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MAP3K1 (mitogen-activated protein kinase kinase kinase 1)

Identity

Alias (NCBI)MAPKKK1
MEKK
MEKK 1
MEKK1
SRXY6
HGNC (Hugo) MAP3K1
HGNC Alias symbMEKK
MAPKKK1
HGNC Previous nameMEKK1
HGNC Previous nameMEKK1
LocusID (NCBI) 4214
Atlas_Id 43341
Location 5q11.2  [Link to chromosome band 5q11]
Location_base_pair Starts at 56815549 and ends at 56896151 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAP3K1 (5q11.2) / CSNK2A2 (16q21)MAP3K1 (5q11.2) / NDUFAF2 (5q12.1)MAP3K1 (5q11.2) / PARN (16p13.12)
MAP3K1 5q11.2 / PARN 16p13.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;16)(q11;q21) MAP3K1/CSNK2A2


External links

 

Nomenclature
HGNC (Hugo)MAP3K1   6848
Cards
Entrez_Gene (NCBI)MAP3K1    mitogen-activated protein kinase kinase kinase 1
AliasesMAPKKK1; MEKK; MEKK; MEKK1; 
SRXY6
GeneCards (Weizmann)MAP3K1
Ensembl hg19 (Hinxton)ENSG00000095015 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000095015 [Gene_View]  ENSG00000095015 [Sequence]  chr5:56815549-56896151 [Contig_View]  MAP3K1 [Vega]
ICGC DataPortalENSG00000095015
TCGA cBioPortalMAP3K1
AceView (NCBI)MAP3K1
Genatlas (Paris)MAP3K1
SOURCE (Princeton)MAP3K1
Genetics Home Reference (NIH)MAP3K1
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K1  -     chr5:56815549-56896151 +  5q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K1  -     5q11.2   [Description]    (hg19-Feb_2009)
GoldenPathMAP3K1 - 5q11.2 [CytoView hg19]  MAP3K1 - 5q11.2 [CytoView hg38]
ImmunoBaseENSG00000095015
Genome Data Viewer NCBIMAP3K1 [Mapview hg19]  
OMIM600982   613762   
Gene and transcription
Genbank (Entrez)AA602425 AF042838 AK307828 BU194120 BX537527
RefSeq transcript (Entrez)NM_005921
Consensus coding sequences : CCDS (NCBI)MAP3K1
Gene ExpressionMAP3K1 [ NCBI-GEO ]   MAP3K1 [ EBI - ARRAY_EXPRESS ]   MAP3K1 [ SEEK ]   MAP3K1 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K1 [ Firebrowse - Broad ]
GenevisibleExpression of MAP3K1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4214
GTEX Portal (Tissue expression)MAP3K1
Human Protein AtlasENSG00000095015-MAP3K1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13233   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13233  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13233
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ13233
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    ZF_RING_2 (PS50089)    ZF_SWIM (PS50966)   
Domains : Interpro (EBI)ARM-like    ARM-type_fold    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS    Znf_RING    Znf_RING/FYVE/PHD    Znf_SWIM   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K1
PDB (RSDB)6WHB   
PDB Europe6WHB   
PDB (PDBSum)6WHB   
PDB (IMB)6WHB   
Structural Biology KnowledgeBase6WHB   
SCOP (Structural Classification of Proteins)6WHB   
CATH (Classification of proteins structures)6WHB   
SuperfamilyQ13233
AlphaFold pdb e-kbQ13233   
Human Protein Atlas [tissue]ENSG00000095015-MAP3K1 [tissue]
Protein Interaction databases
DIP (DOE-UCLA)Q13233
IntAct (EBI)Q13233
BioGRIDMAP3K1
STRING (EMBL)MAP3K1
ZODIACMAP3K1
Ontologies - Pathways
QuickGOQ13233
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  MyD88-dependent toll-like receptor signaling pathway  protein kinase activity  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytosol  protein phosphorylation  zinc ion binding  protein kinase binding  Fc-epsilon receptor signaling pathway  cellular response to mechanical stimulus  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  MyD88-dependent toll-like receptor signaling pathway  protein kinase activity  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytosol  protein phosphorylation  zinc ion binding  protein kinase binding  Fc-epsilon receptor signaling pathway  cellular response to mechanical stimulus  protein serine kinase activity  protein threonine kinase activity  
