Atlas of Genetics and Cytogenetics in Oncology and Haematology

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   
X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MAP2K7 (mitogen-activated protein kinase kinase 7)

Identity

Other namesJnkk2
MAPKK7
MKK7
PRKMK7
SAPKK-4
SAPKK4
HGNC (Hugo) MAP2K7
LocusID (NCBI) 5609
Location 19p13.2
Location_base_pair Starts at 7968765 and ends at 7979363 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MAP2K7   6847
Entrez_Gene (NCBI)MAP2K7  5609  mitogen-activated protein kinase kinase 7
Cards
GeneCards (Weizmann)MAP2K7
Ensembl (Hinxton)ENSG00000076984 [Gene_View]  chr19:7968765-7979363 [Contig_View]  MAP2K7 [Vega]
AceView (NCBI)MAP2K7
Genatlas (Paris)MAP2K7
SOURCE (Stanford)NM_145185
Genomic and cartography
GoldenPath (UCSC)MAP2K7  -  19p13.2   chr19:7968765-7979363 +  19p13.2   [Description]    (hg19-Feb_2009)
EnsemblMAP2K7 - 19p13.2 [CytoView]
Mapping of homologs : NCBIMAP2K7 [Mapview]
OMIM603014   
Gene and transcription
Genbank (Entrez)AF003199 AF006689 AF013588 AF013589 AF014401
RefSeq transcript (SRS)NM_145185
RefSeq transcript (Entrez)NM_145185
RefSeq genomic (SRS)AC_000151 NC_000019 NC_018930 NG_029438 NT_077812 NW_001838480 NW_004078097
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_029438 NT_077812 NW_001838480 NW_004078097
Consensus coding sequences : CCDS (NCBI)MAP2K7
Cluster EST : UnigeneHs.531754 [ SRS ] Hs.531754 [ NCBI ]
CGAP (NCI)Hs.531754
Alternative Splicing : Fast-db (Paris)GSHG0014536
Alternative Splicing GalleryENSG00000076984
Gene ExpressionMAP2K7 [ NCBI-GEO ]   MAP2K7 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14733 (SRS) O14733 (Uniprot)
NextProtO14733
With graphics : InterProO14733
Splice isoforms : SwissVarO14733(Swissvar)
Domaine pattern : Prosite (SRS)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (SRS)Kinase-like_dom    Prot_kinase_cat_dom    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_cat_dom    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Related proteins : CluSTrO14733
Domain families : Pfam (SRS)Pkinase (PF00069)   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM5609
Blocks (Seattle)O14733
PDB (SRS)2DYL   
PDB (PDBSum)2DYL   
PDB (IMB)2DYL   
PDB (RSDB)2DYL   
Human Protein AtlasENSG00000076984
IPIIPI00023636   IPI00302112   IPI00745806   IPI00794495   IPI01022470   IPI00747921   
Protein Interaction databases
DIP (DOE-UCLA)O14733
IntAct (EBI)O14733
FunCoupENSG00000076984
REACTOMEMAP2K7
Protein Interaction Database5609
BioGRIDMAP2K7
InParanoidO14733
Interologous Interaction database O14733
IntegromeDBMAP2K7
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MAP2K7
SNP (GeneSNP Utah)MAP2K7
SNP : HGBaseMAP2K7
Genetic variants : HAPMAPMAP2K7
Somatic Mutations in Cancer : COSMICMAP2K7 
CONAN: Copy Number AnalysisMAP2K7 
Mutations and Diseases : HGMDMAP2K7
OMIM603014   
GENETests603014   
Disease Genetic AssociationMAP2K7
Huge Navigator MAP2K7 [HugePedia]  MAP2K7 [HugeCancerGEM]
Genomic VariantsMAP2K7  MAP2K7 [DGVbeta]
snp3D : Map Gene to Disease5609
General knowledge
Homologs : HomoloGeneMAP2K7
Homology/Alignments : Family Browser (UCSC)MAP2K7
Phylogenetic Trees/Animal Genes : TreeFamMAP2K7
Catalytic activity : Enzyme2.7.12.2 [ Enzyme-Expasy ]   2.7.12.2 [ Enzyme-SRS ]   2.7.12.2 [ IntEnz-EBI ]   2.7.12.2 [ BRENDA ]   2.7.12.2 [ KEGG ]   
Chemical/Protein Interactions : CTD5609
Chemical/Pharm GKB GenePA284
Clinical trialMAP2K7
Cancer Resource (Charite)ENSG00000076984
Ontology : AmiGOmagnesium ion binding  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  protein serine/threonine kinase activity  MAP kinase kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  apoptotic process  response to stress  signal transduction  JNK cascade  activation of JUN kinase activity  protein C-terminus binding  Toll signaling pathway  JUN kinase kinase activity  protein kinase binding  protein phosphatase binding  mitogen-activated protein kinase kinase kinase binding  toll-like receptor 1 signaling pathway  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  positive regulation of neuron apoptotic process  innate immune response  stress-activated MAPK cascade  stress-activated MAPK cascade  
Ontology : EGO-EBImagnesium ion binding  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  protein serine/threonine kinase activity  MAP kinase kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  apoptotic process  response to stress  signal transduction  JNK cascade  activation of JUN kinase activity  protein C-terminus binding  Toll signaling pathway  JUN kinase kinase activity  protein kinase binding  protein phosphatase binding  mitogen-activated protein kinase kinase kinase binding  toll-like receptor 1 signaling pathway  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  positive regulation of neuron apoptotic process  innate immune response  stress-activated MAPK cascade  stress-activated MAPK cascade  
Pathways : BIOCARTAFc Epsilon Receptor I Signaling in Mast Cells [Genes]    MAPKinase Signaling Pathway [Genes]    Keratinocyte Differentiation [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]   
Pathways : KEGGMAPK signaling pathwayGnRH signaling pathwayFc epsilon RI signaling pathway
Other databases
Probes
Litterature
PubMed71 Pubmed reference(s) in Entrez
PubGeneMAP2K7
iHOPMAP2K7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:33:02 CEST 2013
Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.