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MAP2K6 (mitogen-activated protein kinase kinase 6)

Identity

Alias (NCBI)MAPKK6
MEK6
MKK6
PRKMK6
SAPKK-3
SAPKK3
HGNC (Hugo) MAP2K6
HGNC Alias symbMEK6
MKK6
SAPKK3
MAPKK6
HGNC Alias nameprotein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6)
HGNC Previous namePRKMK6
LocusID (NCBI) 5608
Atlas_Id 41274
Location 17q24.3  [Link to chromosome band 17q24]
Location_base_pair Starts at 69414697 and ends at 69553865 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EVPL (17q25.1) / MAP2K6 (17q24.3)MAP2K6 (17q24.3) / MAP2K6 (17q24.3)MAP2K6 (17q24.3) / SLC12A2 (5q23.3)
SDF2 (17q11.2) / MAP2K6 (17q24.3)EVPL 17q25.1 / MAP2K6 17q24.3SDF2 17q11.2 / MAP2K6 17q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MAP2K6   6846
Cards
Entrez_Gene (NCBI)MAP2K6    mitogen-activated protein kinase kinase 6
AliasesMAPKK6; MEK6; MKK6; PRKMK6; 
SAPKK-3; SAPKK3
GeneCards (Weizmann)MAP2K6
Ensembl hg19 (Hinxton)ENSG00000108984 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000108984 [Gene_View]  ENSG00000108984 [Sequence]  chr17:69414697-69553865 [Contig_View]  MAP2K6 [Vega]
ICGC DataPortalENSG00000108984
TCGA cBioPortalMAP2K6
AceView (NCBI)MAP2K6
Genatlas (Paris)MAP2K6
SOURCE (Princeton)MAP2K6
Genetics Home Reference (NIH)MAP2K6
Genomic and cartography
GoldenPath hg38 (UCSC)MAP2K6  -     chr17:69414697-69553865 +  17q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP2K6  -     17q24.3   [Description]    (hg19-Feb_2009)
GoldenPathMAP2K6 - 17q24.3 [CytoView hg19]  MAP2K6 - 17q24.3 [CytoView hg38]
ImmunoBaseENSG00000108984
Genome Data Viewer NCBIMAP2K6 [Mapview hg19]  
OMIM601254   
Gene and transcription
Genbank (Entrez)AA932919 AB451252 AB451376 AK056975 AK225719
RefSeq transcript (Entrez)NM_001330450 NM_002758 NM_031988
Consensus coding sequences : CCDS (NCBI)MAP2K6
Gene ExpressionMAP2K6 [ NCBI-GEO ]   MAP2K6 [ EBI - ARRAY_EXPRESS ]   MAP2K6 [ SEEK ]   MAP2K6 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP2K6 [ Firebrowse - Broad ]
GenevisibleExpression of MAP2K6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5608
GTEX Portal (Tissue expression)MAP2K6
Human Protein AtlasENSG00000108984-MAP2K6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP52564   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP52564  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP52564
Catalytic activity : Enzyme2.7.12.2 [ Enzyme-Expasy ]   2.7.12.22.7.12.2 [ IntEnz-EBI ]   2.7.12.2 [ BRENDA ]   2.7.12.2 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP52564
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP2K6
PDB (RSDB)2Y8O    3ENM    3FME    3VN9    5ETF   
PDB Europe2Y8O    3ENM    3FME    3VN9    5ETF   
PDB (PDBSum)2Y8O    3ENM    3FME    3VN9    5ETF   
PDB (IMB)2Y8O    3ENM    3FME    3VN9    5ETF   
Structural Biology KnowledgeBase2Y8O    3ENM    3FME    3VN9    5ETF   
SCOP (Structural Classification of Proteins)2Y8O    3ENM    3FME    3VN9    5ETF   
CATH (Classification of proteins structures)2Y8O    3ENM    3FME    3VN9    5ETF   
SuperfamilyP52564
AlphaFold pdb e-kbP52564   
Human Protein Atlas [tissue]ENSG00000108984-MAP2K6 [tissue]
HPRD03155
Protein Interaction databases
DIP (DOE-UCLA)P52564
IntAct (EBI)P52564
BioGRIDMAP2K6
STRING (EMBL)MAP2K6
ZODIACMAP2K6
Ontologies - Pathways
QuickGOP52564
Ontology : AmiGOMAPK cascade  activation of MAPK activity  activation of MAPK activity  activation of MAPK activity  osteoblast differentiation  response to ischemia  MAP kinase kinase activity  MAP kinase kinase activity  transmembrane receptor protein tyrosine kinase activity  protein binding  ATP binding  nucleoplasm  nucleoplasm  cytosol  cytosol  cytoskeleton  apoptotic process  DNA damage induced protein phosphorylation  signal transduction  peptidyl-tyrosine phosphorylation  phosphatase activator activity  protein kinase binding  ovulation cycle process  positive regulation of prostaglandin secretion  response to drug  positive regulation of apoptotic process  protein serine/threonine kinase activator activity  regulation of cell cycle  positive regulation of nitric-oxide synthase biosynthetic process  cardiac muscle contraction  bone development  nucleotide-binding oligomerization domain containing