Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MAP3K3 (mitogen-activated protein kinase kinase kinase 3)

Identity

Alias_namesMEKK3
Alias_symbol (synonym)MAPKKK3
Other alias
HGNC (Hugo) MAP3K3
LocusID (NCBI) 4215
Atlas_Id 41280
Location 17q23.3  [Link to chromosome band 17q23]
Location_base_pair Starts at 63622425 and ends at 63696310 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
BCAS3 (17q23.2) / MAP3K3 (17q23.3)KDM2A (11q13.2) / MAP3K3 (17q23.3)MAP3K3 (17q23.3) / LRRC37A3 (17q24.1)
MAP3K3 (17q23.3) / STRN3 (14q12)MAP3K3 (17q23.3) / TNS3 (7p12.3)MRC2 (17q23.2) / MAP3K3 (17q23.3)
MYO15B (17q25.1) / MAP3K3 (17q23.3)STRN3 (14q12) / MAP3K3 (17q23.3)TNS3 (7p12.3) / MAP3K3 (17q23.3)
USP32 (17q23.1) / MAP3K3 (17q23.3)KDM2A 11q13.2 / MAP3K3 17q23.3USP32 17q23.1 / MAP3K3 17q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)MAP3K3   6855
Cards
Entrez_Gene (NCBI)MAP3K3  4215  mitogen-activated protein kinase kinase kinase 3
AliasesMAPKKK3; MEKK3
GeneCards (Weizmann)MAP3K3
Ensembl hg19 (Hinxton)ENSG00000198909 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198909 [Gene_View]  chr17:63622425-63696310 [Contig_View]  MAP3K3 [Vega]
ICGC DataPortalENSG00000198909
TCGA cBioPortalMAP3K3
AceView (NCBI)MAP3K3
Genatlas (Paris)MAP3K3
WikiGenes4215
SOURCE (Princeton)MAP3K3
Genetics Home Reference (NIH)MAP3K3
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K3  -     chr17:63622425-63696310 +  17q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K3  -     17q23.3   [Description]    (hg19-Feb_2009)
EnsemblMAP3K3 - 17q23.3 [CytoView hg19]  MAP3K3 - 17q23.3 [CytoView hg38]
Mapping of homologs : NCBIMAP3K3 [Mapview hg19]  MAP3K3 [Mapview hg38]
OMIM602539   
Gene and transcription
Genbank (Entrez)AF172823 AK022333 AK225784 AK308152 AK315305
RefSeq transcript (Entrez)NM_001330431 NM_002401 NM_203351
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP3K3
Cluster EST : UnigeneHs.29282 [ NCBI ]
CGAP (NCI)Hs.29282
Alternative Splicing GalleryENSG00000198909
Gene ExpressionMAP3K3 [ NCBI-GEO ]   MAP3K3 [ EBI - ARRAY_EXPRESS ]   MAP3K3 [ SEEK ]   MAP3K3 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4215
GTEX Portal (Tissue expression)MAP3K3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99759   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99759  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99759
Splice isoforms : SwissVarQ99759
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
PhosPhoSitePlusQ99759
Domaine pattern : Prosite (Expaxy)PB1 (PS51745)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom    PB1_dom    Prot_kinase_dom   
Domain families : Pfam (Sanger)PB1 (PF00564)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00564    pfam00069   
Domain families : Smart (EMBL)PB1 (SM00666)  S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K3
DMDM Disease mutations4215
Blocks (Seattle)MAP3K3
PDB (SRS)2C60    2JRH    2O2V    2PPH    4Y5O    4YL6   
PDB (PDBSum)2C60    2JRH    2O2V    2PPH    4Y5O    4YL6   
PDB (IMB)2C60    2JRH    2O2V    2PPH    4Y5O    4YL6   
PDB (RSDB)2C60    2JRH    2O2V    2PPH    4Y5O    4YL6   
Structural Biology KnowledgeBase2C60    2JRH    2O2V    2PPH    4Y5O    4YL6   
SCOP (Structural Classification of Proteins)2C60    2JRH    2O2V    2PPH    4Y5O    4YL6   
CATH (Classification of proteins structures)2C60    2JRH    2O2V    2PPH    4Y5O    4YL6   
SuperfamilyQ99759
Human Protein AtlasENSG00000198909
