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MAP3K14 (mitogen-activated protein kinase kinase kinase 14)

Identity

Other namesFTDCR1B
HS
HSNIK
NIK
HGNC (Hugo) MAP3K14
LocusID (NCBI) 9020
Atlas_Id 41279
Location 17q21.31
Location_base_pair Starts at 43340486 and ends at 43394430 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DCAKD (17q21.31) / MAP3K14 (17q21.31)EFTUD2 (17q21.31) / MAP3K14 (17q21.31)MAP3K14 (17q21.31) / WAC (10p12.1)
WAC (10p12.1) / MAP3K14 (17q21.31)DCAKD 17q21.31 / MAP3K14 17q21.31

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  Hodgkin lymphoma

External links

Nomenclature
HGNC (Hugo)MAP3K14   6853
Cards
Entrez_Gene (NCBI)MAP3K14  9020  mitogen-activated protein kinase kinase kinase 14
AliasesFTDCR1B; HS; HSNIK; NIK
GeneCards (Weizmann)MAP3K14
Ensembl hg19 (Hinxton)ENSG00000006062 [Gene_View]  chr17:43340486-43394430 [Contig_View]  MAP3K14 [Vega]
Ensembl hg38 (Hinxton)ENSG00000006062 [Gene_View]  chr17:43340486-43394430 [Contig_View]  MAP3K14 [Vega]
ICGC DataPortalENSG00000006062
TCGA cBioPortalMAP3K14
AceView (NCBI)MAP3K14
Genatlas (Paris)MAP3K14
WikiGenes9020
SOURCE (Princeton)MAP3K14
Genomic and cartography
GoldenPath hg19 (UCSC)MAP3K14  -     chr17:43340486-43394430 -  17q21.31   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAP3K14  -     17q21.31   [Description]    (hg38-Dec_2013)
EnsemblMAP3K14 - 17q21.31 [CytoView hg19]  MAP3K14 - 17q21.31 [CytoView hg38]
Mapping of homologs : NCBIMAP3K14 [Mapview hg19]  MAP3K14 [Mapview hg38]
OMIM604655   
Gene and transcription
Genbank (Entrez)AA564389 AJ008135 AJ008136 AJ008137 AJ008138
RefSeq transcript (Entrez)NM_003954
RefSeq genomic (Entrez)NC_000017 NC_018928 NG_033823 NT_010783 NT_167251 NT_187663 NW_004929407
Consensus coding sequences : CCDS (NCBI)MAP3K14
Cluster EST : UnigeneHs.735695 [ NCBI ]
CGAP (NCI)Hs.735695
Alternative Splicing GalleryENSG00000006062
Gene ExpressionMAP3K14 [ NCBI-GEO ]   MAP3K14 [ EBI - ARRAY_EXPRESS ]   MAP3K14 [ SEEK ]   MAP3K14 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K14 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9020
GTEX Portal (Tissue expression)MAP3K14
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99558 (Uniprot)
NextProtQ99558  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99558
Splice isoforms : SwissVarQ99558 (Swissvar)
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
PhosPhoSitePlusQ99558
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    MAPKKK14    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
DMDM Disease mutations9020
Blocks (Seattle)MAP3K14
PDB (SRS)4DN5    4G3D    4IDT    4IDV   
PDB (PDBSum)4DN5    4G3D    4IDT    4IDV   
PDB (IMB)4DN5    4G3D    4IDT    4IDV   
PDB (RSDB)4DN5    4G3D    4IDT    4IDV   
Structural Biology KnowledgeBase4DN5    4G3D    4IDT    4IDV   
SCOP (Structural Classification of Proteins)4DN5    4G3D    4IDT    4IDV   
CATH (Classification of proteins structures)4DN5    4G3D    4IDT    4IDV   
SuperfamilyQ99558
Human Protein AtlasENSG00000006062
Peptide AtlasQ99558
HPRD05230
IPIIPI00016099   IPI00742705   IPI00645961   
Protein Interaction databases
DIP (DOE-UCLA)Q99558
IntAct (EBI)Q99558
FunCoupENSG00000006062
BioGRIDMAP3K14
STRING (EMBL)MAP3K14
ZODIACMAP3K14
Ontologies - Pathways
QuickGOQ99558
