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MAP2K6 (mitogen-activated protein kinase kinase 6)

Identity

Alias_namesmitogen-activated
kinase 6 (MAP kinase kinase 6)
Alias_symbol (synonym)MEK6
MKK6
SAPKK3
MAPKK6
Other aliasPRKMK6
SAPKK-3
HGNC (Hugo) MAP2K6
LocusID (NCBI) 5608
Atlas_Id 41274
Location 17q24.3  [Link to chromosome band 17q24]
Location_base_pair Starts at 69502222 and ends at 69553861 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
EVPL (17q25.1) / MAP2K6 (17q24.3)MAP2K6 (17q24.3) / MAP2K6 (17q24.3)MAP2K6 (17q24.3) / SLC12A2 (5q23.3)
SDF2 (17q11.2) / MAP2K6 (17q24.3)EVPL 17q25.1 / MAP2K6 17q24.3SDF2 17q11.2 / MAP2K6 17q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAP2K6   6846
Cards
Entrez_Gene (NCBI)MAP2K6  5608  mitogen-activated protein kinase kinase 6
AliasesMAPKK6; MEK6; MKK6; PRKMK6; 
SAPKK-3; SAPKK3
GeneCards (Weizmann)MAP2K6
Ensembl hg19 (Hinxton)ENSG00000108984 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108984 [Gene_View]  chr17:69502222-69553861 [Contig_View]  MAP2K6 [Vega]
ICGC DataPortalENSG00000108984
TCGA cBioPortalMAP2K6
AceView (NCBI)MAP2K6
Genatlas (Paris)MAP2K6
WikiGenes5608
SOURCE (Princeton)MAP2K6
Genetics Home Reference (NIH)MAP2K6
Genomic and cartography
GoldenPath hg38 (UCSC)MAP2K6  -     chr17:69502222-69553861 +  17q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP2K6  -     17q24.3   [Description]    (hg19-Feb_2009)
EnsemblMAP2K6 - 17q24.3 [CytoView hg19]  MAP2K6 - 17q24.3 [CytoView hg38]
Mapping of homologs : NCBIMAP2K6 [Mapview hg19]  MAP2K6 [Mapview hg38]
OMIM601254   
Gene and transcription
Genbank (Entrez)AA932919 AB451252 AB451376 AK225719 AK290747
RefSeq transcript (Entrez)NM_001330450 NM_002758 NM_031988
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP2K6
Cluster EST : UnigeneHs.463978 [ NCBI ]
CGAP (NCI)Hs.463978
Alternative Splicing GalleryENSG00000108984
Gene ExpressionMAP2K6 [ NCBI-GEO ]   MAP2K6 [ EBI - ARRAY_EXPRESS ]   MAP2K6 [ SEEK ]   MAP2K6 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP2K6 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5608
GTEX Portal (Tissue expression)MAP2K6
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52564   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52564  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52564
Splice isoforms : SwissVarP52564
Catalytic activity : Enzyme2.7.12.2 [ Enzyme-Expasy ]   2.7.12.22.7.12.2 [ IntEnz-EBI ]   2.7.12.2 [ BRENDA ]   2.7.12.2 [ KEGG ]   
PhosPhoSitePlusP52564
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP2K6
DMDM Disease mutations5608
Blocks (Seattle)MAP2K6
PDB (SRS)2Y8O    3ENM    3FME    3VN9    5ETF   
PDB (PDBSum)2Y8O    3ENM    3FME    3VN9    5ETF   
PDB (IMB)2Y8O    3ENM    3FME    3VN9    5ETF   
PDB (RSDB)2Y8O    3ENM    3FME    3VN9    5ETF   
Structural Biology KnowledgeBase2Y8O    3ENM    3FME    3VN9    5ETF   
SCOP (Structural Classification of Proteins)2Y8O    3ENM    3FME    3VN9    5ETF   
CATH (Classification of proteins structures)2Y8O    3ENM    3FME    3VN9    5ETF   
SuperfamilyP52564
Human Protein AtlasENSG00000108984
Peptide AtlasP52564
HPRD03155
IPIIPI00003814   IPI00219569   IPI00425919   
Protein Interaction databases
DIP (DOE-UCLA)P52564
IntAct (EBI)P52564
FunCoupENSG00000108984
BioGRIDMAP2K6
STRING (EMBL)MAP2K6
ZODIACMAP2K6
Ontologies - Pathways
QuickGOP52564
