MAP3K21 (mitogen-activated protein kinase kinase kinase 21)

2016-12-01  

Identity

HGNC
LOCATION
1q42.2
LOCUSID
ALIAS
MLK4,dJ862P8.3

Other Information

Locus ID:

NCBI: 84451
MIM: 614793
HGNC: 29798
Ensembl: ENSG00000143674

Variants:

dbSNP: 84451
ClinVar: 84451
TCGA: ENSG00000143674
COSMIC: MAP3K21

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000143674ENST00000366622Q5TCX8
ENSG00000143674ENST00000366623Q5TCX8
ENSG00000143674ENST00000366624Q5TCX8

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
MAPK (JNK) signalingKEGGhsa_M00688
MAPK (p38) signalingKEGGhsa_M00689
MAPK (JNK) signalingKEGGM00688
MAPK (p38) signalingKEGGM00689

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
268594592016Serine/Threonine Kinase MLK4 Determines Mesenchymal Identity in Glioma Stem Cells in an NF-κB-dependent Manner.52
216028442012MLK4 has negative effect on TLR4 signaling.14
233198082013Mixed lineage kinase MLK4 is activated in colorectal cancers where it synergistically cooperates with activated RAS signaling in driving tumorigenesis.8
287573532017Osmotic and heat stress-dependent regulation of MLK4β and MLK3 by the CHIP E3 ligase in ovarian cancer cells.1
305523842019Upregulation of MLK4 promotes migratory and invasive potential of breast cancer cells.0
310715762019Decrease of MLK4 prevents hepatocellular carcinoma (HCC) through reducing metastasis and inducing apoptosis regulated by ROS/MAPKs signaling.0

Citation

Dessen P

MAP3K21 (mitogen-activated protein kinase kinase kinase 21)

Atlas Genet Cytogenet Oncol Haematol. 2016-12-01

Online version: http://atlasgeneticsoncology.org/gene/56675/map3k21