MAP2K6 (mitogen-activated protein kinase kinase 6)

2003-11-01 Affiliation

Identity

HGNC

MAP2K6

LOCATION

17q24.3

LOCUSID

5608

ALIAS

MAPKK6,MEK6,MKK6,PRKMK6,SAPKK-3,SAPKK3

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5608
MIM: 601254
HGNC: 6846
Ensembl: ENSG00000108984

Variants:

dbSNP: 5608
ClinVar: 5608
TCGA: ENSG00000108984
COSMIC: MAP2K6

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000108984	ENST00000359094	A0A0A0MRF7
ENSG00000108984	ENST00000588110	K7EIW3
ENSG00000108984	ENST00000589295	K7ELM6
ENSG00000108984	ENST00000589647	P52564
ENSG00000108984	ENST00000589647	A0A024R8K3
ENSG00000108984	ENST00000590474	P52564
ENSG00000108984	ENST00000590474	A8K3Y2
ENSG00000108984	ENST00000613873	P52564
ENSG00000108984	ENST00000613873	A0A024R8K3

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
MAPK signaling pathway	KEGG	ko04010
Toll-like receptor signaling pathway	KEGG	ko04620
Fc epsilon RI signaling pathway	KEGG	ko04664
GnRH signaling pathway	KEGG	ko04912
Amyotrophic lateral sclerosis (ALS)	KEGG	ko05014
MAPK signaling pathway	KEGG	hsa04010
Toll-like receptor signaling pathway	KEGG	hsa04620
Fc epsilon RI signaling pathway	KEGG	hsa04664
GnRH signaling pathway	KEGG	hsa04912
Amyotrophic lateral sclerosis (ALS)	KEGG	hsa05014
Toxoplasmosis	KEGG	ko05145
Toxoplasmosis	KEGG	hsa05145
Osteoclast differentiation	KEGG	ko04380
Osteoclast differentiation	KEGG	hsa04380
Influenza A	KEGG	ko05164
Influenza A	KEGG	hsa05164
Epstein-Barr virus infection	KEGG	hsa05169
Epstein-Barr virus infection	KEGG	ko05169
TNF signaling pathway	KEGG	hsa04668
TNF signaling pathway	KEGG	ko04668
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
MAPK (p38) signaling	KEGG	hsa_M00689
MAPK (p38) signaling	KEGG	M00689
Disease	REACTOME	R-HSA-1643685
Infectious disease	REACTOME	R-HSA-5663205
Uptake and actions of bacterial toxins	REACTOME	R-HSA-5339562
Uptake and function of anthrax toxins	REACTOME	R-HSA-5210891
Immune System	REACTOME	R-HSA-168256
Innate Immune System	REACTOME	R-HSA-168249
Toll-Like Receptors Cascades	REACTOME	R-HSA-168898
Toll Like Receptor 10 (TLR10) Cascade	REACTOME	R-HSA-168142
MyD88 cascade initiated on plasma membrane	REACTOME	R-HSA-975871
MAP kinase activation in TLR cascade	REACTOME	R-HSA-450294
activated TAK1 mediates p38 MAPK activation	REACTOME	R-HSA-450302
Toll Like Receptor 3 (TLR3) Cascade	REACTOME	R-HSA-168164
MyD88-independent TLR3/TLR4 cascade	REACTOME	R-HSA-166166
TRIF-mediated TLR3/TLR4 signaling	REACTOME	R-HSA-937061
Toll Like Receptor 5 (TLR5) Cascade	REACTOME	R-HSA-168176
Toll Like Receptor 7/8 (TLR7/8) Cascade	REACTOME	R-HSA-168181
MyD88 dependent cascade initiated on endosome	REACTOME	R-HSA-975155
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation	REACTOME	R-HSA-975138
Toll Like Receptor 9 (TLR9) Cascade	REACTOME	R-HSA-168138
Toll Like Receptor 4 (TLR4) Cascade	REACTOME	R-HSA-166016
Activated TLR4 signalling	REACTOME	R-HSA-166054
MyD88:Mal cascade initiated on plasma membrane	REACTOME	R-HSA-166058
Toll Like Receptor 2 (TLR2) Cascade	REACTOME	R-HSA-181438
Toll Like Receptor TLR1:TLR2 Cascade	REACTOME	R-HSA-168179
Toll Like Receptor TLR6:TLR2 Cascade	REACTOME	R-HSA-168188
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways	REACTOME	R-HSA-168643
NOD1/2 Signaling Pathway	REACTOME	R-HSA-168638
Cytokine Signaling in Immune system	REACTOME	R-HSA-1280215
Signaling by Interleukins	REACTOME	R-HSA-449147
Interleukin-1 signaling	REACTOME	R-HSA-446652
Gene Expression	REACTOME	R-HSA-74160
Generic Transcription Pathway	REACTOME	R-HSA-212436
Transcriptional Regulation by TP53	REACTOME	R-HSA-3700989
Developmental Biology	REACTOME	R-HSA-1266738
Myogenesis	REACTOME	R-HSA-525793
CDO in myogenesis	REACTOME	R-HSA-375170
Cellular responses to stress	REACTOME	R-HSA-2262752
Cellular Senescence	REACTOME	R-HSA-2559583
Oxidative Stress Induced Senescence	REACTOME	R-HSA-2559580
Regulation of TP53 Activity	REACTOME	R-HSA-5633007
Regulation of TP53 Activity through Acetylation	REACTOME	R-HSA-6804758
PI5P Regulates TP53 Acetylation	REACTOME	R-HSA-6811555
Fluid shear stress and atherosclerosis	KEGG	ko05418
Fluid shear stress and atherosclerosis	KEGG	hsa05418

