MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1)

2006-10-01  

Identity

HGNC
LOCATION
19q13.2
LOCUSID
ALIAS
HPK1
FUSION GENES

Other Information

Locus ID:

NCBI: 11184
MIM: 601983
HGNC: 6863
Ensembl: ENSG00000104814

Variants:

dbSNP: 11184
ClinVar: 11184
TCGA: ENSG00000104814
COSMIC: MAP4K1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000104814ENST00000585583K7ERT2
ENSG00000104814ENST00000586296K7EKT6
ENSG00000104814ENST00000589130K7ER95
ENSG00000104814ENST00000591517Q92918
ENSG00000104814ENST00000591921K7EJS6

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
164496432006Tumorigenesis suppressor Pdcd4 down-regulates mitogen-activated protein kinase kinase kinase kinase 1 expression to suppress colon carcinoma cell invasion.79
173533682007A novel pathway down-modulating T cell activation involves HPK-1-dependent recruitment of 14-3-3 proteins on SLP-76.29
197065362009Phosphorylation of CARMA1 by HPK1 is critical for NF-kappaB activation in T cells.27
157438302005Activation of hematopoietic progenitor kinase 1 involves relocation, autophosphorylation, and transphosphorylation by protein kinase D1.19
163410932005Activation or suppression of NFkappaB by HPK1 determines sensitivity to activation-induced cell death.19
153649342004Protein phosphatase 4 is a positive regulator of hematopoietic progenitor kinase 1.15
243620262014The CUL7/F-box and WD repeat domain containing 8 (CUL7/Fbxw8) ubiquitin ligase promotes degradation of hematopoietic progenitor kinase 1.15
177120482007Caspase-cleaved HPK1 induces CD95L-independent activation-induced cell death in T and B lymphocytes.14
221053502011Release of serine/threonine-phosphorylated adaptors from signaling microclusters down-regulates T cell activation.13
191416502009Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer.12

Citation

Dessen P

MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43346/map4k1