MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3)

2003-06-01  

Identity

HGNC
MAP4K3
LOCATION
2p22.1
LOCUSID
8491
ALIAS
GLK,MAPKKKK3,MEKKK
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8491
MIM: 604921
HGNC: 6865
Ensembl: ENSG00000011566

Variants:

dbSNP: 8491
ClinVar: 8491
TCGA: ENSG00000011566
COSMIC: MAP4K3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000011566ENST00000263881Q8IVH8
ENSG00000011566ENST00000414968H7C1A4
ENSG00000011566ENST00000429397F8WAZ1
ENSG00000011566ENST00000437545F5H5A3
ENSG00000011566ENST00000437968F8WBC3
ENSG00000011566ENST00000484274V9GY95

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
MAPK signaling pathwayKEGGhsa04010

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
239815812014MicroRNA let-7c inhibits migration and invasion of human non-small cell lung cancer by targeting ITGB3 and MAP4K3.77
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
219838312011The kinase GLK controls autoimmunity and NF-κB signaling by activating the kinase PKC-θ in T cells.56
202273682010PP2A T61 epsilon is an inhibitor of MAP4K3 in nutrient signaling to mTOR.54
228985702013Cellular signaling of amino acids towards mTORC1 activation in impaired human leucine catabolism.20
195872392009MAP4K3 modulates cell death via the post-transcriptional regulation of BH3-only proteins.17
295073402018MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB.17
206280862010Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study.11
280991442017MiR-199a-5p and let-7c cooperatively inhibit migration and invasion by targeting MAP4K3 in hepatocellular carcinoma.11

Citation

Dessen P

MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/41286/map4k3