Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MAP3K14 (mitogen-activated protein kinase kinase kinase 14)

Identity

Alias_symbol (synonym)NIK
HSNIK
FTDCR1B
HS
Other alias
HGNC (Hugo) MAP3K14
LocusID (NCBI) 9020
Atlas_Id 41279
Location 17q21.31  [Link to chromosome band 17q21]
Location_base_pair Starts at 45263119 and ends at 45317064 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
DCAKD (17q21.31) / MAP3K14 (17q21.31)EFTUD2 (17q21.31) / MAP3K14 (17q21.31)MAP3K14 (17q21.31) / WAC (10p12.1)
WAC (10p12.1) / MAP3K14 (17q21.31)DCAKD 17q21.31 / MAP3K14 17q21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 2 ]
  Classical Hodgkin lymphoma
Hodgkin lymphoma


External links

Nomenclature
HGNC (Hugo)MAP3K14   6853
Cards
Entrez_Gene (NCBI)MAP3K14  9020  mitogen-activated protein kinase kinase kinase 14
AliasesFTDCR1B; HS; HSNIK; NIK
GeneCards (Weizmann)MAP3K14
Ensembl hg19 (Hinxton)ENSG00000006062 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000006062 [Gene_View]  chr17:45263119-45317064 [Contig_View]  MAP3K14 [Vega]
ICGC DataPortalENSG00000006062
TCGA cBioPortalMAP3K14
AceView (NCBI)MAP3K14
Genatlas (Paris)MAP3K14
WikiGenes9020
SOURCE (Princeton)MAP3K14
Genetics Home Reference (NIH)MAP3K14
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K14  -     chr17:45263119-45317064 -  17q21.31   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K14  -     17q21.31   [Description]    (hg19-Feb_2009)
EnsemblMAP3K14 - 17q21.31 [CytoView hg19]  MAP3K14 - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBIMAP3K14 [Mapview hg19]  MAP3K14 [Mapview hg38]
OMIM604655   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_003954
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP3K14
Cluster EST : UnigeneHs.735695 [ NCBI ]
CGAP (NCI)Hs.735695
Alternative Splicing GalleryENSG00000006062
Gene ExpressionMAP3K14 [ NCBI-GEO ]   MAP3K14 [ EBI - ARRAY_EXPRESS ]   MAP3K14 [ SEEK ]   MAP3K14 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9020
GTEX Portal (Tissue expression)MAP3K14
Human Protein AtlasENSG00000006062-MAP3K14 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99558   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99558  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99558
Splice isoforms : SwissVarQ99558
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
PhosPhoSitePlusQ99558
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    MAPKKK14    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K14
DMDM Disease mutations9020
Blocks (Seattle)MAP3K14
PDB (SRS)4DN5    4G3D    4IDT    4IDV   
PDB (PDBSum)4DN5    4G3D    4IDT    4IDV   
PDB (IMB)4DN5    4G3D    4IDT    4IDV   
PDB (RSDB)4DN5    4G3D    4IDT    4IDV   
Structural Biology KnowledgeBase4DN5    4G3D    4IDT    4IDV   
SCOP (Structural Classification of Proteins)4DN5    4G3D    4IDT    4IDV   
CATH (Classification of proteins structures)4DN5    4G3D    4IDT    4IDV   
SuperfamilyQ99558
Human Protein Atlas [tissue]ENSG00000006062-MAP3K14 [tissue]
Peptide AtlasQ99558
HPRD05230
IPIIPI00016099   IPI00742705   IPI00645961   
Protein Interaction databases
DIP (DOE-UCLA)Q99558
IntAct (EBI)Q99558
FunCoupENSG00000006062
BioGRIDMAP3K14
STRING (EMBL)MAP3K14
ZODIACMAP3K14
Ontologies - Pathways
QuickGOQ99558
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  fibrillar center  protein kinase activity  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  NF-kappaB-inducing kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  cytosol  immune response  I-kappaB kinase/NF-kappaB signaling  kinase activity  actin cytoskeleton organization  T cell costimulation  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  intracellular membrane-bounded organelle  cellular response to mechanical stimulus  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  fibrillar center  protein kinase activity  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  NF-kappaB-inducing kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  cytosol  immune response  I-kappaB kinase/NF-kappaB signaling  kinase activity  actin cytoskeleton organization  T cell costimulation  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  intracellular membrane-bounded organelle  cellular response to mechanical stimulus  
Pathways : BIOCARTA [Genes]   
Pathways : KEGG   
NDEx NetworkMAP3K14
Atlas of Cancer Signalling NetworkMAP3K14
Wikipedia pathwaysMAP3K14
Orthology - Evolution
OrthoDB9020
GeneTree (enSembl)ENSG00000006062
Phylogenetic Trees/Animal Genes : TreeFamMAP3K14
HOVERGENQ99558
HOGENOMQ99558
Homologs : HomoloGeneMAP3K14
Homology/Alignments : Family Browser (UCSC)MAP3K14
Gene fusions - Rearrangements
Fusion : MitelmanDCAKD/MAP3K14 [17q21.31/17q21.31]  [t(17;17)(q21;q21)]  
Fusion: TCGA_MDACCDCAKD 17q21.31 MAP3K14 17q21.31 HNSC
Tumor Fusion PortalMAP3K14
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K14
dbVarMAP3K14
ClinVarMAP3K14
1000_GenomesMAP3K14 
Exome Variant ServerMAP3K14
ExAC (Exome Aggregation Consortium)ENSG00000006062
GNOMAD BrowserENSG00000006062
Genetic variants : HAPMAP9020
Genomic Variants (DGV)MAP3K14 [DGVbeta]
DECIPHERMAP3K14 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K14 
Mutations
ICGC Data PortalMAP3K14 
TCGA Data PortalMAP3K14 
Broad Tumor PortalMAP3K14
OASIS PortalMAP3K14 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDMAP3K14
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP3K14
DgiDB (Drug Gene Interaction Database)MAP3K14
DoCM (Curated mutations)MAP3K14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K14 (select a term)
intoGenMAP3K14
Cancer3DMAP3K14(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604655   
Orphanet23533   
DisGeNETMAP3K14
MedgenMAP3K14
Genetic Testing Registry MAP3K14
NextProtQ99558 [Medical]
TSGene9020
GENETestsMAP3K14
Target ValidationMAP3K14
Huge Navigator MAP3K14 [HugePedia]
snp3D : Map Gene to Disease9020
BioCentury BCIQMAP3K14
ClinGenMAP3K14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9020
Chemical/Pharm GKB GenePA30597
Clinical trialMAP3K14
Miscellaneous
canSAR (ICR)MAP3K14 (select the gene name)
Probes
Litterature
PubMed118 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K14
EVEXMAP3K14
GoPubMedMAP3K14
iHOPMAP3K14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:21:33 CET 2017

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