Atlas of Genetics and Cytogenetics in Oncology and Haematology

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MAPK11 (mitogen-activated protein kinase 11)

Identity

Alias (NCBI)P38B
P38BETA2
PRKM11
SAPK2
SAPK2B
p38-2
p38Beta
HGNC (Hugo) MAPK11
HGNC Alias symbp38-2
p38Beta
SAPK2
HGNC Previous namePRKM11
LocusID (NCBI) 5600
Atlas_Id 41289
Location 22q13.33  [Link to chromosome band 22q13]
Location_base_pair Starts at 50263713 and ends at 50270380 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  dic(9;17)(p13;q11) PAX5/TAOK1

External links

 

Nomenclature
HGNC (Hugo)MAPK11   6873
Cards
Entrez_Gene (NCBI)MAPK11    mitogen-activated protein kinase 11
AliasesP38B; P38BETA2; PRKM11; SAPK2; 
SAPK2B; p38-2; p38Beta
GeneCards (Weizmann)MAPK11
Ensembl hg19 (Hinxton)ENSG00000185386 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000185386 [Gene_View]  ENSG00000185386 [Sequence]  chr22:50263713-50270380 [Contig_View]  MAPK11 [Vega]
ICGC DataPortalENSG00000185386
TCGA cBioPortalMAPK11
AceView (NCBI)MAPK11
Genatlas (Paris)MAPK11
SOURCE (Princeton)MAPK11
Genetics Home Reference (NIH)MAPK11
Genomic and cartography
GoldenPath hg38 (UCSC)MAPK11  -     chr22:50263713-50270380 -  22q13.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)MAPK11  -     22q13.33   [Description]    (hg19-Feb_2009)
GoldenPathMAPK11 - 22q13.33 [CytoView hg19]  MAPK11 - 22q13.33 [CytoView hg38]
ImmunoBaseENSG00000185386
Genome Data Viewer NCBIMAPK11 [Mapview hg19]  
OMIM602898   
Gene and transcription
Genbank (Entrez)AF001008 AF001174 AF031135 AK291845 AK299745
RefSeq transcript (Entrez)NM_002751
Consensus coding sequences : CCDS (NCBI)MAPK11
Gene ExpressionMAPK11 [ NCBI-GEO ]   MAPK11 [ EBI - ARRAY_EXPRESS ]   MAPK11 [ SEEK ]   MAPK11 [ MEM ]
Gene Expression Viewer (FireBrowse)MAPK11 [ Firebrowse - Broad ]
GenevisibleExpression of MAPK11 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5600
GTEX Portal (Tissue expression)MAPK11
Human Protein AtlasENSG00000185386-MAPK11 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15759   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15759  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15759
Catalytic activity : Enzyme2.7.11.24 [ Enzyme-Expasy ]   2.7.11.242.7.11.24 [ IntEnz-EBI ]   2.7.11.24 [ BRENDA ]   2.7.11.24 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ15759
Domaine pattern : Prosite (Expaxy)MAPK (PS01351)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)   
Domains : Interpro (EBI)Kinase-like_dom_sf    MAP_kinase_CS    MAPK_p38-like    Prot_kinase_dom    Protein_kinase_ATP_BS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)MAPK11
PDB (RSDB)3GC8    3GC9    3GP0   
PDB Europe3GC8    3GC9    3GP0   
PDB (PDBSum)3GC8    3GC9    3GP0   
PDB (IMB)3GC8    3GC9    3GP0   
Structural Biology KnowledgeBase3GC8    3GC9    3GP0   
SCOP (Structural Classification of Proteins)3GC8    3GC9    3GP0   
CATH (Classification of proteins structures)3GC8    3GC9    3GP0   
SuperfamilyQ15759
AlphaFold pdb e-kbQ15759   
Human Protein Atlas [tissue]ENSG00000185386-MAPK11 [tissue]
HPRD04208
Protein Interaction databases
DIP (DOE-UCLA)Q15759
IntAct (EBI)Q15759
BioGRIDMAPK11
STRING (EMBL)MAPK11
ZODIACMAPK11
Ontologies - Pathways
QuickGOQ15759
Ontology : AmiGOactivation of MAPK activity  osteoblast differentiation  protein serine/threonine kinase activity  MAP kinase activity  MAP kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  protein phosphorylation  Ras protein signal transduction  positive regulation of gene expression  phosphatase activator activity  positive regulation of interleukin-12 production  intracellular signal transduction  positive regulation of erythrocyte differentiation  vascular endothelial growth factor receptor signaling pathway  regulation of DNA-binding transcription factor activity  positive regulation of muscle cell differentiation  stress-activated MAPK cascade  negative regulation of cardiac muscle cell proliferation  bone development  cellular response to interleukin-1  cellular response to virus  protein serine kinase activity  protein threonine kinase activity  regulation of signal transduction by p53 class mediator  
