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MAP3K5 (mitogen-activated protein kinase kinase kinase 5)

Identity

Alias_namesMEKK5
Alias_symbol (synonym)MAPKKK5
ASK1
Other alias
HGNC (Hugo) MAP3K5
LocusID (NCBI) 4217
Atlas_Id 41282
Location 6q23.3  [Link to chromosome band 6q23]
Location_base_pair Starts at 136557049 and ends at 136792518 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ALDH5A1 (6p22.3) / MAP3K5 (6q23.3)FTL (19q13.33) / MAP3K5 (6q23.3)KMT2A (11q23.3) / MAP3K5 (6q23.3)
MAP3K5 (6q23.3) / ARFIP1 (4q31.3)MAP3K5 (6q23.3) / CLVS2 (6q22.31)MAP3K5 (6q23.3) / MAP3K5 (6q23.3)
MAP3K5 (6q23.3) / NKAIN2 (6q22.31)MAP3K5 (6q23.3) / PERP (6q23.3)MAP3K5 (6q23.3) / TCF12 (15q21.3)
MAP7 (6q23.3) / MAP3K5 (6q23.3)PSAP (10q22.1) / MAP3K5 (6q23.3)ALDH5A1 6p22.3 / MAP3K5 6q23.3
MAP3K5 6q23.3 / ARFIP1 4q31.3MAP3K5 6q23.3 / CLVS2 6q22.31MAP3K5 6q23.3 / NKAIN2 6q22.31
MAP3K5 6q23.3 / PERP 6q23.3MAP7 6q23.3 / MAP3K5 6q23.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;11)(q23;q23) KMT2A/MAP3K5


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 8 ]
  t(4;6)(q31;q23) MAP3K5/ARFIP1
t(6;6)(p22;q23) ALDH5A1/MAP3K5
t(6;6)(q21;q23) MAP3K5/NKAIN2
t(6;6)(q22;q23) MAP3K5/CLVS2
MAP3K5/PERP (6q23)
MAP7/MAP3K5 (6q23)
t(6;9)(q23;p22) MAP3K5/NFIB
t(6;15)(q23;q21) MAP3K5/TCF12