Ontology : AmiGOMAPK cascade  activation of MAPK activity  response to ischemia  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  MAP kinase kinase activity  MAP kinase kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  cytoskeleton  transcription, DNA-templated  regulation of transcription, DNA-templated  apoptotic process  DNA damage induced protein phosphorylation  cell cycle arrest  signal transduction  peptidyl-tyrosine phosphorylation  protein kinase binding  ovulation cycle process  positive regulation of prostaglandin secretion  proteolysis in other organism  response to drug  positive regulation of apoptotic process  positive regulation of nitric-oxide synthase biosynthetic process  cardiac muscle contraction  nucleotide-binding oligomerization domain containing signaling pathway  cellular response to sorbitol  
Ontology : EGO-EBIMAPK cascade  activation of MAPK activity  response to ischemia  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  MAP kinase kinase activity  MAP kinase kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  cytosol  cytoskeleton  transcription, DNA-templated  regulation of transcription, DNA-templated  apoptotic process  DNA damage induced protein phosphorylation  cell cycle arrest  signal transduction  peptidyl-tyrosine phosphorylation  protein kinase binding  ovulation cycle process  positive regulation of prostaglandin secretion  proteolysis in other organism  response to drug  positive regulation of apoptotic process  positive regulation of nitric-oxide synthase biosynthetic process  cardiac muscle contraction  nucleotide-binding oligomerization domain containing signaling pathway  cellular response to sorbitol  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkMAP2K6
Atlas of Cancer Signalling NetworkMAP2K6
Wikipedia pathwaysMAP2K6
Orthology - Evolution
OrthoDB5608
GeneTree (enSembl)ENSG00000108984
Phylogenetic Trees/Animal Genes : TreeFamMAP2K6
HOVERGENP52564
HOGENOMP52564
Homologs : HomoloGeneMAP2K6
Homology/Alignments : Family Browser (UCSC)MAP2K6
Gene fusions - Rearrangements
Fusion : MitelmanEVPL/MAP2K6 [17q25.1/17q24.3]  [t(17;17)(q24;q25)]  
Fusion : MitelmanSDF2/MAP2K6 [17q11.2/17q24.3]  [t(17;17)(q11;q24)]  
Fusion: TCGAEVPL 17q25.1 MAP2K6 17q24.3 BRCA
Fusion: TCGASDF2 17q11.2 MAP2K6 17q24.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP2K6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP2K6
dbVarMAP2K6
ClinVarMAP2K6
1000_GenomesMAP2K6 
Exome Variant ServerMAP2K6
ExAC (Exome Aggregation Consortium)MAP2K6 (select the gene name)
Genetic variants : HAPMAP5608
Genomic Variants (DGV)MAP2K6 [DGVbeta]
DECIPHERMAP2K6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP2K6 
Mutations
ICGC Data PortalMAP2K6 
TCGA Data PortalMAP2K6 
Broad Tumor PortalMAP2K6
OASIS PortalMAP2K6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP2K6  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP2K6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP2K6
DgiDB (Drug Gene Interaction Database)MAP2K6
DoCM (Curated mutations)MAP2K6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP2K6 (select a term)
intoGenMAP2K6
Cancer3DMAP2K6(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601254   
Orphanet
MedgenMAP2K6
Genetic Testing Registry MAP2K6
NextProtP52564 [Medical]
TSGene5608
GENETestsMAP2K6
Target ValidationMAP2K6
Huge Navigator MAP2K6 [HugePedia]
snp3D : Map Gene to Disease5608
BioCentury BCIQMAP2K6
ClinGenMAP2K6
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5608
Chemical/Pharm GKB GenePA30591
Clinical trialMAP2K6
Miscellaneous
canSAR (ICR)MAP2K6 (select the gene name)
Probes
Litterature
PubMed115 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP2K6
EVEXMAP2K6
GoPubMedMAP2K6
iHOPMAP2K6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:06:15 CEST 2017

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