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MAP3K14 (mitogen-activated protein kinase kinase kinase 14)

Identity

Other namesFTDCR1B
HS
HSNIK
NIK
HGNC (Hugo) MAP3K14
LocusID (NCBI) 9020
Location 17q21.31
Location_base_pair Starts at 43340486 and ends at 43394430 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas)

Leukemias 11q23ChildAMLID1615

External links

Nomenclature
HGNC (Hugo)MAP3K14   6853
Cards
Entrez_Gene (NCBI)MAP3K14  9020  mitogen-activated protein kinase kinase kinase 14
GeneCards (Weizmann)MAP3K14
Ensembl (Hinxton) [Gene_View]  chr17:43340486-43394430 [Contig_View]  MAP3K14 [Vega]
AceView (NCBI)MAP3K14
Genatlas (Paris)MAP3K14
WikiGenes9020
SOURCE (Princeton)NM_003954
Genomic and cartography
GoldenPath (UCSC)MAP3K14  -  17q21.31   chr17:43340486-43394430 -  17q21.31   [Description]    (hg19-Feb_2009)
EnsemblMAP3K14 - 17q21.31 [CytoView]
Mapping of homologs : NCBIMAP3K14 [Mapview]
OMIM604655   
Gene and transcription
Genbank (Entrez)AA564389 AK123696 AK131438 AK290203 AK313085
RefSeq transcript (Entrez)NM_003954
RefSeq genomic (Entrez)AC_000149 NC_000017 NC_018928 NG_033823 NT_010783 NW_001838437 NW_004929407
Consensus coding sequences : CCDS (NCBI)MAP3K14
Cluster EST : UnigeneHs.735695 [ NCBI ]
CGAP (NCI)Hs.735695
Alternative Splicing : Fast-db (Paris)GSHG0013485
Gene ExpressionMAP3K14 [ NCBI-GEO ]     MAP3K14 [ SEEK ]   MAP3K14 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99558 (Uniprot)
NextProtQ99558  [Medical]
With graphics : InterProQ99558
Splice isoforms : SwissVarQ99558 (Swissvar)
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    MAPKKK14    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Related proteins : CluSTrQ99558
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
DMDM Disease mutations9020
Blocks (Seattle)Q99558
PDB (SRS)4DN5    4G3D    4IDT    4IDV   
PDB (PDBSum)4DN5    4G3D    4IDT    4IDV   
PDB (IMB)4DN5    4G3D    4IDT    4IDV   
PDB (RSDB)4DN5    4G3D    4IDT    4IDV   
Peptide AtlasQ99558
HPRD05230
IPIIPI00016099   IPI00742705   IPI00645961   
Protein Interaction databases
DIP (DOE-UCLA)Q99558
IntAct (EBI)Q99558
BioGRIDMAP3K14
InParanoidQ99558
Interologous Interaction database Q99558
IntegromeDBMAP3K14
STRING (EMBL)MAP3K14
Ontologies - Pathways
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  protein kinase activity  NF-kappaB-inducing kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytosol  protein phosphorylation  immune response  I-kappaB kinase/NF-kappaB signaling  T cell costimulation  NIK/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  cellular response to mechanical stimulus  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  protein kinase activity  NF-kappaB-inducing kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytosol  protein phosphorylation  immune response  I-kappaB kinase/NF-kappaB signaling  T cell costimulation  NIK/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  cellular response to mechanical stimulus  
Pathways : BIOCARTASignal transduction through IL1R [Genes]    NFkB activation by Nontypeable Hemophilus influenzae [Genes]    CD40L Signaling Pathway [Genes]    MAPKinase Signaling Pathway [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    TACI and BCMA stimulation of B cell immune responses. [Genes]    Keratinocyte Differentiation [Genes]    NF-kB Signaling Pathway [Genes]    Induction of apoptosis through DR3 and DR4/5 Death Receptors [Genes]    TNF/Stress Related Signaling [Genes]    Toll-Like Receptor Pathway [Genes]    Double Stranded RNA Induced Gene Expression [Genes]    TNFR2 Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    NF-kappa B signaling pathway    Apoptosis    Osteoclast differentiation    T cell receptor signaling pathway    TNF signaling pathway    Intestinal immune network for IgA production    Epithelial cell signaling in Helicobacter pylori infection    HTLV-I infection    Epstein-Barr virus infection   
Protein Interaction DatabaseMAP3K14
Wikipedia pathwaysMAP3K14
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MAP3K14
SNP (GeneSNP Utah)MAP3K14
SNP : HGBaseMAP3K14
Genetic variants : HAPMAPMAP3K14
1000_GenomesMAP3K14 
CONAN: Copy Number AnalysisMAP3K14 
Somatic Mutations in Cancer : COSMICMAP3K14 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Mutations and Diseases : HGMDMAP3K14
OMIM604655   
MedgenMAP3K14
GENETestsMAP3K14
Disease Genetic AssociationMAP3K14
Huge Navigator MAP3K14 [HugePedia]  MAP3K14 [HugeCancerGEM]
Genomic VariantsMAP3K14  MAP3K14 [DGVbeta]
Exome VariantMAP3K14
dbVarMAP3K14
ClinVarMAP3K14
snp3D : Map Gene to Disease9020
General knowledge
Homologs : HomoloGeneMAP3K14
Homology/Alignments : Family Browser (UCSC)MAP3K14
Phylogenetic Trees/Animal Genes : TreeFamMAP3K14
Chemical/Protein Interactions : CTD9020
Chemical/Pharm GKB GenePA30597
Clinical trialMAP3K14
Other databases
Probes
Litterature
PubMed100 Pubmed reference(s) in Entrez
CoreMineMAP3K14
iHOPMAP3K14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 13 12:58:11 CEST 2014

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