Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MAP3K1 (mitogen-activated protein kinase kinase kinase 1)

Identity

Alias_namesMEKK1
mitogen-activated protein kinase kinase kinase 1
mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase
Alias_symbol (synonym)MEKK
MAPKKK1
Other aliasMEKK 1
SRXY6
HGNC (Hugo) MAP3K1
LocusID (NCBI) 4214
Atlas_Id 43341
Location 5q11.2  [Link to chromosome band 5q11]
Location_base_pair Starts at 56815073 and ends at 56896151 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MAP3K1 (5q11.2) / CSNK2A2 (16q21)MAP3K1 (5q11.2) / NDUFAF2 (5q12.1)MAP3K1 (5q11.2) / PARN (16p13.12)
MAP3K1 5q11.2 / PARN 16p13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Breast: Ductal carcinoma


External links

Nomenclature
HGNC (Hugo)MAP3K1   6848
Cards
Entrez_Gene (NCBI)MAP3K1  4214  mitogen-activated protein kinase kinase kinase 1
AliasesMAPKKK1; MEKK; MEKK; MEKK1; 
SRXY6
GeneCards (Weizmann)MAP3K1
Ensembl hg19 (Hinxton)ENSG00000095015 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000095015 [Gene_View]  chr5:56815073-56896151 [Contig_View]  MAP3K1 [Vega]
ICGC DataPortalENSG00000095015
TCGA cBioPortalMAP3K1
AceView (NCBI)MAP3K1
Genatlas (Paris)MAP3K1
WikiGenes4214
SOURCE (Princeton)MAP3K1
Genetics Home Reference (NIH)MAP3K1
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K1  -     chr5:56815073-56896151 +  5q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K1  -     5q11.2   [Description]    (hg19-Feb_2009)
EnsemblMAP3K1 - 5q11.2 [CytoView hg19]  MAP3K1 - 5q11.2 [CytoView hg38]
Mapping of homologs : NCBIMAP3K1 [Mapview hg19]  MAP3K1 [Mapview hg38]
OMIM600982   613762   
Gene and transcription
Genbank (Entrez)AA602425 AF042838 AK307828 BU194120 BX537527
RefSeq transcript (Entrez)NM_005921
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP3K1
Cluster EST : UnigeneHs.653654 [ NCBI ]
CGAP (NCI)Hs.653654
Alternative Splicing GalleryENSG00000095015
Gene ExpressionMAP3K1 [ NCBI-GEO ]   MAP3K1 [ EBI - ARRAY_EXPRESS ]   MAP3K1 [ SEEK ]   MAP3K1 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4214
GTEX Portal (Tissue expression)MAP3K1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13233   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13233  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13233
Splice isoforms : SwissVarQ13233
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
PhosPhoSitePlusQ13233
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_RING_2 (PS50089)    ZF_SWIM (PS50966)   
Domains : Interpro (EBI)ARM-type_fold    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    Znf_RING    Znf_RING/FYVE/PHD    Znf_SWIM   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K1
DMDM Disease mutations4214
Blocks (Seattle)MAP3K1
SuperfamilyQ13233
Human Protein AtlasENSG00000095015
Peptide AtlasQ13233
IPIIPI00855985   
Protein Interaction databases
DIP (DOE-UCLA)Q13233
IntAct (EBI)Q13233
FunCoupENSG00000095015
BioGRIDMAP3K1
STRING (EMBL)MAP3K1
ZODIACMAP3K1
Ontologies - Pathways
QuickGOQ13233
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  MyD88-dependent toll-like receptor signaling pathway  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytoplasm  cytosol  protein phosphorylation  apoptotic process  zinc ion binding  protein kinase binding  actin cytoskeleton organization  Fc-epsilon receptor signaling pathway  cellular response to mechanical stimulus  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  MyD88-dependent toll-like receptor signaling pathway  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytoplasm  cytosol  protein phosphorylation  apoptotic process  zinc ion binding  protein kinase binding  actin cytoskeleton organization  Fc-epsilon receptor signaling pathway  cellular response to mechanical stimulus  
Pathways : BIOCARTA [Genes]   
Pathways : KEGGMAPK signaling pathway    Ubiquitin mediated proteolysis    RIG-I-like receptor signaling pathway    Neurotrophin signaling pathway    GnRH signaling pathway    Hepatitis B    HTLV-I infection   
NDEx NetworkMAP3K1
Atlas of Cancer Signalling NetworkMAP3K1
Wikipedia pathwaysMAP3K1
Orthology - Evolution
OrthoDB4214
GeneTree (enSembl)ENSG00000095015
Phylogenetic Trees/Animal Genes : TreeFamMAP3K1
HOVERGENQ13233
HOGENOMQ13233
Homologs : HomoloGeneMAP3K1
Homology/Alignments : Family Browser (UCSC)MAP3K1
Gene fusions - Rearrangements
Fusion : MitelmanMAP3K1/CSNK2A2 [5q11.2/16q21]  
Fusion : MitelmanMAP3K1/PARN [5q11.2/16p13.12]  [t(5;16)(q11;p13)]  
Fusion: TCGAMAP3K1 5q11.2 PARN 16p13.12 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K1
dbVarMAP3K1
ClinVarMAP3K1
1000_GenomesMAP3K1 
Exome Variant ServerMAP3K1
ExAC (Exome Aggregation Consortium)MAP3K1 (select the gene name)
Genetic variants : HAPMAP4214
Genomic Variants (DGV)MAP3K1 [DGVbeta]
DECIPHERMAP3K1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K1 
Mutations
ICGC Data PortalMAP3K1 
TCGA Data PortalMAP3K1 
Broad Tumor PortalMAP3K1
OASIS PortalMAP3K1 [ Somatic mutations - Copy number]
Cancer Gene: CensusMAP3K1 
Mutations and Diseases : HGMDMAP3K1
intOGen PortalMAP3K1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP3K1
DgiDB (Drug Gene Interaction Database)MAP3K1
DoCM (Curated mutations)MAP3K1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K1 (select a term)
intoGenMAP3K1
Cancer3DMAP3K1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600982    613762   
Orphanet1044    19642   
MedgenMAP3K1
Genetic Testing Registry MAP3K1
NextProtQ13233 [Medical]
TSGene4214
GENETestsMAP3K1
Target ValidationMAP3K1
Huge Navigator MAP3K1 [HugePedia]
snp3D : Map Gene to Disease4214
BioCentury BCIQMAP3K1
ClinGenMAP3K1 (curated)
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4214
Chemical/Pharm GKB GenePA30592
Clinical trialMAP3K1
Miscellaneous
canSAR (ICR)MAP3K1 (select the gene name)
Probes
Litterature
PubMed153 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K1
EVEXMAP3K1
GoPubMedMAP3K1
iHOPMAP3K1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 18 13:58:39 CEST 2017

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