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MAP3K13 (mitogen-activated protein kinase kinase kinase 13)

Identity

Alias_symbol (synonym)LZK
MEKK13
Other aliasMLK
HGNC (Hugo) MAP3K13
LocusID (NCBI) 9175
Atlas_Id 43342
Location 3q27.2  [Link to chromosome band 3q27]
Location_base_pair Starts at 185282941 and ends at 185489094 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAP3K13 (3q27.2) / CD37 (19q13.33)MAP3K13 (3q27.2) / LOC100507412 (-)MAP3K13 (3q27.2) / MALAT1 (11q13.1)
MAP3K13 (3q27.2) / UTS2B (3q28)MAP3K13 (3q27.2) / VPS8 (3q27.2)TFPT (19q13.42) / MAP3K13 (3q27.2)
MAP3K13 3q27.2 / CD37 19q13.33MAP3K13 3q27.2 UTS2DMAP3K13 3q27.2 / VPS8 3q27.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Breast: Ductal carcinoma


External links

Nomenclature
HGNC (Hugo)MAP3K13   6852
Cards
Entrez_Gene (NCBI)MAP3K13  9175  mitogen-activated protein kinase kinase kinase 13
AliasesLZK; MEKK13; MLK
GeneCards (Weizmann)MAP3K13
Ensembl hg19 (Hinxton)ENSG00000073803 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000073803 [Gene_View]  chr3:185282941-185489094 [Contig_View]  MAP3K13 [Vega]
ICGC DataPortalENSG00000073803
TCGA cBioPortalMAP3K13
AceView (NCBI)MAP3K13
Genatlas (Paris)MAP3K13
WikiGenes9175
SOURCE (Princeton)MAP3K13
Genetics Home Reference (NIH)MAP3K13
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K13  -     chr3:185282941-185489094 +  3q27.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K13  -     3q27.2   [Description]    (hg19-Feb_2009)
EnsemblMAP3K13 - 3q27.2 [CytoView hg19]  MAP3K13 - 3q27.2 [CytoView hg38]
Mapping of homologs : NCBIMAP3K13 [Mapview hg19]  MAP3K13 [Mapview hg38]
OMIM604915   
Gene and transcription
Genbank (Entrez)AB001872 AI690808 AK123148 AK296961 AK297646
RefSeq transcript (Entrez)NM_001242314 NM_001242317 NM_004721
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP3K13
Cluster EST : UnigeneHs.634586 [ NCBI ]
CGAP (NCI)Hs.634586
Alternative Splicing GalleryENSG00000073803
Gene ExpressionMAP3K13 [ NCBI-GEO ]   MAP3K13 [ EBI - ARRAY_EXPRESS ]   MAP3K13 [ SEEK ]   MAP3K13 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K13 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9175
GTEX Portal (Tissue expression)MAP3K13
Human Protein AtlasENSG00000073803-MAP3K13 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO43283   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO43283  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO43283
Splice isoforms : SwissVarO43283
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
PhosPhoSitePlusO43283
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    MAP3K12_MAP3K13    MAPKKK13    Prot_kinase_dom    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)   
Domain families : Pfam (NCBI)pfam07714   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K13
DMDM Disease mutations9175
Blocks (Seattle)MAP3K13
SuperfamilyO43283
Human Protein Atlas [tissue]ENSG00000073803-MAP3K13 [tissue]
Peptide AtlasO43283
HPRD05372
IPIIPI00006192   IPI00922004   IPI00922363   IPI00922436   IPI00922192   IPI00790874   IPI00927077   IPI00926409   IPI00926072   IPI00925820   
Protein Interaction databases
DIP (DOE-UCLA)O43283
IntAct (EBI)O43283
FunCoupENSG00000073803
BioGRIDMAP3K13
STRING (EMBL)MAP3K13
ZODIACMAP3K13
Ontologies - Pathways
QuickGOO43283
Ontology : AmiGOactivation of MAPKK activity  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  protein phosphorylation  JNK cascade  IkappaB kinase complex  membrane  protein kinase binding  identical protein binding  protein homodimerization activity  protein autophosphorylation  metal ion binding  positive regulation of NF-kappaB transcription factor activity  
Ontology : EGO-EBIactivation of MAPKK activity  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  protein phosphorylation  JNK cascade  IkappaB kinase complex  membrane  protein kinase binding  identical protein binding  protein homodimerization activity  protein autophosphorylation  metal ion binding  positive regulation of NF-kappaB transcription factor activity  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkMAP3K13
Atlas of Cancer Signalling NetworkMAP3K13
Wikipedia pathwaysMAP3K13
Orthology - Evolution
OrthoDB9175
GeneTree (enSembl)ENSG00000073803
Phylogenetic Trees/Animal Genes : TreeFamMAP3K13
HOVERGENO43283
HOGENOMO43283
Homologs : HomoloGeneMAP3K13
Homology/Alignments : Family Browser (UCSC)MAP3K13
Gene fusions - Rearrangements
Fusion : MitelmanMAP3K13/CD37 [3q27.2/19q13.33]  
Fusion : MitelmanMAP3K13/UTS2B [3q27.2/3q28]  [t(3;3)(q27;q28)]  
Fusion : MitelmanMAP3K13/VPS8 [3q27.2/3q27.2]  [t(3;3)(q27;q27)]  
Fusion: TCGA_MDACCMAP3K13 3q27.2 CD37 19q13.33 GBM
Fusion: TCGA_MDACCMAP3K13 3q27.2 UTS2D LGG
Fusion: TCGA_MDACCMAP3K13 3q27.2 VPS8 3q27.2 LUAD
Tumor Fusion PortalMAP3K13
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K13 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K13
dbVarMAP3K13
ClinVarMAP3K13
1000_GenomesMAP3K13 
Exome Variant ServerMAP3K13
ExAC (Exome Aggregation Consortium)ENSG00000073803
GNOMAD BrowserENSG00000073803
Genetic variants : HAPMAP9175
Genomic Variants (DGV)MAP3K13 [DGVbeta]
DECIPHERMAP3K13 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K13 
Mutations
ICGC Data PortalMAP3K13 
TCGA Data PortalMAP3K13 
Broad Tumor PortalMAP3K13
OASIS PortalMAP3K13 [ Somatic mutations - Copy number]
Cancer Gene: CensusMAP3K13 
Somatic Mutations in Cancer : COSMICMAP3K13  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP3K13
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP3K13
DgiDB (Drug Gene Interaction Database)MAP3K13
DoCM (Curated mutations)MAP3K13 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K13 (select a term)
intoGenMAP3K13
Cancer3DMAP3K13(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604915   
Orphanet
DisGeNETMAP3K13
MedgenMAP3K13
Genetic Testing Registry MAP3K13
NextProtO43283 [Medical]
TSGene9175
GENETestsMAP3K13
Target ValidationMAP3K13
Huge Navigator MAP3K13 [HugePedia]
snp3D : Map Gene to Disease9175
BioCentury BCIQMAP3K13
ClinGenMAP3K13
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9175
Chemical/Pharm GKB GenePA30596
Clinical trialMAP3K13
Miscellaneous
canSAR (ICR)MAP3K13 (select the gene name)
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K13
EVEXMAP3K13
GoPubMedMAP3K13
iHOPMAP3K13
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:21:33 CET 2017

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