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MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)

Identity

Other namesFLH21957
HGK
MEKKK4
NIK
HGNC (Hugo) MAP4K4
LocusID (NCBI) 9448
Location 2q11.2
Location_base_pair Starts at 102314538 and ends at 102511152 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MAP4K4   6866
Cards
Entrez_Gene (NCBI)MAP4K4  9448  mitogen-activated protein kinase kinase kinase kinase 4
GeneCards (Weizmann)MAP4K4
Ensembl (Hinxton)ENSG00000071054 [Gene_View]  chr2:102314538-102511152 [Contig_View]  MAP4K4 [Vega]
ICGC DataPortalENSG00000071054
cBioPortalMAP4K4
AceView (NCBI)MAP4K4
Genatlas (Paris)MAP4K4
WikiGenes9448
SOURCE (Princeton)NM_001242559 NM_001242560 NM_004834 NM_145686 NM_145687
Genomic and cartography
GoldenPath (UCSC)MAP4K4  -  2q11.2   chr2:102314538-102511152 +  2q11.2   [Description]    (hg19-Feb_2009)
EnsemblMAP4K4 - 2q11.2 [CytoView]
Mapping of homologs : NCBIMAP4K4 [Mapview]
OMIM604666   
Gene and transcription
Genbank (Entrez)AB013385 AB014587 AF096300 AK000380 AK001272
RefSeq transcript (Entrez)NM_001242559 NM_001242560 NM_004834 NM_145686 NM_145687
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NT_022171 NW_001838818 NW_004929303
Consensus coding sequences : CCDS (NCBI)MAP4K4
Cluster EST : UnigeneHs.701013 [ NCBI ]
CGAP (NCI)Hs.701013
Alternative Splicing : Fast-db (Paris)GSHG0016720
Alternative Splicing GalleryENSG00000071054
Gene ExpressionMAP4K4 [ NCBI-GEO ]     MAP4K4 [ SEEK ]   MAP4K4 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95819 (Uniprot)
NextProtO95819  [Medical]
With graphics : InterProO95819
Splice isoforms : SwissVarO95819 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)CNH (PS50219)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Citron [organisation]   Kinase-like_dom [organisation]   Prot_kinase_dom [organisation]   Protein_kinase_ATP_BS [organisation]   Ser/Thr_dual-sp_kinase_dom [organisation]   Ser/Thr_kinase_AS [organisation]  
Related proteins : CluSTrO95819
Domain families : Pfam (Sanger)CNH (PF00780)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00780    pfam00069   
Domain families : Smart (EMBL)CNH (SM00036)  S_TKc (SM00220)  
DMDM Disease mutations9448
Blocks (Seattle)O95819
Human Protein AtlasENSG00000071054 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO95819
HPRD05235
IPIIPI00006752   IPI00219800   IPI00639883   IPI00219802   IPI00927735   IPI00015777   IPI01021877   IPI01020880   IPI00604647   IPI00219799   IPI00952975   IPI00924942   
Protein Interaction databases
DIP (DOE-UCLA)O95819
IntAct (EBI)O95819
FunCoupENSG00000071054
BioGRIDMAP4K4
InParanoidO95819
Interologous Interaction database O95819
IntegromeDBMAP4K4
STRING (EMBL)MAP4K4
Ontologies - Pathways
Ontology : AmiGOprotein serine/threonine kinase activity  small GTPase regulator activity  protein binding  ATP binding  cytoplasm  protein phosphorylation  response to stress  intracellular protein kinase cascade  regulation of JNK cascade  
Ontology : EGO-EBIprotein serine/threonine kinase activity  small GTPase regulator activity  protein binding  ATP binding  cytoplasm  protein phosphorylation  response to stress  intracellular protein kinase cascade  regulation of JNK cascade  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway   
Protein Interaction DatabaseMAP4K4
Wikipedia pathwaysMAP4K4
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MAP4K4
snp3D : Map Gene to Disease9448
SNP (GeneSNP Utah)MAP4K4
SNP : HGBaseMAP4K4
Genetic variants : HAPMAPMAP4K4
Exome VariantMAP4K4
1000_GenomesMAP4K4 
ICGC programENSG00000071054 
Somatic Mutations in Cancer : COSMICMAP4K4 
CONAN: Copy Number AnalysisMAP4K4 
Mutations and Diseases : HGMDMAP4K4
Genomic VariantsMAP4K4  MAP4K4 [DGVbeta]
dbVarMAP4K4
ClinVarMAP4K4
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM604666   
MedgenMAP4K4
GENETestsMAP4K4
Disease Genetic AssociationMAP4K4
Huge Navigator MAP4K4 [HugePedia]  MAP4K4 [HugeCancerGEM]
General knowledge
Homologs : HomoloGeneMAP4K4
Homology/Alignments : Family Browser (UCSC)MAP4K4
Phylogenetic Trees/Animal Genes : TreeFamMAP4K4
Chemical/Protein Interactions : CTD9448
Chemical/Pharm GKB GenePA30612
Clinical trialMAP4K4
Cancer Resource (Charite)ENSG00000071054
Other databases
Probes
Litterature
PubMed42 Pubmed reference(s) in Entrez
CoreMineMAP4K4
iHOPMAP4K4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jul 11 17:04:47 CEST 2014

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