MAP3K8 (mitogen-activated protein kinase kinase kinase 8)

Identity

Other names	COT
	EST
	ESTF
	FLJ10486
	TPL2
	Tpl-2
	c-COT
HGNC	MAP3K8
Location	10p11.2
Location_base_pair	Starts at 30762872 and ends at 30790767 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	MAP3K8   6860
Entrez_Gene	MAP3K8  1326  mitogen-activated protein kinase kinase kinase 8
	Cards
GeneCards	MAP3K8
Ensembl	MAP3K8 [Search_View]   ENSG00000107968 [Gene_View]
Genatlas	MAP3K8
GeneLynx	MAP3K8
eGenome	MAP3K8
euGene	1326
	Genomic and cartography
GoldenPath	MAP3K8  -  10p11.2   chr10:30762872-30790767 +  10p11.23   [Description]    (hg18-March_2006)
Ensembl	MAP3K8 - 10p11.23 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	MAP3K8
	Gene and transcription
Genbank	AK290320 [ ENTREZ ]
Genbank	AK313295 [ ENTREZ ]
Genbank	AL547407 [ ENTREZ ]
Genbank	BC104833 [ ENTREZ ]
Genbank	BC113566 [ ENTREZ ]
RefSeq	NM_005204 [ SRS ]    NM_005204 [ ENTREZ ]
RefSeq	AC_000053 [ SRS ]    AC_000053 [ ENTREZ ]
RefSeq	AC_000142 [ SRS ]    AC_000142 [ ENTREZ ]
RefSeq	NC_000010 [ SRS ]    NC_000010 [ ENTREZ ]
RefSeq	NT_008705 [ SRS ]    NT_008705 [ ENTREZ ]
RefSeq	NW_001837931 [ SRS ]    NW_001837931 [ ENTREZ ]
RefSeq	NW_924584 [ SRS ]    NW_924584 [ ENTREZ ]
AceView	MAP3K8 AceView - NCBI
Unigene	Hs.432453 [ SRS ]    Hs.432453 [ NCBI ]     HS432453 [ spliceNest ]
Fast-db	7387 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P41279 [ SRS]    P41279 [ EXPASY ]     P41279 [ INTERPRO ]     P41279 [ UNIPROT ]
Prosite	PS00107 PROTEIN_KINASE_ATP [ SRS ]    PS00107 PROTEIN_KINASE_ATP [ Expasy ]
Prosite	PS50011 PROTEIN_KINASE_DOM [ SRS ]    PS50011 PROTEIN_KINASE_DOM [ Expasy ]
Prosite	PS00108 PROTEIN_KINASE_ST [ SRS ]    PS00108 PROTEIN_KINASE_ST [ Expasy ]
Interpro	IPR017424 MAPKKK8 [ SRS ]    IPR017424 MAPKKK8 [ EBI ]
Interpro	IPR000719 Prot_kinase_core [ SRS ]    IPR000719 Prot_kinase_core [ EBI ]
Interpro	IPR017441 Protein_kinase_ATP_bd_CS [ SRS ]    IPR017441 Protein_kinase_ATP_bd_CS [ EBI ]
Interpro	IPR017442 Se/Thr_pkinase-rel [ SRS ]    IPR017442 Se/Thr_pkinase-rel [ EBI ]
Interpro	IPR008271 Ser_thr_pkin_AS [ SRS ]    IPR008271 Ser_thr_pkin_AS [ EBI ]
CluSTr	P41279
Pfam	PF00069 Pkinase [ SRS ]    PF00069 Pkinase [ Sanger ]    pfam00069 [ NCBI-CDD ]
Prodom	PD000001 Prot_kinase[INRA-Toulouse]
Prodom	P41279 M3K8_HUMAN [ Domain structure ]   P41279 M3K8_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P41279
HPRD	01863
	Protein Interaction databases
DIP	P41279
IntAct	P41279
	Polymorphism : SNP, mutations, diseases
OMIM	191195;211980    [ map ]
GENECLINICS	191195;211980
SNP	MAP3K8 [dbSNP-NCBI]
SNP	NM_005204 [SNP-NCI]
SNP	MAP3K8 [GeneSNPs - Utah]  MAP3K8] [HGBASE - SRS]
HAPMAP	MAP3K8 [HAPMAP]
COSMIC	MAP3K8 [Somatic mutation (COSMIC-CGP-Sanger)]
HGMD	MAP3K8
	General knowledge
Family Browser	MAP3K8 [UCSC Family Browser]
SOURCE	NM_005204
SMD	Hs.432453
SAGE	Hs.432453
Enzyme	2.7.11.25 [ Enzyme-Expasy ]   2.7.11.25 [ Enzyme-SRS ]   2.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   2.7.11.25 [ WIT ]
GO	nucleotide binding [Amigo]  nucleotide binding
GO	magnesium ion binding [Amigo]  magnesium ion binding
GO	protein kinase activity [Amigo]  protein kinase activity
GO	protein serine/threonine kinase activity [Amigo]  protein serine/threonine kinase activity
GO	MAP kinase kinase kinase activity [Amigo]  MAP kinase kinase kinase activity
GO	protein binding [Amigo]  protein binding
GO	ATP binding [Amigo]  ATP binding
GO	cytoplasm [Amigo]  cytoplasm
GO	cytosol [Amigo]  cytosol
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	protein amino acid phosphorylation [Amigo]  protein amino acid phosphorylation
GO	transferase activity [Amigo]  transferase activity
BIOCARTA	MAPKinase Signaling Pathway    [Genes]
KEGG	MAPK signaling pathway
KEGG	T cell receptor signaling pathway
PubGene	MAP3K8
TreeFam	MAP3K8
CTD	1326 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	MAP3K8 Related clones (RZPD - Berlin)
	PubMed
PubMed	40 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Sat Oct 18 14:49:45 2008