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MAP3K6 (mitogen-activated protein kinase kinase kinase 6)

Identity

Alias (NCBI)ASK2
MAPKKK6
MEKK6
HGNC (Hugo) MAP3K6
HGNC Alias symbMAPKKK6
ASK2
MEKK6
HGNC Alias nameapoptosis signal regulating kinase 2
LocusID (NCBI) 9064
Atlas_Id 43344
Location 1p36.11  [Link to chromosome band 1p36]
Location_base_pair Starts at 27355184 and ends at 27366961 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAP3K6 (1p36.11) / MAP3K6 (1p36.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

Nomenclature
HGNC (Hugo)MAP3K6   6858
LRG (Locus Reference Genomic)LRG_1086
Cards
Entrez_Gene (NCBI)MAP3K6    mitogen-activated protein kinase kinase kinase 6
AliasesASK2; MAPKKK6; MEKK6
GeneCards (Weizmann)MAP3K6
Ensembl hg19 (Hinxton)ENSG00000142733 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000142733 [Gene_View]  ENSG00000142733 [Sequence]  chr1:27355184-27366961 [Contig_View]  MAP3K6 [Vega]
ICGC DataPortalENSG00000142733
TCGA cBioPortalMAP3K6
AceView (NCBI)MAP3K6
Genatlas (Paris)MAP3K6
SOURCE (Princeton)MAP3K6
Genetics Home Reference (NIH)MAP3K6
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K6  -     chr1:27355184-27366961 -  1p36.11   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K6  -     1p36.11   [Description]    (hg19-Feb_2009)
GoldenPathMAP3K6 - 1p36.11 [CytoView hg19]  MAP3K6 - 1p36.11 [CytoView hg38]
ImmunoBaseENSG00000142733
genome Data Viewer NCBIMAP3K6 [Mapview hg19]  
OMIM604468   
Gene and transcription
Genbank (Entrez)AB167411 AB208805 AF100318 AI582755 AI658745
RefSeq transcript (Entrez)NM_001297609 NM_004672
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP3K6
Alternative Splicing GalleryENSG00000142733
Gene ExpressionMAP3K6 [ NCBI-GEO ]   MAP3K6 [ EBI - ARRAY_EXPRESS ]   MAP3K6 [ SEEK ]   MAP3K6 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K6 [ Firebrowse - Broad ]
GenevisibleExpression of MAP3K6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9064
GTEX Portal (Tissue expression)MAP3K6
Human Protein AtlasENSG00000142733-MAP3K6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95382   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95382  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95382
Splice isoforms : SwissVarO95382
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO95382
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)DUF4071    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    SAM/pointed_sf    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)DUF4071 (PF13281)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam13281    pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K6
Blocks (Seattle)MAP3K6
SuperfamilyO95382
Human Protein Atlas [tissue]ENSG00000142733-MAP3K6 [tissue]
Peptide AtlasO95382
HPRD05126
IPIIPI00418221   IPI00642537   IPI00847283   IPI00795936   
Protein Interaction databases
DIP (DOE-UCLA)O95382
IntAct (EBI)O95382
BioGRIDMAP3K6
STRING (EMBL)MAP3K6
ZODIACMAP3K6
Ontologies - Pathways
QuickGOO95382
Ontology : AmiGOactivation of MAPKK activity  magnesium ion binding  protein kinase activity  MAP kinase kinase kinase activity  MAP kinase kinase kinase activity  ATP binding  protein phosphorylation  signal transduction  activation of JUN kinase activity  cellular response to stress  
Ontology : EGO-EBIactivation of MAPKK activity  magnesium ion binding  protein kinase activity  MAP kinase kinase kinase activity  MAP kinase kinase kinase activity  ATP binding  protein phosphorylation  signal transduction  activation of JUN kinase activity  cellular response to stress  
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkMAP3K6
Atlas of Cancer Signalling NetworkMAP3K6
Wikipedia pathwaysMAP3K6
Orthology - Evolution
OrthoDB9064
GeneTree (enSembl)ENSG00000142733
Phylogenetic Trees/Animal Genes : TreeFamMAP3K6
HOGENOMO95382
Homologs : HomoloGeneMAP3K6
Homology/Alignments : Family Browser (UCSC)MAP3K6
Gene fusions - Rearrangements
Fusion : QuiverMAP3K6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K6 [hg38]
dbVarMAP3K6
ClinVarMAP3K6
MonarchMAP3K6
1000_GenomesMAP3K6 
Exome Variant ServerMAP3K6
GNOMAD BrowserENSG00000142733
Varsome BrowserMAP3K6
Genomic Variants (DGV)MAP3K6 [DGVbeta]
DECIPHERMAP3K6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K6 
Mutations
ICGC Data PortalMAP3K6 
TCGA Data PortalMAP3K6 
Broad Tumor PortalMAP3K6
OASIS PortalMAP3K6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP3K6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAP3K6
Mutations and Diseases : HGMDMAP3K6
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP3K6
DgiDB (Drug Gene Interaction Database)MAP3K6
DoCM (Curated mutations)MAP3K6 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K6 (select a term)
intoGenMAP3K6
Cancer3DMAP3K6(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604468   
Orphanet8758   
DisGeNETMAP3K6
MedgenMAP3K6
Genetic Testing Registry MAP3K6
NextProtO95382 [Medical]
GENETestsMAP3K6
Target ValidationMAP3K6
Huge Navigator MAP3K6 [HugePedia]
ClinGenMAP3K6
Clinical trials, drugs, therapy
MyCancerGenomeMAP3K6
Protein Interactions : CTD
Pharm GKB GenePA30602
PharosO95382
Clinical trialMAP3K6
Miscellaneous
canSAR (ICR)MAP3K6 (select the gene name)
HarmonizomeMAP3K6
DataMed IndexMAP3K6
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMAP3K6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri Jan 1 18:24:01 CET 2021

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