MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2)

2006-10-01  

Identity

HGNC
MAP4K2
LOCATION
11q13.1
LOCUSID
5871
ALIAS
BL44,GCK,RAB8IP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5871
MIM: 603166
HGNC: 6864
Ensembl: ENSG00000168067

Variants:

dbSNP: 5871
ClinVar: 5871
TCGA: ENSG00000168067
COSMIC: MAP4K2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168067ENST00000294066Q12851
ENSG00000168067ENST00000294066A0A024R567
ENSG00000168067ENST00000424945H7C208
ENSG00000168067ENST00000433890F2Z2B3
ENSG00000168067ENST00000435926F2Z2B3
ENSG00000168067ENST00000439069C9JCU6
ENSG00000168067ENST00000444560F8WCP4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
224338572012A Rab8 guanine nucleotide exchange factor-effector interaction network regulates primary ciliogenesis.57
203321132010CCM3/PDCD10 stabilizes GCKIII proteins to promote Golgi assembly and cell orientation.50
240727142013Intermediates in the guanine nucleotide exchange reaction of Rab8 protein catalyzed by guanine nucleotide exchange factors Rabin8 and GRAB.21
250755582015Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2).17
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
271518882016Pathophysiological significance and therapeutic targeting of germinal center kinase in diffuse large B-cell lymphoma.5
302174502018Activation of JNK signaling in osteoblasts is inversely correlated with collagen synthesis in age-related osteoporosis.5

Citation

Dessen P

MAP4K2 (mitogen-activated protein kinase kinase kinase kinase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43347/map4k2