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MAP3K21 (mitogen-activated protein kinase kinase kinase 21)

Identity

Other aliasKIAA1804
MLK4
dJ862P8.3
HGNC (Hugo) MAP3K21
LocusID (NCBI) 84451
Atlas_Id 56675
Location 1q42.2  [Link to chromosome band 1q42]
Location_base_pair Starts at 233463514 and ends at 233520894 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute


External links

Nomenclature
HGNC (Hugo)MAP3K21   29798
Cards
Entrez_Gene (NCBI)MAP3K21  84451  mitogen-activated protein kinase kinase kinase 21
AliasesKIAA1804; MLK4; dJ862P8.3
GeneCards (Weizmann)MAP3K21
Ensembl hg19 (Hinxton) [Gene_View]  chr1:233463514-233520894 [Contig_View]  MAP3K21 [Vega]
Ensembl hg38 (Hinxton) [Gene_View]  chr1:233463514-233520894 [Contig_View]  MAP3K21 [Vega]
TCGA cBioPortalMAP3K21
AceView (NCBI)MAP3K21
Genatlas (Paris)MAP3K21
WikiGenes84451
SOURCE (Princeton)MAP3K21
Genetics Home Reference (NIH)MAP3K21
Genomic and cartography
GoldenPath hg19 (UCSC)MAP3K21  -     chr1:233463514-233520894 +  1q42.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAP3K21  -     1q42.2   [Description]    (hg38-Dec_2013)
EnsemblMAP3K21 - 1q42.2 [CytoView hg19]  MAP3K21 - 1q42.2 [CytoView hg38]
Mapping of homologs : NCBIMAP3K21 [Mapview hg19]  MAP3K21 [Mapview hg38]
OMIM614793   
Gene and transcription
Genbank (Entrez)AB058707 AJ311797 AJ311798 AK309811 BC136648
RefSeq transcript (Entrez)NM_032435
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP3K21
Cluster EST : UnigeneHs.547779 [ NCBI ]
CGAP (NCI)Hs.547779
Gene ExpressionMAP3K21 [ NCBI-GEO ]   MAP3K21 [ EBI - ARRAY_EXPRESS ]   MAP3K21 [ SEEK ]   MAP3K21 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K21 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84451
GTEX Portal (Tissue expression)MAP3K21
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ5TCX8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ5TCX8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ5TCX8
Splice isoforms : SwissVarQ5TCX8
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
PhosPhoSitePlusQ5TCX8
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom    MLK1/MLK2/MLK4    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_kinase_AS    SH3_domain   
Domain families : Pfam (Sanger)Pkinase_Tyr (PF07714)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam07714    pfam14604   
Domain families : Smart (EMBL)S_TKc (SM00220)  SH3 (SM00326)  
Conserved Domain (NCBI)MAP3K21
DMDM Disease mutations84451
Blocks (Seattle)MAP3K21
PDB (SRS)4UYA   
PDB (PDBSum)4UYA   
PDB (IMB)4UYA   
PDB (RSDB)4UYA   
Structural Biology KnowledgeBase4UYA   
SCOP (Structural Classification of Proteins)4UYA   
CATH (Classification of proteins structures)4UYA   
SuperfamilyQ5TCX8
Peptide AtlasQ5TCX8
IPIIPI00142487   IPI00607875   IPI00607654   
Protein Interaction databases
DIP (DOE-UCLA)Q5TCX8
IntAct (EBI)Q5TCX8
BioGRIDMAP3K21
STRING (EMBL)MAP3K21
ZODIACMAP3K21
Ontologies - Pathways
QuickGOQ5TCX8
Ontology : AmiGOJUN kinase kinase kinase activity  protein binding  ATP binding  cellular_component  cytoplasm  protein phosphorylation  activation of JNKK activity  activation of JUN kinase activity  activation of JUN kinase activity  protein homodimerization activity  protein autophosphorylation  
Ontology : EGO-EBIJUN kinase kinase kinase activity  protein binding  ATP binding  cellular_component  cytoplasm  protein phosphorylation  activation of JNKK activity  activation of JUN kinase activity  activation of JUN kinase activity  protein homodimerization activity  protein autophosphorylation  
NDEx NetworkMAP3K21
Atlas of Cancer Signalling NetworkMAP3K21
Wikipedia pathwaysMAP3K21
Orthology - Evolution
OrthoDB84451
Phylogenetic Trees/Animal Genes : TreeFamMAP3K21
HOVERGENQ5TCX8
HOGENOMQ5TCX8
Homologs : HomoloGeneMAP3K21
Homology/Alignments : Family Browser (UCSC)MAP3K21
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K21 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K21
dbVarMAP3K21
ClinVarMAP3K21
1000_GenomesMAP3K21 
Exome Variant ServerMAP3K21
ExAC (Exome Aggregation Consortium)MAP3K21 (select the gene name)
Genetic variants : HAPMAP84451
Genomic Variants (DGV)MAP3K21 [DGVbeta]
DECIPHER (Syndromes)1:233463514-233520894  
CONAN: Copy Number AnalysisMAP3K21 
Mutations
ICGC Data PortalMAP3K21 
TCGA Data PortalMAP3K21 
Broad Tumor PortalMAP3K21
OASIS PortalMAP3K21 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDMAP3K21
BioMutasearch MAP3K21
DgiDB (Drug Gene Interaction Database)MAP3K21
DoCM (Curated mutations)MAP3K21 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K21 (select a term)
intoGenMAP3K21
Cancer3DMAP3K21(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM614793   
Orphanet
MedgenMAP3K21
Genetic Testing Registry MAP3K21
NextProtQ5TCX8 [Medical]
TSGene84451
GENETestsMAP3K21
Huge Navigator MAP3K21 [HugePedia]
snp3D : Map Gene to Disease84451
BioCentury BCIQMAP3K21
ClinGenMAP3K21
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84451
Clinical trialMAP3K21
Miscellaneous
canSAR (ICR)MAP3K21 (select the gene name)
Probes
Litterature
PubMed14 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K21
EVEXMAP3K21
GoPubMedMAP3K21
iHOPMAP3K21
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:14:24 CET 2017

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