-8 biosynthetic process  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of epithelial cell proliferation  positive regulation of protein metabolic process  negative regulation of response to cytokine stimulus  ERK5 cascade  cellular response to growth factor stimulus  cellular response to laminar fluid shear stress  negative regulation of cell migration involved in sprouting angiogenesis  negative regulation of chemokine (C-X-C motif) ligand 2 production  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  activation of MAPK activity  protein kinase activity  receptor signaling protein serine/threonine kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  spindle  cytosol  signal transduction  heart development  peptidyl-tyrosine phosphorylation  positive regulation of cell growth  negative regulation of NF-kappaB transcription factor activity  negative regulation of heterotypic cell-cell adhesion  negative regulation of cysteine-type endopeptidase activity involved in apoptotic process  negative regulation of interleukin-8 biosynthetic process  positive regulation of transcription from RNA polymerase II promoter  metal ion binding  positive regulation of epithelial cell proliferation  positive regulation of protein metabolic process  negative regulation of response to cytokine stimulus  ERK5 cascade  cellular response to growth factor stimulus  cellular response to laminar fluid shear stress  negative regulation of cell migration involved in sprouting angiogenesis  negative regulation of chemokine (C-X-C motif) ligand 2 production  negative regulation of extrinsic apoptotic signaling pathway in absence of ligand  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Gap junction    Neurotrophin signaling pathway   
NDEx NetworkMAP2K5
Atlas of Cancer Signalling NetworkMAP2K5
Wikipedia pathwaysMAP2K5
Orthology - Evolution
OrthoDB5607
GeneTree (enSembl)ENSG00000137764
Phylogenetic Trees/Animal Genes : TreeFamMAP2K5
HOVERGENQ13163
HOGENOMQ13163
Homologs : HomoloGeneMAP2K5
Homology/Alignments : Family Browser (UCSC)MAP2K5
Gene fusions - Rearrangements
Fusion : MitelmanMAP2K5/ADAMTSL3 [15q23/15q25.2]  
Fusion : MitelmanMAP2K5/RAB27A [15q23/15q21.3]  [t(15;15)(q21;q23)]  
Fusion : MitelmanMAP2K5/SMAD6 [15q23/15q22.31]  [t(15;15)(q22;q23)]  
Fusion: TCGAMAP2K5 15q23 ADAMTSL3 15q25.2 BRCA
Fusion: TCGAMAP2K5 15q23 IQCH 15q23 PRAD
Fusion: TCGAMAP2K5 15q23 RAB27A 15q21.3 HNSC
Fusion: TCGAMAP2K5 15q23 SMAD6 15q22.31 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP2K5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP2K5
dbVarMAP2K5
ClinVarMAP2K5
1000_GenomesMAP2K5 
Exome Variant ServerMAP2K5
ExAC (Exome Aggregation Consortium)MAP2K5 (select the gene name)
Genetic variants : HAPMAP5607
Genomic Variants (DGV)MAP2K5 [DGVbeta]
DECIPHER (Syndromes)15:67841342-68099455  ENSG00000137764
CONAN: Copy Number AnalysisMAP2K5 
Mutations
ICGC Data PortalMAP2K5 
TCGA Data PortalMAP2K5 
Broad Tumor PortalMAP2K5
OASIS PortalMAP2K5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP2K5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP2K5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP2K5
DgiDB (Drug Gene Interaction Database)MAP2K5
DoCM (Curated mutations)MAP2K5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP2K5 (select a term)
intoGenMAP2K5
Cancer3DMAP2K5(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602520   
Orphanet
MedgenMAP2K5
Genetic Testing Registry MAP2K5
NextProtQ13163 [Medical]
TSGene5607
GENETestsMAP2K5
Huge Navigator MAP2K5 [HugePedia]
snp3D : Map Gene to Disease5607
BioCentury BCIQMAP2K5
ClinGenMAP2K5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5607
Chemical/Pharm GKB GenePA30590
Clinical trialMAP2K5
Miscellaneous
canSAR (ICR)MAP2K5 (select the gene name)
Probes
Litterature
PubMed70 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP2K5
EVEXMAP2K5
GoPubMedMAP2K5
iHOPMAP2K5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Nov 18 19:42:53 CET 2016

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