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MAP3K2 (mitogen-activated protein kinase kinase kinase 2)

Identity

Alias_namesMEKK2
Alias_symbol (synonym)MEKK2B
Other alias
HGNC (Hugo) MAP3K2
LocusID (NCBI) 10746
Atlas_Id 43343
Location 2q14.3  [Link to chromosome band 2q14]
Location_base_pair Starts at 127298669 and ends at 127343229 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
ERCC3 (2q14.3) / MAP3K2 (2q14.3)MAP3K2 (2q14.3) / IWS1 (2q14.3)MAP3K2 (2q14.3) / MAP3K2 (2q14.3)
MAP3K2 (2q14.3) / RPL22 (1p36.31)ERCC3 2q14.3 / MAP3K2 2q14.3MAP3K2 2q14.3 / IWS1 2q14.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAP3K2   6854
Cards
Entrez_Gene (NCBI)MAP3K2  10746  mitogen-activated protein kinase kinase kinase 2
AliasesMEKK2; MEKK2B
GeneCards (Weizmann)MAP3K2
Ensembl hg19 (Hinxton)ENSG00000169967 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000169967 [Gene_View]  chr2:127298669-127343229 [Contig_View]  MAP3K2 [Vega]
ICGC DataPortalENSG00000169967
TCGA cBioPortalMAP3K2
AceView (NCBI)MAP3K2
Genatlas (Paris)MAP3K2
WikiGenes10746
SOURCE (Princeton)MAP3K2
Genetics Home Reference (NIH)MAP3K2
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K2  -     chr2:127298669-127343229 -  2q14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K2  -     2q14.3   [Description]    (hg19-Feb_2009)
EnsemblMAP3K2 - 2q14.3 [CytoView hg19]  MAP3K2 - 2q14.3 [CytoView hg38]
Mapping of homologs : NCBIMAP3K2 [Mapview hg19]  MAP3K2 [Mapview hg38]
OMIM609487   
Gene and transcription
Genbank (Entrez)AB208963 AF111105 AF239798 AI760702 AK027345
RefSeq transcript (Entrez)NM_006609
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP3K2
Cluster EST : UnigeneHs.145605 [ NCBI ]
CGAP (NCI)Hs.145605
Alternative Splicing GalleryENSG00000169967
Gene ExpressionMAP3K2 [ NCBI-GEO ]   MAP3K2 [ EBI - ARRAY_EXPRESS ]   MAP3K2 [ SEEK ]   MAP3K2 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10746
GTEX Portal (Tissue expression)MAP3K2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y2U5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y2U5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y2U5
Splice isoforms : SwissVarQ9Y2U5
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
PhosPhoSitePlusQ9Y2U5
Domaine pattern : Prosite (Expaxy)PB1 (PS51745)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom    PB1_dom    Prot_kinase_dom    Protein_kinase_ATP_BS   
Domain families : Pfam (Sanger)PB1 (PF00564)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00564    pfam00069   
Domain families : Smart (EMBL)PB1 (SM00666)  S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K2
DMDM Disease mutations10746
Blocks (Seattle)MAP3K2
PDB (SRS)2CU1    2NPT    5EX0    5HQ8   
PDB (PDBSum)2CU1    2NPT    5EX0    5HQ8   
PDB (IMB)2CU1    2NPT    5EX0    5HQ8   
PDB (RSDB)2CU1    2NPT    5EX0    5HQ8   
Structural Biology KnowledgeBase2CU1    2NPT    5EX0    5HQ8   
SCOP (Structural Classification of Proteins)2CU1    2NPT    5EX0    5HQ8   
CATH (Classification of proteins structures)2CU1    2NPT    5EX0    5HQ8   
SuperfamilyQ9Y2U5
Human Protein AtlasENSG00000169967
Peptide AtlasQ9Y2U5
HPRD10068
IPIIPI00513803   IPI01018007   IPI00917124   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y2U5
IntAct (EBI)Q9Y2U5
FunCoupENSG00000169967
BioGRIDMAP3K2
STRING (EMBL)MAP3K2
ZODIACMAP3K2
Ontologies - Pathways
QuickGOQ9Y2U5
Ontology : AmiGOactivation of MAPKK activity  activation of MAPK activity  protein kinase activity  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  nucleoplasm  cytoplasm  cytosol  protein phosphorylation  activation of JUN kinase activity  protein kinase binding  actin cytoskeleton organization  positive regulation of transcription, DNA-templated  metal ion binding  cellular response to mechanical stimulus  
Ontology : EGO-EBIactivation of MAPKK activity  activation of MAPK activity  protein kinase activity  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  nucleoplasm  cytoplasm  cytosol  protein phosphorylation  activation of JUN kinase activity  protein kinase binding  actin cytoskeleton organization  positive regulation of transcription, DNA-templated  metal ion binding  cellular response to mechanical stimulus  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Gap junction    GnRH signaling pathway   
NDEx NetworkMAP3K2
Atlas of Cancer Signalling NetworkMAP3K2
Wikipedia pathwaysMAP3K2
Orthology - Evolution
OrthoDB10746
GeneTree (enSembl)ENSG00000169967
Phylogenetic Trees/Animal Genes : TreeFamMAP3K2
HOVERGENQ9Y2U5
HOGENOMQ9Y2U5
Homologs : HomoloGeneMAP3K2
Homology/Alignments : Family Browser (UCSC)MAP3K2
Gene fusions - Rearrangements
Fusion : MitelmanERCC3/MAP3K2 [2q14.3/2q14.3]  [t(2;2)(q14;q14)]  
Fusion : MitelmanMAP3K2/IWS1 [2q14.3/2q14.3]  [t(2;2)(q14;q14)]  
Fusion: TCGAERCC3 2q14.3 MAP3K2 2q14.3 LUAD
Fusion: TCGAMAP3K2 2q14.3 IWS1 2q14.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K2
dbVarMAP3K2
ClinVarMAP3K2
1000_GenomesMAP3K2 
Exome Variant ServerMAP3K2
ExAC (Exome Aggregation Consortium)MAP3K2 (select the gene name)
Genetic variants : HAPMAP10746
Genomic Variants (DGV)MAP3K2 [DGVbeta]
DECIPHERMAP3K2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K2 
Mutations
ICGC Data PortalMAP3K2 
TCGA Data PortalMAP3K2 
Broad Tumor PortalMAP3K2
OASIS PortalMAP3K2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP3K2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP3K2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP3K2
DgiDB (Drug Gene Interaction Database)MAP3K2
DoCM (Curated mutations)MAP3K2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K2 (select a term)
intoGenMAP3K2
Cancer3DMAP3K2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609487   
Orphanet
MedgenMAP3K2
Genetic Testing Registry MAP3K2
NextProtQ9Y2U5 [Medical]
TSGene10746
GENETestsMAP3K2
Target ValidationMAP3K2
Huge Navigator MAP3K2 [HugePedia]
snp3D : Map Gene to Disease10746
BioCentury BCIQMAP3K2
ClinGenMAP3K2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10746
Chemical/Pharm GKB GenePA30598
Clinical trialMAP3K2
Miscellaneous
canSAR (ICR)MAP3K2 (select the gene name)
Probes
Litterature
PubMed60 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K2
EVEXMAP3K2
GoPubMedMAP3K2
iHOPMAP3K2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:17:08 CEST 2017

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