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MAP3K19 (mitogen-activated protein kinase kinase kinase 19)

Identity

Alias_namesYSK4
Yeast Sps1/Ste20-related kinase 4 (S. cerevisiae)
yeast Sps1/Ste20-related kinase 4 (S. cerevisiae)
YSK4 Sps1/Ste20-related kinase homolog (S. cerevisiae)
Alias_symbol (synonym)FLJ23074
RCK
Other alias
HGNC (Hugo) MAP3K19
LocusID (NCBI) 80122
Atlas_Id 53350
Location 2q21.3  [Link to chromosome band 2q21]
Location_base_pair Starts at 135722061 and ends at 135782248 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CCNT2 (2q21.3) / MAP3K19 (2q21.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAP3K19   26249
Cards
Entrez_Gene (NCBI)MAP3K19  80122  mitogen-activated protein kinase kinase kinase 19
AliasesRCK; YSK4
GeneCards (Weizmann)MAP3K19
Ensembl hg19 (Hinxton)ENSG00000176601 [Gene_View]  chr2:135722061-135782248 [Contig_View]  MAP3K19 [Vega]
Ensembl hg38 (Hinxton)ENSG00000176601 [Gene_View]  chr2:135722061-135782248 [Contig_View]  MAP3K19 [Vega]
ICGC DataPortalENSG00000176601
TCGA cBioPortalMAP3K19
AceView (NCBI)MAP3K19
Genatlas (Paris)MAP3K19
WikiGenes80122
SOURCE (Princeton)MAP3K19
Genetics Home Reference (NIH)MAP3K19
Genomic and cartography
GoldenPath hg19 (UCSC)MAP3K19  -     chr2:135722061-135782248 -  2q21.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAP3K19  -     2q21.3   [Description]    (hg38-Dec_2013)
EnsemblMAP3K19 - 2q21.3 [CytoView hg19]  MAP3K19 - 2q21.3 [CytoView hg38]
Mapping of homologs : NCBIMAP3K19 [Mapview hg19]  MAP3K19 [Mapview hg38]
Gene and transcription
Genbank (Entrez)AK026727 AK097522 AK122935 AK131216 AK225579
RefSeq transcript (Entrez)NM_001018044 NM_001018045 NM_001018046 NM_001018047 NM_001282883 NM_001321177 NM_025052
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929304
Consensus coding sequences : CCDS (NCBI)MAP3K19
Cluster EST : UnigeneHs.659395 [ NCBI ]
CGAP (NCI)Hs.659395
Alternative Splicing GalleryENSG00000176601
Gene ExpressionMAP3K19 [ NCBI-GEO ]   MAP3K19 [ EBI - ARRAY_EXPRESS ]   MAP3K19 [ SEEK ]   MAP3K19 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K19 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80122
GTEX Portal (Tissue expression)MAP3K19
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ56UN5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ56UN5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ56UN5
Splice isoforms : SwissVarQ56UN5
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ56UN5
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K19
DMDM Disease mutations80122
Blocks (Seattle)MAP3K19
SuperfamilyQ56UN5
Human Protein AtlasENSG00000176601
Peptide AtlasQ56UN5
HPRD08016
IPIIPI00074966   IPI00749020   IPI00743362   IPI00604447   IPI00555896   IPI00743855   IPI00798105   IPI00788924   IPI00927587   
Protein Interaction databases
DIP (DOE-UCLA)Q56UN5
IntAct (EBI)Q56UN5
FunCoupENSG00000176601
BioGRIDMAP3K19
STRING (EMBL)MAP3K19
ZODIACMAP3K19
Ontologies - Pathways
QuickGOQ56UN5
Ontology : AmiGOreceptor signaling protein serine/threonine kinase activity  ATP binding  cytoplasm  signal transduction by protein phosphorylation  actin cytoskeleton organization  
Ontology : EGO-EBIreceptor signaling protein serine/threonine kinase activity  ATP binding  cytoplasm  signal transduction by protein phosphorylation  actin cytoskeleton organization  
NDEx NetworkMAP3K19
Atlas of Cancer Signalling NetworkMAP3K19
Wikipedia pathwaysMAP3K19
Orthology - Evolution
OrthoDB80122
GeneTree (enSembl)ENSG00000176601
Phylogenetic Trees/Animal Genes : TreeFamMAP3K19
HOVERGENQ56UN5
HOGENOMQ56UN5
Homologs : HomoloGeneMAP3K19
Homology/Alignments : Family Browser (UCSC)MAP3K19
Gene fusions - Rearrangements
Fusion : MitelmanCCNT2/MAP3K19 [2q21.3/2q21.3]  [t(2;2)(q21;q21)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K19 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K19
dbVarMAP3K19
ClinVarMAP3K19
1000_GenomesMAP3K19 
Exome Variant ServerMAP3K19
ExAC (Exome Aggregation Consortium)MAP3K19 (select the gene name)
Genetic variants : HAPMAP80122
Genomic Variants (DGV)MAP3K19 [DGVbeta]
DECIPHER (Syndromes)2:135722061-135782248  ENSG00000176601
CONAN: Copy Number AnalysisMAP3K19 
Mutations
ICGC Data PortalMAP3K19 
TCGA Data PortalMAP3K19 
Broad Tumor PortalMAP3K19
OASIS PortalMAP3K19 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDMAP3K19
BioMutasearch MAP3K19
DgiDB (Drug Gene Interaction Database)MAP3K19
DoCM (Curated mutations)MAP3K19 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K19 (select a term)
intoGenMAP3K19
Cancer3DMAP3K19(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenMAP3K19
Genetic Testing Registry MAP3K19
NextProtQ56UN5 [Medical]
TSGene80122
GENETestsMAP3K19
Huge Navigator MAP3K19 [HugePedia]
snp3D : Map Gene to Disease80122
BioCentury BCIQMAP3K19
ClinGenMAP3K19
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80122
Chemical/Pharm GKB GenePA142670554
Clinical trialMAP3K19
Miscellaneous
canSAR (ICR)MAP3K19 (select the gene name)
Probes
Litterature
PubMed6 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K19
EVEXMAP3K19
GoPubMedMAP3K19
iHOPMAP3K19
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:08:28 CEST 2017

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