signaling pathway  cellular response to sorbitol  protein serine kinase activity  protein threonine kinase activity  negative regulation of cold-induced thermogenesis  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIMAPK cascade  activation of MAPK activity  activation of MAPK activity  activation of MAPK activity  osteoblast differentiation  response to ischemia  MAP kinase kinase activity  MAP kinase kinase activity  transmembrane receptor protein tyrosine kinase activity  protein binding  ATP binding  nucleoplasm  nucleoplasm  cytosol  cytosol  cytoskeleton  apoptotic process  DNA damage induced protein phosphorylation  signal transduction  peptidyl-tyrosine phosphorylation  phosphatase activator activity  protein kinase binding  ovulation cycle process  positive regulation of prostaglandin secretion  response to drug  positive regulation of apoptotic process  protein serine/threonine kinase activator activity  regulation of cell cycle  positive regulation of nitric-oxide synthase biosynthetic process  cardiac muscle contraction  bone development  nucleotide-binding oligomerization domain containing signaling pathway  cellular response to sorbitol  protein serine kinase activity  protein threonine kinase activity  negative regulation of cold-induced thermogenesis  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTAHuman Cytomegalovirus and Map Kinase Pathways [Genes]    p38 MAPK Signaling Pathway [Genes]    Keratinocyte Differentiation [Genes]    NFkB activation by Nontypeable Hemophilus influenzae [Genes]    Toll-Like Receptor Pathway [Genes]    IL12 and Stat4 Dependent Signaling Pathway in Th1 Development [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]    Control of skeletal myogenesis by HDAC & calcium/calmodulin-dependent kinase (CaMK) [Genes]    Signal transduction through IL1R [Genes]    TNF/Stress Related Signaling [Genes]    MAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Rap1 signaling pathway    Osteoclast differentiation    Toll-like receptor signaling pathway    Fc epsilon RI signaling pathway    TNF signaling pathway    GnRH signaling pathway    Amyotrophic lateral sclerosis (ALS)    Toxoplasmosis    Influenza A    Epstein-Barr virus infection   
NDEx NetworkMAP2K6
Atlas of Cancer Signalling NetworkMAP2K6
Wikipedia pathwaysMAP2K6
Orthology - Evolution
OrthoDB5608
GeneTree (enSembl)ENSG00000108984
Phylogenetic Trees/Animal Genes : TreeFamMAP2K6
Homologs : HomoloGeneMAP2K6
Homology/Alignments : Family Browser (UCSC)MAP2K6
Gene fusions - Rearrangements
Fusion : MitelmanEVPL/MAP2K6 [17q25.1/17q24.3]  
Fusion : MitelmanSDF2/MAP2K6 [17q11.2/17q24.3]  
Fusion : QuiverMAP2K6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP2K6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP2K6
dbVarMAP2K6
ClinVarMAP2K6
MonarchMAP2K6
1000_GenomesMAP2K6 
Exome Variant ServerMAP2K6
GNOMAD BrowserENSG00000108984
Varsome BrowserMAP2K6
ACMGMAP2K6 variants
VarityP52564
Genomic Variants (DGV)MAP2K6 [DGVbeta]
DECIPHERMAP2K6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP2K6 
Mutations
ICGC Data PortalMAP2K6 
TCGA Data PortalMAP2K6 
Broad Tumor PortalMAP2K6
OASIS PortalMAP2K6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP2K6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAP2K6
Mutations and Diseases : HGMDMAP2K6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMAP2K6
DgiDB (Drug Gene Interaction Database)MAP2K6
DoCM (Curated mutations)MAP2K6
CIViC (Clinical Interpretations of Variants in Cancer)MAP2K6
Cancer3DMAP2K6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601254   
Orphanet
DisGeNETMAP2K6
MedgenMAP2K6
Genetic Testing Registry MAP2K6
NextProtP52564 [Medical]
GENETestsMAP2K6
Target ValidationMAP2K6
Huge Navigator MAP2K6 [HugePedia]
ClinGenMAP2K6
Clinical trials, drugs, therapy
MyCancerGenomeMAP2K6
Protein Interactions : CTDMAP2K6
Pharm GKB GenePA30591
Pharm GKB PathwaysPA165985892   PA2032   
PharosP52564
Clinical trialMAP2K6
Miscellaneous
canSAR (ICR)MAP2K6
HarmonizomeMAP2K6
DataMed IndexMAP2K6
Probes
Litterature
PubMed136 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMAP2K6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:17:40 CEST 2021

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