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MAP3K8 (mitogen-activated protein kinase kinase kinase 8)

Identity

Alias (NCBI)AURA2
COT
EST
ESTF
MEKK8
TPL2
Tpl-2
c-COT
HGNC (Hugo) MAP3K8
HGNC Alias symbTpl-2
EST
c-COT
MEKK8
HGNC Previous nameCOT
 ESTF
LocusID (NCBI) 1326
Atlas_Id 41284
Location 10p11.23  [Link to chromosome band 10p11]
Location_base_pair Starts at 30434184 and ends at 30461833 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MAP3K8 (10p11.23) / MAP3K8 (10p11.23)MAP3K8 (10p11.23) / MROH2B (5p13.1)MAP3K8 10p11.23 HEATR7B2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MAP3K8   6860
Cards
Entrez_Gene (NCBI)MAP3K8    mitogen-activated protein kinase kinase kinase 8
AliasesAURA2; COT; EST; ESTF; 
MEKK8; TPL2; Tpl-2; c-COT
GeneCards (Weizmann)MAP3K8
Ensembl hg19 (Hinxton)ENSG00000107968 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000107968 [Gene_View]  ENSG00000107968 [Sequence]  chr10:30434184-30461833 [Contig_View]  MAP3K8 [Vega]
ICGC DataPortalENSG00000107968
TCGA cBioPortalMAP3K8
AceView (NCBI)MAP3K8
Genatlas (Paris)MAP3K8
SOURCE (Princeton)MAP3K8
Genetics Home Reference (NIH)MAP3K8
Genomic and cartography
GoldenPath hg38 (UCSC)MAP3K8  -     chr10:30434184-30461833 +  10p11.23   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP3K8  -     10p11.23   [Description]    (hg19-Feb_2009)
GoldenPathMAP3K8 - 10p11.23 [CytoView hg19]  MAP3K8 - 10p11.23 [CytoView hg38]
ImmunoBaseENSG00000107968
Genome Data Viewer NCBIMAP3K8 [Mapview hg19]  
OMIM191195   211980   
Gene and transcription
Genbank (Entrez)AA156603 AB209539 AK290320 AK313295 AL547407
RefSeq transcript (Entrez)NM_001244134 NM_001320961 NM_005204
Consensus coding sequences : CCDS (NCBI)MAP3K8
Gene ExpressionMAP3K8 [ NCBI-GEO ]   MAP3K8 [ EBI - ARRAY_EXPRESS ]   MAP3K8 [ SEEK ]   MAP3K8 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K8 [ Firebrowse - Broad ]
GenevisibleExpression of MAP3K8 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)1326
GTEX Portal (Tissue expression)MAP3K8
Human Protein AtlasENSG00000107968-MAP3K8 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP41279   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP41279  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP41279
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusP41279
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    MAPKKK8    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAP3K8
PDB (RSDB)4Y83    4Y85    5IU2   
PDB Europe4Y83    4Y85    5IU2   
PDB (PDBSum)4Y83    4Y85    5IU2   
PDB (IMB)4Y83    4Y85    5IU2   
Structural Biology KnowledgeBase4Y83    4Y85    5IU2   
SCOP (Structural Classification of Proteins)4Y83    4Y85    5IU2   
CATH (Classification of proteins structures)4Y83    4Y85    5IU2   
SuperfamilyP41279
AlphaFold pdb e-kbP41279   
Human Protein Atlas [tissue]ENSG00000107968-MAP3K8 [tissue]
HPRD01863
Protein Interaction databases
DIP (DOE-UCLA)P41279
IntAct (EBI)P41279
BioGRIDMAP3K8
STRING (EMBL)MAP3K8
ZODIACMAP3K8
Ontologies - Pathways
QuickGOP41279
Ontology : AmiGOactivation of MAPKK activity  magnesium ion binding  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytosol  cytosol  protein phosphorylation  cell cycle  T cell costimulation  stress-activated MAPK cascade  interleukin-1-mediated signaling pathway  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIactivation of MAPKK activity  magnesium ion binding  protein serine/threonine kinase activity  MAP kinase kinase kinase activity  protein binding  ATP binding  cytosol  cytosol  protein phosphorylation  cell cycle  T cell costimulation  stress-activated MAPK cascade  interleukin-1-mediated signaling pathway  protein serine kinase activity  protein threonine kinase activity  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway    Toll-like receptor signaling pathway    T cell receptor signaling pathway    TNF signaling pathway   
NDEx NetworkMAP3K8
Atlas of Cancer Signalling NetworkMAP3K8
Wikipedia pathwaysMAP3K8
Orthology - Evolution
OrthoDB1326
GeneTree (enSembl)ENSG00000107968
Phylogenetic Trees/Animal Genes : TreeFamMAP3K8
Homologs : HomoloGeneMAP3K8
Homology/Alignments : Family Browser (UCSC)MAP3K8
Gene fusions - Rearrangements
Fusion : MitelmanMAP3K8/MROH2B [10p11.23/5p13.1]  
Fusion : QuiverMAP3K8
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K8 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K8
dbVarMAP3K8
ClinVarMAP3K8
MonarchMAP3K8
1000_GenomesMAP3K8 
Exome Variant ServerMAP3K8
GNOMAD BrowserENSG00000107968
Varsome BrowserMAP3K8
ACMGMAP3K8 variants
VarityP41279
Genomic Variants (DGV)MAP3K8 [DGVbeta]
DECIPHERMAP3K8 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP3K8 
Mutations
ICGC Data PortalMAP3K8 
TCGA Data PortalMAP3K8 
Broad Tumor PortalMAP3K8
OASIS PortalMAP3K8 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP3K8  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAP3K8
Mutations and Diseases : HGMDMAP3K8
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMAP3K8
DgiDB (Drug Gene Interaction Database)MAP3K8
DoCM (Curated mutations)MAP3K8
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K8
Cancer3DMAP3K8
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM191195    211980   
Orphanet
DisGeNETMAP3K8
MedgenMAP3K8
Genetic Testing Registry MAP3K8
NextProtP41279 [Medical]
GENETestsMAP3K8
Target ValidationMAP3K8
Huge Navigator MAP3K8 [HugePedia]
ClinGenMAP3K8
Clinical trials, drugs, therapy
MyCancerGenomeMAP3K8
Protein Interactions : CTDMAP3K8
Pharm GKB GenePA30606
PharosP41279
Clinical trialMAP3K8
Miscellaneous
canSAR (ICR)MAP3K8
HarmonizomeMAP3K8
DataMed IndexMAP3K8
Probes
Litterature
PubMed123 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMAP3K8
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:17:44 CEST 2021

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