Identity
HGNC
LOCATION
2q11.2
LOCUSID
ALIAS
FLH21957,HEL-S-31,HGK,MEKKK4,NIK
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 9448
MIM: 604666
HGNC: 6866
Ensembl: ENSG00000071054
Variants:
dbSNP: 9448
ClinVar: 9448
TCGA: ENSG00000071054
COSMIC: MAP4K4
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA443560 | Breast Neoplasms | Disease | ClinicalAnnotation | associated | PD | ||
| PA448432 | anastrozole | Chemical | ClinicalAnnotation | associated | PD | ||
| PA449563 | exemestane | Chemical | ClinicalAnnotation | associated | PD |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38383842 | 2024 | MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFβ2-Smad2/3 signaling pathway in cervical cancer. | 0 |
| 38643333 | 2024 | FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner. | 0 |
| 38679877 | 2024 | Syndromic craniosynostosis caused by a novel missense variant in MAP4K4: Expanding the genotype-phenotype relationship in RASopathies. | 0 |
| 38724987 | 2024 | MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1. | 1 |
| 38383842 | 2024 | MAP4K4 and WT1 mediate SOX6-induced cellular senescence by synergistically activating the ATF2-TGFβ2-Smad2/3 signaling pathway in cervical cancer. | 0 |
| 38643333 | 2024 | FTO promotes gastric cancer progression by modulating MAP4K4 expression via demethylation in an m6A-dependent manner. | 0 |
| 38679877 | 2024 | Syndromic craniosynostosis caused by a novel missense variant in MAP4K4: Expanding the genotype-phenotype relationship in RASopathies. | 0 |
| 38724987 | 2024 | MAP4K4 exacerbates cardiac microvascular injury in diabetes by facilitating S-nitrosylation modification of Drp1. | 1 |
| 36469137 | 2023 | Integrated exome and transcriptome analysis prioritizes MAP4K4 de novo frameshift variants in autism spectrum disorder as a novel disease-gene association. | 3 |
| 36922678 | 2023 | MAP4K4 promotes ovarian cancer metastasis through diminishing ADAM10-dependent N-cadherin cleavage. | 5 |
| 37126546 | 2023 | Abrogation of MAP4K4 protein function causes congenital anomalies in humans and zebrafish. | 0 |
| 37312710 | 2023 | Evaluation of the Role of MAP4K4 in Focal Adhesion Dynamics and Regulation of Cell Migration of Breast Cancer Cell Line MDA-MB-231. | 0 |
| 37442529 | 2023 | CircCPSF6 promotes hepatocellular carcinoma cancer progression by regulating MAP4K4 through sponging miR-145-5p. | 1 |
| 36469137 | 2023 | Integrated exome and transcriptome analysis prioritizes MAP4K4 de novo frameshift variants in autism spectrum disorder as a novel disease-gene association. | 3 |
| 36922678 | 2023 | MAP4K4 promotes ovarian cancer metastasis through diminishing ADAM10-dependent N-cadherin cleavage. | 5 |
Citation
Dessen P
MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)
Atlas Genet Cytogenet Oncol Haematol. 2003-11-01
Online version: http://atlasgeneticsoncology.org/gene/41287/map4k4