Peptide AtlasQ99759
HPRD03965
IPIIPI00017801   IPI00181703   
Protein Interaction databases
DIP (DOE-UCLA)Q99759
IntAct (EBI)Q99759
FunCoupENSG00000198909
BioGRIDMAP3K3
STRING (EMBL)MAP3K3
ZODIACMAP3K3
Ontologies - Pathways
QuickGOQ99759
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  blood vessel development  protein kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytoplasm  cytosol  actin cytoskeleton organization  intracellular signal transduction  positive regulation of I-kappaB kinase/NF-kappaB signaling  protein autophosphorylation  metal ion binding  positive regulation of p38MAPK cascade  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  blood vessel development  protein kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytoplasm  cytosol  actin cytoskeleton organization  intracellular signal transduction  positive regulation of I-kappaB kinase/NF-kappaB signaling  protein autophosphorylation  metal ion binding  positive regulation of p38MAPK cascade  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Neurotrophin signaling pathway    GnRH signaling pathway    HTLV-I infection   
NDEx NetworkMAP3K3
Atlas of Cancer Signalling NetworkMAP3K3
Wikipedia pathwaysMAP3K3
Orthology - Evolution
OrthoDB4215
GeneTree (enSembl)ENSG00000198909
Phylogenetic Trees/Animal Genes : TreeFamMAP3K3
HOVERGENQ99759
HOGENOMQ99759
Homologs : HomoloGeneMAP3K3
Homology/Alignments : Family Browser (UCSC)MAP3K3
Gene fusions - Rearrangements
Fusion : MitelmanBCAS3/MAP3K3 [17q23.2/17q23.3]  [t(17;17)(q23;q23)]  
Fusion : MitelmanKDM2A/MAP3K3 [11q13.2/17q23.3]  [t(11;17)(q13;q23)]  
Fusion : MitelmanMAP3K3/TNS3 [17q23.3/7p12.3]  [t(7;17)(p12;q23)]  
Fusion : MitelmanMYO15B/MAP3K3 [17q25.1/17q23.3]  [t(17;17)(q23;q25)]  
Fusion : MitelmanTNS3/MAP3K3 [7p12.3/17q23.3]  [t(7;17)(p12;q23)]  
Fusion : MitelmanUSP32/MAP3K3 [17q23.1/17q23.3]  [t(17;17)(q23;q23)]  
Fusion: TCGAKDM2A 11q13.2 MAP3K3 17q23.3 BRCA
Fusion: TCGAUSP32 17q23.1 MAP3K3 17q23.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K3
dbVarMAP3K3
ClinVarMAP3K3
1000_GenomesMAP3K3 
Exome Variant ServerMAP3K3
ExAC (Exome Aggregation Consortium)MAP3K3 (select the gene name)
Genetic variants : HAPMAP4215
Genomic Variants (DGV)MAP3K3 [DGVbeta]
DECIPHERMAP3K3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K3 
Mutations
ICGC Data PortalMAP3K3 
TCGA Data PortalMAP3K3 
Broad Tumor PortalMAP3K3
OASIS PortalMAP3K3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP3K3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP3K3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP3K3
DgiDB (Drug Gene Interaction Database)MAP3K3
DoCM (Curated mutations)MAP3K3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K3 (select a term)
intoGenMAP3K3
Cancer3DMAP3K3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602539   
Orphanet
MedgenMAP3K3
Genetic Testing Registry MAP3K3
NextProtQ99759 [Medical]
TSGene4215
GENETestsMAP3K3
Target ValidationMAP3K3
Huge Navigator MAP3K3 [HugePedia]
snp3D : Map Gene to Disease4215
BioCentury BCIQMAP3K3
ClinGenMAP3K3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4215
Chemical/Pharm GKB GenePA30599
Clinical trialMAP3K3
Miscellaneous
canSAR (ICR)MAP3K3 (select the gene name)
Probes
Litterature
PubMed83 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K3
EVEXMAP3K3
GoPubMedMAP3K3
iHOPMAP3K3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:42:12 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.