Atlas of Genetics and Cytogenetics in Oncology and Haematology


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MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2)

Identity

Alias_namesRAB8IP
Alias_symbol (synonym)GCK
BL44
Other alias
HGNC (Hugo) MAP4K2
LocusID (NCBI) 5871
Atlas_Id 43347
Location 11q13.1  [Link to chromosome band 11q13]
Location_base_pair Starts at 64556573 and ends at 64570726 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
MAP4K2 (11q13.1) / CDC42BPG (11q13.1)MAP4K2 (11q13.1) / NETO2 (16q12.1)MAP4K2 11q13.1 / NETO2 16q12.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)MAP4K2   6864
Cards
Entrez_Gene (NCBI)MAP4K2  5871  mitogen-activated protein kinase kinase kinase kinase 2
AliasesBL44; GCK; RAB8IP
GeneCards (Weizmann)MAP4K2
Ensembl hg19 (Hinxton)ENSG00000168067 [Gene_View]  chr11:64556573-64570726 [Contig_View]  MAP4K2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000168067 [Gene_View]  chr11:64556573-64570726 [Contig_View]  MAP4K2 [Vega]
ICGC DataPortalENSG00000168067
TCGA cBioPortalMAP4K2
AceView (NCBI)MAP4K2
Genatlas (Paris)MAP4K2
WikiGenes5871
SOURCE (Princeton)MAP4K2
Genetics Home Reference (NIH)MAP4K2
Genomic and cartography
GoldenPath hg19 (UCSC)MAP4K2  -     chr11:64556573-64570726 -  11q13.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAP4K2  -     11q13.1   [Description]    (hg38-Dec_2013)
EnsemblMAP4K2 - 11q13.1 [CytoView hg19]  MAP4K2 - 11q13.1 [CytoView hg38]
Mapping of homologs : NCBIMAP4K2 [Mapview hg19]  MAP4K2 [Mapview hg38]
OMIM603166   
Gene and transcription
Genbank (Entrez)AK298383 AK304495 AW574847 BC039839 BC047865
RefSeq transcript (Entrez)NM_001307990 NM_004579
RefSeq genomic (Entrez)NC_000011 NC_018922 NG_033040 NT_167190 NW_004929380
Consensus coding sequences : CCDS (NCBI)MAP4K2
Cluster EST : UnigeneHs.534341 [ NCBI ]
CGAP (NCI)Hs.534341
Alternative Splicing GalleryENSG00000168067
Gene ExpressionMAP4K2 [ NCBI-GEO ]   MAP4K2 [ EBI - ARRAY_EXPRESS ]   MAP4K2 [ SEEK ]   MAP4K2 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP4K2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5871
GTEX Portal (Tissue expression)MAP4K2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ12851   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ12851  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ12851
Splice isoforms : SwissVarQ12851
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ12851
Domaine pattern : Prosite (Expaxy)CNH (PS50219)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)CNH_dom    Kinase-like_dom    MAPKKKK    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase   
Domain families : Pfam (Sanger)CNH (PF00780)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00780    pfam00069   
Domain families : Smart (EMBL)CNH (SM00036)  S_TKc (SM00220)  
Conserved Domain (NCBI)MAP4K2
DMDM Disease mutations5871
Blocks (Seattle)MAP4K2
SuperfamilyQ12851
Human Protein AtlasENSG00000168067
Peptide AtlasQ12851
HPRD04408
IPIIPI00149094   IPI00909190   IPI00658102   IPI00657795   IPI00894151   IPI00894497   IPI00894243   
Protein Interaction databases
DIP (DOE-UCLA)Q12851
IntAct (EBI)Q12851
FunCoupENSG00000168067
BioGRIDMAP4K2
STRING (EMBL)MAP4K2
ZODIACMAP4K2
Ontologies - Pathways
QuickGOQ12851
Ontology : AmiGOGolgi membrane  activation of MAPKKK activity  protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  protein binding  ATP binding  protein phosphorylation  vesicle targeting  immune response  JNK cascade  activation of JUN kinase activity  MAP kinase kinase kinase kinase activity  basolateral plasma membrane  mitogen-activated protein kinase kinase kinase binding  intracellular signal transduction  innate immune response  positive regulation of JNK cascade  
Ontology : EGO-EBIGolgi membrane  activation of MAPKKK activity  protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  protein binding  ATP binding  protein phosphorylation  vesicle targeting  immune response  JNK cascade  activation of JUN kinase activity  MAP kinase kinase kinase kinase activity  basolateral plasma membrane  mitogen-activated protein kinase kinase kinase binding  intracellular signal transduction  innate immune response  positive regulation of JNK cascade  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]    Role of MAL in Rho-Mediated Activation of SRF [Genes]    TNF/Stress Related Signaling [Genes]   
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkMAP4K2
Atlas of Cancer Signalling NetworkMAP4K2
Wikipedia pathwaysMAP4K2
Orthology - Evolution
OrthoDB5871
GeneTree (enSembl)ENSG00000168067
Phylogenetic Trees/Animal Genes : TreeFamMAP4K2
HOVERGENQ12851
HOGENOMQ12851
Homologs : HomoloGeneMAP4K2
Homology/Alignments : Family Browser (UCSC)MAP4K2
Gene fusions - Rearrangements
Fusion : MitelmanMAP4K2/NETO2 [11q13.1/16q12.1]  
Fusion: TCGAMAP4K2 11q13.1 NETO2 16q12.1 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP4K2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP4K2
dbVarMAP4K2
ClinVarMAP4K2
1000_GenomesMAP4K2 
Exome Variant ServerMAP4K2
ExAC (Exome Aggregation Consortium)MAP4K2 (select the gene name)
Genetic variants : HAPMAP5871
Genomic Variants (DGV)MAP4K2 [DGVbeta]
DECIPHER (Syndromes)11:64556573-64570726  ENSG00000168067
CONAN: Copy Number AnalysisMAP4K2 
Mutations
ICGC Data PortalMAP4K2 
TCGA Data PortalMAP4K2 
Broad Tumor PortalMAP4K2
OASIS PortalMAP4K2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP4K2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP4K2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP4K2
DgiDB (Drug Gene Interaction Database)MAP4K2
DoCM (Curated mutations)MAP4K2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP4K2 (select a term)
intoGenMAP4K2
Cancer3DMAP4K2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603166   
Orphanet
MedgenMAP4K2
Genetic Testing Registry MAP4K2
NextProtQ12851 [Medical]
TSGene5871
GENETestsMAP4K2
Huge Navigator MAP4K2 [HugePedia]
snp3D : Map Gene to Disease5871
BioCentury BCIQMAP4K2
ClinGenMAP4K2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5871
Chemical/Pharm GKB GenePA30610
Clinical trialMAP4K2
Miscellaneous
canSAR (ICR)MAP4K2 (select the gene name)
Probes
Litterature
PubMed22 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP4K2
EVEXMAP4K2
GoPubMedMAP4K2
iHOPMAP4K2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:14:26 CET 2017

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