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MAP4K3 (mitogen-activated protein kinase kinase kinase kinase 3)

Identity

Alias (NCBI)GLK
MAPKKKK3
MEKKK 3
MEKKK3
RAB8IPL1
HGNC (Hugo) MAP4K3
HGNC Alias symbGLK
MAPKKKK3
HGNC Previous nameRAB8IPL1
LocusID (NCBI) 8491
Atlas_Id 41286
Location 2p22.1  [Link to chromosome band 2p22]
Location_base_pair Starts at 39249266 and ends at 39437285 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MALAT1 (11q13.1) / MAP4K3 (2p22.1)MAP4K3 (2p22.1) / HACD4 (9p21.3)MAP4K3 (2p22.1) / MAP4K3 (2p22.1)
MAP4K3 (2p22.1) / PRKCE (2p21)MAP4K3 (2p22.1) / TMEM178A (2p22.1)MAP4K3 (2p22.1) / WDPCP (2p15)
RAB3GAP1 (2q21.3) / MAP4K3 (2p22.1)SOS1 (2p22.1) / MAP4K3 (2p22.1)THADA (2p21) / MAP4K3 (2p22.1)
MAP4K3 2p22.1 PTPLAD2MAP4K3 2p22.1 TMEM178RAB3GAP1 2q21.3 / MAP4K3 2p22.1
SOS1 2p22.1 / MAP4K3 2p22.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MAP4K3   6865
Cards
Entrez_Gene (NCBI)MAP4K3    mitogen-activated protein kinase kinase kinase kinase 3
AliasesGLK; MAPKKKK3; MEKKK; MEKKK3; 
RAB8IPL1
GeneCards (Weizmann)MAP4K3
Ensembl hg19 (Hinxton)ENSG00000011566 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000011566 [Gene_View]  ENSG00000011566 [Sequence]  chr2:39249266-39437285 [Contig_View]  MAP4K3 [Vega]
ICGC DataPortalENSG00000011566
TCGA cBioPortalMAP4K3
AceView (NCBI)MAP4K3
Genatlas (Paris)MAP4K3
SOURCE (Princeton)MAP4K3
Genetics Home Reference (NIH)MAP4K3
Genomic and cartography
GoldenPath hg38 (UCSC)MAP4K3  -     chr2:39249266-39437285 -  2p22.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP4K3  -     2p22.1   [Description]    (hg19-Feb_2009)
GoldenPathMAP4K3 - 2p22.1 [CytoView hg19]  MAP4K3 - 2p22.1 [CytoView hg38]
ImmunoBaseENSG00000011566
Genome Data Viewer NCBIMAP4K3 [Mapview hg19]  
OMIM604921   
Gene and transcription
Genbank (Entrez)AK021553 AK291467 AK299889 AK314487 AK316144
RefSeq transcript (Entrez)NM_001270425 NM_003618
Consensus coding sequences : CCDS (NCBI)MAP4K3
Gene ExpressionMAP4K3 [ NCBI-GEO ]   MAP4K3 [ EBI - ARRAY_EXPRESS ]   MAP4K3 [ SEEK ]   MAP4K3 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP4K3 [ Firebrowse - Broad ]
GenevisibleExpression of MAP4K3 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8491
GTEX Portal (Tissue expression)MAP4K3
Human Protein AtlasENSG00000011566-MAP4K3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8IVH8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8IVH8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8IVH8
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ8IVH8
Domaine pattern : Prosite (Expaxy)CNH (PS50219)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)CNH_dom    Kinase-like_dom_sf    MAPKKKK    Prot_kinase_dom    Protein_kinase_ATP_BS   
Domain families : Pfam (Sanger)CNH (PF00780)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00780    pfam00069   
Domain families : Smart (EMBL)CNH (SM00036)  S_TKc (SM00220)  
Conserved Domain (NCBI)MAP4K3
PDB (RSDB)5J5T   
PDB Europe5J5T   
PDB (PDBSum)5J5T   
PDB (IMB)5J5T   
Structural Biology KnowledgeBase5J5T   
SCOP (Structural Classification of Proteins)5J5T   
