Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MAP3K20 (mitogen-activated protein kinase kinase kinase 20)

Identity

Other aliasAZK
CNM6
MLK7
MLT
MLTK
MLTKalpha
MLTKbeta
MRK
SFMMP
ZAK
mlklak
pk
HGNC (Hugo) MAP3K20
LocusID (NCBI) 51776
Atlas_Id 56651
Location 2q31.1  [Link to chromosome band 2q31]
Location_base_pair Starts at 173075837 and ends at 173227145 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)MAP3K20   17797
Cards
Entrez_Gene (NCBI)MAP3K20  51776  mitogen-activated protein kinase kinase kinase 20
AliasesAZK; CNM6; MLK7; MLT; 
MLTK; MLTKalpha; MLTKbeta; MRK; SFMMP; ZAK; mlklak; pk
GeneCards (Weizmann)MAP3K20
Ensembl hg19 (Hinxton)ENSG00000091436 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000091436 [Gene_View]  ENSG00000091436 [Sequence]  chr2:173075837-173227145 [Contig_View]  MAP3K20 [Vega]
ICGC DataPortalENSG00000091436
TCGA cBioPortalMAP3K20
AceView (NCBI)MAP3K20
Genatlas (Paris)MAP3K20
WikiGenes51776
SOURCE (Princeton)MAP3K20
Genetics Home Reference (NIH)MAP3K20
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K20  -     chr2:173075837-173227145 +  2q31.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K20  -     2q31.1   [Description]    (hg19-Feb_2009)
EnsemblMAP3K20 - 2q31.1 [CytoView hg19]  MAP3K20 - 2q31.1 [CytoView hg38]
Mapping of homologs : NCBIMAP3K20 [Mapview hg19]  MAP3K20 [Mapview hg38]
OMIM609479   616890   617760   
Gene and transcription
Genbank (Entrez)AA258354 AB030034 AB041883 AB049733 AB049734
RefSeq transcript (Entrez)NM_016653 NM_133646
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP3K20
Cluster EST : UnigeneHs.444451 [ NCBI ]
CGAP (NCI)Hs.444451
Alternative Splicing GalleryENSG00000091436
Gene ExpressionMAP3K20 [ NCBI-GEO ]   MAP3K20 [ EBI - ARRAY_EXPRESS ]   MAP3K20 [ SEEK ]   MAP3K20 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K20 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)51776
GTEX Portal (Tissue expression)MAP3K20
Human Protein AtlasENSG00000091436-MAP3K20 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NYL2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NYL2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NYL2
Splice isoforms : SwissVarQ9NYL2
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
PhosPhoSitePlusQ9NYL2
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    SAM_DOMAIN (PS50105)   
Domains : Interpro (EBI)Kinase-like_dom_sf    MLTK    Prot_kinase_dom    SAM    SAM/pointed_sf    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SAM_1 (PF00536)   
Domain families : Pfam (NCBI)pfam07714    pfam00536   
Domain families : Smart (EMBL)S_TKc (SM00220)  SAM (SM00454)  
Conserved Domain (NCBI)MAP3K20
DMDM Disease mutations51776
Blocks (Seattle)MAP3K20
PDB (SRS)5HES    5X5O   
PDB (PDBSum)5HES    5X5O   
PDB (IMB)5HES    5X5O   
PDB (RSDB)5HES    5X5O   
Structural Biology KnowledgeBase5HES    5X5O   
SCOP (Structural Classification of Proteins)5HES    5X5O   
CATH (Classification of proteins structures)5HES    5X5O   
SuperfamilyQ9NYL2
Human Protein Atlas [tissue]ENSG00000091436-MAP3K20 [tissue]
Peptide AtlasQ9NYL2
IPIIPI00329638   IPI00029643   IPI00384771   IPI00941127   IPI00952629   
Protein Interaction databases
DIP (DOE-UCLA)Q9NYL2
IntAct (EBI)Q9NYL2
FunCoupENSG00000091436
BioGRIDMAP3K20
STRING (EMBL)MAP3K20
ZODIACMAP3K20
Ontologies - Pathways
QuickGOQ9NYL2
Ontology : AmiGODNA damage checkpoint  activation of MAPKK activity  magnesium ion binding  RNA binding  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  protein phosphorylation  cytoskeleton organization  cell cycle arrest  mitotic cell cycle checkpoint  activation of JUN kinase activity  cell death  cell proliferation  cell differentiation  embryonic digit morphogenesis  positive regulation of apoptotic process  stress-activated MAPK cascade  limb development  cellular response to gamma radiation  
Ontology : EGO-EBIDNA damage checkpoint  activation of MAPKK activity  magnesium ion binding  RNA binding  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  protein phosphorylation  cytoskeleton organization  cell cycle arrest  mitotic cell cycle checkpoint  activation of JUN kinase activity  cell death  cell proliferation  cell differentiation  embryonic digit morphogenesis  positive regulation of apoptotic process  stress-activated MAPK cascade  limb development  cellular response to gamma radiation  
NDEx NetworkMAP3K20
Atlas of Cancer Signalling NetworkMAP3K20
Wikipedia pathwaysMAP3K20
Orthology - Evolution
OrthoDB51776
GeneTree (enSembl)ENSG00000091436
Phylogenetic Trees/Animal Genes : TreeFamMAP3K20
HOVERGENQ9NYL2
HOGENOMQ9NYL2
Homologs : HomoloGeneMAP3K20
Homology/Alignments : Family Browser (UCSC)MAP3K20
Gene fusions - Rearrangements
Fusion : QuiverMAP3K20
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K20 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K20
dbVarMAP3K20
ClinVarMAP3K20
1000_GenomesMAP3K20 
Exome Variant ServerMAP3K20
ExAC (Exome Aggregation Consortium)ENSG00000091436
GNOMAD BrowserENSG00000091436
Varsome BrowserMAP3K20
Genetic variants : HAPMAP51776
Genomic Variants (DGV)MAP3K20 [DGVbeta]
DECIPHERMAP3K20 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K20 
Mutations
ICGC Data PortalMAP3K20 
TCGA Data PortalMAP3K20 
Broad Tumor PortalMAP3K20
OASIS PortalMAP3K20 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDMAP3K20
BioMutasearch MAP3K20
DgiDB (Drug Gene Interaction Database)MAP3K20
DoCM (Curated mutations)MAP3K20 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K20 (select a term)
intoGenMAP3K20
Cancer3DMAP3K20(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609479    616890    617760   
Orphanet
DisGeNETMAP3K20
MedgenMAP3K20
Genetic Testing Registry MAP3K20
NextProtQ9NYL2 [Medical]
TSGene51776
GENETestsMAP3K20
Target ValidationMAP3K20
Huge Navigator MAP3K20 [HugePedia]
snp3D : Map Gene to Disease51776
BioCentury BCIQMAP3K20
ClinGenMAP3K20
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD51776
Clinical trialMAP3K20
Miscellaneous
canSAR (ICR)MAP3K20 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K20
EVEXMAP3K20
GoPubMedMAP3K20
iHOPMAP3K20
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:18:47 CET 2018

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