Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MAP3K15 (mitogen-activated protein kinase kinase kinase 15)

Identity

Alias (NCBI)ASK3
bA723P2.3
HGNC (Hugo) MAP3K15
HGNC Alias symbbA723P2.3
FLJ16518
ASK3
LocusID (NCBI) 389840
Atlas_Id 49916
Location Xp22.12  [Link to chromosome band Xp22]
Location_base_pair Starts at 19360058 and ends at 19515261 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
POLA1 (Xp22.11) / MAP3K15 (Xp22.12)POLA1 Xp22.11 / MAP3K15 Xp22.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  POLA1/MAP3K15 (Xp22)

External links

Nomenclature
HGNC (Hugo)MAP3K15   31689
Cards
Entrez_Gene (NCBI)MAP3K15    mitogen-activated protein kinase kinase kinase 15
AliasesASK3; bA723P2.3
GeneCards (Weizmann)MAP3K15
Ensembl hg19 (Hinxton)ENSG00000180815 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000180815 [Gene_View]  ENSG00000180815 [Sequence]  chrX:19360058-19515261 [Contig_View]  MAP3K15 [Vega]
ICGC DataPortalENSG00000180815
TCGA cBioPortalMAP3K15
AceView (NCBI)MAP3K15
Genatlas (Paris)MAP3K15
SOURCE (Princeton)MAP3K15
Genetics Home Reference (NIH)MAP3K15
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K15  -     chrX:19360058-19515261 -  Xp22.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K15  -     Xp22.12   [Description]    (hg19-Feb_2009)
GoldenPathMAP3K15 - Xp22.12 [CytoView hg19]  MAP3K15 - Xp22.12 [CytoView hg38]
ImmunoBaseENSG00000180815
genome Data Viewer NCBIMAP3K15 [Mapview hg19]  
OMIM300820   
Gene and transcription
Genbank (Entrez)AK122632 AK131412 AK131477 CN293540 DV080548
RefSeq transcript (Entrez)NM_001001671
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP3K15
Alternative Splicing GalleryENSG00000180815
Gene ExpressionMAP3K15 [ NCBI-GEO ]   MAP3K15 [ EBI - ARRAY_EXPRESS ]   MAP3K15 [ SEEK ]   MAP3K15 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K15 [ Firebrowse - Broad ]
GenevisibleExpression of MAP3K15 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)389840
GTEX Portal (Tissue expression)MAP3K15
Human Protein AtlasENSG00000180815-MAP3K15 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZN16   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZN16  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZN16
Splice isoforms : SwissVarQ6ZN16
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ6ZN16
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)DUF4071    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    SAM/pointed_sf    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)DUF4071 (PF13281)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam13281    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K15
Blocks (Seattle)MAP3K15
SuperfamilyQ6ZN16
Human Protein Atlas [tissue]ENSG00000180815-MAP3K15 [tissue]
Peptide AtlasQ6ZN16
HPRD14359
IPIIPI00412740   IPI00797566   IPI00418575   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZN16
IntAct (EBI)Q6ZN16
BioGRIDMAP3K15
STRING (EMBL)MAP3K15
ZODIACMAP3K15
Ontologies - Pathways
QuickGOQ6ZN16
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  protein kinase activity  MAP kinase kinase kinase activity  ATP binding  cellular response to stress  metal ion binding  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  protein kinase activity  MAP kinase kinase kinase activity  ATP binding  cellular response to stress  metal ion binding  
NDEx NetworkMAP3K15
Atlas of Cancer Signalling NetworkMAP3K15
Wikipedia pathwaysMAP3K15
Orthology - Evolution
OrthoDB389840
GeneTree (enSembl)ENSG00000180815
Phylogenetic Trees/Animal Genes : TreeFamMAP3K15
HOGENOMQ6ZN16
Homologs : HomoloGeneMAP3K15
Homology/Alignments : Family Browser (UCSC)MAP3K15
Gene fusions - Rearrangements
Fusion : MitelmanPOLA1/MAP3K15 [Xp22.11/Xp22.12]  
Fusion PortalPOLA1 Xp22.11 MAP3K15 Xp22.12 BRCA
Fusion : QuiverMAP3K15
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K15 [hg38]
dbVarMAP3K15
ClinVarMAP3K15
MonarchMAP3K15
1000_GenomesMAP3K15 
Exome Variant ServerMAP3K15
GNOMAD BrowserENSG00000180815
Varsome BrowserMAP3K15
Genomic Variants (DGV)MAP3K15 [DGVbeta]
DECIPHERMAP3K15 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K15 
Mutations
ICGC Data PortalMAP3K15 
TCGA Data PortalMAP3K15 
Broad Tumor PortalMAP3K15
OASIS PortalMAP3K15 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP3K15  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAP3K15
Mutations and Diseases : HGMDMAP3K15
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)X-chromosome gene database
BioMutasearch MAP3K15
DgiDB (Drug Gene Interaction Database)MAP3K15
DoCM (Curated mutations)MAP3K15 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K15 (select a term)
intoGenMAP3K15
Cancer3DMAP3K15(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM300820   
Orphanet
DisGeNETMAP3K15
MedgenMAP3K15
Genetic Testing Registry MAP3K15
NextProtQ6ZN16 [Medical]
GENETestsMAP3K15
Target ValidationMAP3K15
Huge Navigator MAP3K15 [HugePedia]
ClinGenMAP3K15
Clinical trials, drugs, therapy
MyCancerGenomeMAP3K15
Protein Interactions : CTD
Pharm GKB GenePA134935369
PharosQ6ZN16
Clinical trialMAP3K15
Miscellaneous
canSAR (ICR)MAP3K15 (select the gene name)
HarmonizomeMAP3K15
DataMed IndexMAP3K15
Probes
Litterature
PubMed13 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMAP3K15
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:23:59 CET 2021
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