Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MAP4K1 (mitogen-activated protein kinase kinase kinase kinase 1)

Identity

Alias_symbol (synonym)HPK1
Other alias
HGNC (Hugo) MAP4K1
LocusID (NCBI) 11184
Atlas_Id 43346
Location 19q13.2  [Link to chromosome band 19q13]
Location_base_pair Starts at 38587640 and ends at 38618035 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MAP4K1/OK () / SW-cl.16 ()SCAF1 (19q13.33) / MAP4K1 (19q13.2)SPINT2 (19q13.2) / MAP4K1 (19q13.2)
SCAF1 19q13.33 / MAP4K1 19q13.2SPINT2 19q13.2 / MAP4K1 19q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAP4K1   6863
Cards
Entrez_Gene (NCBI)MAP4K1  11184  mitogen-activated protein kinase kinase kinase kinase 1
AliasesHPK1
GeneCards (Weizmann)MAP4K1
Ensembl hg19 (Hinxton)ENSG00000104814 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000104814 [Gene_View]  chr19:38587640-38618035 [Contig_View]  MAP4K1 [Vega]
ICGC DataPortalENSG00000104814
TCGA cBioPortalMAP4K1
AceView (NCBI)MAP4K1
Genatlas (Paris)MAP4K1
WikiGenes11184
SOURCE (Princeton)MAP4K1
Genetics Home Reference (NIH)MAP4K1
Genomic and cartography
GoldenPath hg38 (UCSC)MAP4K1  -     chr19:38587640-38618035 -  19q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP4K1  -     19q13.2   [Description]    (hg19-Feb_2009)
EnsemblMAP4K1 - 19q13.2 [CytoView hg19]  MAP4K1 - 19q13.2 [CytoView hg38]
Mapping of homologs : NCBIMAP4K1 [Mapview hg19]  MAP4K1 [Mapview hg38]
OMIM601983   
Gene and transcription
Genbank (Entrez)AA995240 AK303267 AW137524 BC148359 BC152994
RefSeq transcript (Entrez)NM_001042600 NM_007181
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP4K1
Cluster EST : UnigeneHs.95424 [ NCBI ]
CGAP (NCI)Hs.95424
Alternative Splicing GalleryENSG00000104814
Gene ExpressionMAP4K1 [ NCBI-GEO ]   MAP4K1 [ EBI - ARRAY_EXPRESS ]   MAP4K1 [ SEEK ]   MAP4K1 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP4K1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)11184
GTEX Portal (Tissue expression)MAP4K1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ92918   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ92918  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ92918
Splice isoforms : SwissVarQ92918
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ92918
Domaine pattern : Prosite (Expaxy)CNH (PS50219)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)CNH_dom    Kinase-like_dom    MAPKKKK    Prot_kinase_dom    Protein_kinase_ATP_BS   
Domain families : Pfam (Sanger)CNH (PF00780)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00780    pfam00069   
Domain families : Smart (EMBL)CNH (SM00036)  S_TKc (SM00220)  
Conserved Domain (NCBI)MAP4K1
DMDM Disease mutations11184
Blocks (Seattle)MAP4K1
SuperfamilyQ92918
Human Protein AtlasENSG00000104814
Peptide AtlasQ92918
HPRD03583
IPIIPI00020258   IPI00784270   IPI00908435   
Protein Interaction databases
DIP (DOE-UCLA)Q92918
IntAct (EBI)Q92918
FunCoupENSG00000104814
BioGRIDMAP4K1
STRING (EMBL)MAP4K1
ZODIACMAP4K1
Ontologies - Pathways
QuickGOQ92918
Ontology : AmiGOactivation of MAPKKK activity  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  protein phosphorylation  response to stress  activation of JUN kinase activity  cell proliferation  MAP kinase kinase kinase kinase activity  membrane  peptidyl-serine phosphorylation  intracellular signal transduction  protein autophosphorylation  
Ontology : EGO-EBIactivation of MAPKKK activity  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  protein phosphorylation  response to stress  activation of JUN kinase activity  cell proliferation  MAP kinase kinase kinase kinase activity  membrane  peptidyl-serine phosphorylation  intracellular signal transduction  protein autophosphorylation  
Pathways : BIOCARTASignaling of Hepatocyte Growth Factor Receptor [Genes]    MAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkMAP4K1
Atlas of Cancer Signalling NetworkMAP4K1
Wikipedia pathwaysMAP4K1
Orthology - Evolution
OrthoDB11184
GeneTree (enSembl)ENSG00000104814
Phylogenetic Trees/Animal Genes : TreeFamMAP4K1
HOVERGENQ92918
HOGENOMQ92918
Homologs : HomoloGeneMAP4K1
Homology/Alignments : Family Browser (UCSC)MAP4K1
Gene fusions - Rearrangements
Fusion : MitelmanSCAF1/MAP4K1 [19q13.33/19q13.2]  [t(19;19)(q13;q13)]  
Fusion : MitelmanSPINT2/MAP4K1 [19q13.2/19q13.2]  [t(19;19)(q13;q13)]  
Fusion: TCGASCAF1 19q13.33 MAP4K1 19q13.2 BRCA
Fusion: TCGASPINT2 19q13.2 MAP4K1 19q13.2 LUAD
Fusion Cancer (Beijing)MAP4K1 [19q13.2]  -  OK/SW-cl.16 [FUSC001208]
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP4K1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP4K1
dbVarMAP4K1
ClinVarMAP4K1
1000_GenomesMAP4K1 
Exome Variant ServerMAP4K1
ExAC (Exome Aggregation Consortium)MAP4K1 (select the gene name)
Genetic variants : HAPMAP11184
Genomic Variants (DGV)MAP4K1 [DGVbeta]
DECIPHERMAP4K1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP4K1 
Mutations
ICGC Data PortalMAP4K1 
TCGA Data PortalMAP4K1 
Broad Tumor PortalMAP4K1
OASIS PortalMAP4K1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP4K1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP4K1
intOGen PortalMAP4K1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP4K1
DgiDB (Drug Gene Interaction Database)MAP4K1
DoCM (Curated mutations)MAP4K1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP4K1 (select a term)
intoGenMAP4K1
Cancer3DMAP4K1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601983   
Orphanet
MedgenMAP4K1
Genetic Testing Registry MAP4K1
NextProtQ92918 [Medical]
TSGene11184
GENETestsMAP4K1
Target ValidationMAP4K1
Huge Navigator MAP4K1 [HugePedia]
snp3D : Map Gene to Disease11184
BioCentury BCIQMAP4K1
ClinGenMAP4K1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD11184
Chemical/Pharm GKB GenePA30609
Clinical trialMAP4K1
Miscellaneous
canSAR (ICR)MAP4K1 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP4K1
EVEXMAP4K1
GoPubMedMAP4K1
iHOPMAP4K1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:42:13 CEST 2017

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