CATH (Classification of proteins structures)5J5T   
SuperfamilyQ8IVH8
AlphaFold pdb e-kbQ8IVH8   
Human Protein Atlas [tissue]ENSG00000011566-MAP4K3 [tissue]
HPRD05373
Protein Interaction databases
DIP (DOE-UCLA)Q8IVH8
IntAct (EBI)Q8IVH8
BioGRIDMAP4K3
STRING (EMBL)MAP4K3
ZODIACMAP4K3
Ontologies - Pathways
QuickGOQ8IVH8
Ontology : AmiGOactivation of MAPKKK activity  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  protein phosphorylation  JNK cascade  MAP kinase kinase kinase kinase activity  response to UV  response to tumor necrosis factor  intracellular signal transduction  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIactivation of MAPKKK activity  protein kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  protein phosphorylation  JNK cascade  MAP kinase kinase kinase kinase activity  response to UV  response to tumor necrosis factor  intracellular signal transduction  protein serine kinase activity  protein threonine kinase activity  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkMAP4K3
Atlas of Cancer Signalling NetworkMAP4K3
Wikipedia pathwaysMAP4K3
Orthology - Evolution
OrthoDB8491
GeneTree (enSembl)ENSG00000011566
Phylogenetic Trees/Animal Genes : TreeFamMAP4K3
Homologs : HomoloGeneMAP4K3
Homology/Alignments : Family Browser (UCSC)MAP4K3
Gene fusions - Rearrangements
Fusion : MitelmanMAP4K3/HACD4 [2p22.1/9p21.3]  
Fusion : MitelmanMAP4K3/PRKCE [2p22.1/2p21]  
Fusion : MitelmanMAP4K3/TMEM178A [2p22.1/2p22.1]  
Fusion : MitelmanRAB3GAP1/MAP4K3 [2q21.3/2p22.1]  
Fusion : MitelmanSOS1/MAP4K3 [2p22.1/2p22.1]  
Fusion : MitelmanTHADA/MAP4K3 [2p21/2p22.1]  
Fusion : QuiverMAP4K3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP4K3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP4K3
dbVarMAP4K3
ClinVarMAP4K3
MonarchMAP4K3
1000_GenomesMAP4K3 
Exome Variant ServerMAP4K3
GNOMAD BrowserENSG00000011566
Varsome BrowserMAP4K3
ACMGMAP4K3 variants
VarityQ8IVH8
Genomic Variants (DGV)MAP4K3 [DGVbeta]
DECIPHERMAP4K3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP4K3 
Mutations
ICGC Data PortalMAP4K3 
TCGA Data PortalMAP4K3 
Broad Tumor PortalMAP4K3
OASIS PortalMAP4K3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP4K3  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAP4K3
Mutations and Diseases : HGMDMAP4K3
intOGen PortalMAP4K3
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMAP4K3
DgiDB (Drug Gene Interaction Database)MAP4K3
DoCM (Curated mutations)MAP4K3
CIViC (Clinical Interpretations of Variants in Cancer)MAP4K3
Cancer3DMAP4K3
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604921   
Orphanet
DisGeNETMAP4K3
MedgenMAP4K3
Genetic Testing Registry MAP4K3
NextProtQ8IVH8 [Medical]
GENETestsMAP4K3
Target ValidationMAP4K3
Huge Navigator MAP4K3 [HugePedia]
ClinGenMAP4K3
Clinical trials, drugs, therapy
MyCancerGenomeMAP4K3
Protein Interactions : CTDMAP4K3
Pharm GKB GenePA30611
PharosQ8IVH8
Clinical trialMAP4K3
Miscellaneous
canSAR (ICR)MAP4K3
HarmonizomeMAP4K3
DataMed IndexMAP4K3
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMAP4K3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:17:45 CEST 2021

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