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MAP3K3 (mitogen-activated protein kinase kinase kinase 3)

Identity

Alias (NCBI)MAPKKK3
MEKK3
HGNC (Hugo) MAP3K3
HGNC Alias symbMAPKKK3
HGNC Alias nameMAP/ERK kinase kinase 3
 MAPK/ERK kinase kinase 3
HGNC Previous nameMEKK3
LocusID (NCBI) 4215
Atlas_Id 41280
Location 17q23.3  [Link to chromosome band 17q23]
Location_base_pair Starts at 63622417 and ends at 63696305 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
BCAS3 (17q23.2) / MAP3K3 (17q23.3)KDM2A (11q13.2) / MAP3K3 (17q23.3)MAP3K3 (17q23.3) / LRRC37A3 (17q24.1)
MAP3K3 (17q23.3) / STRN3 (14q12)MAP3K3 (17q23.3) / TNS3 (7p12.3)MRC2 (17q23.2) / MAP3K3 (17q23.3)
MYO15B (17q25.1) / MAP3K3 (17q23.3)STRN3 (14q12) / MAP3K3 (17q23.3)TNS3 (7p12.3) / MAP3K3 (17q23.3)
USP32 (17q23.1) / MAP3K3 (17q23.3)KDM2A 11q13.2 / MAP3K3 17q23.3USP32 17q23.1 / MAP3K3 17q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MAP3K3   6855
Cards
Entrez_Gene (NCBI)MAP3K3    mitogen-activated protein kinase kinase kinase 3
AliasesMAPKKK3; MEKK3
GeneCards (Weizmann)MAP3K3
Ensembl hg19 (Hinxton)ENSG00000198909 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000198909 [Gene_View]  ENSG00000198909 [Sequence]  chr17:63622417-63696305 [Contig_View]  MAP3K3 [Vega]
ICGC DataPortalENSG00000198909
TCGA cBioPortalMAP3K3
AceView (NCBI)MAP3K3
Genatlas (Paris)MAP3K3
SOURCE (Princeton)MAP3K3
Genetics Home Reference (NIH)MAP3K3
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K3  -     chr17:63622417-63696305 +  17q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K3  -     17q23.3   [Description]    (hg19-Feb_2009)
GoldenPathMAP3K3 - 17q23.3 [CytoView hg19]  MAP3K3 - 17q23.3 [CytoView hg38]
ImmunoBaseENSG00000198909
Genome Data Viewer NCBIMAP3K3 [Mapview hg19]  
OMIM602539   
Gene and transcription
Genbank (Entrez)AF172823 AK022333 AK225784 AK308152 AK315305
RefSeq transcript (Entrez)NM_001330431 NM_001363768 NM_002401 NM_203351
Consensus coding sequences : CCDS (NCBI)MAP3K3
Gene ExpressionMAP3K3 [ NCBI-GEO ]   MAP3K3 [ EBI - ARRAY_EXPRESS ]   MAP3K3 [ SEEK ]   MAP3K3 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K3 [ Firebrowse - Broad ]
GenevisibleExpression of MAP3K3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4215
GTEX Portal (Tissue expression)MAP3K3
Human Protein AtlasENSG00000198909-MAP3K3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99759   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99759  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99759
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ99759
Domaine pattern : Prosite (Expaxy)PB1 (PS51745)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom_sf    PB1_dom    PB1_MEKK2/3    Prot_kinase_dom   
Domain families : Pfam (Sanger)PB1 (PF00564)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00564    pfam00069   
Domain families : Smart (EMBL)PB1 (SM00666)  S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K3
PDB (RSDB)2C60    2JRH    2O2V    2PPH    4Y5O    4YL6   
PDB Europe2C60    2JRH    2O2V    2PPH    4Y5O    4YL6   
PDB (PDBSum)2C60    2JRH    2O2V    2PPH    4Y5O    4YL6   
PDB (IMB)2C60    2JRH    2O2V    2PPH    4Y5O    4YL6   
Structural Biology KnowledgeBase2C60    2JRH    2O2V    2PPH    4Y5O    4YL6   
SCOP (Structural Classification of Proteins)2C60    2JRH    2O2V    2PPH    4Y5O    4YL6   
CATH (Classification of proteins structures)2C60    2JRH    2O2V    2PPH    4Y5O    4YL6   
SuperfamilyQ99759
AlphaFold pdb e-kbQ99759   
Human Protein Atlas [tissue]ENSG00000198909-MAP3K3 [tissue]
HPRD03965
Protein Interaction databases
