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MAP3K2 (mitogen-activated protein kinase kinase kinase 2)

Identity

Alias (NCBI)MEKK2
MEKK2B
HGNC (Hugo) MAP3K2
HGNC Alias symbMEKK2B
HGNC Alias nameMAP/ERK kinase kinase 2
HGNC Previous nameMEKK2
LocusID (NCBI) 10746
Atlas_Id 43343
Location 2q14.3  [Link to chromosome band 2q14]
Location_base_pair Starts at 127298668 and ends at 127343229 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ERCC3 (2q14.3) / MAP3K2 (2q14.3)MAP3K2 (2q14.3) / IWS1 (2q14.3)MAP3K2 (2q14.3) / MAP3K2 (2q14.3)
MAP3K2 (2q14.3) / RPL22 (1p36.31)ERCC3 2q14.3 / MAP3K2 2q14.3MAP3K2 2q14.3 / IWS1 2q14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MAP3K2   6854
Cards
Entrez_Gene (NCBI)MAP3K2    mitogen-activated protein kinase kinase kinase 2
AliasesMEKK2; MEKK2B
GeneCards (Weizmann)MAP3K2
Ensembl hg19 (Hinxton)ENSG00000169967 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169967 [Gene_View]  ENSG00000169967 [Sequence]  chr2:127298668-127343229 [Contig_View]  MAP3K2 [Vega]
ICGC DataPortalENSG00000169967
TCGA cBioPortalMAP3K2
AceView (NCBI)MAP3K2
Genatlas (Paris)MAP3K2
SOURCE (Princeton)MAP3K2
Genetics Home Reference (NIH)MAP3K2
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K2  -     chr2:127298668-127343229 -  2q14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K2  -     2q14.3   [Description]    (hg19-Feb_2009)
GoldenPathMAP3K2 - 2q14.3 [CytoView hg19]  MAP3K2 - 2q14.3 [CytoView hg38]
ImmunoBaseENSG00000169967
Genome Data Viewer NCBIMAP3K2 [Mapview hg19]  
OMIM609487   
Gene and transcription
Genbank (Entrez)AB208963 AF111105 AF239798 AI760702 AK027345
RefSeq transcript (Entrez)NM_001371910 NM_001371911 NM_006609
Consensus coding sequences : CCDS (NCBI)MAP3K2
Gene ExpressionMAP3K2 [ NCBI-GEO ]   MAP3K2 [ EBI - ARRAY_EXPRESS ]   MAP3K2 [ SEEK ]   MAP3K2 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K2 [ Firebrowse - Broad ]
GenevisibleExpression of MAP3K2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10746
GTEX Portal (Tissue expression)MAP3K2
Human Protein AtlasENSG00000169967-MAP3K2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2U5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2U5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2U5
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9Y2U5
Domaine pattern : Prosite (Expaxy)PB1 (PS51745)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom_sf    PB1_dom    PB1_MEKK2/3    Prot_kinase_dom    Protein_kinase_ATP_BS   
Domain families : Pfam (Sanger)PB1 (PF00564)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00564    pfam00069   
Domain families : Smart (EMBL)PB1 (SM00666)  S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K2
PDB (RSDB)2CU1    2NPT    5EX0    5HQ8   
PDB Europe2CU1    2NPT    5EX0    5HQ8   
PDB (PDBSum)2CU1    2NPT    5EX0    5HQ8   
PDB (IMB)2CU1    2NPT    5EX0    5HQ8   
Structural Biology KnowledgeBase2CU1    2NPT    5EX0    5HQ8   
SCOP (Structural Classification of Proteins)2CU1    2NPT    5EX0    5HQ8   
CATH (Classification of proteins structures)2CU1    2NPT    5EX0    5HQ8   
SuperfamilyQ9Y2U5
AlphaFold pdb e-kbQ9Y2U5   
Human Protein Atlas [tissue]ENSG00000169967-MAP3K2 [tissue]
HPRD10068
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2U5
IntAct (EBI)Q9Y2U5
BioGRIDMAP3K2
STRING (EMBL)MAP3K2
ZODIACMAP3K2
Ontologies - Pathways
QuickGOQ9Y2U5
Ontology : AmiGOactivation of MAPKK activity  activation of MAPK activity  protein kinase activity  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  nucleoplasm  cytosol  protein phosphorylation  activation of JUN kinase activity  protein kinase binding  positive regulation of transcription, DNA-templated  metal ion binding  cellular response to mechanical stimulus  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIactivation of MAPKK activity  activation of MAPK activity  protein kinase activity  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  nucleoplasm  cytosol  protein phosphorylation  activation of JUN kinase activity  protein kinase binding  positive regulation of transcription, DNA-templated  metal ion binding  cellular response to mechanical stimulus  protein serine kinase activity  protein threonine kinase activity  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Gap junction    GnRH signaling pathway   
NDEx NetworkMAP3K2
Atlas of Cancer Signalling NetworkMAP3K2
Wikipedia pathwaysMAP3K2
Orthology - Evolution
OrthoDB10746
GeneTree (enSembl)ENSG00000169967
Phylogenetic Trees/Animal Genes : TreeFamMAP3K2
Homologs : HomoloGeneMAP3K2
Homology/Alignments : Family Browser (UCSC)MAP3K2
Gene fusions - Rearrangements
Fusion : MitelmanERCC3/MAP3K2 [2q14.3/2q14.3]  
Fusion : MitelmanMAP3K2/IWS1 [2q14.3/2q14.3]  
Fusion : QuiverMAP3K2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K2
dbVarMAP3K2
ClinVarMAP3K2
MonarchMAP3K2
1000_GenomesMAP3K2 
Exome Variant ServerMAP3K2
GNOMAD BrowserENSG00000169967
Varsome BrowserMAP3K2
ACMGMAP3K2 variants
VarityQ9Y2U5
Genomic Variants (DGV)MAP3K2 [DGVbeta]
DECIPHERMAP3K2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K2 
Mutations
ICGC Data PortalMAP3K2 
TCGA Data PortalMAP3K2 
Broad Tumor PortalMAP3K2
OASIS PortalMAP3K2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP3K2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAP3K2
Mutations and Diseases : HGMDMAP3K2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMAP3K2
DgiDB (Drug Gene Interaction Database)MAP3K2
DoCM (Curated mutations)MAP3K2
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K2
Cancer3DMAP3K2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609487   
Orphanet
DisGeNETMAP3K2
MedgenMAP3K2
Genetic Testing Registry MAP3K2
NextProtQ9Y2U5 [Medical]
GENETestsMAP3K2
Target ValidationMAP3K2
Huge Navigator MAP3K2 [HugePedia]
ClinGenMAP3K2
Clinical trials, drugs, therapy
MyCancerGenomeMAP3K2
Protein Interactions : CTDMAP3K2
Pharm GKB GenePA30598
PharosQ9Y2U5
Clinical trialMAP3K2
Miscellaneous
canSAR (ICR)MAP3K2
HarmonizomeMAP3K2
DataMed IndexMAP3K2
Probes
Litterature
PubMed77 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMAP3K2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:17:42 CEST 2021

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