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  protein kinase activity  protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  NF-kappaB-inducing kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytoplasm  cytosol  immune response  I-kappaB kinase/NF-kappaB signaling  kinase activity  signal transduction by protein phosphorylation  T cell costimulation  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  cellular response to mechanical stimulus  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  protein kinase activity  protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  NF-kappaB-inducing kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytoplasm  cytosol  immune response  I-kappaB kinase/NF-kappaB signaling  kinase activity  signal transduction by protein phosphorylation  T cell costimulation  tumor necrosis factor-mediated signaling pathway  NIK/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  cellular response to mechanical stimulus  
Pathways : BIOCARTASignal transduction through IL1R [Genes]    NFkB activation by Nontypeable Hemophilus influenzae [Genes]    CD40L Signaling Pathway [Genes]    MAPKinase Signaling Pathway [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    TACI and BCMA stimulation of B cell immune responses. [Genes]    Keratinocyte Differentiation [Genes]    NF-kB Signaling Pathway [Genes]    Induction of apoptosis through DR3 and DR4/5 Death Receptors [Genes]    TNF/Stress Related Signaling [Genes]    Toll-Like Receptor Pathway [Genes]    Double Stranded RNA Induced Gene Expression [Genes]    TNFR2 Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    NF-kappa B signaling pathway    Apoptosis    Osteoclast differentiation    T cell receptor signaling pathway    TNF signaling pathway    Intestinal immune network for IgA production    Epithelial cell signaling in Helicobacter pylori infection    HTLV-I infection    Epstein-Barr virus infection   
NDEx Network
Atlas of Cancer Signalling NetworkMAP3K14
Wikipedia pathwaysMAP3K14
Orthology - Evolution
OrthoDB9020
GeneTree (enSembl)ENSG00000006062
Phylogenetic Trees/Animal Genes : TreeFamMAP3K14
Homologs : HomoloGeneMAP3K14
Homology/Alignments : Family Browser (UCSC)MAP3K14
Gene fusions - Rearrangements
Fusion: TCGADCAKD 17q21.31 MAP3K14 17q21.31 HNSC
Polymorphisms : SNP, variants
NCBI Variation ViewerMAP3K14 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K14
dbVarMAP3K14
ClinVarMAP3K14
1000_GenomesMAP3K14 
Exome Variant ServerMAP3K14
ExAC (Exome Aggregation Consortium)MAP3K14 (select the gene name)
Genetic variants : HAPMAP9020
Genomic Variants (DGV)MAP3K14 [DGVbeta]
Mutations
ICGC Data PortalMAP3K14 
TCGA Data PortalMAP3K14 
Broad Tumor PortalMAP3K14
OASIS PortalMAP3K14 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP3K14 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP3K14
DgiDB (Drug Gene Interaction Database)MAP3K14
DoCM (Curated mutations)MAP3K14 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K14 (select a term)
intoGenMAP3K14
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)17:43340486-43394430  ENSG00000006062
CONAN: Copy Number AnalysisMAP3K14 
Mutations and Diseases : HGMDMAP3K14
OMIM604655   
MedgenMAP3K14
Genetic Testing Registry MAP3K14
NextProtQ99558 [Medical]
TSGene9020
GENETestsMAP3K14
Huge Navigator MAP3K14 [HugePedia]
snp3D : Map Gene to Disease9020
BioCentury BCIQMAP3K14
ClinGenMAP3K14
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD9020
Chemical/Pharm GKB GenePA30597
Clinical trialMAP3K14
Miscellaneous
canSAR (ICR)MAP3K14 (select the gene name)
Probes
Litterature
PubMed112 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K14
EVEXMAP3K14
GoPubMedMAP3K14
iHOPMAP3K14
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat May 28 11:10:03 CEST 2016

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