Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MAP3K8 (mitogen-activated protein kinase kinase kinase 8)

Identity

Alias_namesCOT
ESTF
Alias_symbol (synonym)Tpl-2
EST
c-COT
MEKK8
Other aliasAURA2
TPL2
HGNC (Hugo) MAP3K8
LocusID (NCBI) 1326
Atlas_Id 41284
Location 10p11.23  [Link to chromosome band 10p11]
Location_base_pair Starts at 30434021 and ends at 30461833 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MAP3K8 (10p11.23) / MAP3K8 (10p11.23)MAP3K8 (10p11.23) / MROH2B (5p13.1)MAP3K8 10p11.23 HEATR7B2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAP3K8   6860
Cards
Entrez_Gene (NCBI)MAP3K8  1326  mitogen-activated protein kinase kinase kinase 8
AliasesAURA2; COT; EST; ESTF; 
MEKK8; TPL2; Tpl-2; c-COT
GeneCards (Weizmann)MAP3K8
Ensembl hg19 (Hinxton)ENSG00000107968 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107968 [Gene_View]  chr10:30434021-30461833 [Contig_View]  MAP3K8 [Vega]
ICGC DataPortalENSG00000107968
TCGA cBioPortalMAP3K8
AceView (NCBI)MAP3K8
Genatlas (Paris)MAP3K8
WikiGenes1326
SOURCE (Princeton)MAP3K8
Genetics Home Reference (NIH)MAP3K8
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K8  -     chr10:30434021-30461833 +  10p11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K8  -     10p11.23   [Description]    (hg19-Feb_2009)
EnsemblMAP3K8 - 10p11.23 [CytoView hg19]  MAP3K8 - 10p11.23 [CytoView hg38]
Mapping of homologs : NCBIMAP3K8 [Mapview hg19]  MAP3K8 [Mapview hg38]
OMIM191195   211980   
Gene and transcription
Genbank (Entrez)AA156603 AB209539 AK290320 AK313295 AL547407
RefSeq transcript (Entrez)NM_001244134 NM_001320961 NM_005204
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP3K8
Cluster EST : UnigeneHs.731448 [ NCBI ]
CGAP (NCI)Hs.731448
Alternative Splicing GalleryENSG00000107968
Gene ExpressionMAP3K8 [ NCBI-GEO ]   MAP3K8 [ EBI - ARRAY_EXPRESS ]   MAP3K8 [ SEEK ]   MAP3K8 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K8 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1326
GTEX Portal (Tissue expression)MAP3K8
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41279   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41279  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41279
Splice isoforms : SwissVarP41279
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
PhosPhoSitePlusP41279
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    MAPKKK8    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K8
DMDM Disease mutations1326
Blocks (Seattle)MAP3K8
PDB (SRS)4Y83    4Y85    5IU2   
PDB (PDBSum)4Y83    4Y85    5IU2   
PDB (IMB)4Y83    4Y85    5IU2   
PDB (RSDB)4Y83    4Y85    5IU2   
Structural Biology KnowledgeBase4Y83    4Y85    5IU2   
SCOP (Structural Classification of Proteins)4Y83    4Y85    5IU2   
CATH (Classification of proteins structures)4Y83    4Y85    5IU2   
SuperfamilyP41279
Human Protein AtlasENSG00000107968
Peptide AtlasP41279
HPRD01863
IPIIPI00298726   IPI00759772   IPI00513741   IPI00645837   IPI00647460   IPI00514746   
Protein Interaction databases
DIP (DOE-UCLA)P41279
IntAct (EBI)P41279
FunCoupENSG00000107968
BioGRIDMAP3K8
STRING (EMBL)MAP3K8
ZODIACMAP3K8
Ontologies - Pathways
QuickGOP41279
Ontology : AmiGOactivation of MAPKK activity  magnesium ion binding  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytoplasm  cytosol  cytosol  protein phosphorylation  cell cycle  T cell costimulation  stress-activated MAPK cascade  
Ontology : EGO-EBIactivation of MAPKK activity  magnesium ion binding  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytoplasm  cytosol  cytosol  protein phosphorylation  cell cycle  T cell costimulation  stress-activated MAPK cascade  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Toll-like receptor signaling pathway    T cell receptor signaling pathway    TNF signaling pathway   
NDEx NetworkMAP3K8
Atlas of Cancer Signalling NetworkMAP3K8
Wikipedia pathwaysMAP3K8
Orthology - Evolution
OrthoDB1326
GeneTree (enSembl)ENSG00000107968
Phylogenetic Trees/Animal Genes : TreeFamMAP3K8
HOVERGENP41279
HOGENOMP41279
Homologs : HomoloGeneMAP3K8
Homology/Alignments : Family Browser (UCSC)MAP3K8
Gene fusions - Rearrangements
Fusion : MitelmanMAP3K8/MROH2B [10p11.23/5p13.1]  
Fusion: TCGAMAP3K8 10p11.23 HEATR7B2 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K8
dbVarMAP3K8
ClinVarMAP3K8
1000_GenomesMAP3K8 
Exome Variant ServerMAP3K8
ExAC (Exome Aggregation Consortium)MAP3K8 (select the gene name)
Genetic variants : HAPMAP1326
Genomic Variants (DGV)MAP3K8 [DGVbeta]
DECIPHERMAP3K8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K8 
Mutations
ICGC Data PortalMAP3K8 
TCGA Data PortalMAP3K8 
Broad Tumor PortalMAP3K8
OASIS PortalMAP3K8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP3K8  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP3K8
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP3K8
DgiDB (Drug Gene Interaction Database)MAP3K8
DoCM (Curated mutations)MAP3K8 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K8 (select a term)
intoGenMAP3K8
Cancer3DMAP3K8(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191195    211980   
Orphanet
MedgenMAP3K8
Genetic Testing Registry MAP3K8
NextProtP41279 [Medical]
TSGene1326
GENETestsMAP3K8
Target ValidationMAP3K8
Huge Navigator MAP3K8 [HugePedia]
snp3D : Map Gene to Disease1326
BioCentury BCIQMAP3K8
ClinGenMAP3K8
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD1326
Chemical/Pharm GKB GenePA30606
Clinical trialMAP3K8
Miscellaneous
canSAR (ICR)MAP3K8 (select the gene name)
Probes
Litterature
PubMed99 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K8
EVEXMAP3K8
GoPubMedMAP3K8
iHOPMAP3K8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:42:13 CEST 2017

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