DIP (DOE-UCLA)Q99759
IntAct (EBI)Q99759
BioGRIDMAP3K3
STRING (EMBL)MAP3K3
ZODIACMAP3K3
Ontologies - Pathways
QuickGOQ99759
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  blood vessel development  protein kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytosol  intracellular signal transduction  positive regulation of I-kappaB kinase/NF-kappaB signaling  protein autophosphorylation  metal ion binding  interleukin-1-mediated signaling pathway  positive regulation of cell proliferation in bone marrow  positive regulation of cell migration involved in sprouting angiogenesis  protein serine kinase activity  protein threonine kinase activity  positive regulation of p38MAPK cascade  negative regulation of cellular senescence  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  blood vessel development  protein kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytosol  intracellular signal transduction  positive regulation of I-kappaB kinase/NF-kappaB signaling  protein autophosphorylation  metal ion binding  interleukin-1-mediated signaling pathway  positive regulation of cell proliferation in bone marrow  positive regulation of cell migration involved in sprouting angiogenesis  protein serine kinase activity  protein threonine kinase activity  positive regulation of p38MAPK cascade  negative regulation of cellular senescence  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Neurotrophin signaling pathway    GnRH signaling pathway    HTLV-I infection   
NDEx NetworkMAP3K3
Atlas of Cancer Signalling NetworkMAP3K3
Wikipedia pathwaysMAP3K3
Orthology - Evolution
OrthoDB4215
GeneTree (enSembl)ENSG00000198909
Phylogenetic Trees/Animal Genes : TreeFamMAP3K3
Homologs : HomoloGeneMAP3K3
Homology/Alignments : Family Browser (UCSC)MAP3K3
Gene fusions - Rearrangements
Fusion : MitelmanBCAS3/MAP3K3 [17q23.2/17q23.3]  
Fusion : MitelmanKDM2A/MAP3K3 [11q13.2/17q23.3]  
Fusion : MitelmanMAP3K3/TNS3 [17q23.3/7p12.3]  
Fusion : MitelmanMYO15B/MAP3K3 [17q25.1/17q23.3]  
Fusion : MitelmanTNS3/MAP3K3 [7p12.3/17q23.3]  
Fusion : MitelmanUSP32/MAP3K3 [17q23.1/17q23.3]  
Fusion : QuiverMAP3K3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K3
dbVarMAP3K3
ClinVarMAP3K3
MonarchMAP3K3
1000_GenomesMAP3K3 
Exome Variant ServerMAP3K3
GNOMAD BrowserENSG00000198909
Varsome BrowserMAP3K3
ACMGMAP3K3 variants
VarityQ99759
Genomic Variants (DGV)MAP3K3 [DGVbeta]
DECIPHERMAP3K3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K3 
Mutations
ICGC Data PortalMAP3K3 
TCGA Data PortalMAP3K3 
Broad Tumor PortalMAP3K3
OASIS PortalMAP3K3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP3K3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAP3K3
Mutations and Diseases : HGMDMAP3K3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMAP3K3
DgiDB (Drug Gene Interaction Database)MAP3K3
DoCM (Curated mutations)MAP3K3
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K3
Cancer3DMAP3K3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602539   
Orphanet
DisGeNETMAP3K3
MedgenMAP3K3
Genetic Testing Registry MAP3K3
NextProtQ99759 [Medical]
GENETestsMAP3K3
Target ValidationMAP3K3
Huge Navigator MAP3K3 [HugePedia]
ClinGenMAP3K3
Clinical trials, drugs, therapy
MyCancerGenomeMAP3K3
Protein Interactions : CTDMAP3K3
Pharm GKB GenePA30599
PharosQ99759
Clinical trialMAP3K3
Miscellaneous
canSAR (ICR)MAP3K3
HarmonizomeMAP3K3
DataMed IndexMAP3K3
Probes
Litterature
PubMed101 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMAP3K3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:17:43 CEST 2021

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