Ontology : EGO-EBIactivation of MAPK activity  osteoblast differentiation  protein serine/threonine kinase activity  MAP kinase activity  MAP kinase activity  protein binding  ATP binding  nucleus  nucleoplasm  cytoplasm  cytosol  protein phosphorylation  Ras protein signal transduction  positive regulation of gene expression  phosphatase activator activity  positive regulation of interleukin-12 production  intracellular signal transduction  positive regulation of erythrocyte differentiation  vascular endothelial growth factor receptor signaling pathway  regulation of DNA-binding transcription factor activity  positive regulation of muscle cell differentiation  stress-activated MAPK cascade  negative regulation of cardiac muscle cell proliferation  bone development  cellular response to interleukin-1  cellular response to virus  protein serine kinase activity  protein threonine kinase activity  regulation of signal transduction by p53 class mediator  
Pathways : BIOCARTAMAPKinase Signaling Pathway [Genes]    NFkB activation by Nontypeable Hemophilus influenzae [Genes]   
Pathways : KEGGMAPK signaling pathway    Rap1 signaling pathway    FoxO signaling pathway    Adrenergic signaling in cardiomyocytes    VEGF signaling pathway    Osteoclast differentiation    Toll-like receptor signaling pathway    NOD-like receptor signaling pathway    RIG-I-like receptor signaling pathway    T cell receptor signaling pathway    Fc epsilon RI signaling pathway    TNF signaling pathway    Leukocyte transendothelial migration    Neurotrophin signaling pathway    Retrograde endocannabinoid signaling    Dopaminergic synapse    GnRH signaling pathway    Progesterone-mediated oocyte maturation    Prolactin signaling pathway    Amyotrophic lateral sclerosis (ALS)    Epithelial cell signaling in Helicobacter pylori infection    Shigellosis    Salmonella infection    Pertussis    Leishmaniasis    Chagas disease (American trypanosomiasis)    Toxoplasmosis    Tuberculosis    Hepatitis C    Influenza A    Epstein-Barr virus infection    Proteoglycans in cancer   
NDEx NetworkMAPK11
Atlas of Cancer Signalling NetworkMAPK11
Wikipedia pathwaysMAPK11
Orthology - Evolution
OrthoDB5600
GeneTree (enSembl)ENSG00000185386
Phylogenetic Trees/Animal Genes : TreeFamMAPK11
Homologs : HomoloGeneMAPK11
Homology/Alignments : Family Browser (UCSC)MAPK11
Gene fusions - Rearrangements
Fusion : QuiverMAPK11
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerMAPK11 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)MAPK11
dbVarMAPK11
ClinVarMAPK11
MonarchMAPK11
1000_GenomesMAPK11 
Exome Variant ServerMAPK11
GNOMAD BrowserENSG00000185386
Varsome BrowserMAPK11
ACMGMAPK11 variants
VarityQ15759
Genomic Variants (DGV)MAPK11 [DGVbeta]
DECIPHERMAPK11 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisMAPK11 
Mutations
ICGC Data PortalMAPK11 
TCGA Data PortalMAPK11 
Broad Tumor PortalMAPK11
OASIS PortalMAPK11 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICMAPK11  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DMAPK11
Mutations and Diseases : HGMDMAPK11
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaMAPK11
DgiDB (Drug Gene Interaction Database)MAPK11
DoCM (Curated mutations)MAPK11
CIViC (Clinical Interpretations of Variants in Cancer)MAPK11
Cancer3DMAPK11
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602898   
Orphanet
DisGeNETMAPK11
MedgenMAPK11
Genetic Testing Registry MAPK11
NextProtQ15759 [Medical]
GENETestsMAPK11
Target ValidationMAPK11
Huge Navigator MAPK11 [HugePedia]
ClinGenMAPK11
Clinical trials, drugs, therapy
MyCancerGenomeMAPK11
Protein Interactions : CTDMAPK11
Pharm GKB GenePA30618
Pharm GKB PathwaysPA2032   
PharosQ15759
Clinical trialMAPK11
Miscellaneous
canSAR (ICR)MAPK11
HarmonizomeMAPK11
DataMed IndexMAPK11
Probes
Litterature
PubMed126 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXMAPK11
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Mon Oct 4 15:17:46 CEST 2021
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