External links

Nomenclature
HGNC (Hugo)MAP3K5   6857
Cards
Entrez_Gene (NCBI)MAP3K5  4217  mitogen-activated protein kinase kinase kinase 5
AliasesASK1; MAPKKK5; MEKK5
GeneCards (Weizmann)MAP3K5
Ensembl hg19 (Hinxton)ENSG00000197442 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197442 [Gene_View]  ENSG00000197442 [Sequence]  chr6:136557049-136792518 [Contig_View]  MAP3K5 [Vega]
ICGC DataPortalENSG00000197442
TCGA cBioPortalMAP3K5
AceView (NCBI)MAP3K5
Genatlas (Paris)MAP3K5
WikiGenes4217
SOURCE (Princeton)MAP3K5
Genetics Home Reference (NIH)MAP3K5
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K5  -     chr6:136557049-136792518 -  6q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K5  -     6q23.3   [Description]    (hg19-Feb_2009)
EnsemblMAP3K5 - 6q23.3 [CytoView hg19]  MAP3K5 - 6q23.3 [CytoView hg38]
Mapping of homologs : NCBIMAP3K5 [Mapview hg19]  MAP3K5 [Mapview hg38]
OMIM602448   
Gene and transcription
Genbank (Entrez)AB209093 AK293953 AK294507 AK310942 BC054503
RefSeq transcript (Entrez)NM_005923
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP3K5
Cluster EST : UnigeneHs.186486 [ NCBI ]
CGAP (NCI)Hs.186486
Alternative Splicing GalleryENSG00000197442
Gene ExpressionMAP3K5 [ NCBI-GEO ]   MAP3K5 [ EBI - ARRAY_EXPRESS ]   MAP3K5 [ SEEK ]   MAP3K5 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K5 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4217
GTEX Portal (Tissue expression)MAP3K5
Human Protein AtlasENSG00000197442-MAP3K5 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99683   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ99683  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ99683
Splice isoforms : SwissVarQ99683
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
PhosPhoSitePlusQ99683
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)DUF4071    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    SAM/pointed_sf    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)DUF4071 (PF13281)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam13281    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K5
DMDM Disease mutations4217
Blocks (Seattle)MAP3K5
PDB (SRS)2CLQ    3VW6    4BF2    4BHN    4BIB    4BIC    4BID    4BIE    5ULM    5UOR    5UOX    5UP3    5V19    5V24    5VIL    5VIO    6EJL   
PDB (PDBSum)2CLQ    3VW6    4BF2    4BHN    4BIB    4BIC    4BID    4BIE    5ULM    5UOR    5UOX    5UP3    5V19    5V24    5VIL    5VIO    6EJL   
PDB (IMB)2CLQ    3VW6    4BF2    4BHN    4BIB    4BIC    4BID    4BIE    5ULM    5UOR    5UOX    5UP3    5V19    5V24    5VIL    5VIO    6EJL   
PDB (RSDB)2CLQ    3VW6    4BF2    4BHN    4BIB    4BIC    4BID    4BIE    5ULM    5UOR    5UOX    5UP3    5V19    5V24    5VIL    5VIO    6EJL   
Structural Biology KnowledgeBase2CLQ    3VW6    4BF2    4BHN    4BIB    4BIC    4BID    4BIE    5ULM    5UOR    5UOX    5UP3    5V19    5V24    5VIL    5VIO    6EJL   
SCOP (Structural Classification of Proteins)2CLQ    3VW6    4BF2    4BHN    4BIB    4BIC    4BID    4BIE    5ULM    5UOR    5UOX    5UP3    5V19    5V24    5VIL    5VIO    6EJL   
CATH (Classification of proteins structures)2CLQ    3VW6    4BF2    4BHN    4BIB    4BIC    4BID    4BIE    5ULM    5UOR    5UOX    5UP3    5V19    5V24    5VIL    5VIO    6EJL   
SuperfamilyQ99683
Human Protein Atlas [tissue]ENSG00000197442-MAP3K5 [tissue]
Peptide AtlasQ99683
HPRD03904
IPIIPI00412433   IPI00479216   IPI00748581   
Protein Interaction databases
DIP (DOE-UCLA)Q99683
IntAct (EBI)Q99683
FunCoupENSG00000197442
BioGRIDMAP3K5
STRING (EMBL)MAP3K5
ZODIACMAP3K5
Ontologies - Pathways
QuickGOQ99683
Ontology : AmiGOMAPK cascade  activation of MAPKK activity  activation of MAPKK activity  magnesium ion binding  response to ischemia  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytosol  protein phosphorylation  JNK cascade  activation of JUN kinase activity  intrinsic apoptotic signaling pathway in response to oxidative stress  intrinsic apoptotic signaling pathway in response to oxidative stress  external side of plasma membrane  positive regulation of cardiac muscle cell apoptotic process  viral process  protein kinase binding  protein phosphatase binding  protein domain specific binding  protein-containing complex  cellular response to amino acid starvation  response to endoplasmic reticulum stress  p38MAPK cascade  wound healing  identical protein binding  protein homodimerization activity  positive regulation of apoptotic process  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of JUN kinase activity  innate immune response  positive regulation of myoblast differentiation  positive regulation of transcription, DNA-templated  positive regulation of JNK cascade  stress-activated MAPK cascade  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  cellular response to hydrogen peroxide  cellular response to tumor necrosis factor  endothelial cell apoptotic process  apoptotic signaling pathway  programmed necrotic cell death  positive regulation of p38MAPK cascade  positive regulation of neuron death  positive regulation of neuron death  cellular response to reactive nitrogen species  protein kinase complex  positive regulation of vascular smooth muscle cell proliferation  IRE1-TRAF2-ASK1 complex  
