Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MAP2K7 (mitogen-activated protein kinase kinase 7)

Identity

Other namesJNKK2
MAPKK7
MEK
MEK 7
MKK7
PRKMK7
SAPKK-4
SAPKK4
HGNC (Hugo) MAP2K7
LocusID (NCBI) 5609
Atlas_Id 41275
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 7968665 and ends at 7979368 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
LONP1 (19p13.3) / MAP2K7 (19p13.2)MAP2K7 (19p13.2) / MAP2K7 (19p13.2)MAP2K7 (19p13.2) / SH3GL1 (19p13.3)
MAP2K7 (19p13.2) / SUPT3H (6p21.1)LONP1 19p13.3 / MAP2K7 19p13.2MAP2K7 19p13.2 / SH3GL1 19p13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAP2K7   6847
Cards
Entrez_Gene (NCBI)MAP2K7  5609  mitogen-activated protein kinase kinase 7
AliasesJNKK2; MAPKK7; MEK; MEK; 
MKK7; PRKMK7; SAPKK-4; SAPKK4
GeneCards (Weizmann)MAP2K7
Ensembl hg19 (Hinxton)ENSG00000076984 [Gene_View]  chr19:7968665-7979368 [Contig_View]  MAP2K7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000076984 [Gene_View]  chr19:7968665-7979368 [Contig_View]  MAP2K7 [Vega]
ICGC DataPortalENSG00000076984
TCGA cBioPortalMAP2K7
AceView (NCBI)MAP2K7
Genatlas (Paris)MAP2K7
WikiGenes5609
SOURCE (Princeton)MAP2K7
Genomic and cartography
GoldenPath hg19 (UCSC)MAP2K7  -     chr19:7968665-7979368 +  19p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAP2K7  -     19p13.2   [Description]    (hg38-Dec_2013)
EnsemblMAP2K7 - 19p13.2 [CytoView hg19]  MAP2K7 - 19p13.2 [CytoView hg38]
Mapping of homologs : NCBIMAP2K7 [Mapview hg19]  MAP2K7 [Mapview hg38]
OMIM603014   
Gene and transcription
Genbank (Entrez)AF003199 AF006689 AF013588 AF013589 AF014401
RefSeq transcript (Entrez)NM_001297555 NM_001297556 NM_145185
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_029438 NT_011295 NW_004929413
Consensus coding sequences : CCDS (NCBI)MAP2K7
Cluster EST : UnigeneHs.531754 [ NCBI ]
CGAP (NCI)Hs.531754
Alternative Splicing GalleryENSG00000076984
Gene ExpressionMAP2K7 [ NCBI-GEO ]   MAP2K7 [ EBI - ARRAY_EXPRESS ]   MAP2K7 [ SEEK ]   MAP2K7 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP2K7 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5609
GTEX Portal (Tissue expression)MAP2K7
Protein : pattern, domain, 3D structure
UniProt/SwissProtO14733 (Uniprot)
NextProtO14733  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO14733
Splice isoforms : SwissVarO14733 (Swissvar)
Catalytic activity : Enzyme2.7.12.2 [ Enzyme-Expasy ]   2.7.12.22.7.12.2 [ IntEnz-EBI ]   2.7.12.2 [ BRENDA ]   2.7.12.2 [ KEGG ]   
PhosPhoSitePlusO14733
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
DMDM Disease mutations5609
Blocks (Seattle)MAP2K7
PDB (SRS)2DYL    3WZU    4UX9   
PDB (PDBSum)2DYL    3WZU    4UX9   
PDB (IMB)2DYL    3WZU    4UX9   
PDB (RSDB)2DYL    3WZU    4UX9   
Structural Biology KnowledgeBase2DYL    3WZU    4UX9   
SCOP (Structural Classification of Proteins)2DYL    3WZU    4UX9   
CATH (Classification of proteins structures)2DYL    3WZU    4UX9   
SuperfamilyO14733
Human Protein AtlasENSG00000076984
Peptide AtlasO14733
IPIIPI00023636   IPI00302112   IPI00745806   IPI00794495   IPI01022470   IPI00747921   
Protein Interaction databases
DIP (DOE-UCLA)O14733
IntAct (EBI)O14733
FunCoupENSG00000076984
BioGRIDMAP2K7
STRING (EMBL)MAP2K7
ZODIACMAP2K7
Ontologies - Pathways
QuickGOO14733
Ontology : AmiGOmagnesium ion binding  receptor signaling protein serine/threonine kinase activity  MAP kinase kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  cytosol  apoptotic process  response to osmotic stress  signal transduction  JNK cascade  activation of JUN kinase activity  protein C-terminus binding  JUN kinase kinase activity  response to heat  response to UV  peptidyl-tyrosine phosphorylation  enzyme binding  protein kinase binding  protein phosphatase binding  mitogen-activated protein kinase kinase kinase binding  positive regulation of telomere maintenance via telomerase  response to tumor necrosis factor  proteolysis in other organism  Fc-epsilon receptor signaling pathway  positive regulation of neuron apoptotic process  stress-activated MAPK cascade  positive regulation of telomerase activity  cellular response to sorbitol  positive regulation of telomere capping  
