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MAP4K4 (mitogen-activated protein kinase kinase kinase kinase 4)

Identity

Alias (NCBI)FLH21957
HEL-S-31
HGK
MEKKK4
NIK
HGNC (Hugo) MAP4K4
HGNC Alias symbHGK
NIK
FLH21957
HGNC Alias nameHPK/GCK-like kinase
 hepatocyte progenitor kinase-like/germinal center kinase-like kinase
LocusID (NCBI) 9448
Atlas_Id 41287
Location 2q11.2  [Link to chromosome band 2q11]
Location_base_pair Starts at 101697707 and ends at 101894690 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
LRRC59 (17q21.33) / MAP4K4 (2q11.2)MAP4K4 (2q11.2) / ASH1L (1q22)MAP4K4 (2q11.2) / MAP4K4 (2q11.2)
MAP4K4 (2q11.2) / MUCL1 (12q13.2)MAP4K4 (2q11.2) / PPM1A (14q23.1)NCL (2q37.1) / MAP4K4 (2q11.2)
P4HB (17q25.3) / MAP4K4 (2q11.2)PKP4 (2q24.1) / MAP4K4 (2q11.2)PPP2R5E (14q23.2) / MAP4K4 (2q11.2)
MAP4K4 2q11.2 / MUCL1 12q13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)MAP4K4   6866
Cards
Entrez_Gene (NCBI)MAP4K4    mitogen-activated protein kinase kinase kinase kinase 4
AliasesFLH21957; HEL-S-31; HGK; MEKKK4; 
NIK
GeneCards (Weizmann)MAP4K4
Ensembl hg19 (Hinxton)ENSG00000071054 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000071054 [Gene_View]  ENSG00000071054 [Sequence]  chr2:101697707-101894690 [Contig_View]  MAP4K4 [Vega]
ICGC DataPortalENSG00000071054
TCGA cBioPortalMAP4K4
AceView (NCBI)MAP4K4
Genatlas (Paris)MAP4K4
SOURCE (Princeton)MAP4K4
Genetics Home Reference (NIH)MAP4K4
Genomic and cartography
GoldenPath hg38 (UCSC)MAP4K4  -     chr2:101697707-101894690 +  2q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAP4K4  -     2q11.2   [Description]    (hg19-Feb_2009)
GoldenPathMAP4K4 - 2q11.2 [CytoView hg19]  MAP4K4 - 2q11.2 [CytoView hg38]
ImmunoBaseENSG00000071054
Genome Data Viewer NCBIMAP4K4 [Mapview hg19]  
OMIM604666   
Gene and transcription
Genbank (Entrez)AB013385 AB014587 AF096300 AK000380 AK001272
RefSeq transcript (Entrez)NM_001242559 NM_001242560 NM_001384476 NM_001384477 NM_001384478 NM_001384481 NM_001384482 NM_001384483 NM_001384484 NM_001384485 NM_001384486 NM_001384487 NM_001384488 NM_001384490 NM_001384491 NM_001384492 NM_001384493 NM_001384494 NM_001384495 NM_001384496 NM_001384497 NM_001384506 NM_001384507 NM_001384508 NM_001384509 NM_001384520 NM_001384543 NM_001384548 NM_001384549 NM_001384550 NM_001384551 NM_001384552 NM_001384553 NM_001384554 NM_001384555 NM_001384556 NM_001384557 NM_001384558 NM_001384559 NM_001384560 NM_001384561 NM_001384562 NM_001384563 NM_001384564 NM_001384567 NM_001384572 NM_001384579 NM_001395002 NM_004834 NM_145686 NM_145687
Consensus coding sequences : CCDS (NCBI)MAP4K4
Gene ExpressionMAP4K4 [ NCBI-GEO ]   MAP4K4 [ EBI - ARRAY_EXPRESS ]   MAP4K4 [ SEEK ]   MAP4K4 [ MEM ]
Gene Expression Viewer (FireBrowse)MAP4K4 [ Firebrowse - Broad ]
GenevisibleExpression of MAP4K4 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)9448
GTEX Portal (Tissue expression)MAP4K4
Human Protein AtlasENSG00000071054-MAP4K4 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95819   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95819  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95819
Catalytic activity : Enzyme2.7.11.1 [ Enzyme-Expasy ]   2.7.11.12.7.11.1 [ IntEnz-EBI ]   2.7.11.1 [ BRENDA ]   2.7.11.1 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusO95819
Domaine pattern : Prosite (Expaxy)CNH (PS50219)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)CNH_dom    Kinase-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)CNH (PF00780)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00780    pfam00069   
Domain families : Smart (EMBL)CNH (SM00036)  S_TKc (SM00220)  
Conserved Domain (NCBI)MAP4K4
PDB (RSDB)4OBO    4OBP    4OBQ    4RVT    4U3Y    4U3Z    4U40    4U41    4U42    4U43    4U44    4U45    4ZK5    4ZP5    5DI1    5J95    5W5Q   
PDB Europe4OBO    4OBP    4OBQ    4RVT    4U3Y    4U3Z    4U40    4U41    4U42    4U43    4U44    4U45    4ZK5    4ZP5    5DI1    5J95    5W5Q   
PDB (PDBSum)4OBO    4OBP    4OBQ    4RVT    4U3Y    4U3Z    4U40    4U41    4U42    4U43    4U44    4U45    4ZK5    4ZP5    5DI1    5J95    5W5Q   
PDB (IMB)4OBO    4OBP    4OBQ    4RVT    4U3Y    4U3Z    4U40    4U41    4U42    4U43    4U44    4U45    4ZK5    4ZP5    5DI1    5J95    5W5Q   
Structural Biology KnowledgeBase4OBO    4OBP    4OBQ    4RVT    4U3Y    4U3Z    4U40    4U41    4U42    4U43    4U44    4U45    4ZK5    4ZP5    5DI1    5J95    5W5Q   
SCOP (Structural Classification of Proteins)4OBO    4OBP    4OBQ    4RVT    4U3Y    4U3Z    4U40    4U41    4U42    4U43    4U44    4U45    4ZK5    4ZP5    5DI1    5J95    5W5Q   
