MAP3K5 (mitogen-activated protein kinase kinase kinase 5)

2003-05-01  

Identity

HGNC
LOCATION
6q23.3
LOCUSID
ALIAS
ASK1,MAPKKK5,MEKK5
FUSION GENES

Other Information

Locus ID:

NCBI: 4217
MIM: 602448
HGNC: 6857
Ensembl: ENSG00000197442

Variants:

dbSNP: 4217
ClinVar: 4217
TCGA: ENSG00000197442
COSMIC: MAP3K5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197442ENST00000359015Q99683

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
ApoptosisKEGGko04210
Tight junctionKEGGko04530
Amyotrophic lateral sclerosis (ALS)KEGGko05014
MAPK signaling pathwayKEGGhsa04010
ApoptosisKEGGhsa04210
Tight junctionKEGGhsa04530
Amyotrophic lateral sclerosis (ALS)KEGGhsa05014
Neurotrophin signaling pathwayKEGGko04722
Neurotrophin signaling pathwayKEGGhsa04722
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
TNF signaling pathwayKEGGhsa04668
TNF signaling pathwayKEGGko04668
Non-alcoholic fatty liver disease (NAFLD)KEGGhsa04932
Non-alcoholic fatty liver disease (NAFLD)KEGGko04932
MAPK (JNK) signalingKEGGhsa_M00688
MAPK (p38) signalingKEGGhsa_M00689
MAPK (JNK) signalingKEGGM00688
MAPK (p38) signalingKEGGM00689
Sphingolipid signaling pathwayKEGGhsa04071
Sphingolipid signaling pathwayKEGGko04071
Cellular responses to stressREACTOMER-HSA-2262752
Cellular SenescenceREACTOMER-HSA-2559583
Oxidative Stress Induced SenescenceREACTOMER-HSA-2559580
Platinum drug resistanceKEGGko01524
Platinum drug resistanceKEGGhsa01524
Fluid shear stress and atherosclerosisKEGGko05418
Fluid shear stress and atherosclerosisKEGGhsa05418

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445833ThalassemiaDiseaseClinicalAnnotationassociatedPD23556445
PA449942hydroxyureaChemicalClinicalAnnotationassociatedPD23556445

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
178833302008Apoptosis signal-regulating kinase 1 in stress and immune response.83
221979302011Frequent somatic mutations in MAP3K5 and MAP3K9 in metastatic melanoma identified by exome sequencing.83
165320362006Inhibition of NADPH oxidase 4 activates apoptosis via the AKT/apoptosis signal-regulating kinase 1 pathway in pancreatic cancer PANC-1 cells.78
190013752009How does arrestin assemble MAPKs into a signaling complex?68
199038882009DAB2IP coordinates both PI3K-Akt and ASK1 pathways for cell survival and apoptosis.68
178273882007Genetic variation in 1253 immune and inflammation genes and risk of non-Hodgkin lymphoma.67
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
157821212005Hsp90-Akt phosphorylates ASK1 and inhibits ASK1-mediated apoptosis.61
182118882008Requirement of reactive oxygen species-dependent activation of ASK1-p38 MAPK pathway for extracellular ATP-induced apoptosis in macrophage.60

Citation

Dessen P

MAP3K5 (mitogen-activated protein kinase kinase kinase 5)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41282/map3k5