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MAP3K9 (mitogen-activated protein kinase kinase kinase 9)

Identity

Alias_namesMLK1
Alias_symbol (synonym)PRKE1
MEKK9
Other alias
HGNC (Hugo) MAP3K9
LocusID (NCBI) 4293
Atlas_Id 41285
Location 14q24.2  [Link to chromosome band 14q24]
Location_base_pair Starts at 71189243 and ends at 71275888 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PDZD2 (5p13.3) / MAP3K9 (14q24.2)SLC39A9 (14q24.1) / MAP3K9 (14q24.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Kidney: Clear cell sarcoma with t(10;17)(q22;p13) YWHAE/NUTM2E


External links

Nomenclature
HGNC (Hugo)MAP3K9   6861
Cards
Entrez_Gene (NCBI)MAP3K9  4293  mitogen-activated protein kinase kinase kinase 9
AliasesMEKK9; MLK1; PRKE1
GeneCards (Weizmann)MAP3K9
Ensembl hg19 (Hinxton)ENSG00000006432 [Gene_View]  chr14:71189243-71275888 [Contig_View]  MAP3K9 [Vega]
Ensembl hg38 (Hinxton)ENSG00000006432 [Gene_View]  chr14:71189243-71275888 [Contig_View]  MAP3K9 [Vega]
ICGC DataPortalENSG00000006432
TCGA cBioPortalMAP3K9
AceView (NCBI)MAP3K9
Genatlas (Paris)MAP3K9
WikiGenes4293
SOURCE (Princeton)MAP3K9
Genetics Home Reference (NIH)MAP3K9
Genomic and cartography
GoldenPath hg19 (UCSC)MAP3K9  -     chr14:71189243-71275888 -  14q24.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAP3K9  -     14q24.2   [Description]    (hg38-Dec_2013)
EnsemblMAP3K9 - 14q24.2 [CytoView hg19]  MAP3K9 - 14q24.2 [CytoView hg38]
Mapping of homologs : NCBIMAP3K9 [Mapview hg19]  MAP3K9 [Mapview hg38]
OMIM600136   
Gene and transcription
Genbank (Entrez)AF251442 AK091645 AK123430 AK294571 AK299727
RefSeq transcript (Entrez)NM_001284230 NM_001284231 NM_001284232 NM_033141
RefSeq genomic (Entrez)NC_000014 NC_018925 NT_026437 NW_004929393
Consensus coding sequences : CCDS (NCBI)MAP3K9
Cluster EST : UnigeneHs.593542 [ NCBI ]
CGAP (NCI)Hs.593542
Alternative Splicing GalleryENSG00000006432
Gene ExpressionMAP3K9 [ NCBI-GEO ]   MAP3K9 [ EBI - ARRAY_EXPRESS ]   MAP3K9 [ SEEK ]   MAP3K9 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP3K9 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)4293
GTEX Portal (Tissue expression)MAP3K9
Protein : pattern, domain, 3D structure
UniProt/SwissProtP80192   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP80192  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP80192
Splice isoforms : SwissVarP80192
Catalytic activity : Enzyme2.7.11.25 [ Enzyme-Expasy ]   2.7.11.252.7.11.25 [ IntEnz-EBI ]   2.7.11.25 [ BRENDA ]   2.7.11.25 [ KEGG ]   
PhosPhoSitePlusP80192
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)    SH3 (PS50002)   
Domains : Interpro (EBI)Kinase-like_dom    MLK1/MLK2/MLK4    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser-Thr/Tyr_kinase_cat_dom    Ser/Thr_kinase_AS    SH3_domain    Tyr_kinase_cat_dom   
Domain families : Pfam (Sanger)Pkinase (PF00069)    SH3_9 (PF14604)   
Domain families : Pfam (NCBI)pfam00069    pfam14604   
Domain families : Smart (EMBL)SH3 (SM00326)  TyrKc (SM00219)  
Conserved Domain (NCBI)MAP3K9
DMDM Disease mutations4293
Blocks (Seattle)MAP3K9
PDB (SRS)3DTC    4UY9   
PDB (PDBSum)3DTC    4UY9   
PDB (IMB)3DTC    4UY9   
PDB (RSDB)3DTC    4UY9   
Structural Biology KnowledgeBase3DTC    4UY9   
SCOP (Structural Classification of Proteins)3DTC    4UY9   