Ontology : EGO-EBImagnesium ion binding  receptor signaling protein serine/threonine kinase activity  MAP kinase kinase activity  protein tyrosine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytoplasm  cytosol  apoptotic process  response to osmotic stress  signal transduction  JNK cascade  activation of JUN kinase activity  protein C-terminus binding  JUN kinase kinase activity  response to heat  response to UV  peptidyl-tyrosine phosphorylation  enzyme binding  protein kinase binding  protein phosphatase binding  mitogen-activated protein kinase kinase kinase binding  positive regulation of telomere maintenance via telomerase  response to tumor necrosis factor  proteolysis in other organism  Fc-epsilon receptor signaling pathway  positive regulation of neuron apoptotic process  stress-activated MAPK cascade  positive regulation of telomerase activity  cellular response to sorbitol  positive regulation of telomere capping  
Pathways : BIOCARTAFc Epsilon Receptor I Signaling in Mast Cells [Genes]    MAPKinase Signaling Pathway [Genes]    Keratinocyte Differentiation [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]   
Pathways : KEGGMAPK signaling pathway    ErbB signaling pathway    Protein processing in endoplasmic reticulum    Osteoclast differentiation    Toll-like receptor signaling pathway    T cell receptor signaling pathway    Fc epsilon RI signaling pathway    TNF signaling pathway    Neurotrophin signaling pathway    GnRH signaling pathway    Influenza A    Epstein-Barr virus infection   
NDEx NetworkMAP2K7
Atlas of Cancer Signalling NetworkMAP2K7
Wikipedia pathwaysMAP2K7
Orthology - Evolution
OrthoDB5609
GeneTree (enSembl)ENSG00000076984
Phylogenetic Trees/Animal Genes : TreeFamMAP2K7
Homologs : HomoloGeneMAP2K7
Homology/Alignments : Family Browser (UCSC)MAP2K7
Gene fusions - Rearrangements
Fusion: TCGALONP1 19p13.3 MAP2K7 19p13.2 BRCA
Fusion: TCGAMAP2K7 19p13.2 SH3GL1 19p13.3 BRCA
Polymorphisms : SNP, variants
NCBI Variation ViewerMAP2K7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP2K7
dbVarMAP2K7
ClinVarMAP2K7
1000_GenomesMAP2K7 
Exome Variant ServerMAP2K7
ExAC (Exome Aggregation Consortium)MAP2K7 (select the gene name)
Genetic variants : HAPMAP5609
Genomic Variants (DGV)MAP2K7 [DGVbeta]
Mutations
ICGC Data PortalMAP2K7 
TCGA Data PortalMAP2K7 
Broad Tumor PortalMAP2K7
OASIS PortalMAP2K7 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP2K7 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP2K7
DgiDB (Drug Gene Interaction Database)MAP2K7
DoCM (Curated mutations)MAP2K7 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP2K7 (select a term)
intoGenMAP2K7
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)19:7968665-7979368  ENSG00000076984
CONAN: Copy Number AnalysisMAP2K7 
Mutations and Diseases : HGMDMAP2K7
OMIM603014   
MedgenMAP2K7
Genetic Testing Registry MAP2K7
NextProtO14733 [Medical]
TSGene5609
GENETestsMAP2K7
Huge Navigator MAP2K7 [HugePedia]
snp3D : Map Gene to Disease5609
BioCentury BCIQMAP2K7
ClinGenMAP2K7
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5609
Chemical/Pharm GKB GenePA284
Clinical trialMAP2K7
Miscellaneous
canSAR (ICR)MAP2K7 (select the gene name)
Probes
Litterature
PubMed97 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP2K7
EVEXMAP2K7
GoPubMedMAP2K7
iHOPMAP2K7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 19 18:59:31 CEST 2016

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