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PMIDs
PA283	MAPK8	Gene	Pathway	associated	20124951
PA30594	MAP3K11	Gene	Pathway	associated	23922006
PA30603	MAP3K7	Gene	Pathway	associated	23922006
PA30616	MAPK1	Gene	Pathway	associated	20124951
PA30617	MAPK10	Gene	Pathway	associated	20124951
PA30618	MAPK11	Gene	Pathway	associated	20124951
PA30619	MAPK12	Gene	Pathway	associated	20124951
PA30620	MAPK13	Gene	Pathway	associated	20124951
PA30621	MAPK14	Gene	Pathway	associated	20124951, 23922006
PA30622	MAPK3	Gene	Pathway	associated	20124951
PA30623	MAPK4	Gene	Pathway	associated	20124951
PA30624	MAPK6	Gene	Pathway	associated	20124951
PA30625	MAPK7	Gene	Pathway	associated	20124951
PA30630	MAPK9	Gene	Pathway	associated	20124951
PA34183	RAF1	Gene	Pathway	associated	20124951

References

Pubmed ID	Year	Title	Citations
16728640	2006	Yersinia YopJ acetylates and inhibits kinase activation by blocking phosphorylation.	238
11971971	2002	Sequential activation of the MEK-extracellular signal-regulated kinase and MKK3/6-p38 mitogen-activated protein kinase pathways mediates oncogenic ras-induced premature senescence.	138
12509443	2003	p38 Mitogen-activated protein kinase-dependent and -independent signaling of mRNA stability of AU-rich element-containing transcripts.	98
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
15677464	2005	H-Ras-specific activation of Rac-MKK3/6-p38 pathway: its critical role in invasion and migration of breast epithelial cells.	43
15790570	2005	Activation of p38 has opposing effects on the proliferation and migration of endothelial cells.	38
15492008	2005	Overexpression of mitogen-activated protein kinase kinase 6 in the heart improves functional recovery from ischemia in vitro and protects against myocardial infarction in vivo.	36
15778394	2005	Regulation of p38 MAPK by MAPK kinases 3 and 6 in fibroblast-like synoviocytes.	30
15550393	2005	Activation of p21-activated kinase 6 by MAP kinase kinase 6 and p38 MAP kinase.	21
16342939	2005	Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase.	19

Citation

Dessen P

MAP2K6 (mitogen-activated protein kinase kinase 6)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/41274/map2k6