CATH (Classification of proteins structures)3DTC    4UY9   
SuperfamilyP80192
Human Protein AtlasENSG00000006432
Peptide AtlasP80192
HPRD15965
IPIIPI00008115   IPI00179189   IPI01016037   IPI01026380   IPI01025713   IPI01026507   IPI01025836   
Protein Interaction databases
DIP (DOE-UCLA)P80192
IntAct (EBI)P80192
FunCoupENSG00000006432
BioGRIDMAP3K9
STRING (EMBL)MAP3K9
ZODIACMAP3K9
Ontologies - Pathways
QuickGOP80192
Ontology : AmiGOprotein serine/threonine kinase activity  JUN kinase kinase kinase activity  MAP kinase kinase activity  protein binding  ATP binding  cellular_component  intracellular  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  apoptotic process  activation of JNKK activity  activation of JUN kinase activity  protein homodimerization activity  positive regulation of apoptotic process  protein autophosphorylation  
Ontology : EGO-EBIprotein serine/threonine kinase activity  JUN kinase kinase kinase activity  MAP kinase kinase activity  protein binding  ATP binding  cellular_component  intracellular  transcription, DNA-templated  regulation of transcription, DNA-templated  protein phosphorylation  apoptotic process  activation of JNKK activity  activation of JUN kinase activity  protein homodimerization activity  positive regulation of apoptotic process  protein autophosphorylation  
Pathways : BIOCARTAp38 MAPK Signaling Pathway [Genes]    MAPKinase Signaling Pathway [Genes]   
NDEx NetworkMAP3K9
Atlas of Cancer Signalling NetworkMAP3K9
Wikipedia pathwaysMAP3K9
Orthology - Evolution
OrthoDB4293
GeneTree (enSembl)ENSG00000006432
Phylogenetic Trees/Animal Genes : TreeFamMAP3K9
HOVERGENP80192
HOGENOMP80192
Homologs : HomoloGeneMAP3K9
Homology/Alignments : Family Browser (UCSC)MAP3K9
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP3K9 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP3K9
dbVarMAP3K9
ClinVarMAP3K9
1000_GenomesMAP3K9 
Exome Variant ServerMAP3K9
ExAC (Exome Aggregation Consortium)MAP3K9 (select the gene name)
Genetic variants : HAPMAP4293
Genomic Variants (DGV)MAP3K9 [DGVbeta]
DECIPHER (Syndromes)14:71189243-71275888  ENSG00000006432
CONAN: Copy Number AnalysisMAP3K9 
Mutations
ICGC Data PortalMAP3K9 
TCGA Data PortalMAP3K9 
Broad Tumor PortalMAP3K9
OASIS PortalMAP3K9 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP3K9  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP3K9
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP3K9
DgiDB (Drug Gene Interaction Database)MAP3K9
DoCM (Curated mutations)MAP3K9 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP3K9 (select a term)
intoGenMAP3K9
Cancer3DMAP3K9(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600136   
Orphanet
MedgenMAP3K9
Genetic Testing Registry MAP3K9
NextProtP80192 [Medical]
TSGene4293
GENETestsMAP3K9
Huge Navigator MAP3K9 [HugePedia]
snp3D : Map Gene to Disease4293
BioCentury BCIQMAP3K9
ClinGenMAP3K9
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD4293
Chemical/Pharm GKB GenePA30607
Clinical trialMAP3K9
Miscellaneous
canSAR (ICR)MAP3K9 (select the gene name)
Probes
Litterature
PubMed17 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP3K9
EVEXMAP3K9
GoPubMedMAP3K9
iHOPMAP3K9
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:08:30 CEST 2017

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