Pathways : BIOCARTAAngiotensin II mediated activation of JNK Pathway via Pyk2 dependent signaling [Genes]    fMLP induced chemokine gene expression in HMC-1 cells [Genes]    EGF Signaling Pathway [Genes]    FAS signaling pathway ( CD95 ) [Genes]    Inhibition of Cellular Proliferation by Gleevec [Genes]    Keratinocyte Differentiation [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    BCR Signaling Pathway [Genes]    Rac 1 cell motility signaling pathway [Genes]    The 4-1BB-dependent immune response [Genes]    Ceramide Signaling Pathway [Genes]    Fc Epsilon Receptor I Signaling in Mast Cells [Genes]    Human Cytomegalovirus and Map Kinase Pathways [Genes]    MAPKinase Signaling Pathway [Genes]    Neuropeptides VIP and PACAP inhibit the apoptosis of activated T cells [Genes]    CD40L Signaling Pathway [Genes]    T Cell Receptor Signaling Pathway [Genes]    Signal transduction through IL1R [Genes]    Role of MAL in Rho-Mediated Activation of SRF [Genes]    NF-kB Signaling Pathway [Genes]    PDGF Signaling Pathway [Genes]    TNF/Stress Related Signaling [Genes]    Map Kinase Inactivation of SMRT Corepressor [Genes]    p38 MAPK Signaling Pathway [Genes]    Links between Pyk2 and Map Kinases [Genes]    TNFR1 Signaling Pathway [Genes]    TNFR2 Signaling Pathway [Genes]    Toll-Like Receptor Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Ubiquitin mediated proteolysis    RIG-I-like receptor signaling pathway    Neurotrophin signaling pathway    GnRH signaling pathway    Hepatitis B    HTLV-I infection   
NDEx NetworkMAP3K1
Atlas of Cancer Signalling NetworkMAP3K1
Wikipedia pathwaysMAP3K1
Orthology - Evolution
OrthoDB4214
GeneTree (enSembl)ENSG00000095015
Phylogenetic Trees/Animal Genes : TreeFamMAP3K1
Homologs : HomoloGeneMAP3K1
Homology/Alignments : Family Browser (UCSC)MAP3K1
Gene fusions - Rearrangements
Fusion : MitelmanMAP3K1/CSNK2A2 [5q11.2/16q21]  
Fusion : MitelmanMAP3K1/PARN [5q11.2/16p13.12]  
Fusion : QuiverMAP3K1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K1
dbVarMAP3K1
ClinVarMAP3K1
MonarchMAP3K1
1000_GenomesMAP3K1 
Exome Variant ServerMAP3K1
GNOMAD BrowserENSG00000095015
Varsome BrowserMAP3K1
ACMGMAP3K1 variants
VarityQ13233
Genomic Variants (DGV)MAP3K1 [DGVbeta]
DECIPHERMAP3K1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K1 
Mutations
ICGC Data PortalMAP3K1 
TCGA Data PortalMAP3K1 
Broad Tumor PortalMAP3K1
OASIS PortalMAP3K1 [ Somatic mutations - Copy number]
Cancer Gene: CensusMAP3K1 
Somatic Mutations in Cancer : COSMICMAP3K1  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAP3K1
Mutations and Diseases : HGMDMAP3K1
intOGen PortalMAP3K1
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMAP3K1
DgiDB (Drug Gene Interaction Database)MAP3K1
DoCM (Curated mutations)MAP3K1
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K1
Cancer3DMAP3K1
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600982    613762   
Orphanet1044    19642   
DisGeNETMAP3K1
MedgenMAP3K1
Genetic Testing Registry MAP3K1
NextProtQ13233 [Medical]
GENETestsMAP3K1
Target ValidationMAP3K1
Huge Navigator MAP3K1 [HugePedia]
ClinGenMAP3K1 (curated)
Clinical trials, drugs, therapy
MyCancerGenomeMAP3K1
Protein Interactions : CTDMAP3K1
Pharm GKB GenePA30592
Pharm GKB PathwaysPA162356267   PA165985892   
PharosQ13233
Clinical trialMAP3K1
Miscellaneous
canSAR (ICR)MAP3K1
HarmonizomeMAP3K1
DataMed IndexMAP3K1
Probes
Litterature
PubMed172 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMAP3K1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:17:41 CEST 2021

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