Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MAP3K4 (mitogen-activated protein kinase kinase kinase 4)

Identity

Alias_namesMEKK4
Alias_symbol (synonym)MTK1
MAPKKK4
KIAA0213
Other aliasMEKK 4
PRO0412
HGNC (Hugo) MAP3K4
LocusID (NCBI) 4216
Atlas_Id 41281
Location 6q26  [Link to chromosome band 6q26]
Location_base_pair Starts at 160991727 and ends at 161117385 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
FBLN1 (22q13.31) / MAP3K4 (6q26)MAP3K4 (6q26) / FNDC1 (6q25.3)MAP3K4 (6q26) / METTL24 (6q21)
MAP3K4 6q26 C6orf186MAP3K4 6q26 / FNDC1 6q25.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;6)(q25;q26) MAP3K4/FNDC1

External links

Nomenclature
HGNC (Hugo)MAP3K4   6856
Cards
Entrez_Gene (NCBI)MAP3K4  4216  mitogen-activated protein kinase kinase kinase 4
AliasesMAPKKK4; MEKK; MEKK4; MTK1; 
PRO0412
GeneCards (Weizmann)MAP3K4
Ensembl hg19 (Hinxton)ENSG00000085511 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000085511 [Gene_View]  ENSG00000085511 [Sequence]  chr6:160991727-161117385 [Contig_View]  MAP3K4 [Vega]
ICGC DataPortalENSG00000085511
TCGA cBioPortalMAP3K4
AceView (NCBI)MAP3K4
Genatlas (Paris)MAP3K4
WikiGenes4216
SOURCE (Princeton)MAP3K4
Genetics Home Reference (NIH)MAP3K4
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K4  -     chr6:160991727-161117385 +  6q26   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K4  -     6q26   [Description]    (hg19-Feb_2009)
GoldenPathMAP3K4 - 6q26 [CytoView hg19]  MAP3K4 - 6q26 [CytoView hg38]
Genome Data Viewer NCBIMAP3K4 [Mapview hg19]  
OMIM602425   
Gene and transcription
Genbank (Entrez)AA314177 AF002715 AF116604 AK124430 AK307866
RefSeq transcript (Entrez)NM_001291958 NM_001301072 NM_001363582 NM_005922 NM_006724
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP3K4
Alternative Splicing GalleryENSG00000085511
Gene ExpressionMAP3K4 [ NCBI-GEO ]   MAP3K4 [ EBI - ARRAY_EXPRESS ]   MAP3K4 [ SEEK ]   MAP3K4 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K4 [ Firebrowse - Broad ]
GenevisibleExpression of MAP3K4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4216
GTEX Portal (Tissue expression)MAP3K4
Human Protein AtlasENSG00000085511-MAP3K4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6R4   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6R4  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6R4
Splice isoforms : SwissVarQ9Y6R4
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ9Y6R4
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K4
DMDM Disease mutations4216
SuperfamilyQ9Y6R4
Human Protein Atlas [tissue]ENSG00000085511-MAP3K4 [tissue]
Peptide AtlasQ9Y6R4
HPRD03886
IPIIPI00186536   IPI01012754   IPI00935603   IPI00386260   IPI01011035   IPI01012282   IPI00979004   IPI01009698   IPI01015947   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6R4
IntAct (EBI)Q9Y6R4
FunCoupENSG00000085511
BioGRIDMAP3K4
STRING (EMBL)MAP3K4
ZODIACMAP3K4
Ontologies - Pathways
QuickGOQ9Y6R4
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  placenta development  MAP kinase kinase kinase activity  protein binding  ATP binding  cytoplasm  response to UV-C  regulation of gene expression  male germ-line sex determination  positive regulation of telomere maintenance via telomerase  intracellular signal transduction  positive regulation of JUN kinase activity  metal ion binding  perinuclear region of cytoplasm  positive regulation of telomerase activity  chorionic trophoblast cell differentiation  positive regulation of p38MAPK cascade  positive regulation of telomere capping  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  placenta development  MAP kinase kinase kinase activity  protein binding  ATP binding  cytoplasm  response to UV-C  regulation of gene expression  male germ-line sex determination  positive regulation of telomere maintenance via telomerase  intracellular signal transduction  positive regulation of JUN kinase activity  metal ion binding  perinuclear region of cytoplasm  positive regulation of telomerase activity  chorionic trophoblast cell differentiation  positive regulation of p38MAPK cascade  positive regulation of telomere capping  
Pathways : KEGGMAPK signaling pathway    GnRH signaling pathway   
NDEx NetworkMAP3K4
Atlas of Cancer Signalling NetworkMAP3K4
Wikipedia pathwaysMAP3K4
Orthology - Evolution
OrthoDB4216
GeneTree (enSembl)ENSG00000085511
Phylogenetic Trees/Animal Genes : TreeFamMAP3K4
HOGENOMQ9Y6R4
Homologs : HomoloGeneMAP3K4
Homology/Alignments : Family Browser (UCSC)MAP3K4
Gene fusions - Rearrangements
Fusion : MitelmanMAP3K4/FNDC1 [6q26/6q25.3]  
Fusion PortalMAP3K4 6q26 C6orf186 LGG
Fusion PortalMAP3K4 6q26 FNDC1 6q25.3 BRCA
Fusion : QuiverMAP3K4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K4
dbVarMAP3K4
ClinVarMAP3K4
1000_GenomesMAP3K4 
Exome Variant ServerMAP3K4
GNOMAD BrowserENSG00000085511
Varsome BrowserMAP3K4
Genetic variants : HAPMAP4216
Genomic Variants (DGV)MAP3K4 [DGVbeta]
DECIPHERMAP3K4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K4 
Mutations
ICGC Data PortalMAP3K4 
TCGA Data PortalMAP3K4 
Broad Tumor PortalMAP3K4
OASIS PortalMAP3K4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP3K4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAP3K4
Mutations and Diseases : HGMDMAP3K4
intOGen PortalMAP3K4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect MAP3K4
DgiDB (Drug Gene Interaction Database)MAP3K4
DoCM (Curated mutations)MAP3K4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K4 (select a term)
intoGenMAP3K4
Cancer3DMAP3K4 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602425   
Orphanet
DisGeNETMAP3K4
MedgenMAP3K4
Genetic Testing Registry MAP3K4
NextProtQ9Y6R4 [Medical]
TSGene4216
GENETestsMAP3K4
Open Targets GeneticsENSG00000085511  [validation]
snp3D : Map Gene to Disease4216
BioCentury BCIQMAP3K4
ClinGenMAP3K4
Clinical trials, drugs, therapy
Protein Interactions : CTD4216
Pharm GKB GenePA30600
Clinical trialMAP3K4
Miscellaneous
canSAR (ICR)MAP3K4 (select the gene name)
HarmonizomeMAP3K4
DataMed IndexMAP3K4
Probes
Litterature
PubMed53 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K4
EVEXMAP3K4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 19:57:13 CEST 2020
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