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MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3)

Identity

Alias_namesRAB8IPL1
Alias_symbol (synonym)GLK
MAPKKKK3
Other aliasMEKKK 3
MEKKK3
HGNC (Hugo) MAP4K3
LocusID (NCBI) 8491
Atlas_Id 41286
Location 2p22.1  [Link to chromosome band 2p22]
Location_base_pair Starts at 39249266 and ends at 39437312 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MALAT1 (11q13.1) / MAP4K3 (2p22.1)MAP4K3 (2p22.1) / HACD4 (9p21.3)MAP4K3 (2p22.1) / MAP4K3 (2p22.1)
MAP4K3 (2p22.1) / PRKCE (2p21)MAP4K3 (2p22.1) / TMEM178A (2p22.1)MAP4K3 (2p22.1) / WDPCP (2p15)
RAB3GAP1 (2q21.3) / MAP4K3 (2p22.1)SOS1 (2p22.1) / MAP4K3 (2p22.1)THADA (2p21) / MAP4K3 (2p22.1)
MAP4K3 2p22.1 PTPLAD2MAP4K3 2p22.1 TMEM178RAB3GAP1 2q21.3 / MAP4K3 2p22.1
SOS1 2p22.1 / MAP4K3 2p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Lung: Translocations in Adenocarcinoma