CATH (Classification of proteins structures)4OBO    4OBP    4OBQ    4RVT    4U3Y    4U3Z    4U40    4U41    4U42    4U43    4U44    4U45    4ZK5    4ZP5    5DI1    5J95    5W5Q   
SuperfamilyO95819
AlphaFold pdb e-kbO95819   
Human Protein Atlas [tissue]ENSG00000071054-MAP4K4 [tissue]
HPRD05235
Protein Interaction databases
DIP (DOE-UCLA)O95819
IntAct (EBI)O95819
BioGRIDMAP4K4
STRING (EMBL)MAP4K4
ZODIACMAP4K4
Ontologies - Pathways
QuickGOO95819
Ontology : AmiGOMAPK cascade  negative regulation of cell-matrix adhesion  creatine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytoplasm  focal adhesion  protein phosphorylation  protein phosphorylation  microtubule binding  microvillus assembly  positive regulation of cell migration  positive regulation of ARF protein signal transduction  activation of protein kinase activity  intracellular signal transduction  intracellular signal transduction  negative regulation of apoptotic process  regulation of MAPK cascade  positive regulation of GTPase activity  regulation of JNK cascade  neuron projection morphogenesis  positive regulation of keratinocyte migration  positive regulation of focal adhesion assembly  negative regulation of insulin secretion involved in cellular response to glucose stimulus  negative regulation of neuron projection regeneration  protein serine kinase activity  protein threonine kinase activity  positive regulation of focal adhesion disassembly  
Ontology : EGO-EBIMAPK cascade  negative regulation of cell-matrix adhesion  creatine kinase activity  protein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  cytoplasm  cytoplasm  focal adhesion  protein phosphorylation  protein phosphorylation  microtubule binding  microvillus assembly  positive regulation of cell migration  positive regulation of ARF protein signal transduction  activation of protein kinase activity  intracellular signal transduction  intracellular signal transduction  negative regulation of apoptotic process  regulation of MAPK cascade  positive regulation of GTPase activity  regulation of JNK cascade  neuron projection morphogenesis  positive regulation of keratinocyte migration  positive regulation of focal adhesion assembly  negative regulation of insulin secretion involved in cellular response to glucose stimulus  negative regulation of neuron projection regeneration  protein serine kinase activity  protein threonine kinase activity  positive regulation of focal adhesion disassembly  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]   
Pathways : KEGGMAPK signaling pathway   
NDEx NetworkMAP4K4
Atlas of Cancer Signalling NetworkMAP4K4
Wikipedia pathwaysMAP4K4
Orthology - Evolution
OrthoDB9448
GeneTree (enSembl)ENSG00000071054
Phylogenetic Trees/Animal Genes : TreeFamMAP4K4
Homologs : HomoloGeneMAP4K4
Homology/Alignments : Family Browser (UCSC)MAP4K4
Gene fusions - Rearrangements
Fusion : MitelmanMAP4K4/MUCL1 [2q11.2/12q13.2]  
Fusion : QuiverMAP4K4
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAP4K4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAP4K4
dbVarMAP4K4
ClinVarMAP4K4
MonarchMAP4K4
1000_GenomesMAP4K4 
Exome Variant ServerMAP4K4
GNOMAD BrowserENSG00000071054
Varsome BrowserMAP4K4
ACMGMAP4K4 variants
VarityO95819
Genomic Variants (DGV)MAP4K4 [DGVbeta]
DECIPHERMAP4K4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAP4K4 
Mutations
ICGC Data PortalMAP4K4 
TCGA Data PortalMAP4K4 
Broad Tumor PortalMAP4K4
OASIS PortalMAP4K4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAP4K4  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAP4K4
Mutations and Diseases : HGMDMAP4K4
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMAP4K4
DgiDB (Drug Gene Interaction Database)MAP4K4
DoCM (Curated mutations)MAP4K4
CIViC (Clinical Interpretations of Variants in Cancer)MAP4K4
Cancer3DMAP4K4
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604666   
Orphanet
DisGeNETMAP4K4
MedgenMAP4K4
Genetic Testing Registry MAP4K4
NextProtO95819 [Medical]
GENETestsMAP4K4
Target ValidationMAP4K4
Huge Navigator MAP4K4 [HugePedia]
ClinGenMAP4K4
Clinical trials, drugs, therapy
MyCancerGenomeMAP4K4
Protein Interactions : CTDMAP4K4
Pharm GKB GenePA30612
PharosO95819
Clinical trialMAP4K4
Miscellaneous
canSAR (ICR)MAP4K4
HarmonizomeMAP4K4
DataMed IndexMAP4K4
Probes
Litterature
PubMed96 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMAP4K4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Oct 4 15:17:45 CEST 2021

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