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MAP3K10 (mitogen-activated protein kinase kinase kinase 10)

Identity

Other namesMEKK10
MLK2
MST
HGNC (Hugo) MAP3K10
LocusID (NCBI) 4294
Location 19q13.2
Location_base_pair Starts at 40697651 and ends at 40721482 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MAP3K10   6849
Entrez_Gene (NCBI)MAP3K10  4294  mitogen-activated protein kinase kinase kinase 10
Cards
GeneCards (Weizmann)MAP3K10
Ensembl (Hinxton)ENSG00000130758 [Gene_View]  chr19:40697651-40721482 [Contig_View]  MAP3K10 [Vega]
AceView (NCBI)MAP3K10
Genatlas (Paris)MAP3K10
SOURCE (Stanford)NM_002446
Genomic and cartography
GoldenPath (UCSC)MAP3K10  -  19q13.2   chr19:40697651-40721482 +  19q13.2   [Description]    (hg19-Feb_2009)
EnsemblMAP3K10 - 19q13.2 [CytoView]
Mapping of homologs : NCBIMAP3K10 [Mapview]
OMIM600137   
Gene and transcription
Genbank (Entrez)BC111460 BF594729 BU633407 X90846 Z48615
RefSeq transcript (SRS)NM_002446
RefSeq transcript (Entrez)NM_002446
RefSeq genomic (SRS)AC_000151 NC_000019 NC_018930 NT_011109 NW_001838496 NW_004078099
RefSeq genomic (Entrez)AC_000151 NC_000019 NC_018930 NT_011109 NW_001838496 NW_004078099
Consensus coding sequences : CCDS (NCBI)MAP3K10
Cluster EST : UnigeneHs.466743 [ SRS ] Hs.466743 [ NCBI ]
CGAP (NCI)Hs.466743
Alternative Splicing : Fast-db (Paris)GSHG0014927
Alternative Splicing GalleryENSG00000130758
Gene ExpressionMAP3K10 [ NCBI-GEO ]   MAP3K10 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02779 (SRS) Q02779 (Uniprot)
NextProtQ02779
With graphics : InterProQ02779
Splice isoforms : SwissVarQ02779(Swissvar)
Domaine pattern : Prosite (SRS)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    SH3 (PS50002)   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    SH3 (PS50002)   
Domains : Interpro (SRS)Kinase-like_dom    MAPKKK9/10/11    MAPKKK9/10/11-like    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_kinase_AS    SH3_2    SH3_domain   
Domains : Interpro (EBI)Kinase-like_dom    MAPKKK9/10/11    MAPKKK9/10/11-like    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_kinase_AS    SH3_2    SH3_domain   
Related proteins : CluSTrQ02779
Domain families : Pfam (SRS)Pkinase_Tyr (PF07714)    SH3_2 (PF07653)   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH3_2 (PF07653)   
Domain families : Pfam (NCBI)pfam07714    pfam07653   
Domain families : Smart (EMBL)SH3 (SM00326)  
DMDM4294
Blocks (Seattle)Q02779
PDB (SRS)2RF0   
PDB (PDBSum)2RF0   
PDB (IMB)2RF0   
PDB (RSDB)2RF0   
Human Protein AtlasENSG00000130758
HPRD02533
IPIIPI00295401   
Protein Interaction databases
DIP (DOE-UCLA)Q02779
IntAct (EBI)Q02779
FunCoupENSG00000130758
REACTOMEMAP3K10
Protein Interaction Database4294
BioGRIDMAP3K10
InParanoidQ02779
Interologous Interaction database Q02779
IntegromeDBMAP3K10
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MAP3K10
SNP (GeneSNP Utah)MAP3K10
SNP : HGBaseMAP3K10
Genetic variants : HAPMAPMAP3K10
Somatic Mutations in Cancer : COSMICMAP3K10 
CONAN: Copy Number AnalysisMAP3K10 
Mutations and Diseases : HGMDMAP3K10
OMIM600137   
GENETests600137   
Disease Genetic AssociationMAP3K10
Huge Navigator MAP3K10 [HugePedia]  MAP3K10 [HugeCancerGEM]
Genomic VariantsMAP3K10  MAP3K10 [DGVbeta]
snp3D : Map Gene to Disease4294
General knowledge
Homologs : HomoloGeneMAP3K10
Homology/Alignments : Family Browser (UCSC)MAP3K10
Phylogenetic Trees/Animal Genes : TreeFamMAP3K10
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.25 [ Enzyme-SRS ]   2.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
Chemical/Protein Interactions : CTD4294
Chemical/Pharm GKB GenePA30593
Clinical trialMAP3K10
Cancer Resource (Charite)ENSG00000130758
Ontology : AmiGOtranscription corepressor activity  protein kinase activity  protein serine/threonine kinase activity  JUN kinase kinase kinase activity  ATP binding  cytoplasm  induction of apoptosis  signal transduction  smoothened signaling pathway  JNK cascade  activation of JNKK activity  activation of JUN kinase activity  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  protein homodimerization activity  bHLH transcription factor binding  negative regulation of sequence-specific DNA binding transcription factor activity  positive regulation of JUN kinase activity  negative regulation of transcription, DNA-dependent  negative regulation of transcription, DNA-dependent  positive regulation of JNK cascade  protein autophosphorylation  
Ontology : EGO-EBItranscription corepressor activity  protein kinase activity  protein serine/threonine kinase activity  JUN kinase kinase kinase activity  ATP binding  cytoplasm  induction of apoptosis  signal transduction  smoothened signaling pathway  JNK cascade  activation of JNKK activity  activation of JUN kinase activity  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  protein homodimerization activity  bHLH transcription factor binding  negative regulation of sequence-specific DNA binding transcription factor activity  positive regulation of JUN kinase activity  negative regulation of transcription, DNA-dependent  negative regulation of transcription, DNA-dependent  positive regulation of JNK cascade  protein autophosphorylation  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway
Other databases
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
PubGeneMAP3K10
iHOPMAP3K10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:24:12 CEST 2013
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