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MAP3K10 (mitogen-activated protein kinase kinase kinase 10)

Identity

Alias_namesMLK2
Alias_symbol (synonym)MST
MEKK10
Other alias
HGNC (Hugo) MAP3K10
LocusID (NCBI) 4294
Atlas_Id 41276
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 40191744 and ends at 40215575 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		DVL2 (17p13.1) / MAP3K10 (19q13.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Soft tissue tumors: an overview

External links

Nomenclature
HGNC (Hugo)MAP3K10   6849
Cards
Entrez_Gene (NCBI)MAP3K10  4294  mitogen-activated protein kinase kinase kinase 10
AliasesMEKK10; MLK2; MST
GeneCards (Weizmann)MAP3K10
Ensembl hg19 (Hinxton)ENSG00000130758 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000130758 [Gene_View]  chr19:40191744-40215575 [Contig_View]  MAP3K10 [Vega]
ICGC DataPortalENSG00000130758
TCGA cBioPortalMAP3K10
AceView (NCBI)MAP3K10
Genatlas (Paris)MAP3K10
WikiGenes4294
SOURCE (Princeton)MAP3K10
Genetics Home Reference (NIH)MAP3K10
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K10  -     chr19:40191744-40215575 +  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K10  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblMAP3K10 - 19q13.2 [CytoView hg19]  MAP3K10 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIMAP3K10 [Mapview hg19]  MAP3K10 [Mapview hg38]
OMIM600137   
Gene and transcription
Genbank (Entrez)BC111460 BF594729 BU633407 X90846 Z48615
RefSeq transcript (Entrez)NM_002446
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP3K10
Cluster EST : UnigeneHs.466743 [ NCBI ]
CGAP (NCI)Hs.466743
Alternative Splicing GalleryENSG00000130758
Gene ExpressionMAP3K10 [ NCBI-GEO ]   MAP3K10 [ EBI - ARRAY_EXPRESS ]   MAP3K10 [ SEEK ]   MAP3K10 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4294
GTEX Portal (Tissue expression)MAP3K10
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ02779   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ02779  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ02779
Splice isoforms : SwissVarQ02779
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
PhosPhoSitePlusQ02779
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom    MAP3K10    MLK1/MLK2/MLK4    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_kinase_AS    SH3_domain   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam07714    pfam14604   
Domain families : Smart (EMBL)S_TKc (SM00220)  SH3 (SM00326)  
Conserved Domain (NCBI)MAP3K10
DMDM Disease mutations4294
Blocks (Seattle)MAP3K10
PDB (SRS)2RF0   
PDB (PDBSum)2RF0   
PDB (IMB)2RF0   
PDB (RSDB)2RF0   
Structural Biology KnowledgeBase2RF0   
SCOP (Structural Classification of Proteins)2RF0   
CATH (Classification of proteins structures)2RF0   
SuperfamilyQ02779
Human Protein AtlasENSG00000130758
Peptide AtlasQ02779
HPRD02533
IPIIPI00295401   
Protein Interaction databases
DIP (DOE-UCLA)Q02779
IntAct (EBI)Q02779
FunCoupENSG00000130758
BioGRIDMAP3K10
STRING (EMBL)MAP3K10
ZODIACMAP3K10
Ontologies - Pathways
QuickGOQ02779
Ontology : AmiGOtranscription corepressor activity  protein kinase activity  protein serine/threonine kinase activity  JUN kinase kinase kinase activity  JUN kinase kinase kinase activity  ATP binding  cytoplasm  apoptotic process  signal transduction  smoothened signaling pathway  JNK cascade  activation of JNKK activity  activation of JUN kinase activity  activation of JUN kinase activity  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  protein homodimerization activity  positive regulation of apoptotic process  bHLH transcription factor binding  negative regulation of sequence-specific DNA binding transcription factor activity  positive regulation of JUN kinase activity  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of JNK cascade  protein autophosphorylation  
Ontology : EGO-EBItranscription corepressor activity  protein kinase activity  protein serine/threonine kinase activity  JUN kinase kinase kinase activity  JUN kinase kinase kinase activity  ATP binding  cytoplasm  apoptotic process  signal transduction  smoothened signaling pathway  JNK cascade  activation of JNKK activity  activation of JUN kinase activity  activation of JUN kinase activity  peptidyl-serine phosphorylation  peptidyl-threonine phosphorylation  protein homodimerization activity  positive regulation of apoptotic process  bHLH transcription factor binding  negative regulation of sequence-specific DNA binding transcription factor activity  positive regulation of JUN kinase activity  negative regulation of transcription, DNA-templated  negative regulation of transcription, DNA-templated  positive regulation of JNK cascade  protein autophosphorylation  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
NDEx NetworkMAP3K10
Atlas of Cancer Signalling NetworkMAP3K10
Wikipedia pathwaysMAP3K10
Orthology - Evolution
OrthoDB4294
GeneTree (enSembl)ENSG00000130758
Phylogenetic Trees/Animal Genes : TreeFamMAP3K10
HOVERGENQ02779
HOGENOMQ02779
Homologs : HomoloGeneMAP3K10
Homology/Alignments : Family Browser (UCSC)MAP3K10
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K10
dbVarMAP3K10
ClinVarMAP3K10
1000_GenomesMAP3K10 
Exome Variant ServerMAP3K10
ExAC (Exome Aggregation Consortium)MAP3K10 (select the gene name)
Genetic variants : HAPMAP4294
Genomic Variants (DGV)MAP3K10 [DGVbeta]
DECIPHERMAP3K10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K10 
Mutations
ICGC Data PortalMAP3K10 
TCGA Data PortalMAP3K10 
Broad Tumor PortalMAP3K10
OASIS PortalMAP3K10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP3K10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP3K10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP3K10
DgiDB (Drug Gene Interaction Database)MAP3K10
DoCM (Curated mutations)MAP3K10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K10 (select a term)
intoGenMAP3K10
Cancer3DMAP3K10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600137   
Orphanet
MedgenMAP3K10
Genetic Testing Registry MAP3K10
NextProtQ02779 [Medical]
TSGene4294
GENETestsMAP3K10
Target ValidationMAP3K10
Huge Navigator MAP3K10 [HugePedia]
snp3D : Map Gene to Disease4294
BioCentury BCIQMAP3K10
ClinGenMAP3K10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4294
Chemical/Pharm GKB GenePA30593
Clinical trialMAP3K10
Miscellaneous
canSAR (ICR)MAP3K10 (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K10
EVEXMAP3K10
GoPubMedMAP3K10
iHOPMAP3K10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:06:15 CEST 2017
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