External links

Nomenclature
HGNC (Hugo)MAP4K3   6865
Cards
Entrez_Gene (NCBI)MAP4K3  8491  mitogen-activated protein kinase kinase kinase kinase 3
AliasesGLK; MAPKKKK3; MEKKK; MEKKK3; 
RAB8IPL1
GeneCards (Weizmann)MAP4K3
Ensembl hg19 (Hinxton)ENSG00000011566 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011566 [Gene_View]  chr2:39249266-39437312 [Contig_View]  MAP4K3 [Vega]
ICGC DataPortalENSG00000011566
TCGA cBioPortalMAP4K3
AceView (NCBI)MAP4K3
Genatlas (Paris)MAP4K3
WikiGenes8491
SOURCE (Princeton)MAP4K3
Genetics Home Reference (NIH)MAP4K3
Genomic and cartography
GoldenPath hg38 (UCSC)MAP4K3  -     chr2:39249266-39437312 -  2p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP4K3  -     2p22.1   [Description]    (hg19-Feb_2009)
EnsemblMAP4K3 - 2p22.1 [CytoView hg19]  MAP4K3 - 2p22.1 [CytoView hg38]
Mapping of homologs : NCBIMAP4K3 [Mapview hg19]  MAP4K3 [Mapview hg38]
OMIM604921   
Gene and transcription
Genbank (Entrez)AK021553 AK291467 AK299889 AK314487 AK316144
RefSeq transcript (Entrez)NM_001270425 NM_003618
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)MAP4K3
Cluster EST : UnigeneHs.655750 [ NCBI ]
CGAP (NCI)Hs.655750
Alternative Splicing GalleryENSG00000011566
Gene ExpressionMAP4K3 [ NCBI-GEO ]   MAP4K3 [ EBI - ARRAY_EXPRESS ]   MAP4K3 [ SEEK ]   MAP4K3 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP4K3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8491
GTEX Portal (Tissue expression)MAP4K3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IVH8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IVH8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IVH8
Splice isoforms : SwissVarQ8IVH8
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
PhosPhoSitePlusQ8IVH8
Domaine pattern : Prosite (Expaxy)CNH (PS50219)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)CNH_dom    Kinase-like_dom    MAPKKKK    Prot_kinase_dom    Protein_kinase_ATP_BS   
Domain families : Pfam (Sanger)CNH (PF00780)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00780    pfam00069   
Domain families : Smart (EMBL)CNH (SM00036)  S_TKc (SM00220)  
Conserved Domain (NCBI)MAP4K3
DMDM Disease mutations8491
Blocks (Seattle)MAP4K3
PDB (SRS)5J5T   
PDB (PDBSum)5J5T   
PDB (IMB)5J5T   
PDB (RSDB)5J5T   
Structural Biology KnowledgeBase5J5T   
SCOP (Structural Classification of Proteins)5J5T   
CATH (Classification of proteins structures)5J5T   
SuperfamilyQ8IVH8
Human Protein AtlasENSG00000011566
Peptide AtlasQ8IVH8
HPRD05373
IPIIPI00217024   IPI00219509   IPI00219510   IPI00917525   IPI00917423   IPI00917101   IPI01014531   
Protein Interaction databases
DIP (DOE-UCLA)Q8IVH8
IntAct (EBI)Q8IVH8
FunCoupENSG00000011566
BioGRIDMAP4K3
STRING (EMBL)MAP4K3
ZODIACMAP4K3
Ontologies - Pathways
QuickGOQ8IVH8
Ontology : AmiGOactivation of MAPKKK activity  protein kinase activity  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  protein phosphorylation  JNK cascade  MAP kinase kinase kinase kinase activity  response to UV  response to tumor necrosis factor  intracellular signal transduction  
Ontology : EGO-EBIactivation of MAPKKK activity  protein kinase activity  protein serine/threonine kinase activity  signal transducer, downstream of receptor, with serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  protein phosphorylation  JNK cascade  MAP kinase kinase kinase kinase activity  response to UV  response to tumor necrosis factor  intracellular signal transduction  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkMAP4K3
Atlas of Cancer Signalling NetworkMAP4K3
Wikipedia pathwaysMAP4K3
Orthology - Evolution
OrthoDB8491
GeneTree (enSembl)ENSG00000011566
Phylogenetic Trees/Animal Genes : TreeFamMAP4K3
HOVERGENQ8IVH8
HOGENOMQ8IVH8
Homologs : HomoloGeneMAP4K3
Homology/Alignments : Family Browser (UCSC)MAP4K3
Gene fusions - Rearrangements
Fusion : MitelmanMAP4K3/HACD4 [2p22.1/9p21.3]  
Fusion : MitelmanMAP4K3/PRKCE [2p22.1/2p21]  [t(2;2)(p21;p22)]  
Fusion : MitelmanMAP4K3/TMEM178A [2p22.1/2p22.1]  [t(2;2)(p22;p22)]  
Fusion : MitelmanRAB3GAP1/MAP4K3 [2q21.3/2p22.1]  [t(2;2)(p22;q21)]  
Fusion : MitelmanSOS1/MAP4K3 [2p22.1/2p22.1]  [t(2;2)(p22;p22)]  
Fusion : MitelmanTHADA/MAP4K3 [2p21/2p22.1]  [t(2;2)(p21;p22)]  
Fusion: TCGAMAP4K3 2p22.1 PTPLAD2 LUAD
Fusion: TCGAMAP4K3 2p22.1 TMEM178 PRAD
Fusion: TCGARAB3GAP1 2q21.3 MAP4K3 2p22.1 BRCA
Fusion: TCGASOS1 2p22.1 MAP4K3 2p22.1 THCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP4K3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP4K3
dbVarMAP4K3
ClinVarMAP4K3
1000_GenomesMAP4K3 
Exome Variant ServerMAP4K3
ExAC (Exome Aggregation Consortium)MAP4K3 (select the gene name)
Genetic variants : HAPMAP8491
Genomic Variants (DGV)MAP4K3 [DGVbeta]
DECIPHERMAP4K3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP4K3 
Mutations
ICGC Data PortalMAP4K3 
TCGA Data PortalMAP4K3 
Broad Tumor PortalMAP4K3
OASIS PortalMAP4K3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP4K3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDMAP4K3
intOGen PortalMAP4K3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch MAP4K3
DgiDB (Drug Gene Interaction Database)MAP4K3
DoCM (Curated mutations)MAP4K3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)MAP4K3 (select a term)
intoGenMAP4K3
Cancer3DMAP4K3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604921   
Orphanet
MedgenMAP4K3
Genetic Testing Registry MAP4K3
NextProtQ8IVH8 [Medical]
TSGene8491
GENETestsMAP4K3
Huge Navigator MAP4K3 [HugePedia]
snp3D : Map Gene to Disease8491
BioCentury BCIQMAP4K3
ClinGenMAP4K3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8491
Chemical/Pharm GKB GenePA30611
Clinical trialMAP4K3
Miscellaneous
canSAR (ICR)MAP4K3 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMineMAP4K3
EVEXMAP4K3
GoPubMedMAP4K3
iHOPMAP4K3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:24:09 CEST 2017

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