Ontology : EGO-EBIMAPK cascade  activation of MAPKK activity  activation of MAPKK activity  magnesium ion binding  response to ischemia  protein kinase activity  protein kinase activity  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytosol  protein phosphorylation  JNK cascade  activation of JUN kinase activity  intrinsic apoptotic signaling pathway in response to oxidative stress  intrinsic apoptotic signaling pathway in response to oxidative stress  external side of plasma membrane  positive regulation of cardiac muscle cell apoptotic process  viral process  protein kinase binding  protein phosphatase binding  protein domain specific binding  protein-containing complex  cellular response to amino acid starvation  response to endoplasmic reticulum stress  p38MAPK cascade  wound healing  identical protein binding  protein homodimerization activity  positive regulation of apoptotic process  positive regulation of cysteine-type endopeptidase activity involved in apoptotic process  positive regulation of JUN kinase activity  innate immune response  positive regulation of myoblast differentiation  positive regulation of transcription, DNA-templated  positive regulation of JNK cascade  stress-activated MAPK cascade  intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress  cellular response to hydrogen peroxide  cellular response to tumor necrosis factor  endothelial cell apoptotic process  apoptotic signaling pathway  programmed necrotic cell death  positive regulation of p38MAPK cascade  positive regulation of neuron death  positive regulation of neuron death  cellular response to reactive nitrogen species  protein kinase complex  positive regulation of vascular smooth muscle cell proliferation  IRE1-TRAF2-ASK1 complex  
Pathways : KEGGMAPK signaling pathway    Protein processing in endoplasmic reticulum    TNF signaling pathway    Neurotrophin signaling pathway    Non-alcoholic fatty liver disease (NAFLD)    Amyotrophic lateral sclerosis (ALS)   
NDEx NetworkMAP3K5
Atlas of Cancer Signalling NetworkMAP3K5
Wikipedia pathwaysMAP3K5
Orthology - Evolution
OrthoDB4217
GeneTree (enSembl)ENSG00000197442
Phylogenetic Trees/Animal Genes : TreeFamMAP3K5
HOVERGENQ99683
HOGENOMQ99683
Homologs : HomoloGeneMAP3K5
Homology/Alignments : Family Browser (UCSC)MAP3K5
Gene fusions - Rearrangements
Fusion : MitelmanALDH5A1/MAP3K5 [6p22.3/6q23.3]  [t(6;6)(p22;q23)]  
Fusion : MitelmanMAP3K5/ARFIP1 [6q23.3/4q31.3]  [t(4;6)(q31;q23)]  
Fusion : MitelmanMAP3K5/CLVS2 [6q23.3/6q22.31]  [t(6;6)(q22;q23)]  
Fusion : MitelmanMAP3K5/NKAIN2 [6q23.3/6q22.31]  [t(6;6)(q21;q23)]  
Fusion : MitelmanMAP3K5/PERP [6q23.3/6q23.3]  [t(6;6)(q23;q23)]  
Fusion : MitelmanMAP3K5/TCF12 [6q23.3/15q21.3]  [t(6;15)(q23;q21)]  
Fusion : MitelmanMAP7/MAP3K5 [6q23.3/6q23.3]  [t(6;6)(q23;q23)]  
Fusion PortalALDH5A1 6p22.3 MAP3K5 6q23.3 LUAD
Fusion PortalMAP3K5 6q23.3 ARFIP1 4q31.3 HNSC
Fusion PortalMAP3K5 6q23.3 CLVS2 6q22.31 PRAD
Fusion PortalMAP3K5 6q23.3 NKAIN2 6q22.31 LUSC
Fusion PortalMAP3K5 6q23.3 PERP 6q23.3 BLCA
Fusion PortalMAP7 6q23.3 MAP3K5 6q23.3 PRAD
Fusion : QuiverMAP3K5
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K5 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K5
dbVarMAP3K5
ClinVarMAP3K5
1000_GenomesMAP3K5 
Exome Variant ServerMAP3K5
ExAC (Exome Aggregation Consortium)ENSG00000197442
GNOMAD BrowserENSG00000197442
Varsome BrowserMAP3K5
Genetic variants : HAPMAP4217
Genomic Variants (DGV)MAP3K5 [DGVbeta]
DECIPHERMAP3K5 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K5 
Mutations
ICGC Data PortalMAP3K5 
TCGA Data PortalMAP3K5 
Broad Tumor PortalMAP3K5
OASIS PortalMAP3K5 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP3K5  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP3K5
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)The Globin Gene Server
BioMutasearch MAP3K5
DgiDB (Drug Gene Interaction Database)MAP3K5
DoCM (Curated mutations)MAP3K5 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K5 (select a term)
intoGenMAP3K5
Cancer3DMAP3K5(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602448   
Orphanet
DisGeNETMAP3K5
MedgenMAP3K5
Genetic Testing Registry MAP3K5
NextProtQ99683 [Medical]
TSGene4217
GENETestsMAP3K5
Target ValidationMAP3K5
Huge Navigator MAP3K5 [HugePedia]
snp3D : Map Gene to Disease4217
BioCentury BCIQMAP3K5
ClinGenMAP3K5
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4217
Chemical/Pharm GKB GenePA30601
Clinical trialMAP3K5
Miscellaneous
canSAR (ICR)MAP3K5 (select the gene name)
Probes
Litterature
PubMed259 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K5
EVEXMAP3K5
GoPubMedMAP3K5
iHOPMAP3K5
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 6 11:18:49 CET 2018

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