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MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)

Identity

Other namesFLH21957
HGK
MEKKK4
NIK
HGNC (Hugo) MAP4K4
LocusID (NCBI) 9448
Location 2q11.2
Location_base_pair Starts at 102314538 and ends at 102511152 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)MAP4K4   6866
Entrez_Gene (NCBI)MAP4K4  9448  mitogen-activated protein kinase kinase kinase kinase 4
Cards
GeneCards (Weizmann)MAP4K4
Ensembl (Hinxton) [Gene_View]  chr2:102314538-102511152 [Contig_View]  MAP4K4 [Vega]
AceView (NCBI)MAP4K4
Genatlas (Paris)MAP4K4
SOURCE (Stanford)NM_001242559 NM_001242560 NM_004834 NM_145686 NM_145687
Genomic and cartography
GoldenPath (UCSC)MAP4K4  -  2q11.2   chr2:102314538-102511152 +  2q11.2   [Description]    (hg19-Feb_2009)
EnsemblMAP4K4 - 2q11.2 [CytoView]
Mapping of homologs : NCBIMAP4K4 [Mapview]
OMIM604666   
Gene and transcription
Genbank (Entrez)AB013385 AB014587 AF096300 AK000380 AK001272
RefSeq transcript (SRS)NM_001242559 NM_001242560 NM_004834 NM_145686 NM_145687
RefSeq transcript (Entrez)NM_001242559 NM_001242560 NM_004834 NM_145686 NM_145687
RefSeq genomic (SRS)AC_000134 NC_000002 NC_018913 NT_022171 NW_001838818 NW_004078008
RefSeq genomic (Entrez)AC_000134 NC_000002 NC_018913 NT_022171 NW_001838818 NW_004078008
Consensus coding sequences : CCDS (NCBI)MAP4K4
Cluster EST : UnigeneHs.701013 [ SRS ] Hs.701013 [ NCBI ]
CGAP (NCI)Hs.701013
Alternative Splicing : Fast-db (Paris)GSHG0016720
Gene ExpressionMAP4K4 [ NCBI-GEO ]   MAP4K4 [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95819 (SRS) O95819 (Uniprot)
NextProtO95819
With graphics : InterProO95819
Splice isoforms : SwissVarO95819(Swissvar)
Domaine pattern : Prosite (SRS)CNH (PS50219)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domaine pattern : Prosite (Expaxy)CNH (PS50219)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (SRS)Citron    Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Domains : Interpro (EBI)Citron    Kinase-like_dom    Prot_kinase_cat_dom    Protein_kinase_ATP_BS    Ser/Thr_dual-sp_kinase_dom    Ser/Thr_kinase_AS   
Related proteins : CluSTrO95819
Domain families : Pfam (SRS)CNH (PF00780)    Pkinase (PF00069)   
Domain families : Pfam (Sanger)CNH (PF00780)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00780    pfam00069   
Domain families : Smart (EMBL)CNH (SM00036)  S_TKc (SM00220)  
DMDM9448
Blocks (Seattle)O95819
HPRD05235
IPIIPI00006752   IPI00219800   IPI00639883   IPI00219802   IPI00927735   IPI00015777   IPI01021877   IPI01020880   IPI00604647   IPI00219799   IPI00952975   IPI00924942   
Protein Interaction databases
DIP (DOE-UCLA)O95819
IntAct (EBI)O95819
REACTOMEMAP4K4
Protein Interaction Database9448
BioGRIDMAP4K4
InParanoidO95819
Interologous Interaction database O95819
IntegromeDBMAP4K4
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)MAP4K4
SNP (GeneSNP Utah)MAP4K4
SNP : HGBaseMAP4K4
Genetic variants : HAPMAPMAP4K4
Somatic Mutations in Cancer : COSMICMAP4K4 
CONAN: Copy Number AnalysisMAP4K4 
Mutations and Diseases : HGMDMAP4K4
OMIM604666   
GENETests604666   
Disease Genetic AssociationMAP4K4
Huge Navigator MAP4K4 [HugePedia]  MAP4K4 [HugeCancerGEM]
Genomic VariantsMAP4K4  MAP4K4 [DGVbeta]
ClinVarMAP4K4
snp3D : Map Gene to Disease9448
General knowledge
Homologs : HomoloGeneMAP4K4
Homology/Alignments : Family Browser (UCSC)MAP4K4
Phylogenetic Trees/Animal Genes : TreeFamMAP4K4
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.1 [ Enzyme-SRS ]   2.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   
Chemical/Protein Interactions : CTD9448
Chemical/Pharm GKB GenePA30612
Clinical trialMAP4K4
Ontology : AmiGOprotein serine/threonine kinase activity  small GTPase regulator activity  protein binding  ATP binding  cytoplasm  protein phosphorylation  response to stress  intracellular protein kinase cascade  regulation of JNK cascade  
Ontology : EGO-EBIprotein serine/threonine kinase activity  small GTPase regulator activity  protein binding  ATP binding  cytoplasm  protein phosphorylation  response to stress  intracellular protein kinase cascade  regulation of JNK cascade  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway
Other databases
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
PubGeneMAP4K4
iHOPMAP4K4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 14 17:50:15 CEST 2013
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