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MAP2K7 (mitogen-activated protein kinase kinase 7)

Identity

Other namesJNKK2
MAPKK7
MEK
MEK 7
MKK7
PRKMK7
SAPKK-4
SAPKK4
HGNC (Hugo) MAP2K7
LocusID (NCBI) 5609
Location 19p13.2
Location_base_pair Starts at 7968765 and ends at 7979363 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MAP2K7   6847
Cards
Entrez_Gene (NCBI)MAP2K7  5609  mitogen-activated protein kinase kinase 7
GeneCards (Weizmann)MAP2K7
Ensembl (Hinxton)ENSG00000076984 [Gene_View]  chr19:7968765-7979363 [Contig_View]  MAP2K7 [Vega]
ICGC DataPortalENSG00000076984
cBioPortalMAP2K7
AceView (NCBI)MAP2K7
Genatlas (Paris)MAP2K7
WikiGenes5609
SOURCE (Princeton)NM_001297555 NM_001297556 NM_145185
Genomic and cartography
GoldenPath (UCSC)MAP2K7  -  19p13.2   chr19:7968765-7979363 +  19p13.2   [Description]    (hg19-Feb_2009)
EnsemblMAP2K7 - 19p13.2 [CytoView]
Mapping of homologs : NCBIMAP2K7 [Mapview]
OMIM603014   
Gene and transcription
Genbank (Entrez)AF003199 AF006689 AF013588 AF013589 AF014401
RefSeq transcript (Entrez)NM_001297555 NM_001297556 NM_145185
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NG_029438 NT_011295 NW_001838480 NW_004929413
Consensus coding sequences : CCDS (NCBI)MAP2K7
Cluster EST : UnigeneHs.531754 [ NCBI ]
CGAP (NCI)Hs.531754
Alternative Splicing : Fast-db (Paris)GSHG0014536
Alternative Splicing GalleryENSG00000076984
Gene ExpressionMAP2K7 [ NCBI-GEO ]     MAP2K7 [ SEEK ]   MAP2K7 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14733 (Uniprot)
NextProtO14733  [Medical]
With graphics : InterProO14733
Splice isoforms : SwissVarO14733 (Swissvar)
Catalytic activity : Enzyme2.7.12.2 [ Enzyme-Expasy ]   2.7.12.22.7.12.2 [ IntEnz-EBI ]   2.7.12.2 [ BRENDA ]   2.7.12.2 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom [organisation]   Prot_kinase_dom [organisation]   Ser/Thr_dual-sp_kinase_dom [organisation]   Ser/Thr_kinase_AS [organisation]  
Related proteins : CluSTrO14733
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM Disease mutations5609
Blocks (Seattle)O14733
PDB (SRS)2DYL   
PDB (PDBSum)2DYL   
PDB (IMB)2DYL   
PDB (RSDB)2DYL   
Human Protein AtlasENSG00000076984 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO14733
IPIIPI00023636   IPI00302112   IPI00745806   IPI00794495   IPI01022470   IPI00747921   
Protein Interaction databases
DIP (DOE-UCLA)O14733
IntAct (EBI)O14733
FunCoupENSG00000076984
BioGRIDMAP2K7
InParanoidO14733
Interologous Interaction database O14733
IntegromeDBMAP2K7
STRING (EMBL)MAP2K7
Ontologies - Pathways
Ontology : AmiGOmagnesium ion binding  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  protein serine/threonine kinase activity  MAP kinase kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  apoptotic process  response to stress  signal transduction  JNK cascade  activation of JUN kinase activity  protein C-terminus binding  JUN kinase kinase activity  peptidyl-tyrosine phosphorylation  protein kinase binding  protein phosphatase binding  mitogen-activated protein kinase kinase kinase binding  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 5 signaling pathway  toll-like receptor 9 signaling pathway  toll-like receptor 10 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  Fc-epsilon receptor signaling pathway  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  positive regulation of neuron apoptotic process  innate immune response  stress-activated MAPK cascade  stress-activated MAPK cascade  cellular response to sorbitol  
Ontology : EGO-EBImagnesium ion binding  toll-like receptor signaling pathway  MyD88-dependent toll-like receptor signaling pathway  MyD88-independent toll-like receptor signaling pathway  protein serine/threonine kinase activity  MAP kinase kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  apoptotic process  response to stress  signal transduction  JNK cascade  activation of JUN kinase activity  protein C-terminus binding  JUN kinase kinase activity  peptidyl-tyrosine phosphorylation  protein kinase binding  protein phosphatase binding  mitogen-activated protein kinase kinase kinase binding  toll-like receptor 2 signaling pathway  toll-like receptor 3 signaling pathway  toll-like receptor 4 signaling pathway  toll-like receptor 5 signaling pathway  toll-like receptor 9 signaling pathway  toll-like receptor 10 signaling pathway  TRIF-dependent toll-like receptor signaling pathway  Fc-epsilon receptor signaling pathway  toll-like receptor TLR1:TLR2 signaling pathway  toll-like receptor TLR6:TLR2 signaling pathway  positive regulation of neuron apoptotic process  innate immune response  stress-activated MAPK cascade  stress-activated MAPK cascade  cellular response to sorbitol  
Pathways : BIOCARTAFc Epsilon Receptor I Signaling in Mast Cells [Genes]    MAPKinase Signaling Pathway [Genes]    Keratinocyte Differentiation [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Protein processing in endoplasmic reticulum    Osteoclast differentiation    Toll-like receptor signaling pathway    T cell receptor signaling pathway    Fc epsilon RI signaling pathway    TNF signaling pathway    Neurotrophin signaling pathway    GnRH signaling pathway    Influenza A    Epstein-Barr virus infection   
Protein Interaction DatabaseMAP2K7
Wikipedia pathwaysMAP2K7
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MAP2K7
snp3D : Map Gene to Disease5609
SNP (GeneSNP Utah)MAP2K7
SNP : HGBaseMAP2K7
Genetic variants : HAPMAPMAP2K7
Exome VariantMAP2K7
1000_GenomesMAP2K7 
ICGC programENSG00000076984 
Somatic Mutations in Cancer : COSMICMAP2K7 
CONAN: Copy Number AnalysisMAP2K7 
Mutations and Diseases : HGMDMAP2K7
Genomic VariantsMAP2K7  MAP2K7 [DGVbeta]
dbVarMAP2K7
ClinVarMAP2K7
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM603014   
MedgenMAP2K7
GENETestsMAP2K7
Disease Genetic AssociationMAP2K7
Huge Navigator MAP2K7 [HugePedia]  MAP2K7 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneMAP2K7
Homology/Alignments : Family Browser (UCSC)MAP2K7
Phylogenetic Trees/Animal Genes : TreeFamMAP2K7
Chemical/Protein Interactions : CTD5609
Chemical/Pharm GKB GenePA284
Clinical trialMAP2K7
Cancer Resource (Charite)ENSG00000076984
Other databases
Probes
Litterature
PubMed86 Pubmed reference(s) in Entrez
CoreMineMAP2K7
iHOPMAP2K7
OncoSearchMAP2K7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:38:19 CEST 2014

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