Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)

Identity

Other namesFLH21957
HEL-S-31
HGK
MEKKK4
NIK
HGNC (Hugo) MAP4K4
LocusID (NCBI) 9448
Atlas_Id 41287
Location 2q11.2
Location_base_pair Starts at 102314538 and ends at 102511152 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MAP4K4   6866
Cards
Entrez_Gene (NCBI)MAP4K4  9448  mitogen-activated protein kinase kinase kinase kinase 4
GeneCards (Weizmann)MAP4K4
Ensembl hg19 (Hinxton)ENSG00000071054 [Gene_View]  chr2:102314538-102511152 [Contig_View]  MAP4K4 [Vega]
Ensembl hg38 (Hinxton)ENSG00000071054 [Gene_View]  chr2:102314538-102511152 [Contig_View]  MAP4K4 [Vega]
ICGC DataPortalENSG00000071054
TCGA cBioPortalMAP4K4
AceView (NCBI)MAP4K4
Genatlas (Paris)MAP4K4
WikiGenes9448
SOURCE (Princeton)MAP4K4
Genomic and cartography
GoldenPath hg19 (UCSC)MAP4K4  -     chr2:102314538-102511152 +  2q11.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)MAP4K4  -     2q11.2   [Description]    (hg38-Dec_2013)
EnsemblMAP4K4 - 2q11.2 [CytoView hg19]  MAP4K4 - 2q11.2 [CytoView hg38]
Mapping of homologs : NCBIMAP4K4 [Mapview hg19]  MAP4K4 [Mapview hg38]
OMIM604666   
Gene and transcription
Genbank (Entrez)AB013385 AB014587 AF096300 AK000380 AK001272
RefSeq transcript (Entrez)NM_001242559 NM_001242560 NM_004834 NM_145686 NM_145687
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929303
Consensus coding sequences : CCDS (NCBI)MAP4K4
Cluster EST : UnigeneHs.701013 [ NCBI ]
CGAP (NCI)Hs.701013
Alternative Splicing : Fast-db (Paris)GSHG0016720
Alternative Splicing GalleryENSG00000071054
Gene ExpressionMAP4K4 [ NCBI-GEO ]     MAP4K4 [ SEEK ]   MAP4K4 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95819 (Uniprot)
NextProtO95819  [Medical]
With graphics : InterProO95819
Splice isoforms : SwissVarO95819 (Swissvar)
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)CNH (PS50219)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Citron    Kinase-like_dom    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase    Ser/Thr_kinase_AS   
Related proteins : CluSTrO95819
Domain families : Pfam (Sanger)CNH (PF00780)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00780    pfam00069   
Domain families : Smart (EMBL)CNH (SM00036)  S_TKc (SM00220)  
DMDM Disease mutations9448
Blocks (Seattle)O95819
PDB (SRS)4OBO    4OBP    4OBQ    4U43    4U44    4U45   
PDB (PDBSum)4OBO    4OBP    4OBQ    4U43    4U44    4U45   
PDB (IMB)4OBO    4OBP    4OBQ    4U43    4U44    4U45   
PDB (RSDB)4OBO    4OBP    4OBQ    4U43    4U44    4U45   
Human Protein AtlasENSG00000071054
Peptide AtlasO95819
HPRD05235
IPIIPI00006752   IPI00219800   IPI00639883   IPI00219802   IPI00927735   IPI00015777   IPI01021877   IPI01020880   IPI00604647   IPI00219799   IPI00952975   IPI00924942   
Protein Interaction databases
DIP (DOE-UCLA)O95819
IntAct (EBI)O95819
FunCoupENSG00000071054
BioGRIDMAP4K4
IntegromeDBMAP4K4
STRING (EMBL)MAP4K4
Ontologies - Pathways
QuickGOO95819
Ontology : AmiGOcreatine kinase activity  protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  protein phosphorylation  signal transduction by phosphorylation  microvillus assembly  intracellular signal transduction  negative regulation of apoptotic process  regulation of JNK cascade  
Ontology : EGO-EBIcreatine kinase activity  protein serine/threonine kinase activity  receptor signaling protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  protein phosphorylation  signal transduction by phosphorylation  microvillus assembly  intracellular signal transduction  negative regulation of apoptotic process  regulation of JNK cascade  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway   
Protein Interaction DatabaseMAP4K4
DoCM (Curated mutations)MAP4K4
Wikipedia pathwaysMAP4K4
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerMAP4K4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP4K4
dbVarMAP4K4
ClinVarMAP4K4
1000_GenomesMAP4K4 
Exome Variant ServerMAP4K4
SNP (GeneSNP Utah)MAP4K4
SNP : HGBaseMAP4K4
Genetic variants : HAPMAPMAP4K4
Genomic Variants (DGV)MAP4K4 [DGVbeta]
Mutations
ICGC Data PortalMAP4K4 
TCGA Data PortalMAP4K4 
Tumor PortalMAP4K4
Somatic Mutations in Cancer : COSMICMAP4K4 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)2:102314538-102511152
CONAN: Copy Number AnalysisMAP4K4 
Mutations and Diseases : HGMDMAP4K4
OMIM604666   
MedgenMAP4K4
NextProtO95819 [Medical]
GENETestsMAP4K4
Disease Genetic AssociationMAP4K4
Huge Navigator MAP4K4 [HugePedia]  MAP4K4 [HugeCancerGEM]
snp3D : Map Gene to Disease9448
DGIdb (Drug Gene Interaction db)MAP4K4
General knowledge
Homologs : HomoloGeneMAP4K4
Homology/Alignments : Family Browser (UCSC)MAP4K4
Phylogenetic Trees/Animal Genes : TreeFamMAP4K4
Chemical/Protein Interactions : CTD9448
Chemical/Pharm GKB GenePA30612
Clinical trialMAP4K4
Cancer Resource (Charite)ENSG00000071054
Other databases
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
CoreMineMAP4K4
GoPubMedMAP4K4
iHOPMAP4K4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 14:44:52 CEST 2015

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.