MAP6 (microtubule associated protein 6)

2014-11-01  

Identity

HGNC
MAP6
LOCATION
11q13.5
LOCUSID
4135
ALIAS
MAP6-N,MTAP6,N-STOP,STOP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4135
MIM: 601783
HGNC: 6868
Ensembl: ENSG00000171533

Variants:

dbSNP: 4135
ClinVar: 4135
TCGA: ENSG00000171533
COSMIC: MAP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000171533ENST00000304771Q96JE9
ENSG00000171533ENST00000434603Q96JE9
ENSG00000171533ENST00000526740Q96JE9

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
191655272009Prefrontal cortex shotgun proteome analysis reveals altered calcium homeostasis and immune system imbalance in schizophrenia.56
243575812014The FTLD risk factor TMEM106B and MAP6 control dendritic trafficking of lysosomes.45
229043212012MAP6-F is a temperature sensor that directly binds to and protects microtubules from cold-induced depolymerization.18
166245262006Genetic and expression analyses of the STOP (MAP6) gene in schizophrenia.15
238316862013Structural basis for the association of MAP6 protein with microtubules and its regulation by calmodulin.10
275413462016Reduced plasma levels of microtubule-associated STOP/MAP6 protein in autistic patients.4

Citation

Dessen P

MAP6 (microtubule associated protein 6)

Atlas Genet Cytogenet Oncol Haematol. 2014-11-01

Online version: http://atlasgeneticsoncology.org/gene/68796/map6